[Text] : статья / Yu.I. Shokin, V.V. Moskvichev, V.V. Nicheporchuk // Vulnerability, Uncertainty, and Risk: Analysis, Modeling, and Management. Proceedings of The First International Conference on Vulnerability and Risk Analysis and Management (ICVRAM 2011) and The Fifth International Symposium on Uncertainty Modeling and Analysis (ISUMA 2011). - Reston : ASCE, 2011. - p. 442-449, DOI 10.1061/41170(400)54
. - ISBN 978-0-7844-1170-4
Полный текст
Держатели документа:
ИВМ СО РАН : 660036, Красноярск, Академгородок, 50, стр.44
Доп.точки доступа:
Moskvichev, V.V.; Москвичев, Владимир Викторович; Nicheporchuk, V.V.; Ничепорчук, Валерий Васильевич; Шокин, Юрий Иванович; International Conference on Vulnerability and Risk Analysis and Management(I ; April 11-13, 2011 ; Hyattsville); International Symposium on Uncertainty Modeling and Analysis(V ; April 11-13, 2011 ; Hyattsville)
Труды сотрудников ИВМ СО РАН
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Найдено документов в текущей БД: 13
Method of Assessment of Human-Induced Area Risks and Creation of Risk Map Using Geoinformation Systems
Dynamical modeling of microRNA action on the protein translation process
[Text] / A.Zinovyev [et al.] // BMC Syst. Biol. - 2010. - Vol. 4. - Ст. 13, DOI 10.1186/1752-0509-4-13. - Cited References: 66. - We acknowledge support from Agence Nationale de la Recherche (project ANR-08-SYSC-003 CALAMAR) and from the Projet Incitatif Collaboratif "Bioinformatics and Biostatistics of Cancer" at Institut Curie. AZ and EB are members of the team "Systems Biology of Cancer" Equipe labellis'ee par la Ligue Nationale Contre le Cancer. This work was supported by the European Commission Sixth Framework Programme Integrated Project SIROCCO contract number LSHG-CT-2006-037900. We thank Vitaly Volpert and Laurence Calzone for inspiring and useful discussions.
. - ISSN 1752-0509
РУБ Mathematical & Computational Biology
Аннотация: Background: Protein translation is a multistep process which can be represented as a cascade of biochemical reactions (initiation, ribosome assembly, elongation, etc.), the rate of which can be regulated by small non-coding microRNAs through multiple mechanisms. It remains unclear what mechanisms of microRNA action are the most dominant: moreover, many experimental reports deliver controversial messages on what is the concrete mechanism actually observed in the experiment. Nissan and Parker have recently demonstrated that it might be impossible to distinguish alternative biological hypotheses using the steady state data on the rate of protein synthesis. For their analysis they used two simple kinetic models of protein translation. Results: In contrary to the study by Nissan and Parker, we show that dynamical data allow discriminating some of the mechanisms of microRNA action. We demonstrate this using the same models as developed by Nissan and Parker for the sake of comparison but the methods developed (asymptotology of biochemical networks) can be used for other models. We formulate a hypothesis that the effect of microRNA action is measurable and observable only if it affects the dominant system (generalization of the limiting step notion for complex networks) of the protein translation machinery. The dominant system can vary in different experimental conditions that can partially explain the existing controversy of some of the experimental data. Conclusions: Our analysis of the transient protein translation dynamics shows that it gives enough information to verify or reject a hypothesis about a particular molecular mechanism of microRNA action on protein translation. For multiscale systems only that action of microRNA is distinguishable which affects the parameters of dominant system (critical parameters), or changes the dominant system itself. Dominant systems generalize and further develop the old and very popular idea of limiting step. Algorithms for identifying dominant systems in multiscale kinetic models are straightforward but not trivial and depend only on the ordering of the model parameters but not on their concrete values. Asymptotic approach to kinetic models allows putting in order diverse experimental observations in complex situations when many alternative hypotheses co-exist.
