Труды сотрудников ИВМ СО РАН

/ A. Divin [et al.] // J. Geophys. Res-Space Phys. - 2012. - Vol. 117. - Ст. A06217, DOI 10.1029/2011JA017464. - Cited References: 43. - The present work is supported partially by the Onderzoekfonds KU Leuven (Research Fund KU Leuven), by the NASA MMS grant NNX08AO84G and by the European Commission's Seventh Framework Programme (FP7/2007-2013) under the grant agreement 263340 (SWIFF project, www. swiff. eu) and 269198 - Geoplasmas (Marie Curie International Research Staff Exchange Scheme). Additional support is provided by RFBR grants 09-05-91000-ANF-a, 12-05-00152-a and 12-05-00918-a, Austrian Science Fund project T193-N16 and by SPSU grants 11.38.47.2011 and 11.38.84.2012. The simulations were conducted on the resources of the Vlaams Supercomputer Centrum (VSC) at the Katholieke Universiteit Leuven. The authors wish to thank the reviewers for their comments that helped to improve the manuscript. . - ISSN 2169-9380РУБ Astronomy & Astrophysics

Аннотация: The Sweet-Parker analysis of the inner electron diffusion region of collisionless magnetic reconnection is presented. The study includes charged particles motion near the X-line and an appropriate approximation of the off-diagonal term for the electron pressure tensor. The obtained scaling shows that the width of the inner electron diffusion region is equal to the electron inertial length, and that electrons are accelerated up to the electron Alfven velocity in X-line direction. The estimated effective plasma conductivity is based on the electron gyrofrequency rather than the binary collision frequency, and gives the extreme (minimal) value of the plasma conductivity similar to Bohm diffusion. The scaling properties are verified by means of Particle-in-Cell simulations. An ad hoc parameter needs to be introduced to the scaling relations in order to better match the theory and simulations.


Доп.точки доступа:
Divin, A.; Lapenta, G.; Markidis, S.; Semenov, V.S.; Erkaev, N.V.; Еркаев, Николай Васильевич; Korovinskiy, D.B.; Biernat, H.K.

[Text] / A. Divin [et al.] // Phys. Plasmas. - 2010. - Vol. 17, Is. 12. - Ст. 122102, DOI 10.1063/1.3521576. - Cited References: 42. - The present work is supported partially by the Onderzoekfonds KU Leuven (Research Fund KU Leuven) and by the European Commission's Seventh Framework Programme (FP7/2007-2013) under grant Agreement No. 218816 (SOTERIA project, www.soteria- space.eu). Additional support is provided by RFBR (Grant No. 09-05-91000-ANF-a). V.S.S. thanks ISSI for hospitality and financial support. The simulations were conducted on the resources of the Vlaams Supercomputer Centrum (VSC) at the Katholieke Universiteit Leuven. . - ISSN 1070-664XРУБ Physics, Fluids & Plasmas

Аннотация: A new model of the electron pressure anisotropy in the electron diffusion region in collisionless magnetic reconnection is presented for the case of antiparallel configuration of magnetic fields. The plasma anisotropy is investigated as source of collisionless dissipation. By separating electrons in the vicinity of the neutral line into two broad classes of inflowing and accelerating populations, it is possible to derive a simple closure for the off-diagonal electron pressure component. The appearance of these two electron populations near the neutral line is responsible for the anisotropy and collisionless dissipation in the magnetic reconnection. Particle-in-cell simulations verify the proposed model, confirming first the presence of two particle populations and second the analytical results for the off-diagonal electron pressure component. Furthermore, test-particle calculations are performed to compare our approach with the model of electron pressure anisotropy in the inner electron diffusion region by Fujimoto and Sydora [Phys. Plasmas 16, 112309 (2009)]. (C) 2010 American Institute of Physics. [doi:10.1063/1.3521576]


Доп.точки доступа:
Divin, A.; Markidis, S.; Lapenta, G.; Semenov, V.S.; Erkaev, N.V.; Еркаев, Николай Васильевич; Biernat, H.K.

