[Текст] : статья / S. Ahnert, T. Fink, A. Zinovyev // Journal of Theoretical Biology. - 2008. - Vol. 252, Iss. 4. - p. 587–592DOI 10.1016/j.jtbi.2008.02.005
. -
Аннотация: Despite tremendous advances in the field of genomics, the amount and function of the large non-coding part of the genome in higher organisms remains poorly understood. Here we report an observation, made for 37 fully sequenced eukaryotic genomes, which indicates that eukaryotes require a certain minimum amount of non-coding DNA (ncDNA). This minimum increases quadratically with the amount of DNA located in exons. Based on a simple model of the growth of regulatory networks, we derive a theoretical prediction of the required quantity of ncDNA and find it to be in excellent agreement with the data. The amount of additional ncDNA (in basepairs) which eukaryotes require obeys Ndef=1/2 (Nc/Np) (Nc−Np), where Nc is the amount of exonic DNA, and Np is a constant of about 10 Mb. This value Ndef corresponds to a few percent of the genome in Homo sapiens and other mammals, and up to half the genome in simpler eukaryotes. Thus, our findings confirm that eukaryotic life depends on a substantial fraction of ncDNA and also make a prediction of the size of this fraction, which matches the data closely.
Полный текст на сайте издательства
Доп.точки доступа:
Fink, Thomas M.A.; Zinovyev, Andrei; Зиновьев, Андрей Юрьевич
Труды сотрудников ИВМ СО РАН
w10=
Найдено документов в текущей БД: 2
Strong inhomogeneity in triplet distribution alongside a genome
/ M. Sadovsky, X. Nikitina // (15 April 2015 through 17 April 2015. - 2015. - Vol. 9044. - P248-255
. -
Кл.слова (ненормированные):
Inhomogeneity -- Longest gap -- Order -- Periodicity -- Track -- Bioinformatics -- Biomedical engineering -- Mammals -- Inhomogeneities -- Longest gap -- Order -- Periodicity -- Track -- Genes
Аннотация: The distribution of triplets alongside a genome is studied.We explored the distribution to the nearest neighbour, that is the pattern where two triplets are fixed, and the distance is determined from the former to the latter so that the second triplet takes place nowhere inside the observed gap surrounded with the couple of the given triplets. The distribution differs strongly, for different organisms. Yeast and bacteria seem to have rather smooth pattern, while mammalia and other higher eukaryotes exhibit very complex patterns with long-range correlations in the triplet distribution. © Springer International Publishing Switzerland 2015.
Scopus
Держатели документа:
Institute of computational modelling of SB RASAkademgorodok, Krasnoyarsk, Russian Federation
ИВМ СО РАН
Доп.точки доступа:
Sadovsky, M.G.; Садовский, Михаил Георгиевич; Nikitina, X.
Кл.слова (ненормированные):
Inhomogeneity -- Longest gap -- Order -- Periodicity -- Track -- Bioinformatics -- Biomedical engineering -- Mammals -- Inhomogeneities -- Longest gap -- Order -- Periodicity -- Track -- Genes
Аннотация: The distribution of triplets alongside a genome is studied.We explored the distribution to the nearest neighbour, that is the pattern where two triplets are fixed, and the distance is determined from the former to the latter so that the second triplet takes place nowhere inside the observed gap surrounded with the couple of the given triplets. The distribution differs strongly, for different organisms. Yeast and bacteria seem to have rather smooth pattern, while mammalia and other higher eukaryotes exhibit very complex patterns with long-range correlations in the triplet distribution. © Springer International Publishing Switzerland 2015.
Scopus
Держатели документа:
Institute of computational modelling of SB RASAkademgorodok, Krasnoyarsk, Russian Federation
ИВМ СО РАН
Доп.точки доступа:
Sadovsky, M.G.; Садовский, Михаил Георгиевич; Nikitina, X.