Доп.точки доступа:
Zinovyev, A.; Morozova, N.; Nonne, N.; Barillot, E.; Harel-Bellan, A.; Gorban, A.N.; Горбань, Александр Николаевич
Рубрики:
MESSENGER-RNAS
CHEMICAL-KINETICS
HUMAN-CELLS
MAMMALIAN-CELLS
LET-7 MICRORNA
INITIATION
REPRESSION
INHIBITION
GENE
MANIFOLDS
MESSENGER-RNAS
CHEMICAL-KINETICS
HUMAN-CELLS
MAMMALIAN-CELLS
LET-7 MICRORNA
INITIATION
REPRESSION
INHIBITION
GENE
MANIFOLDS
Аннотация: Background: Protein translation is a multistep process which can be represented as a cascade of biochemical reactions (initiation, ribosome assembly, elongation, etc.), the rate of which can be regulated by small non-coding microRNAs through multiple mechanisms. It remains unclear what mechanisms of microRNA action are the most dominant: moreover, many experimental reports deliver controversial messages on what is the concrete mechanism actually observed in the experiment. Nissan and Parker have recently demonstrated that it might be impossible to distinguish alternative biological hypotheses using the steady state data on the rate of protein synthesis. For their analysis they used two simple kinetic models of protein translation. Results: In contrary to the study by Nissan and Parker, we show that dynamical data allow discriminating some of the mechanisms of microRNA action. We demonstrate this using the same models as developed by Nissan and Parker for the sake of comparison but the methods developed (asymptotology of biochemical networks) can be used for other models. We formulate a hypothesis that the effect of microRNA action is measurable and observable only if it affects the dominant system (generalization of the limiting step notion for complex networks) of the protein translation machinery. The dominant system can vary in different experimental conditions that can partially explain the existing controversy of some of the experimental data. Conclusions: Our analysis of the transient protein translation dynamics shows that it gives enough information to verify or reject a hypothesis about a particular molecular mechanism of microRNA action on protein translation. For multiscale systems only that action of microRNA is distinguishable which affects the parameters of dominant system (critical parameters), or changes the dominant system itself. Dominant systems generalize and further develop the old and very popular idea of limiting step. Algorithms for identifying dominant systems in multiscale kinetic models are straightforward but not trivial and depend only on the ordering of the model parameters but not on their concrete values. Asymptotic approach to kinetic models allows putting in order diverse experimental observations in complex situations when many alternative hypotheses co-exist.
Доп.точки доступа:
Zinovyev, A.; Morozova, N.; Nonne, N.; Barillot, E.; Harel-Bellan, A.; Gorban, A.N.; Горбань, Александр Николаевич
A comprehensive modular map of molecular interactions in RB/E2F pathway
[Text] : статья / L. Calzone [et al.] // Molecular Systems Biology. - 2008. - Vol. 4. - p. 174-178DOI 10.1038/msb.2008.7
. -
Аннотация: We present, here, a detailed and curated map of molecular interactions taking place in the regulation of the cell cycle by the retinoblastoma protein (RB/RB1). Deregulations and/or mutations in this pathway are observed in most human cancers. The map was created using Systems Biology Graphical Notation language with the help of CellDesigner 3.5 software and converted into BioPAX 2.0 pathway description format. In the current state the map contains 78 proteins, 176 genes, 99 protein complexes, 208 distinct chemical species and 165 chemical reactions. Overall, the map recapitulates biological facts from approximately 350 publications annotated in the diagram. The network contains more details about RB/E2F interaction network than existing large‐scale pathway databases. Structural analysis of the interaction network revealed a modular organization of the network, which was used to elaborate a more summarized, higher‐level representation of RB/E2F network. The simplification of complex networks opens the road for creating realistic computational models of this regulatory pathway.
Держатели документа:
ИВМ СО РАН : 660036, Красноярск, Академгородок, 50, стр.44
Доп.точки доступа:
Calzone, Laurence; Gelay, Amélie; Zinovyev, Andrei; Зиновьев, Андрей Юрьевич; Radvanyi, François; Barillot, Emmanuel
Аннотация: We present, here, a detailed and curated map of molecular interactions taking place in the regulation of the cell cycle by the retinoblastoma protein (RB/RB1). Deregulations and/or mutations in this pathway are observed in most human cancers. The map was created using Systems Biology Graphical Notation language with the help of CellDesigner 3.5 software and converted into BioPAX 2.0 pathway description format. In the current state the map contains 78 proteins, 176 genes, 99 protein complexes, 208 distinct chemical species and 165 chemical reactions. Overall, the map recapitulates biological facts from approximately 350 publications annotated in the diagram. The network contains more details about RB/E2F interaction network than existing large‐scale pathway databases. Structural analysis of the interaction network revealed a modular organization of the network, which was used to elaborate a more summarized, higher‐level representation of RB/E2F network. The simplification of complex networks opens the road for creating realistic computational models of this regulatory pathway.