[Text] / Y. Gaponenko, V. Shevtsova // Acta Astronaut. - 2010. - Vol. 66, Is. 01.02.2013. - pp. 174-182, DOI 10.1016/j.actaastro.2009.05.019. - Cited References: 10 . - ISSN 0094-5765РУБ Engineering, Aerospace

Аннотация: We report on a numerical study of the mixing of two miscible fluids in gravitationally stable configuration. In the absence of external forces the diffusion process leads to the mixing of species. The aim of this study is to analyze the physical mechanism by which vibrations affect the mixing characteristic of two stratified miscible fluids. The translational periodic vibrations of a rigid cell filled with different mixtures of water-isopropanol are imposed. The vibrations with a constant frequency and amplitude are directed along the interface. In absence of gravity vibration-induced mass transport is incomparably faster than in diffusion regime. Our results highlight the strong interplay between gravity and vibrational impact, the relative weight of each effect is determined by ratio vibrational and classical Rayleigh numbers. (C) 2009 Elsevier Ltd. All rights reserved.


Доп.точки доступа:
Gaponenko, Y.; Гапоненко, Юрий Анатольевич; Shevtsova, V.

[Text] : статья / L. Calzone [et al.] // Molecular Systems Biology. - 2008. - Vol. 4. - p. 174-178DOI 10.1038/msb.2008.7 . -
Аннотация: We present, here, a detailed and curated map of molecular interactions taking place in the regulation of the cell cycle by the retinoblastoma protein (RB/RB1). Deregulations and/or mutations in this pathway are observed in most human cancers. The map was created using Systems Biology Graphical Notation language with the help of CellDesigner 3.5 software and converted into BioPAX 2.0 pathway description format. In the current state the map contains 78 proteins, 176 genes, 99 protein complexes, 208 distinct chemical species and 165 chemical reactions. Overall, the map recapitulates biological facts from approximately 350 publications annotated in the diagram. The network contains more details about RB/E2F interaction network than existing large‐scale pathway databases. Structural analysis of the interaction network revealed a modular organization of the network, which was used to elaborate a more summarized, higher‐level representation of RB/E2F network. The simplification of complex networks opens the road for creating realistic computational models of this regulatory pathway.

Держатели документа:
ИВМ СО РАН : 660036, Красноярск, Академгородок, 50, стр.44

Доп.точки доступа:
Calzone, Laurence; Gelay, Amélie; Zinovyev, Andrei; Зиновьев, Андрей Юрьевич; Radvanyi, François; Barillot, Emmanuel

[Text] : статья / Y. A. Gaponenko, V. Shevtsova // Microgravity Science and Technology. - 2008. - Vol. 20, Iss. 3-4 . - p. 307-311, DOI 10.1007/s12217-008-9075-7 . - ISSN 0938-0108
Аннотация: The aim of this study is to analyze the physical mechanism by which vibrations affect the mixing characteristic of two initially stratified miscible fluids. The translational periodic vibrations of a rigid cell filled with different mixtures (Sc = 7125) are considered. The vibrations with a constant frequency are imposed parallel to the initially planar interface. The ability of the applied vibrations to enhance the flow is examined. At the early stage after imposing the vibrations the Kelvin-Helmholtz instability is observed in absence and at low level of gravity. Later in time the system undergoes a transition to Rayleigh-Taylor instability. With increasing of gravity level the life-time of Kelvin-Helmholtz instability is decreased. We found the critical value of Gr above which this instability do not developed.

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Доп.точки доступа:
Shevtsova, V.; Гапоненко, Юрий Анатольевич

[Text] : статья / A. Mialdun [et al.] // Physical review letters. - 2008. - Vol. 101. - Ст. 084501DOI 10.1103/PhysRevLett.101.084501 . -
Аннотация: We report experimental evidence of convection caused by translational vibration of nonuniformly heated fluid in low gravity. The theory of vibrational convection in weightlessness is well developed but direct experimental proof has been missing. An innovative point of the experiment is the observation of a temperature field in the front and side views of the cubic cell. In addition, particle tracing is employed. The evolution of this field is studied systematically in a wide range of frequencies and amplitudes. The flow structures reported in previous numerical studies are confirmed. The transition from four-vortex flow to the pattern with three vortices is observed in the transient state.

