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Труды сотрудников ИБФ СО РАН

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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shumilova A. A., Myltygashev M. P., Kirichenko A. K., Nikolaeva E. D., Volova T. G., Shishatskaya E. I.
Заглавие : Porous 3D implants of degradable poly-3-hydroxybutyrate used to enhance regeneration of rat cranial defect
Колич.характеристики :12 с
Коллективы : Russian Academy of Sciences [01201351505]
Место публикации : J. Biomed. Mater. Res. Part A: WILEY-BLACKWELL, 2017. - Vol. 105, Is. 2. - С. 566-577. - ISSN 1549-3296, DOI 10.1002/jbm.a.35933. - ISSN 1552-4965(eISSN)
Примечания : Cited References:53. - Contract grant sponsor: The state budget allocated to the fundamental research at the Russian Academy of Sciences; contract grant number: 01201351505
Предметные рубрики: BONE TISSUE REGENERATION
CRITICAL SIZE DEFECT
IN-VITRO
CALVARIAL
Ключевые слова (''Своб.индексиров.''): 3d implants--poly-3-hydroxybutyrate--msc differentiation--grafts for--osteogenesis--regeneration of defect cranial
Аннотация: The study describes preparation and testing of porous 3D implants of natural degradable polymer of 3-hydroxybutyric acid P(3HB) for regeneration of bone tissue defects. The ability of the P(3HB) implants to favor attachment and facilitate proliferation and directed differentiation of mesenchymal stem cells (MSCs) was studied in the culture of MSCs isolated from bone marrow and adipose tissue. Tissue-engineered hybrid systems (grafts) constructed using P(3HB) and P(3HB) in combination with osteoblasts were used in experiments on laboratory animals (n=48) with bone defect model. The defect model (5 mm in diameter) was created in the rat parietal bone, and filling of the defect by the new bone tissue was monitored in the groups of animals with P(3HB) implants, with commercial material, and without implants (negative control). Computed tomography (CT) and histologic examination showed that after 120 days, in the group with the osteoblast-seeded P(3HB) implants, the defect was completely closed; in the group with the cell-free P(3HB) implants, the remaining defect was no more than 10% of the initial one (0.5 mm); in both the negative and positive controls, the size of the defect was about 1.0-1.2 mm. These results suggest that P(3HB) has good potential as osteoplastic material for reconstructive osteogenesis. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 566-577, 2017.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Volova T. G., Tarasevich A. A., Golubev A. I., Boyandin A. N., Shumilova A. A., Nikolaeva E. D., Shishatskaya E. I.
Заглавие : Laser processing of polymer constructs from poly(3-hydroxybutyrate)
Место публикации : J. Biomater. Sci. Polym. Ed. - 2015. - Vol. 26, Is. 16. - С. 1210-1228. - ISSN 09205063 (ISSN) , DOI 10.1080/09205063.2015.1082810
Ключевые слова (''Своб.индексиров.''): biocompatibility--biopolymers--laser processing--poly(3-hydroxybutyrate)--polymer materials--biocompatibility--biomechanics--biopolymers--bone--cell culture--pulsed lasers--scaffolds (biology)--stem cells--3t3 mouse fibroblasts--bone marrow--bone regeneration--laser process--mesenchymal stem cell--poly-3-hydroxybutyrate--polymer materials--pulsed mode--laser materials processing
Аннотация: CO2 laser radiation was used to process poly(3-hydroxybutyrate) constructs - films and 3D pressed plates. Laser processing increased the biocompatibility of unperforated films treated with moderate uniform radiation, as estimated by the number and degree of adhesion of NIH 3T3 mouse fibroblast cells. The biocompatibility of perforated films modified in the pulsed mode did not change significantly. At the same time, pulsed laser processing of the 3D plates produced perforated scaffolds with improved mechanical properties and high biocompatibility with bone marrow-derived multipotent, mesenchymal stem cells, which show great promise for bone regeneration. © 2015 Taylor & Francis.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Kamendov I.V., Starosvetsky S.I., Vinnik Y.S., Markelova N.N., Shageev A.A., Khorzhevsky V.A., Peryanova O.V., Shumilova A.A.