Держатели документа:
ИВМ СО РАН : 660036, Красноярск, Академгородок, 50, стр.44
Доп.точки доступа:
Calzone, Laurence; Gelay, Amélie; Zinovyev, Andrei; Зиновьев, Андрей Юрьевич; Radvanyi, François; Barillot, Emmanuel
Results of analysis of human impact on environment using the time series of vegetation satellite images around large industrial centers
[Text] / A. Shevyrnogov [et al.] // Adv. Space Res. - 2008. - Vol. 41, Is. 1. - P36-40, DOI 10.1016/j.asr.2007.02.008. - Cited References: 7
. - ISSN 0273-1177
РУБ Astronomy & Astrophysics + Geosciences, Multidisciplinary + Meteorology & Atmospheric Sciences
Кл.слова (ненормированные):
remote sensing -- industrial wastes -- vegetation index -- vegetation dynamics
Аннотация: The paper shows the efficiency of an application of the vegetation index image time series to determine long-term vegetation dynamics. The influence of large industrial centers of Siberia on the near-by vegetation is demonstrated. The analysis of the data shows that the influence of industrial waste is stronger in the Siberian North. These regions are characterized by critical conditions for vegetation existence. In the south of the Krasnoyarsk region, human impact is also important, but the possibility of vegetation self-rehabilitation is higher. The present-day economic situation in Russia is unique, with a temporary abrupt fall of industrial production and its following increase. Thus, we managed to analyze the degree of human impact on the environment within a relatively short-time interval. (C) 2007 Published by Elsevier Ltd on behalf of COSPAR.
Доп.точки доступа:
Shevyrnogov, A.; Vysotskaya, G.; Высоцкая, Галина Степановна; Sukhinin, A.; Frolikova, O.; Tchernetsky, M.
Кл.слова (ненормированные):
remote sensing -- industrial wastes -- vegetation index -- vegetation dynamics
Аннотация: The paper shows the efficiency of an application of the vegetation index image time series to determine long-term vegetation dynamics. The influence of large industrial centers of Siberia on the near-by vegetation is demonstrated. The analysis of the data shows that the influence of industrial waste is stronger in the Siberian North. These regions are characterized by critical conditions for vegetation existence. In the south of the Krasnoyarsk region, human impact is also important, but the possibility of vegetation self-rehabilitation is higher. The present-day economic situation in Russia is unique, with a temporary abrupt fall of industrial production and its following increase. Thus, we managed to analyze the degree of human impact on the environment within a relatively short-time interval. (C) 2007 Published by Elsevier Ltd on behalf of COSPAR.
Доп.точки доступа:
Shevyrnogov, A.; Vysotskaya, G.; Высоцкая, Галина Степановна; Sukhinin, A.; Frolikova, O.; Tchernetsky, M.
Effect of RNA quality on transcript intensity levels in microarray analysis of human post-mortem brain tissues
[Text] : статья / T. Popova [et al.] // BMC Genomics. - 2008. - Vol. 9. - Ст. 91DOI 10.1186/1471-2164-9-91
. -
Полный текст на сайте правообладателя
Доп.точки доступа:
Popova, Tatiana; Попова Т.Г.; Mennerich, Detlev; Weith, Andreas; Quast, Karsten
Полный текст на сайте правообладателя
Доп.точки доступа:
Popova, Tatiana; Попова Т.Г.; Mennerich, Detlev; Weith, Andreas; Quast, Karsten
THE COMPARATIVE REDUNDANCY OF GENES OF VARIOUS ORGANISMS AND VIRUSES
[Текст] / A. N. GORBAN [и др.] // Genetika. - 1993. - Vol. 29, Is. 9. - С. 1413-1419. - Cited References: 20
. - ISSN 0016-6758
РУБ Genetics & Heredity
Аннотация: This paper is devoted to the comparative stude of redundancy of genetic texts of various organisms and viruses. To determine the tedundance of a gene, we have introduced the strict measure for that latter. The measure for a text's redundance is the length of restriction of Frequence/Correlation Dictionary of a given genetic text. Frequence/Correlation Dictionary is the ser of all subsequences belang to a given genetic text, accompanied by the frequencies of their occurrence. The restriction length is defined as that one, for which all the subsequences (of that length) are unique. We have found, that genes of human viruses are less redundant, in comparison to those of human genes. Other aspects of a comparative redundance invastigations of the genes are discussed. The problem of the determination of <> intron could be treated by this methodology, as well, as the evolution of genome.