Держатели документа:
ИВМ СО РАН : 660036, Красноярск, Академгородок, 50, стр.44

Доп.точки доступа:
Mialdun, A.; Ryzhkov, I.I.; Рыжков, Илья Игоревич; Melnikov, D.E.; Shevtsova, V.

[Text] : статья / D. E. Melnikov [et al.] // Microgravity Science and Technology. - 2008. - Vol. 20, Iss. 1. - p. 29-39, DOI 10.1007/s12217-008-9011-x . - ISSN 0938-0108
Аннотация: This work describes the preparation of the future experiments on thermovibrational convection in microgravity during parabolic flights. The experimental setup for observing thermovibrational flows is designed. It consists of a cubic cell with liquid, which is subjected to controlled vibration, and equipment for registering velocity and temperature fields with a help of optical digital interferometry. The question of choosing working liquid and control parameters of the experiment is addressed. A 3D numerical simulation of thermovibrational convection in a cubic cavity is performed for real parabolic flight conditions. The study is aimed at estimating the values of physical quantities that manifest the presence of thermovibrational flows and can be experimentally measured during short microgravity time (20 s).

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Доп.точки доступа:
Melnikov, D.E.; Ryzhkov, I.I.; Рыжков, Илья Игоревич; Mialdun, A.; Shevtsova, V.

[Text] / V. M. Sadovskii, O. V. Sadovskaya // ECCOMAS Thematic Conference - COMPDYN 2013: 4th International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering, Proceedings - An IACM Special Interest Conference. - 2013. - P4277-4286
Аннотация: Mathematical model for the description of deformation of a porous material with a random distribution of pores is constructed on the basis of generalized rheological method taking into account the different resistance of a material to tension and compression. Phenomenological parameters of the model are determined by means of the approximate computations for the problem of static loading of a cubic periodicity cell with spherical cavities. Within the framework of this theory the fields of displacements and stresses around expanding cavity of spherical shape in a homogenious space are constructed. It is shown that the porosity does not change at the stage of elastic deformation. When the pressure increases, a zone of plastic compaction is formed in the vicinity of a cavity, and in a part of this zone the collapse of pores takes place. Engineering formulas for calculation of critical pressures of the elastic limit state and the limit state of a medium with open pores, and also the formulas for determining the radiuses of interfaces of zones of plasticity and compaction are obtained. A complex of parallel programs for numerical analysis of the dynamic deformation of porous materials on multiprocessor computer systems is worked out. By means of this complex a series of computations for deformation of the protection elements, made of metal foams, under the action of localizedim pulsive loads was performed. The random nature of distribution of the pores size is taken into account with the help of computer modeling. Computations allow one to estimate plastic dissipative part of the energy of impact.

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Доп.точки доступа:
Sadovskaya, O.V.; Садовская, Оксана Викторовна; Садовский, Владимир Михайлович

[Text] / I. V. Krasnov // Chin. Phys. B. - 2015. - Vol. 24, Is. 6. - Ст. 063701, DOI 10.1088/1674-1056/24/6/063701. - Cited References:22 . - ISSN 1674-1056. - ISSN 1741-4199РУБ Physics, Multidisciplinary

Аннотация: Conditions have been studied under which a polychromatic optical superlattice can form and trap the Coulomb cluster of two strongly interacting ions. In our previous work (Krasnov I V and Kamenshchikov L P 2014 Opt. Comm. 312 192) this new all-optical method of obtaining and confining the Coulomb clusters was demonstrated by numerical simulations for special values of the optical superlattice parameters and in the case of Yb ions. In the present paper the conditions are explicitly formulated, under which the long-lived two-ion cluster in the superlattice cell is formed. The peculiarity of these conditions is the renormalization of the ion-ion Coulomb interaction. Notably, the renormalized Coulomb force is determined by the effective charge which depends on the light field parameters and can strongly differ from the "bare" ion charge. This result can be accounted for by the combined manifestation of the quantum fluctuations of optical forces, nonlinear dependence of these forces on the velocity, and non-Maxwellian (Tsallis type) velocity distribution of the ions in the optical superlattice. Explicit analytical formulas are also obtained for the parameters of the optical two-ion cluster.