Заглавие : An in vivo study of osteoplastic properties of resorbable poly-3-hydroxybutyrate in models of segmental osteotomy and chronic osteomyelitis
Место публикации : Artif. Cells, Nanomed. Biotechnol. - 2014. - Vol. 42, Is. 5. - С. 344-355. - ISSN 21691401 (ISSN) , DOI 10.3109/21691401.2013.816312
Ключевые слова (''Своб.индексиров.''): 3d implants--bone substitute--histological analysis and radiography--hydroxyapatite--p3hb--polymer of 3-hydroxybutyric acid--reconstructive osteogenesis--3-hydroxybutyric acid--bone substitutes--histological analysis--osteogenesis--p3hb--hydroxyapatite
Аннотация: A series of 3D implants and filling materials prepared from powdered biodegradable polymers, polyhydroxyalkanoates (PHAs), have been designed for the purposes of reparative osteogenesis. The 3D implants are made of resorbable polymer of hydroxybutyric acid (poly-3-hydroxybutyrate, P3HB) and a composite of this polymer with hydroxyapatite (HA) (P3HB/HA). The properties of the implants were studied in vivo in a model of segmental osteotomy and compared with commercial material Bio-Oss®. All implants containing P3HB as the main component facilitate reconstructive osteogenesis. P3HB and P3HB/HA show pronounced osteoplastic properties; their in vivo degradation is slow and corresponds to the growth of a new bone tissue, facilitating normal reparative osteogenesis. Also, powdered P3HB and P3HB/tienam can be used as filling materials for osteoplasty of bone cavities infected by Staphylococcus aureus. Biodegradable 3D implants and P3HB-based filling materials show pronounced osteoplastic properties and degrade in vivo at a slow rate, enabling normal reparative osteogenesis.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Nikolaeva E.D., Shumilova A.A., Shabanov A.V., Volova T.G.
Заглавие : Cultivation of multipotent mesenchymal bone marrow cells on matrixes made of resorbable bioplastotan
Место публикации : Cellular Transplantation and Tissue Engineering. - 2013. - Vol. 8, Is. 1. - С. 57-65. - ISSN 1815445X (ISSN)
Ключевые слова (''Своб.индексиров.''): alkaline phosphatase--differentiation--extracellular calcium precipitates--multipotent mesenchymal stromal cells--osteopontin--resorbable bioplastotan
Аннотация: Series of cell carriers made of resorbable polyester Bioplastotan, which is a copolymer of 3- And 4-hydroxybutyric acid, are characterized in this work. With use of various technologies membranes, 3D scaffolds, and nanomatrixes formed by ultrafine fibers produced with electrostatic spinning were constructed. All types of scaffolds provide adhesion of multipotent mesenchymal stromal cells and are suitable for the cultivation and differentiation of cells in the osteoblastes, that confirmed by detection of extracellular calcium precipitates, alkaline phosphatase activity and osteopontin production in cell culture. В© Human stem cells institute, 2013.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Zotina T., Trofimova E., Dementyev D., Bolsunovsky A.
Заглавие : Transfer of americium-241 from food and water to organs and tissues of the crucian carp *
Место публикации : Radioprotection. - 2011. - Vol. 46, Is. 6 SUPPL. - С. S69-S73. - ISSN 00338451 (ISSN) , DOI 10.1051/radiopro/20116648s
Аннотация: The transfer of transuranium element americium-241 (241Am) from food and water to organs and tissues of freshwater fish (Carassius auratus gibelio, crucian carp) has been investigated in laboratory experiments. The fishes were fed with homogenized biomass of submerged macrophytes labeled with 241Am, through catheter. For the first two days after force-feeding, fishes excreted up to 80% of ingested americium, for four days - 98%. 241Am was registered in internal organs and tissues that had no direct contact with americium (liver, bones, muscles) as early as two days after the feeding and after eight days, when the digestive tract was depurated. Among internal organs, the highest activity concentration was recorded in the liver (up to 427 Bq/kg). Activity concentration in bones (19-31 Bq/kg) was several times higher than in muscles, indicating the affinity of americium to bone tissue. Assimilation of 241Am in organs and tissues of crucian carp from water occurred mainly via the digestive tract too. В© 2011 EDP Sciences.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I.
Заглавие : Biomedical investigations of biodegradable PHAs
Место публикации : Macromolecular Symposia. - 2008. - Vol. 269, Is. 1. - С. 65-81. - ISSN 10221360 (ISSN) , DOI 10.1002/masy.200850909
Ключевые слова (''Своб.индексиров.''): biodegradable polymers--biomedical investigations--pha--abs resins--biodegradable polymers--biopolymers--biotechnology--bone--cell culture--endothelial cells--fibers--functional polymers--osteoblasts--polymers--surgery--abdominal surgeries--biocompatible--biodegradable--biomedical--biomedical investigations--bone defects--ectopic bones--hepatocytes--in vitro--microparticles--oral surgeries--osteogenesis--pha--polyhydroxybutyrate--polymer devices--ralstonia--russian academy of sciences--two types--polymer films
Аннотация: This work is a review of the results of biomedical studies of polymer devices (films, fibers, microparticles, 30 implants) made from resorbable PHAs synthesized by the bacterium Wautersia (Ralstonia) eutropha 65786, using the technology developed at the Institute of Biophysics of the Siberian Branch of the Russian Academy of Sciences. Two types of PHAs - polyhydroxybutyrate (PHB) and a hydroxybutyrate/hydroxyvalerate copolymer (PHB/PHV) - have been proven to be biocompatible in vitro in cultures of fibroblasts, endothelial cells, hepatocytes, and osteoblasts, and in short- and long-duration experiments on animals. Polymer films and membranes have been found to be usable as scaffolds for functioning cells and monofilament suture fibers - for stitching muscular-fascial wounds and in abdominal surgery. Ectopic bone formation assay and experiments with the model of segmental osteotomy showed that 30 PHB and PHB/HA implants can be used for reparative osteogenesis. The paper reports beneficial results of using polymers to repair bone defects in oral surgery. Copyright В© 2008 WILEY-VCH Verlag GmbH & Co. KGaA.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Khlusov I.A., Volova T.G.
