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α-C-Mannosyltryptophan is a Structural Analog of the Luciferin from Bioluminescent Siberian Earthworm Henlea sp. / M. A. Dubinnyi, I. A. Ivanov, N. S. Rodionova [et al.] // ChemistrySelect. - 2020. - Vol. 5, Is. 42. - P13155-13159, DOI 10.1002/slct.202003075 . - ISSN 2365-6549
Кл.слова (ненормированные):
Bioluminescence -- Earthworm -- Henlea -- Natural products -- NMR spectroscopy
Аннотация: Cold extract from bioluminescent earthworm Henlea sp. was studied by HPLC, 1D and 2D NMR and LC-HRMS analysis. An abundant structural analog of the luciferin was isolated and identified as ?-C-mannosyltryptophan (ManTrp), the product of unusual C2-glycosylation found earlier in humans, ascidians and other animals. Two compounds in cold extract (P300b, P300c) were characterized as C2-substituted derivatives of tryptophan. We hypothesize that a series of tryptophan-containing compounds are possible participants of bioluminescence-related metabolism in Henlea sp. © 2020 Wiley-VCH GmbH

Scopus
Держатели документа:
Shemyakin-Ovchinnikov Institute of bioorganic chemistry, Russian academy of Sciences GSP-7, Miklukho-Maklaya str., 16/10, Moscow, 117997, Russian Federation
Institute of Biophysics, Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation
Pirogov Russian National Research Medical University, 1 Ostrovityanova st., Moscow, 117997, Russian Federation

Доп.точки доступа:
Dubinnyi, M. A.; Ivanov, I. A.; Rodionova, N. S.; Kovalchuk, S. I.; Kaskova, Z. M.; Petushkov, V. N.

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Trace elements exchange in experimental closed life support systems [Text] / I. V. Gribovskaya, V. Y. Rygalov ; ed. ya, IV Gribovs // SIXTH EUROPEAN SYMPOSIUM ON SPACE ENVIRONMENTAL CONTROL SYSTEMS, VOLS 1 AND 2. Ser. ESA SPECIAL PUBLICATIONS : EUROPEAN SPACE AGENCY, 1997. - Vol. 400: 6th European Symposium on Space Environmental Control Systems (MAY 20-22, 1997, NOORDWIJK, NETHERLANDS). - P. 859-862. - Cited References: 0 . - ISBN 0379-6566. - ISBN 92-9092-283-4

РУБ Engineering, Aerospace

Аннотация: Measurements of trace elements incoming and exiting ''Bios-3'' biological-engineering life support system evidence presence of a source of these elements inside the system. This source is, most probably, structural units (steel walls, hose rubber, plastic coatings), catalysts of the thermal catalytic incinerator, expanded clay aggregate mechanically fixing plants and so on. The trace elements are received by the nutrient solutions and build up in the plant biomass. As a consequence the crew may receive elevated doses of such trace elements as aluminum, lead, nickel, chromium. To reduce income of trace elements to LSS requires thorough selection and preliminary treatment of structural materials with reduced desorption capacities and running-in of the system in idle mode prior to exploitation. This mode involves operation of the engineering part of the system (without plants and humans, but with nutrient solutions) for several months.

WOS : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Gribovskaya, I.V.; Rygalov, V.Y.; Gribovs, ya, IV \ed.\

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Theoretical and experimental decisions in the creation of an artificial ecosystem for human life support in space. / L. V. Kirensky [et al.] // Life sciences and space research. - 1971. - Vol. 9. - P75-80 . - ISSN 0075-9422
Кл.слова (ненормированные):
article -- bacterium -- biotechnology -- Chlorella -- energy metabolism -- human -- instrumentation -- man machine interaction -- metabolism -- microclimate -- space flight -- weightlessness -- Bacteria -- Biotechnology -- Chlorella -- Ecological Systems, Closed -- Energy Metabolism -- Environment, Controlled -- Humans -- Life Support Systems -- Man-Machine Systems -- Space Flight -- Weightlessness
Аннотация: All of man's former space flights were not real ventures into space in the biological sense, as his life was supported with unregenerated earth supplies. The coming stage of space exploration requires man's long existence in the cosmos and on the other planets. This stage of man's activity outside the earth become possible only by creating small man-made ecosystems, permitting the support of his metabolism by the recycling of substances of the terrestrial biosphere. Creation of such systems is a new scientific and technical task. Man-made ecosystems are a new product of man's activity, which have no complete analogy, either in nature, or in technology. Stochastic mechanisms, which stabilize biogeocenosis, cannot be effective in small ecosystems. A technique of parametric control over biosynthesis made it possible to calculate, and put to practice, an ecosystem for man with a cyclic regeneration of the atmosphere, water and, partially, food. The specific bio-technological properties of small man-made ecosystems are being analysed. The possibility of their application for man's excursions into space and for the settlement of other planets is being considered.