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Держатели документа:
Russian Acad Sci, Siberian Div, Inst Computat Modeling, Krasnoyarsk 660036, Russia.

Доп.точки доступа:
Krasnov, I.V.; Краснов, Игорь Васильевич

[Text] / A. A. Chesnokov, I. V. Stepanova // Appl. Math. Comput. - 2015. - Vol. 265. - P320-328, DOI 10.1016/j.amc.2015.05.019. - Cited References:19. - The work is supported by Russian Foundation of Basic Research (project 14-31-50572), the Program of Leading Scientific Schools Supporting (project 2133.2014.1) and Integrating project of SB RAS (44). . - ISSN 0096-3003. - ISSN 1873-5649РУБ Mathematics, Applied

Аннотация: A mathematical model describing motion of an inhomogeneous incompressible fluid in a Hele-Shaw cell is considered. Linear stability analysis of shear flow class is provided. The role of inertia, linear friction and impermeable boundaries in Kelvin Helmholtz instability is studied. Hierarchy of simplified one-dimensional models of viscosity- and density stratified flows is obtained in long wave approximation. Interpretation of Saffman-Taylor instability is given in the framework of these models. (C) 2015 Elsevier Inc. All rights reserved.

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Держатели документа:
Novosibirsk State Univ, Novosibirsk 630090, Russia.
RAS, SB, Lavrentyev Inst Hydrodynam, Novosibirsk, Russia.
RAS, SB, Inst Computat Modeling, Krasnoyarsk, Russia.

Доп.точки доступа:
Stepanova, I.V.; Степанова, Ирина Владимировна; Russian Foundation of Basic Research [14-31-50572]; Program of Leading Scientific Schools Supporting [2133.2014.1]Integrating project of SB RAS

/ J. C. Legros [et al.] // Phys. Chem. Chem. Phys. - 2015. - Vol. 17, Is. 41. - P27713-27725, DOI 10.1039/c5cp04745e . - ISSN 1463-9076
Аннотация: We present a comprehensive experimental study of isothermal Fickian diffusion in the ternary and binary liquid mixtures of water, ethanol, and triethylene glycol over the entire ternary composition space. 21 ternary mixtures inside the composition triangle have been investigated by means of the Taylor dispersion technique and 30 binary mixtures by Taylor dispersion and/or optical beam deflection in a Soret cell. The scalar binary diffusion coefficient has been determined along all three binary boundaries of the composition space and compared with estimations based on the Stokes-Einstein relation using stick or slip boundary conditions. The four elements of the ternary diffusion matrix and the diffusion eigenvalues were determined over a large portion of the composition triangle. The pseudo-binary diffusion coefficients obtained in Taylor dispersion experiments with either one of the two independent concentrations kept constant are comparable to the two diffusion eigenvalues. One of the two off-diagonal elements of the diffusion matrix is of the same order as the diagonal ones and, hence, not negligible, whereas the other one is approximately one order of magnitude smaller. Where available, our results compare well with literature data. The investigated compositions also comprise the five compositions that are scheduled for microgravity experiments in the ESA DCMIX3 project. This journal is © the Owner Societies 2015.

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Держатели документа:
Microgravity Research Center, Universite Libre de Bruxelles (ULB), CP-165/62 Av. F.D. Roosevelt 50, B-1050 Brussels, Belgium
Institute of Computational Modelling SB RAS, Krasnoyarsk, Russian Federation
Physikalisches Institut, Universitat Bayreuth, Bayreuth, Germany
National Research Tomsk Polytechnic University, Russian Federation

Доп.точки доступа:
Legros, J. C.; Gaponenko, Y.; Гапоненко, Юрий Анатольевич; Mialdun, A.; Triller, T.; Hammon, A.; Bauer, C.; Kohler, W.; Shevtsova, V.