Заглавие : A hybrid PHB-hydroxyapatite composite for biomedical application: Production, in vitro and in vivo investigation
Место публикации : Journal of Biomaterials Science, Polymer Edition. - 2006. - Vol. 17, Is. 5. - С. 481-498. - ISSN 09205063 (ISSN) , DOI 10.1163/156856206776986242
Ключевые слова (''Своб.индексиров.''): biocompatibility--hydroxyapatite (ha)--phb-hydroxyapatite composite--polyhydroxyalkanoate (pha)--polyhydroxybutyrate (p(3hb))--properties--biocompatibility--differential thermal analysis--electron microscopy--free energy--interfacial energy--physical properties--surface properties--x ray analysis--biomedical application--physicochemical properties--polyhydroxyalkanoate (pha)--polyhydroxybutyrate (phb)--hydroxyapatite--hydroxyapatite--poly(3 hydroxybutyric acid)--polymer--biomaterial--hydroxybutyric acid--adhesion--animal cell--animal tissue--article--biomedicine--bone marrow cell--cell differentiation--cell growth--chemical structure--composite material--controlled study--crystallization--decomposition--electron microscopy--in vitro study--in vivo study--melting point--mouse--nonhuman--ossification--osteoblast--physical chemistry--priority journal--rat--strength--structure analysis--surface property--synthesis--temperature measurement--thermal analysis--tissue engineering--wettability--animal--biomechanics--bioremediation--bone prosthesis--cattle--cell culture--chemistry--cytology--differential scanning calorimetry--drug effect--human--materials testing--prostheses and orthoses--scanning electron microscopy--standard--wistar rat--murinae--animals--biocompatible materials--biodegradation, environmental--biomechanics--bone substitutes--cattle--cells, cultured--differential thermal analysis--durapatite--humans--hydroxybutyrates--materials testing--microscopy, electron, scanning--osteoblasts--prostheses and implants--rats--rats, wistar--surface properties
Аннотация: Samples of a hybrid composite of polyhydroxybutyrate (PHB), a biodegradable polyester, and hydroxyapatite (HA), with different PHB/HA ratios, have been prepared using mechanical-physical method. Electron microscopy, X-ray structure analysis and differential thermal analysis have been used to investigate the structure and physicochemical properties of the composite, depending on the PHB/HA ratio. The properties of the surface of the HA-loaded composite are significantly different from those of the pure polymer. As the HA percentage in the composite increases, free interface energy, the cohesive force, i.e., the strength of the adhesive bond between the composite surface and the water phase, and surface wettability increase. The HA percentage of the composite does not influence its melting temperature, but affects the temperature for the onset of decomposition: as the HA content increases from 0 to 10% (w/w), Td decreases from 260В°C to 225В°C. The degree of crystallinity of PHB/HA increases from 77% to 89% with an increase in the HA fraction from 10% to 50%. Functional properties of the composites have been investigated in vitro and in vivo. The best parameters of growth and differentiation of murine marrow osteoblasts are registered on PHB/HA samples containing 10% and 20% HA. In ectopic bone formation assay it has been proven that the hybrid PHB/HA composites can function as scaffolds and that bone tissue develops on their surface and in pores. В© VSP 2006.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : NEFEDOV V.P., NEFEDOVA V.V., KONONYKHINA V.S., MORGULIS I.I.
Заглавие : EFFECT OF SEROTONIN ON HEMATOPOIETIC STEM-CELLS IN BONE-MARROW
Колич.характеристики :3 с
Место публикации : Bull. Exp. Biol. Med.: PLENUM PUBL CORP, 1991. - Vol. 112, Is. 11. - P1582-1584. - ISSN 0007-4888, DOI 10.1007/BF00840418
Примечания : Cited References: 13
Ключевые слова (''Своб.индексиров.''): serotonin--hematopoietic stem cell--bone marrow--proliferation
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gitelzon I.I., Nefedov V.P., Mezhevikin V.V.
Заглавие : Effect of hypoxemia on erythropoietic activity of perfused organs
Место публикации : Byulleten Eksperimentalnoi Biologii i Meditsiny. - 1977. - Vol. 84, Is. 7. - С. 23-24. - ISSN 03659615 (ISSN)
Ключевые слова (''Своб.индексиров.''): animal--bone marrow--cell proliferation--erythropoiesis--histology--hypoxemia--injury--mammal--perfusion fluid--theoretical study--article--dog--kidney--liver--metabolism--perfusion--spleen--sternum--erythropoietin--animal--anoxemia--dogs--english abstract--erythropoietin--kidney--liver--perfusion--spleen--sternum
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