WOS,
Scopus
Держатели документа:
RUSSIAN ACAD SCI,CTR COMP,KRASNOYARSK,RUSSIA
ИВМ СО РАН
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Доп.точки доступа:
GORBAN, A.N.; Горбань, Александр Николаевич; MIRKES, E.M.; POPOVA, T.G.; SADOVSKY, M.G.; Садовский, Михаил Георгиевич
Рубрики:
CODON
Кл.слова (ненормированные):
article -- dna content -- evolution -- genome -- nonhuman -- restriction mapping -- virus -- amino acid sequence -- comparative study -- gene frequency -- human -- molecular genetics -- nucleotide sequence -- restriction mapping -- virus gene -- Amino Acid Sequence -- Base Sequence -- Comparative Study -- English Abstract -- Gene Frequency -- Genes, Viral -- Human -- Molecular Sequence Data -- Restriction Mapping
CODON
Кл.слова (ненормированные):
article -- dna content -- evolution -- genome -- nonhuman -- restriction mapping -- virus -- amino acid sequence -- comparative study -- gene frequency -- human -- molecular genetics -- nucleotide sequence -- restriction mapping -- virus gene -- Amino Acid Sequence -- Base Sequence -- Comparative Study -- English Abstract -- Gene Frequency -- Genes, Viral -- Human -- Molecular Sequence Data -- Restriction Mapping
Аннотация: This paper is devoted to the comparative stude of redundancy of genetic texts of various organisms and viruses. To determine the tedundance of a gene, we have introduced the strict measure for that latter. The measure for a text's redundance is the length of restriction of Frequence/Correlation Dictionary of a given genetic text. Frequence/Correlation Dictionary is the ser of all subsequences belang to a given genetic text, accompanied by the frequencies of their occurrence. The restriction length is defined as that one, for which all the subsequences (of that length) are unique. We have found, that genes of human viruses are less redundant, in comparison to those of human genes. Other aspects of a comparative redundance invastigations of the genes are discussed. The problem of the determination of <
WOS,
Scopus
Держатели документа:
RUSSIAN ACAD SCI,CTR COMP,KRASNOYARSK,RUSSIA
ИВМ СО РАН
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Доп.точки доступа:
GORBAN, A.N.; Горбань, Александр Николаевич; MIRKES, E.M.; POPOVA, T.G.; SADOVSKY, M.G.; Садовский, Михаил Георгиевич
Modeling of CO2 fluxes between atmosphere and boreal forest
/ Y. V. Barkhatov [et al.] ; ed.: Z Yang, Z Yang // 18TH BIENNIAL ISEM CONFERENCE ON ECOLOGICAL MODELLING FOR GLOBAL CHANGE AND COUPLED HUMAN AND NATURAL SYSTEM. Ser. Procedia Environmental Sciences : ELSEVIER SCIENCE BV, 2012. - Vol. 13: 18th Biennial ISEM Conference on Ecological Modelling for Global Change and Coupled Human and Natural Systems (SEP 20-23, 2011, Beijing, PEOPLES R CHINA). - P. 621-625, DOI 10.1016/j.proenv.2012.01.053. - Cited References: 17
. - ISBN 1878-0296
РУБ Ecology + Environmental Sciences
Кл.слова (ненормированные):
Global carbon cycle -- Siberian boreal forests -- mathematical modeling -- atmospheric boundary layer budget method
Аннотация: Difficulties in estimating terrestrial ecosystem CO2 fluxes on regional scales have significantly limited our understanding of the global carbon cycle. We present a method of using tall-tower-based CO2 concentrations for estimating CO2 fluxes over a forested region. With long-term measurements of the CO2 mixing ratio at a 300-m-tall tower, regional CO2 fluxes were estimated for several months, from the first obtained data. Estimates of a monthly-integrated surface CO2 flux over the region were obtained by the analysis of average gradients and estimates of the rate of vertical mixing between the atmospheric boundary layer (ABL) and the free troposphere. For the comparison of the ABL budget method and field measurements a zero-dimensional mathematical model of the ecosystem of Siberian boreal forests was used. The model is a system of ordinary differential equations with additional conditions superimposed on the parameters. The main occurring processes are described - photosynthesis, respiration, seasonal changes of active phytomass, water balance of trees, the influence of light, humidity, and temperature on photosynthesis and respiration. (C) 2011 Published by Elsevier B. V. Selection and/or peer-review under responsibility of School of Environment, Beijing Normal University.
Полный текст на сайте правообладателя
Доп.точки доступа:
Barkhatov, Y.V.; Belolipetsky, P.V.; Белолипецкий, Павел Викторович; Degermendzhi, A.G.; Belolipetskii, V.M.; Белолипецкий, Виктор Михайлович; Verkhovets, S.V.; Timokhina, A.V.; Panov, A.V.; Shchemel, A.L.; Vedrova, E.F.; Trephilova, O.V.; Yang, Z \ed.\
Кл.слова (ненормированные):
Global carbon cycle -- Siberian boreal forests -- mathematical modeling -- atmospheric boundary layer budget method
Аннотация: Difficulties in estimating terrestrial ecosystem CO2 fluxes on regional scales have significantly limited our understanding of the global carbon cycle. We present a method of using tall-tower-based CO2 concentrations for estimating CO2 fluxes over a forested region. With long-term measurements of the CO2 mixing ratio at a 300-m-tall tower, regional CO2 fluxes were estimated for several months, from the first obtained data. Estimates of a monthly-integrated surface CO2 flux over the region were obtained by the analysis of average gradients and estimates of the rate of vertical mixing between the atmospheric boundary layer (ABL) and the free troposphere. For the comparison of the ABL budget method and field measurements a zero-dimensional mathematical model of the ecosystem of Siberian boreal forests was used. The model is a system of ordinary differential equations with additional conditions superimposed on the parameters. The main occurring processes are described - photosynthesis, respiration, seasonal changes of active phytomass, water balance of trees, the influence of light, humidity, and temperature on photosynthesis and respiration. (C) 2011 Published by Elsevier B. V. Selection and/or peer-review under responsibility of School of Environment, Beijing Normal University.