[Text] / I. V. Krasnov, L. P. Kamenshchikov // Laser Phys. - 2015. - Vol. 25, Is. 11. - Ст. 115501, DOI 10.1088/1054-660X/25/11/115501. - Cited References:26 . - ISSN 1054-660X. - ISSN 1555-6611РУБ Optics + Physics, Applied

Аннотация: On the basis of numerical simulations and analytical calculations it is proved that the dissipative optical superlattice induced by the rectified gradient force is able to create and trap cold ion Coulomb clusters. In contrast to our previous work (2014 Opt. Commun. 312 192), in the present paper, we do not use the approximation of slow ions (SI), but take into account the non-conservative nature of the trapping force in the optical superlattice as well as the velocity dependence of the friction coefficient of ions and multiplicative nature of the quantum fluctuations of optical forces. It is shown that these factors significantly affect both the formations conditions of the ion Coulomb clusters and their characteristics. It is also demonstrated that their consequences can be well-described by the renormalized SI model. In this model, the electric ion charge is replaced by the effective charge which depends on the light field parameters.

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Держатели документа:
Russian Acad Sci, Inst Computat Modelling, Siberian Div, Krasnoyarsk 660036, Russia.

Доп.точки доступа:
Kamenshchikov, L.P.; Каменщиков, Леонид Петрович; Краснов, Игорь Васильевич

[Text] / V. M. Sadovskii, O. V. Sadovskaya ; ed. M. D. Todorov // APPLICATION OF MATHEMATICS IN TECHNICAL AND NATURAL SCIENCES : AMER INST PHYSICS, 2015. - Vol. 1684: 7th International Conference on Application of Mathematics in Technical (JUN 28-JUL 03, 2015, Albena, BULGARIA). - Ст. UNSP 070006. - (AIP Conference Proceedings), DOI 10.1063/1.4934307. - Cited References:18 . - РУБ Mathematics, Applied + Physics, Applied

Аннотация: Based on the generalized rheological method, the mathematical model describing small deformations of a single-phase porous medium without regard to the effects of a fluid or gas in pores is constructed. The change in resistance of a material to the external mechanical impacts at the moment of pore collapse is taken into account by means of the von Mises-Schleicher strength condition. In order to consider irreversible deformations, alongside with the classical yield conditions by von Mises and Tresca-Saint-Venant, the special condition modeling the plastic loss of stability of a porous skeleton is used. The random nature of the pore size distribution is taken into account. It is shown that the proposed mathematical model satisfies the principles of thermodynamics of irreversible processes. Phenomenological parameters of the model are determined on the basis of the approximate calculation of the problem on quasi-static loading of a cubic periodicity cell with spherical voids. In the framework of the obtained model, the process of propagation of plane longitudinal waves of the compression in a homogenous porous medium, accompanied by the plastic deformation of a skeleton and the collapse of pores, is analyzed.

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Держатели документа:
SB RAS, Inst Computat Modeling, Akademgorodok 50-44, Krasnoyarsk 660036, Russia.

Доп.точки доступа:
Sadovskii, V. M.; Sadovskaya, O. V.; Todorov, M.D. \ed.\

[Текст] : статья / С. С. Замай [и др.] // Сибирское медицинское обозрение. - 2015. - № 6. - С. 48-54 . - ISSN 1819-9496
   Перевод заглавия: Functionalized by the aptamers magnetic nanodiscs for nanosurgery of the tumors