Scopus
Держатели документа:
Institute of Physics, Akademgorodok, Krasnoyarsk, USSR. : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Kirensky, L.V.; Gitelson, I.I.; Terskov, I.A.; Kovrov, B.G.; Lisovsky, G.M.; Okladnikov, Y.N.

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The role of volatile metabolites in microbial communities of the LSS higher plant link / L. S. Tirranen, I. I. Gitelson // Advances in Space Research. - 2006. - Vol. 38, Is. 6. - P1227-1232, DOI 10.1016/j.asr.2006.02.038 . - ISSN 0273-1177
Кл.слова (ненормированные):
Inhibiting, bactericidal, stimulating effect -- Microbial interaction -- Type of interaction -- Volatile and non-volatile metabolites -- Growth kinetics -- Microbiology -- Microorganisms -- Plants (botany) -- Sensitivity analysis -- Toxic materials -- Inhibiting, bactericidal, stimulating effect -- Microbial interaction -- Type of interaction -- Volatile and non-volatile metabolites -- Metabolites
Аннотация: The paper addresses the possibility of controlling the microbial community composition through metabolites produced by microbes. The comparative analysis of experimental data has shown that volatile metabolites make a much greater contribution to the microbial interactions than nonvolatile ones. It has been found that interaction of microorganisms via the volatiles they release occurs frequently and is typical of a number of microorganisms. Volatile metabolites released by microorganisms produce an inhibitory, sometimes bactericidal, effect on the vital functions of bacteria. The stimulating action occurs 6-8 times less frequently. The range of action on the growth of the test cultures and the range of sensitivity to the effect of volatile metabolites of the study microbes have been found to be individual. Comparative cluster analysis of the ranges of action of 100 study cultures has shown that in the investigated set of microorganism species interaction was performed via a set of volatiles of an inhibiting action (82) and of a stimulating action (52). It has been found that release of volatile metabolites by the studied microorganisms depends upon the culture age, concentrations of components of the nutrient medium, and volatile by-products released by other microorganisms. This production can be increased or decreased by the action of volatile metabolites of other microbes. This is related to strain features and culture age. The prospects of using these regulating metabolites depend on the "range", specificity and safety for other members of the microbial community in insufficient concentrations. Volatiles produced by plants and microorganisms as well as by other components of the system - humans and processing equipment installed inside the closed ecosystem - could influence the formation not only of the microbial community but also of the gas composition of the system's atmosphere, through which they could affect the state of the plants. Specially performed experiments have shown that volatile metabolites of microorganisms can accumulate in their habitat, dissolve in the atmospheric water, and maintain their biological activity for days. It has been determined that volatile metabolites of some microorganisms are toxic for plants. Growth of seedling roots is inhibited more than growth of stems. В© 2006 COSPAR.

Scopus
Держатели документа:
Institute of Biophysics SB RAS, Akademgorodok, 660036 Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Tirranen, L.S.; Gitelson, I.I.

