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Общее количество найденных документов : 6
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Xu, Shicai, Wang, Tiejun, Liu, Guofeng, Cao, Zanxia, Frank, Ludmila A., Jiang, Shouzhen, Zhang, Chao, Li, Zhenhua, Krasitskaya, Vasilisa V., Li, Qiang, Sha, Yujie, Zhang, Xiumei, Liu, Huilan, Wang, Jihua
Заглавие : Analysis of interactions between proteins and small-molecule drugs by a biosensor based on a graphene field-effect transistor
Колич.характеристики :9 с
Коллективы : Taishan Scholars Program of Shandong Province [tsqn201812104]; Qingchuang Science and Technology Plan of Shandong Province [2019KJJ017, 2020KJC004]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61671107, 62071085, 11704059, 31802309]; Youth Innovation Team Lead-Education Project of Shandong Educational Committee
Место публикации : Sens. Actuator B-Chem.: ELSEVIER SCIENCE SA, 2021. - Vol. 326. - Ст.128991. - ISSN 0925-4005(eISSN), DOI 10.1016/j.snb.2020.128991
Примечания : Cited References:66. - We are grateful for financial support from the Taishan Scholars Program of Shandong Province (tsqn201812104), the Qingchuang Science and Technology Plan of Shandong Province (2019KJJ017 and 2020KJC004), the National Natural Science Foundation of China (61671107, 62071085, 11704059, and 31802309), and the Youth Innovation Team Lead-Education Project of Shandong Educational Committee.
Предметные рубрики: LABEL-FREE DETECTION
CHEMICAL-VAPOR-DEPOSITION
DNA HYBRIDIZATION
Аннотация: We synthesized large-area single-crystal graphene sheets to use them in biosensors based on field-effect transistors (FET) for quantitative analysis of interaction kinetics and affinity between the imatinib drug and its target protein kinase Abl1. The G-FET biosensor showed an excellent performance and recognized imatinib at as low as 15.5 fM. The biosensor also showed a linear response to the logarithm of imatinib concentration in the 0.1 pM-10 mu M range. This graphene-based FET biosensor (G-FET) was also applied toquantify Abl1 Y253 F mutation and Abl1 dependency on Mg2+ to bind to imatinib in real-time. Results demonstrated in this work clearly showed that the novel G-FET biosensors are very promising to analyze interactions between proteins and low molecular weight drugs.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Xu S., Wang T., Liu G., Cao Z., Frank L. A., Jiang S., Zhang C., Li Z., Krasitskaya V. V., Li Q., Sha Y., Zhang X., Liu H., Wang J.
Заглавие : Analysis of interactions between proteins and small-molecule drugs by a biosensor based on a graphene field-effect transistor
Место публикации : Sens Actuators, B Chem: Elsevier B.V., 2021. - Vol. 326. - Ст.128991. - ISSN 09254005 (ISSN), DOI 10.1016/j.snb.2020.128991
Аннотация: We synthesized large-area single-crystal graphene sheets to use them in biosensors based on field-effect transistors (FET) for quantitative analysis of interaction kinetics and affinity between the imatinib drug and its target protein kinase Abl1. The G-FET biosensor showed an excellent performance and recognized imatinib at as low as 15.5 fM. The biosensor also showed a linear response to the logarithm of imatinib concentration in the 0.1 pM-10 ?M range. This graphene-based FET biosensor (G-FET) was also applied to quantify Abl1 Y253 F mutation and Abl1 dependency on Mg2+ to bind to imatinib in real-time. Results demonstrated in this work clearly showed that the novel G-FET biosensors are very promising to analyze interactions between proteins and low molecular weight drugs. © 2020 Elsevier B.V.
Scopus
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Tian, Meng, Qiao, Mei, Shen, Congcong, Meng, Fanlu, Frank, Ludmila A., Krasitskaya, Vasilisa V., Wang, Tiejun, Zhang, Xiumei, Song, Ruihong, Li, Yingxian, Liu, Jianjian, Xu, Shicai, Wang, Jihua
Заглавие : Highly-sensitive graphene field effect transistor biosensor using PNA and DNA probes for RNA detection
Колич.характеристики :10 с
Коллективы : National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [11604040, 61671107]; Taishan Scholars Program of Shandong Province [tsqn201812104]; Natural Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2019PC026]; Qingchuang Science and Technology Plan of Shandong Province [2019KJJ017]
Место публикации : Appl. Surf. Sci.: ELSEVIER, 2020. - Vol. 527. - Ст.146839. - ISSN 0169-4332, DOI 10.1016/j.apsusc.2020.146839. - ISSN 1873-5584(eISSN)
Примечания : Cited References:62. - We are grateful for financial support from National Natural Science Foundation of China (11604040, 61671107), Taishan Scholars Program of Shandong Province (tsqn201812104), Natural Science Foundation of Shandong Province (ZR2019PC026) and Qingchuang Science and Technology Plan of Shandong Province (2019KJJ017).