Полный текст на сайте правообладателя
Доп.точки доступа:
Barkhatov, Y.V.; Belolipetsky, P.V.; Белолипецкий, Павел Викторович; Degermendzhi, A.G.; Belolipetskii, V.M.; Белолипецкий, Виктор Михайлович; Verkhovets, S.V.; Timokhina, A.V.; Panov, A.V.; Shchemel, A.L.; Vedrova, E.F.; Trephilova, O.V.; Yang, Z \ed.\
Web mapping application for spatial data actualization system on human settlements in the region
[Text] : abstract / A. A. Kadochnikov // Modern Information Technologies in Earth Sciences: Proceedings of the IV International Conference. - Vladivostok : Dalnauka, 2016. - P77-78
Доп.точки доступа:
Кадочников, Алексей Анатольевич
Доп.точки доступа:
Кадочников, Алексей Анатольевич
Веб-приложения и сервисы для системы актуализации пространственных данных по населенным пунктам региона
[Текст] : доклад, тезисы доклада / А. А. Кадочников, О. Э. Якубайлик // Распределенные информационно-вычислительные ресурсы. Наука – цифровой экономике (DICR-2017) : труды XVI всероссийской конференции. - Новосибирск : Институт вычислительных технологий Сибирского отделения РАН, 2017. - С. 386-391
. - ISBN 978-5-905569-10-4
Перевод заглавия: WEB Applications and Services for Spatial Data Actualization System on Human Settlements in the Region
Кл.слова (ненормированные):
geographic information system -- geoportal -- geospatial data -- web mapping -- web application -- map service -- tiled background -- геоинформационная система -- геопортал -- геопространственные данные -- веб-картография -- веб-приложение -- картографический сервис -- тайловая подложка
Аннотация: В работе рассматривается задача формирования и актуализации базовых пространственных данных некоторого региона с целью создания на их основе информационно-аналитических систем для мониторинга различных социально-экономических и экологических процессов и спутникового мониторинга транспорта. Предложена методика и комплекс программных инструментов для актуализации пространственной информации в многопользовательском режиме без прямого подключения к хранилищу данных.
In the present work considers the problem of forming and actualization the basic spatial data of some of the region in order to create on their basis of information-analytical systems for environmental monitoring of the natural environment and resources, monitoring systems of different socio-economic processes, satellite monitoring of transport. A technique and a complex of software tools for actualizing the spatial information in multi-user mode without a direct connection to the data store is proposed.
РИНЦ,
Источник статьи,
Полный текст
Держатели документа:
Федеральный исследовательский центр "Красноярский научный центр Сибирского отделения Российской академии наук
Доп.точки доступа:
Кадочников, А.А.; Kadochnikov A.A.; Якубайлик, О.Э.; Yakubailik O.E.; Распределенные информационно-вычислительные ресурсы. Наука – цифровой экономике (DICR-2017)(2017 ; 04.12 - 07.12 ; Новосибирск)
Нет сведений об экземплярах (Источник в БД не найден)
Перевод заглавия: WEB Applications and Services for Spatial Data Actualization System on Human Settlements in the Region
Кл.слова (ненормированные):
geographic information system -- geoportal -- geospatial data -- web mapping -- web application -- map service -- tiled background -- геоинформационная система -- геопортал -- геопространственные данные -- веб-картография -- веб-приложение -- картографический сервис -- тайловая подложка
Аннотация: В работе рассматривается задача формирования и актуализации базовых пространственных данных некоторого региона с целью создания на их основе информационно-аналитических систем для мониторинга различных социально-экономических и экологических процессов и спутникового мониторинга транспорта. Предложена методика и комплекс программных инструментов для актуализации пространственной информации в многопользовательском режиме без прямого подключения к хранилищу данных.
In the present work considers the problem of forming and actualization the basic spatial data of some of the region in order to create on their basis of information-analytical systems for environmental monitoring of the natural environment and resources, monitoring systems of different socio-economic processes, satellite monitoring of transport. A technique and a complex of software tools for actualizing the spatial information in multi-user mode without a direct connection to the data store is proposed.