УДК

577.29

Аннотация: Цель исследования. Определение перспектив использования функционализированных ДНК-аптамерами магнитных никелевых нанодисков с золотым покрытием для адресной клеточной хирургии онкологических заболеваний. Матери алы и методы. В качестве модели опухоли была использована асцитная карцинома Эрлиха. Теоретически и экспериментально исследованы структуры магнитного поля пермаллоевых и кобальтовых дисков Au-Fe(20)Ni(80)-Au и Au-Co-Au. Результаты. Выполнены оценки механического воздействия нанодисков на клеточную мембрану в переменном магнитном поле. Определены оптимальные состав, геометрия и структура остаточной намагниченности нанодисков. Экспериментально in vitro и in vivo для асцитной карциномы Эрлиха показана возможность использования функционализированных ДНК-аптамерами трехслойных Au-Ni-Au нанодисков с дипольной структурой остаточной намагниченности для адресного разрушения клеток-мишеней. 3аключе-ие. На основании теоретических расчетов и экспериментальных данных сделано заключение о том, что нанодиски Au-Ni-Au, обладающие магнитными свойствами, могут быть использованы для разработки новых методов и препаратов для малоинвазивной клеточной нанохирургии, которая позволяет адресно и дозировано уничтожать только клетки опухоли, в том числе, и метастазы.
The aim of the research. Determination of the prospects of application the functionalized by DNA-aptamers magnetic nickel nanodiscs with gold coating for targeted cell cancer surgery. Materials and methods. As tumor model was used Ehrlich ascites carcinoma. Theoretically and experimentally were investigated the structures of the magnetic field of permalloy and cobalt disks Au-Fe (20) Ni (80) -Au and Au-Co-Au. Results. It were executed the estimation of the mechanical impact of nanodiscs to the cell membrane in an alternating magnetic field. It was determined the optimum composition, geometry and structure of the residual magnetization of nanodiscs. Experimentally in vitro and in vivo for Ehrlich ascites carcinoma was showed the use of functionalized DNA-aptamers three layer Au-Ni-Au nanodisks with dipole structure of the residual magnetization for address destruction of the target cells. Conclusion. On the basis of theoretical calculations and experimental data, it was concluded that nanodiscs Au-Ni-Au, with magnetic properties, can be used to develop new methods and products for minimally invasive cellular nanosurgery that allows targeted and dosed destroy only tumor cells, including metastasis.

РИНЦ

Держатели документа:
ГАОУ ВПО Сибирский федеральный университет
ГБОУ ВПО Красноярский государственный медицинский университет имени проф. В. Ф. Войно-Ясенецкого Министерства здравоохранения РФ
ГБОУ ВПО Красноярский государственный педагогический университет им. В. П. Астафьева Министерства образования и науки РФ
Институт вычислительного моделирования СО РАН
Красноярский научный центр СО РАН

Доп.точки доступа:
Замай, Сергей Сергеевич; Zamay Sergey Sergeevich; Прокопенко, Владимир Семенович; Prokopenko Vladimir Semenovich; Замай, Анна Сергеевна; Zamay Anna Sergeevna; Денисенко, Валерий Васильевич; Denisenko V.V.; Ким, Петр Дементьевич; Kim Petr Dementievich; Орлов, Виталий Александрович; Orlov Vitaly Alerksandrovich; Замай, Галина Сергеевна; Zamay Galina Sergeevna; Иванченко, Татьяна Ивановна; Ivanchenko Tatiana Ivanovna; Замай, Татьяна Николаевна; Zamay Tatiana Nikolaevna

/ V. S. Gerasimov [et al.] // Colloid J. - 2016. - Vol. 78, Is. 4. - P435-442, DOI 10.1134/S1061933X16040050 . - ISSN 1061-933X
Аннотация: Selective action of laser radiation on membranes of malignant cells has been studied in different regimes using conjugates of gold nanoparticles with oligonucleotides by the example of DNA aptamers. Under the conditions of a contact between a bioconjugate and a cell surface and the development of substantial and rapidly relaxing temperature gradients near a nanoparticle, the membranes of malignant cells alone are efficiently damaged due to the local hyperthermia of a cellular membrane. It has been shown that employment of pulsed instead of continuous wave laser radiation provides the localization of the damaging action, which does not involve healthy cells. © 2016, Pleiades Publishing, Ltd.