Предметные рубрики: PEPTIDE NUCLEIC-ACID
LABEL-FREE DETECTION
SELECTIVE RECOGNITION
Аннотация: DNA probe-based biosensors have been widely developed for detecting a range of analytes. However, the DNA probe-based sensors suffer from many problems, such as long hybridization time, background electrical noise, and relatively poor specificity. In this paper, we report the ultrasensitive detection for RNA by graphene field effect transistor (G-FET) biosensor using PNA and DNA probes. The limit of detection (LOD) of the PNA probe modified G-FET sensor is down to 0.1 aM, which is three orders of magnitude lower than that of DNA probe modified G-FET sensor. We demonstrate that both PNA and DNA probe-modified G-FET have great potential in quantitative detection of RNA. A good linear electrical response to RNA concentrations is obtained in a broad range from 0.1 aM to 1 pM for PNA probe-modified G-FET and from 100 aM to 1 pM for DNA probe-modified GFET, respectively. The PNA probe-modified G-FET sensors significantly reduce the detection time compared to DNA probe-modified G-FET sensors. Moreover, the electrical response of PNA probe-modified G-FET biosensor to non-complementary RNA is negligible, showing high specificity for RNA detection. What's more, the G-FET sensor was also used to detect RNA in human serum, making it a promising way for future detection of RNA in biomedical research and early clinical diagnosis.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Tian M., Qiao M., Shen C., Meng F., Frank L. A., Krasitskaya V. V., Wang T., Zhang X., Song R., Li Y., Liu J., Xu S., Wang J.
Заглавие : Highly-sensitive graphene field effect transistor biosensor using PNA and DNA probes for RNA detection
Место публикации : Appl Surf Sci: Elsevier B.V., 2020. - Vol. 527. - Ст.146839. - ISSN 01694332 (ISSN), DOI 10.1016/j.apsusc.2020.146839
Аннотация: DNA probe-based biosensors have been widely developed for detecting a range of analytes. However, the DNA probe-based sensors suffer from many problems, such as long hybridization time, background electrical noise, and relatively poor specificity. In this paper, we report the ultrasensitive detection for RNA by graphene field effect transistor (G-FET) biosensor using PNA and DNA probes. The limit of detection (LOD) of the PNA probe-modified G-FET sensor is down to 0.1 aM, which is three orders of magnitude lower than that of DNA probe-modified G-FET sensor. We demonstrate that both PNA and DNA probe-modified G-FET have great potential in quantitative detection of RNA. A good linear electrical response to RNA concentrations is obtained in a broad range from 0.1 aM to 1 pM for PNA probe-modified G-FET and from 100 aM to 1 pM for DNA probe-modified G-FET, respectively. The PNA probe-modified G-FET sensors significantly reduce the detection time compared to DNA probe-modified G-FET sensors. Moreover, the electrical response of PNA probe-modified G-FET biosensor to non-complementary RNA is negligible, showing high specificity for RNA detection. What's more, the G-FET sensor was also used to detect RNA in human serum, making it a promising way for future detection of RNA in biomedical research and early clinical diagnosis. © 2020 Elsevier B.V.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Smolyarova, Tatyana E., Shanidze, Lev, V, Lukyanenko, Anna, V, Baron, Filipp A., Krasitskaya, Vasilisa V., Kichkailo, Anna S., Tarasov, Anton S., Volkov, Nikita
Заглавие : Protein biosensor based on Schottky barrier nanowire field effect transistor
Колич.характеристики :6 с
Коллективы : RFBRRussian Foundation for Basic Research (RFBR) [20-32-90134]; Krasnoyarsk Regional Fund of Science [20-42-243007, 20-42-240013]; Government of the Russian Feder-ation, Mega Grant for the Creation of Competitive World-Class Labora-tories [075-15-2019-1886]; RFBRRussian Foundation for Basic Research (RFBR); Krasnoyarsk Terri-tory
Место публикации : Talanta: ELSEVIER, 2022. - Vol. 239. - Ст.123092. - ISSN 0039-9140, DOI 10.1016/j.talanta.2021.123092. - ISSN 1873-3573(eISSN)
Примечания : Cited References:44. - The reported study was funded by RFBR according to the research project N? 20-32-90134. The authors thank RFBR, Krasnoyarsk Terri-tory and Krasnoyarsk Regional Fund of Science (projects nos. 20-42-243007 and 20-42-240013) and the Government of the Russian Feder-ation, Mega Grant for the Creation of Competitive World-Class Labora-tories (Agreement no. 075-15-2019-1886) for financial support. Electron microscopy investigations were conducted with the help of equipment of the Krasnoyarsk Territorial Shared Resource Center, Krasnoyarsk Scientific Center, Russian Academy of Sciences.
Предметные рубрики: SIMULATION
MODEL
Аннотация: A top-down nanofabrication approach involving molecular beam epitaxy and electron beam lithography was used to obtain silicon nanowire-based back gate field-effect transistors with Schottky contacts on silicon-oninsulator (SOI) wafers. The resulting device is applied in biomolecular detection based on the changes in the drain-source current (I-DS). In this context, we have explained the physical mechanisms of charge carrier transport in the nanowire using energy band diagrams and numerical 2D simulations in TCAD. The results of the experiment and numerical modeling matched well and may be used to develop novel types of nanowire-based biosensors.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Smolyarova T. E., Shanidze L. V., Lukyanenko A. V., Baron F. A., Krasitskaya V. V., Kichkailo A. S., Tarasov A. S., Volkov N.
Заглавие : Protein biosensor based on Schottky barrier nanowire field effect transistor
Место публикации : Talanta: Elsevier B.V., 2022. - Vol. 239. - Ст.123092. - ISSN 00399140 (ISSN), DOI 10.1016/j.talanta.2021.123092
Аннотация: A top-down nanofabrication approach involving molecular beam epitaxy and electron beam lithography was used to obtain silicon nanowire-based back gate field-effect transistors with Schottky contacts on silicon-on-insulator (SOI) wafers. The resulting device is applied in biomolecular detection based on the changes in the drain-source current (IDS). In this context, we have explained the physical mechanisms of charge carrier transport in the nanowire using energy band diagrams and numerical 2D simulations in TCAD. The results of the experiment and numerical modeling matched well and may be used to develop novel types of nanowire-based biosensors. © 2021 Elsevier B.V.
Scopus
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