Труды сотрудников ИВМ СО РАН

/ M. G. Sadovsky, M. Y. Senashova, A. V. Malyshev // BMC Bioinformatics. - 2020. - Vol. 21. - Ст. 83, DOI 10.1186/s12859-020-3350-z. - Cited References:45 . - ISSN 1471-2105РУБ Biochemical Research Methods + Biotechnology & Applied Microbiology

Аннотация: Background Previously, a seven-cluster pattern claiming to be a universal one in bacterial genomes has been reported. Keeping in mind the most popular theory of chloroplast origin, we checked whether a similar pattern is observed in chloroplast genomes. Results Surprisingly, eight cluster structure has been found, for chloroplasts. The pattern observed for chloroplasts differs rather significantly, from bacterial one, and from that latter observed for cyanobacteria. The structure is provided by clustering of the fragments of equal length isolated within a genome so that each fragment is converted in triplet frequency dictionary with non-overlapping triplets with no gaps in frame tiling. The points in 63-dimensional space were clustered due to elastic map technique. The eight cluster found in chloroplasts comprises the fragments of a genome bearing tRNA genes and exhibiting excessively high GC-content, in comparison to the entire genome. Conclusion Chloroplasts exhibit very specific symmetry type in distribution of coding and non-coding fragments of a genome in the space of triplet frequencies: this is mirror symmetry. Cyanobacteria may have both mirror symmetry, and the rotational symmetry typical for other bacteria.

WOS

Держатели документа:
RAS, SB, Inst Computat Modelling, Krasnoyarsk 660036, Russia.
Siberian Fed Univ, Svobodny Prosp 79, Krasnoyarsk 660041, Russia.
VF Voino Yasenetsky Krasnoyarsk State Med Univ, P Zheleznjaka Str 1, Krasnoyarsk 660022, Russia.

Доп.точки доступа:
Sadovsky, Michael G.; Senashova, Maria Yu; Malyshev, Andrew V.