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The general evolution of energy–matter interactions on earth: From a gas whirlwind to a technogenic civilization / N. S. Pechurkin, A. N. Shuvaev // Biophysics. - 2015. - Vol. 60, Is. 2. - P331-334, DOI 10.1134/S0006350915020153 . - ISSN 0006-3509
Кл.слова (ненормированные):
biosphere -- energy transfer -- evolution -- Animalia -- Mammalia -- Protozoa
Аннотация: An idea of the general evolution through the long-term response of the Earth to the external flow of radiant energy from the Sun is proposed. Due to the finiteness of matter on Earth, as well as on any other planet, the continuous pumping flow of radiant energy has been shown to lead to cyclization of transformations and mass transfer along the emerging gradients. The evolution of the energy–matter interaction follows the pathway of capturing and transferring more energy by a smaller quantity of matter, i.e., the pathway of the increase in the amount of energy used by each unit mass. According to this parameter, the least effective mass transfer is a simple transfer as vortices of gases along the gradients of temperature and pressure, which took place on the primary surface of the planet. Long-term natural selection towards water accumulation on the planet has played a special role in the development of the interaction between energy and matter. Phase transitions (ice, water, and vapor) and mechanical transfers are the most common energy–matter processes. Chemical transformation of substances became possible based on water cycles, cyclic transfers, and transformations and developed with time into biological transformation. This type of energy–matter interaction is the most efficient. In particular, the energy of our star is captured during photosynthesis and utilized in the most active region of its radiation spectrum. During the biological evolution of heterotrophs, a increase in the coefficient that characterizes the energy exchange intensity from protozoa to mammals by several hundred times is most illustrative. The development and current dominance of humans as the species that is most active in the capturing of energy and meaningful organization of its new flows, in particular, based on the organic debris of former biospheres, is amazing but quite natural from the energy standpoint. During the technological evolution of humankind, the energy-exchange intensity for homoiotherms (warm-blooded animals) has increased by 20 times if it is recalculated for the technological energy that is used by the average inhabitant of the Earth. Thus, the victory of our species in planetary evolution fits well into the mainstream of the general evolution through energy–matter interactions: a multiple increase in star energy has been used to transform the matter on the surface of the irradiated planet. © 2015, Pleiades Publishing, Inc.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Institute of Engineering Physics and Radioelectronics, Siberian Federal University, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Pechurkin, N.S.; Shuvaev, A.N.

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Structural and temporal links between the components of humoral immunity. / T. M. Ovchinnikova [et al.] // Doklady Biochemistry. - 2000. - Vol. 374, Is. 1-6. - P186-188 . - ISSN 0012-4958
Кл.слова (ненормированные):
immunoglobulin A -- immunoglobulin D -- immunoglobulin G -- immunoglobulin M -- antibody production -- article -- biological model -- blood -- herpes simplex -- human -- immunology -- physiology -- regression analysis -- Antibody Formation -- Herpes Simplex -- Humans -- Immunoglobulin A -- Immunoglobulin D -- Immunoglobulin G -- Immunoglobulin M -- Models, Immunological -- Regression Analysis

Scopus
Держатели документа:
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, Russia. : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Ovchinnikova, T.M.; Savchenko, A.A.; Sukhovol'skii, V.G.; Khlebopros, R.G.