РИНЦ,
Источник статьи,
Полный текст
Держатели документа:
Федеральный исследовательский центр "Красноярский научный центр Сибирского отделения Российской академии наук
Доп.точки доступа:
Кадочников, А.А.; Kadochnikov A.A.; Якубайлик, О.Э.; Yakubailik O.E.; Распределенные информационно-вычислительные ресурсы. Наука – цифровой экономике (DICR-2017)(2017 ; 04.12 - 07.12 ; Новосибирск)
Нет сведений об экземплярах (Источник в БД не найден)
544.77+541.18+535.8+616-006.04
О-62
О-62
ОПТИМИЗАЦИЯ ФОТОТЕРМИЧЕСКИХ МЕТОДОВ ЛАЗЕРНОЙ ГИПЕРТЕРМИИ ЗЛОКАЧЕСТВЕННЫХ КЛЕТОК С ПРИМЕНЕНИЕМ БИОКОНЪЮГАТОВ МНОГОСЛОЙНЫХ НАНОЧАСТИЦ С ДНК-АПТАМЕРАМИ
[Текст] : статья / А. С. Костюков [и др.] // Решетневские чтения. - 2018. - Т. 1, № 22. - С. 529-531
. - ISSN 1990-7702
Перевод заглавия: OPTIMIZATION OF PHOTOTHERMAL METHODS OF HYPERTHERMIA OF MALIGNANT CELLS USING NANOPARTICLE CORE-SHELL BIOCONJUGATES WITH DNA APTAMERS
Кл.слова (ненормированные):
плазмонная фототермическая терапия -- многослойные наночастицы -- Plasmonic photothermal therapy -- multilayered core-shell nanoparticles
Аннотация: Изучение влияния высокой радиационной нагрузки на организм человека в условиях космического полета является важным направлением онкологии и космической медицины. В работе исследуются особенности импульсной лазерной гипертермии злокачественных клеток с помощью многослойных плазмонных наночастиц.
Effect of corpuscular radiation on a human organism during space flight is an important area of oncology and space medicine. Peculiarities of pulsed laser hyperthermia of malignant cells are studied using multilayer plasmonic nanoparticles
РИНЦ
Держатели документа:
Институт вычислительного моделирования СО РАН
Институт теплофизики имени С. С. Кутателадзе СО РАН
Институт физики имени Л. В. Киренского
Сибирский государственный университет науки и технологий имени академика М. Ф. Решетнева
Сибирский федеральный университет
Доп.точки доступа:
Костюков, А.С.; Kostyukov A.S.; Филимонов, С.А.; Filimonov S.A.; Ершов, А.Е.; Ershov A.E.; Герасимов, В.С.; Gerasimov V.S.; Карпов, С.В.; Karpov S.V.
Перевод заглавия: OPTIMIZATION OF PHOTOTHERMAL METHODS OF HYPERTHERMIA OF MALIGNANT CELLS USING NANOPARTICLE CORE-SHELL BIOCONJUGATES WITH DNA APTAMERS
| УДК |
Кл.слова (ненормированные):
плазмонная фототермическая терапия -- многослойные наночастицы -- Plasmonic photothermal therapy -- multilayered core-shell nanoparticles
Аннотация: Изучение влияния высокой радиационной нагрузки на организм человека в условиях космического полета является важным направлением онкологии и космической медицины. В работе исследуются особенности импульсной лазерной гипертермии злокачественных клеток с помощью многослойных плазмонных наночастиц.
Effect of corpuscular radiation on a human organism during space flight is an important area of oncology and space medicine. Peculiarities of pulsed laser hyperthermia of malignant cells are studied using multilayer plasmonic nanoparticles
РИНЦ
Держатели документа:
Институт вычислительного моделирования СО РАН
Институт теплофизики имени С. С. Кутателадзе СО РАН
Институт физики имени Л. В. Киренского
Сибирский государственный университет науки и технологий имени академика М. Ф. Решетнева
Сибирский федеральный университет
Доп.точки доступа:
Костюков, А.С.; Kostyukov A.S.; Филимонов, С.А.; Filimonov S.A.; Ершов, А.Е.; Ershov A.E.; Герасимов, В.С.; Gerasimov V.S.; Карпов, С.В.; Karpov S.V.