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Держатели документа:
Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, Russian Federation
Institute of Computational Modeling, Siberian Branch, Russian Academy of Sciences, Akademgorodok 50/44, Krasnoyarsk, Russian Federation
Kirenskii Institute of Physics, Siberian Branch, Russian Academy of Sciences, Akademgorodok 50/38, Krasnoyarsk, Russian Federation
Reshetnev State Siberian State Aerospace University, pr. Gazety “Krasnoyarskii rabochii” 31, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Gerasimov, V. S.; Ershov, A. E.; Karpov, S. V.; Polyutov, S. P.; Semina, P. N.

[Text] / I. V. Stepanova, A. A. Chesnokov, V. Y. Liapidevskii // ALL-RUSSIAN CONFERENCE ON NONLINEAR WAVES: THEORY AND NEW APPLICATIONS : IOP PUBLISHING LTD, 2016. - Vol. 722: All-Russian Conference on Nonlinear Waves - Theory and New Applications (FEB 29-MAR 02, 2016, Novosibirsk, RUSSIA). - Ст. UNSP 012036. - (Journal of Physics Conference Series), DOI 10.1088/1742-6596/722/1/012036. - Cited References:13 . - РУБ Physics, Applied + Physics, Multidisciplinary

Аннотация: In this paper we study the emergence and development of roll waves in two-layer fluid flow in a Hele-Shaw cell. We propose the mathematical model of such flow and define the conditions of transition from stable state to instability in the form of the roll waves. We find out the physical parameters of flows at which the roll waves exist. A linear stability analysis and the Whitham criterion of roll waves existence are used for solving the problem and arrive to identical conclusions on depths of upper and lower layers at which violation of flow stability occurs. The numerical calculations for the obtained mathematical model at found ratios of densities, viscosities and depths of layers are performed. They confirm development of the roll waves of finite amplitude from small oscillations of the interface.

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Держатели документа:
Novosibirsk State Univ, Novosibirsk, Russia.
Inst Computat Modelling SB RAS, Krasnoyarsk, Russia.
Lavrentyev Inst Hydrodynam SB RAS, Novosibirsk, Russia.

Доп.точки доступа:
Stepanova, I. V.; Chesnokov, A. A.; Liapidevskii, V. Yu

/ Y. A. Ponomareva, E. A. Ivanova // Contemp. Probl. Ecol. - 2016. - Vol. 9, Is. 5. - P582-589, DOI 10.1134/S1995425516050115 . - ISSN 1995-4255
Аннотация: Based on a daily examination of phytoplankton in the Yenisei River downstream of the Krasnoyarsk Hydroelectric Power Station (HPS) within a 4-year period, the ratio between living and dead cells is estimated and the size fractions of phytoplankton are described. It is found that, despite the certain negative effects of passing through the turbine blades of the high-head dam, high current speed, and influence of water discharges from the HPS, living algae cells dominate over dead ones in the water column of the studied reach of the Yenisei River during almost the entire year, except for several dates in late autumn and winter. It is shown that microphytoplankton (20–64 ?m in size) and nanophytoplankton (2–20 ?m), which make up 83% of the total algae count, pass through the turbine blades of the HPS and mostly remain undamaged, with the fraction of living cells varying from 21% in the winter period to 96% in the spring–summer period. © 2016, Pleiades Publishing, Ltd.

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Держатели документа:
Siberian Federal University, pr. Svobodny 79, Krasnoyarsk, Russian Federation
Institute of Computational Modeling, Siberian Branch, Russian Academy of Sciences, Akademgorodok 50/44, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Ponomareva, Y. A.; Ivanova, E. A.

/ V. V. Denisenko, V. M. Sadovskii, S. S. Zamay // J. Sib. Fed. Univ. Math. Phys. - 2016. - Vol. 9, Is. 4. - P432-442, DOI 10.17516/1997-1397-2016-9-4-432-442 . - ISSN 1997-1397
Аннотация: An analytical solution of the problem on elastic deformation of a membrane allows analyzing deformation of typical living cells under the influence of magnetic disks attached to the cells. Based on the numerical solution of two-dimensional elliptic boundary value problems, the magnetic polarizabilities of the disks are obtained as the functions of magnetic permeability of the disk substance. It is shown that typical thin disks made of iron, nickel and cobalt in the mode far from saturation are magnetized substantially the same as a disk with infinite magnetic permeability. Though the solved problems are stationary, the results are also usable in the analysis of quasi-stationary processes such as low-frequency variation of external magnetic field. © Siberian Federal University. All rights reserved.

