Кл.слова (ненормированные):
Biomolecules -- Cell membranes -- Cells -- Continuous wave lasers -- Cytology -- Fiber optic sensors -- Gold -- Laser radiation -- Metal nanoparticles -- Nanoparticles -- Oligonucleotides -- Bioconjugates -- Cell surfaces -- Cellular membranes -- DNA aptamers -- Gold Nanoparticles -- Malignant cells -- Photothermal methods -- Pulsed lasers
Аннотация: Selective action of laser radiation on membranes of malignant cells has been studied in different regimes using conjugates of gold nanoparticles with oligonucleotides by the example of DNA aptamers. Under the conditions of a contact between a bioconjugate and a cell surface and the development of substantial and rapidly relaxing temperature gradients near a nanoparticle, the membranes of malignant cells alone are efficiently damaged due to the local hyperthermia of a cellular membrane. It has been shown that employment of pulsed instead of continuous wave laser radiation provides the localization of the damaging action, which does not involve healthy cells. © 2016, Pleiades Publishing, Ltd.
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Держатели документа:
Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, Russian Federation
Institute of Computational Modeling, Siberian Branch, Russian Academy of Sciences, Akademgorodok 50/44, Krasnoyarsk, Russian Federation
Kirenskii Institute of Physics, Siberian Branch, Russian Academy of Sciences, Akademgorodok 50/38, Krasnoyarsk, Russian Federation
Reshetnev State Siberian State Aerospace University, pr. Gazety “Krasnoyarskii rabochii” 31, Krasnoyarsk, Russian Federation
Доп.точки доступа:
Gerasimov, V. S.; Ershov, A. E.; Karpov, S. V.; Polyutov, S. P.; Semina, P. N.