614.84.001.5
Т 36
Т 36
ТЕСТИРОВАНИЕ КОМПЬЮТЕРНЫХ ПРОГРАММ ПО РАСЧЕТУ ВРЕМЕНИ ЭВАКУАЦИИ НА ПРИМЕРЕ МОДУЛЯ SigmaEva
[Текст] : статья / Екатерина Сергеевна Кирик, Андрей Валериевич Малышев // Пожарная безопасность. - 2014. - № 1. - С. 78-85
. - ISSN 2411-3778
Перевод заглавия: Testing of computer programmes for evacuation time calculation by the example of SigmaEva module
Кл.слова (ненормированные):
evacuation modeling -- evacuation time computation -- testing -- fundamental diagram -- speed -- density -- specific flow -- моделирование эвакуации -- расчет времени эвакуации -- тестирование -- фундаментальная диаграмма -- скорость -- плотность -- удельный поток
Аннотация: Рассмотрено тестирование программных комплексов по расчету времени эвакуации людей. Выделены ключевые участки путей, совокупность которых образует путь эвакуации. Приведены способы тестирования явлений, свойственных людскому потоку, на прямых участках и в сужениях. Апробирование тестов осуществлялось на примере анализа программного модуля SigmaEva, в котором реализована модель индивидуально-поточного типа.
Testing of programme systems for calculations of human evacuation time was considered. The key path parts which form the escape path were submitted. There were ways to test the human flow dynamics along straight paths and bottlenecks. These ways were examined by the example of SigmaEva module that realizes the model of individual pedestrian movement.
РИНЦ
Держатели документа:
ИВМ СО РАН
Доп.точки доступа:
Кирик, Екатерина Сергеевна; Kirik Ekaterina Sergeevna; Малышев, Андрей Валериевич; Malyshev Andrey Valerievich
Перевод заглавия: Testing of computer programmes for evacuation time calculation by the example of SigmaEva module
| УДК |
Кл.слова (ненормированные):
evacuation modeling -- evacuation time computation -- testing -- fundamental diagram -- speed -- density -- specific flow -- моделирование эвакуации -- расчет времени эвакуации -- тестирование -- фундаментальная диаграмма -- скорость -- плотность -- удельный поток
Аннотация: Рассмотрено тестирование программных комплексов по расчету времени эвакуации людей. Выделены ключевые участки путей, совокупность которых образует путь эвакуации. Приведены способы тестирования явлений, свойственных людскому потоку, на прямых участках и в сужениях. Апробирование тестов осуществлялось на примере анализа программного модуля SigmaEva, в котором реализована модель индивидуально-поточного типа.
Testing of programme systems for calculations of human evacuation time was considered. The key path parts which form the escape path were submitted. There were ways to test the human flow dynamics along straight paths and bottlenecks. These ways were examined by the example of SigmaEva module that realizes the model of individual pedestrian movement.
РИНЦ
Держатели документа:
ИВМ СО РАН
Доп.точки доступа:
Кирик, Екатерина Сергеевна; Kirik Ekaterina Sergeevna; Малышев, Андрей Валериевич; Malyshev Andrey Valerievich
614.8.01
З-12
З-12
За прогресс мы платим авариями
[Текст] : статья / А. М. Лепихин // Охрана труда и техника безопасности на промышленных предприятиях. - 2014. - № 6. - С. 44-49
. - ISSN 2074-8779
Перевод заглавия: Progress is paid in accidents
Кл.слова (ненормированные):
технический прогресс -- предотвращение аварий -- прогноз технических опасностей -- техногенные факторы опасности -- стандарты безопасности -- оценка рисков -- technical progress -- accidents prevention -- technical hazards forecast -- man-caused hazards factors -- Safety Standards -- risks assessment
Аннотация: Почему технологии безопасности не всегда успевают за развитием прогресса? И что чаще становится причиной аварий - неисправность техники или безалаберность человека? На эти и многие другие вопросы корреспондента газеты «Наш Красноярский край» Бауэр И. отвечает Лепихин А.М., ведущий специалист в области теории безопасности и риск-анализа сложных систем, эксперт в области промышленной безопасности и оценки риска аварий и чрезвычайных ситуаций природного и техногенного характера.
Why do not safety technologies always catch up with progressive development? And what does more frequently become the reason of accident: faulty equipment or human negligence? These and many other questions are answered by Mr. Lepikhin A. M., leading expert in the fi eld of safety theory and complex systems risks analysis, expert in the fi eld of occupational safety and risk assessment in emergency situations of natural and man-caused nature, in his interview to Bauer I., correspondent of newspaper “Our Krasnoiarsk Region”.
РИНЦ
Держатели документа:
Институт вычислительного моделирования Сибирского отделения РАН (ИВМ СО РАН)
Специальное конструкторско-технологическое бюро «Наука» Красноярского научного центра СО РАН (СКТБ «Наука» КНЦ СО РАН)
Доп.точки доступа:
Лепихин, А.М.; Lepikhin A.M.