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Держатели документа:
Institute of Computational Modeling SB RAS, Akademgorodok, 50/44, Krasnoyarsk, Russian Federation
Institute of Mathematics and Computer Science, Siberian Federal University, Svobodny, 79, Krasnoyarsk, Russian Federation
Krasnoyarsk Scientific Center SB RAS, Akademgorodok, 50, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Denisenko, V. V.; Sadovskii, V. M.; Zamay, S. S.

/ T. N. Zamay [et al.] // Nucleic Acid Therape. - 2017. - Vol. 27, Is. 2. - P105-114, DOI 10.1089/nat.2016.0634 . - ISSN 2159-3337
Аннотация: Magnetomechanical cell disruption using nano- and microsized structures is a promising biomedical technology used for noninvasive elimination of diseased cells. It applies alternating magnetic field (AMF) for ferromagnetic microdisks making them oscillate and causing cell membrane disruption with cell death followed by apoptosis. In this study, we functionalized the magnetic microdisks with cell-binding DNA aptamers and guided the microdisks to recognize cancerous cells in a mouse tumor in vivo. Only 10 min of the treatment with a 100 Hz AMF was enough to eliminate cancer cells from a malignant tumor. Our results demonstrate a good perspective of using aptamer-modified magnetic microdisks for noninvasive microsurgery for tumors. © Mary Ann Liebert, Inc. 2017.

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Держатели документа:
Laboratory of Biomolecular and Medical Technologies, Krasnoyarsk State Medical University, 1, P. Zheleznyaka, Krasnoyarsk, Russian Federation
Siberian Federal University, Krasnoyarsk, Russian Federation
Krasnoyarsk Research Center, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Institute of Computational Modeling, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Institute of Semiconductor Physics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
Institute of Physics, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Krasnoyarsk State Pedagogical University, Krasnoyarsk, Russian Federation
Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada

Доп.точки доступа:
Zamay, T. N.; Zamay, G. S.; Belyanina, I. V.; Zamay, S. S.; Denisenko, V.V.; Денисенко, Валерий Васильевич; Kolovskaya, O. S.; Ivanchenko, T. I.; Grigorieva, V. L.; Garanzha, I. V.; Veprintsev, D. V.; Glazyrin, Y. E.; Shabanov, A. V.; Prinz, V. Y.; Seleznev, V. A.; Sokolov, A. E.; Prokopenko, V. S.; Kim, P. D.; Gargaun, A.; Berezovski, M. V.; Zamay, A. S.

/ V. Salmin [et al.] // (26 April 2017 through 28 April 2017 : Springer Verlag, 2017. - Vol. 10208 LNCS. - P591-601, DOI 10.1007/978-3-319-56148-6_53 . -
Аннотация: We studied the model of cerebral angiogenesis in vitro using lactate-releasing gelatin bioscaffolds and primary culture of brain endothelial cells. We found that development of microvessels from actively proliferating rat brain microvessels endothelial cells was greatly modified by the presence of lactate at the surface of the scaffold with different lactate-releasing ability. Fractal dimension of newly-established vessel loops allows precise characterizing the local microenvironment supporting cell growth on various types of gelatin scaffolds. © Springer International Publishing AG 2017.

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Держатели документа:
Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University, p. Zheleznyaka str., 1, Krasnoyarsk, Russian Federation
Institute of Computational Modelling of SB RAS, Akademgorodok, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Salmin, V.; Morgun, A.; Khilazheva, E.; Pisareva, N.; Boitsova, E.; Lavrentiev, P.; Sadovsky, M.G.; Садовский, Михаил Георгиевич; Salmina, A.