Кл.слова (ненормированные):
Angiogenesis in vitro -- Brain microvessel endothelial cells -- Form factor -- Fractal dimension -- Gelatin scaffold -- Bioinformatics -- Biomedical engineering -- Blood vessels -- Brain -- Cells -- Cytology -- Endothelial cells -- Fractal dimension -- Fractals -- Angiogenesis -- Bio-scaffolds -- Form factors -- In-vitro -- Microenvironments -- Microvessel -- Microvessels -- Primary culture -- Scaffolds (biology)
Аннотация: We studied the model of cerebral angiogenesis in vitro using lactate-releasing gelatin bioscaffolds and primary culture of brain endothelial cells. We found that development of microvessels from actively proliferating rat brain microvessels endothelial cells was greatly modified by the presence of lactate at the surface of the scaffold with different lactate-releasing ability. Fractal dimension of newly-established vessel loops allows precise characterizing the local microenvironment supporting cell growth on various types of gelatin scaffolds. © Springer International Publishing AG 2017.
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Держатели документа:
Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University, p. Zheleznyaka str., 1, Krasnoyarsk, Russian Federation
Institute of Computational Modelling of SB RAS, Akademgorodok, Krasnoyarsk, Russian Federation
Доп.точки доступа:
Salmin, V.; Morgun, A.; Khilazheva, E.; Pisareva, N.; Boitsova, E.; Lavrentiev, P.; Sadovsky, M.G.; Садовский, Михаил Георгиевич; Salmina, A.