Перевод заглавия: Progress is paid in accidents
| УДК |
Кл.слова (ненормированные):
технический прогресс -- предотвращение аварий -- прогноз технических опасностей -- техногенные факторы опасности -- стандарты безопасности -- оценка рисков -- technical progress -- accidents prevention -- technical hazards forecast -- man-caused hazards factors -- Safety Standards -- risks assessment
Аннотация: Почему технологии безопасности не всегда успевают за развитием прогресса? И что чаще становится причиной аварий - неисправность техники или безалаберность человека? На эти и многие другие вопросы корреспондента газеты «Наш Красноярский край» Бауэр И. отвечает Лепихин А.М., ведущий специалист в области теории безопасности и риск-анализа сложных систем, эксперт в области промышленной безопасности и оценки риска аварий и чрезвычайных ситуаций природного и техногенного характера.
Why do not safety technologies always catch up with progressive development? And what does more frequently become the reason of accident: faulty equipment or human negligence? These and many other questions are answered by Mr. Lepikhin A. M., leading expert in the fi eld of safety theory and complex systems risks analysis, expert in the fi eld of occupational safety and risk assessment in emergency situations of natural and man-caused nature, in his interview to Bauer I., correspondent of newspaper “Our Krasnoiarsk Region”.
РИНЦ
Держатели документа:
Институт вычислительного моделирования Сибирского отделения РАН (ИВМ СО РАН)
Специальное конструкторско-технологическое бюро «Наука» Красноярского научного центра СО РАН (СКТБ «Наука» КНЦ СО РАН)
Доп.точки доступа:
Лепихин, А.М.; Lepikhin A.M.
Matching disparate dimensions for analytical integration of heterogeneous data sources
/ A. Korobko, A. Korobko // 11th International Conference on Management of Digital EcoSystems, MEDES 2019 : Association for Computing Machinery, Inc, 2019. - 11th International Conference on Management of Digital EcoSystems, MEDES 2019 (12 November 2019 through 14 November 2019, ) Conference code: 156715. - P66-72, DOI 10.1145/3297662.3365809
. -
Кл.слова (ненормированные):
Analytical Data Integration -- FCA -- Heterogeneous Data -- OLAP -- Semantic Analysis -- Analytical models -- Ecosystems -- Mapping -- Semantics -- Virtual reality -- Analytical integration -- Conceptual analysis -- Heterogeneous data -- Heterogeneous data sources -- Multiple heterogeneous data source -- OLAP -- Semantic analysis -- Virtual integration -- Data integration
Аннотация: The paper presents the first steps towards an authorial integration methodology for heterogeneous data. Exposing information from multiple heterogeneous data sources demands a global (mediated) schema. We need a model to couple with the mismatches between schemata of different sources and to provide uniform access to the data. The virtual global schema is apparently more convenient for assembling big data sources because of useless time consumption during the processes of materialization and synchronization. Thus, an integral analytical model has been proposed as the global schema of heterogeneous data sources. The suggested model provides virtual integration of complex and diverse information for further analytical processing. It combines the original multidimensional design and lattice structure according to the formal conceptual analysis. The main goal of the paper is to suggest an approach to automatic mapping between the schemata of the disparate data sources and virtual integral analytical model with human moderation. © 2019 Copyright is held by the owner/author(s).
Scopus
Держатели документа:
Department of Applied Computer Science, ICM SB RAS, Krasnoyarsk, Russian Federation
Доп.точки доступа:
Korobko, A.
Кл.слова (ненормированные):
Analytical Data Integration -- FCA -- Heterogeneous Data -- OLAP -- Semantic Analysis -- Analytical models -- Ecosystems -- Mapping -- Semantics -- Virtual reality -- Analytical integration -- Conceptual analysis -- Heterogeneous data -- Heterogeneous data sources -- Multiple heterogeneous data source -- OLAP -- Semantic analysis -- Virtual integration -- Data integration
Аннотация: The paper presents the first steps towards an authorial integration methodology for heterogeneous data. Exposing information from multiple heterogeneous data sources demands a global (mediated) schema. We need a model to couple with the mismatches between schemata of different sources and to provide uniform access to the data. The virtual global schema is apparently more convenient for assembling big data sources because of useless time consumption during the processes of materialization and synchronization. Thus, an integral analytical model has been proposed as the global schema of heterogeneous data sources. The suggested model provides virtual integration of complex and diverse information for further analytical processing. It combines the original multidimensional design and lattice structure according to the formal conceptual analysis. The main goal of the paper is to suggest an approach to automatic mapping between the schemata of the disparate data sources and virtual integral analytical model with human moderation. © 2019 Copyright is held by the owner/author(s).
Scopus
Держатели документа:
Department of Applied Computer Science, ICM SB RAS, Krasnoyarsk, Russian Federation
Доп.точки доступа:
Korobko, A.