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Some methods for human liquid and solid waste utilization in bioregenerative life-support systems / S. A. Ushakova [et al.] // Applied Biochemistry and Biotechnology. - 2008. - Vol. 151, Is. 2-3. - P676-685, DOI 10.1007/s12010-008-8291-3 . - ISSN 0273-2289
Кл.слова (ненормированные):
Closure -- Human waste -- Life-support systems -- Salicornia -- Sodium chloride -- Above-ground biomass -- Biological lives -- Bioregenerative -- Closure -- Cultivation process -- Culture methods -- Human waste -- Irrigation waters -- Life-support systems -- Manned space missions -- Mineral elements -- Physico-chemical methods -- Salicornia -- Salicornia europaea -- Salt-tolerant -- Soil-like substrates -- Biomass -- Body fluids -- Electrodialysis -- Grain (agricultural product) -- Irrigation -- Liquids -- Metal refining -- Minerals -- Mining -- Oxidation -- Plant shutdowns -- Sodium chloride -- Soils -- Solid wastes -- Substrates -- Water supply -- Vegetation -- article -- biomass -- controlled study -- electrodialysis -- halophyte -- irrigation (agriculture) -- microclimate -- nonhuman -- recycling -- Salicornia europaea -- solid waste -- bioremediation -- dialysis -- feces -- goosefoot -- growth, development and aging -- human -- methodology -- salt tolerance -- urine -- waste management -- wheat -- Batis maritima -- Salicornia -- Salicornia europaea -- Triticum aestivum -- Biodegradation, Environmental -- Chenopodiaceae -- Dialysis -- Feces -- Humans -- Life Support Systems -- Salt-Tolerance -- Triticum -- Urine -- Waste Management
Аннотация: Bioregenerative life-support systems (BLSS) are studied for developing the technology for a future biological life-support system for long-term manned space missions. Ways to utilize human liquid and solid wastes to increase the closure degree of BLSS were investigated. First, urine and faeces underwent oxidation by Kudenko's physicochemical method. The products were then used for root nutrition of wheat grown by the soil-like substrate culture method. Two means of eliminating sodium chloride, introduced into the irrigation solution together with the products of urine oxidation, were investigated. The first was based on routine electrodialysis of irrigation water at the end of wheat vegetation. Dialysis eliminated about 50% of Na from the solution. This desalinization was performed for nine vegetations. The second method was new: after wheat cultivation, the irrigation solution and the solution obtained by washing the substrate containing mineral elements not absorbed by the plants were used to grow salt-tolerant Salicornia europaea L. plants (saltwort). The above-ground biomass of this plant can be used as a food, and roots can be added to the soil-like substrate. Four consecutive wheat and Salicornia vegetations were cultivated. As a result of this wheat and Salicornia cultivation process, the soil-like substrate salinization by NaCl were considerably decreased. В© 2008 Humana Press.

Scopus
Держатели документа:
Institute of Biophysics, Russian Academy of Science, Siberian Branch, 660036 Krasnoyarsk, Russian Federation
K.A. Timiraziev Institute of Plant Physiology, Russian Academy of Science, 35 Botanisheskaya, 127276 Moscow, Russian Federation
LGCB, Universite Blaise Pascal, Polytech'Clermont-Ferrand, P.O. Box 206, 63174 Aubiere cedex, France : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Ushakova, S.A.; Zolotukhin, I.G.; Tikhomirov, A.A.; Tikhomirova, N.A.; Kudenko, Yu.A.; Gribovskaya, I.V.; Balnokin, Yu.; Gros, J.B.

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Secondary Production of Highly Unsaturated Fatty Acids by Zoobenthos Across Rivers Contrasting in Temperature [Text] / M. I. Gladyshev [et al.] // River Res. Appl. - 2016. - Vol. 32, Is. 6. - P1252-1263, DOI 10.1002/rra.2945. - Cited References:55. - The work was supported by the project no. 6.1089.214/K of Siberian Federal University carried out according to Federal Tasks of Ministry of Education and Science of Russian Federation and by Russian Federal Tasks of Fundamental Research (project no. 51.1.1). . - ISSN 1535-1459. - ISSN 1535-1467

РУБ Environmental Sciences + Water Resources
Рубрики:
AQUATIC ECOSYSTEMS
   CLIMATE-CHANGE
   YENISEI RIVER
   ALPINE PONDS
   LAKE
Кл.слова (ненормированные):
essential polyunsaturated fatty acids -- river zoobenthos -- secondary -- production -- biodiversity -- water temperature -- climate warming
Аннотация: Highly unsaturated fatty acids (HUFA), namely eicosapentaenoic acid (20:5n-3, EPA) and docosahexaenoic acid (22:6n-3, DHA), which are essential for many animals, including humans, are mainly produced in aquatic trophic webs. In fast-flowing rivers, macrozoobenthos is the main source of HUFA for fish and may be particularly vulnerable to thermal alterations associated with climate change. We studied benthic communities in a unique natural ecosystem: the Yenisei River downstream of the dam of Krasnoyarsk Hydroelectric Power Station with very low temperature in summer because of discharge of cold water from deep in the reservoir and its tributaries with high summer temperature. This natural experiment' allowed to get rid of confounding factors, such as differences in light, seasonality, geology (biogeochemistry) and biogeography (regional species pools). As found, in spite of an increase of biodiversity and rates of daily production in warm rivers compared with cold sites, DHA and partly EPA production of zoobenthos decreased with the increase of temperature because of changes in species composition. Thus, in a climate warming context, we can predict a decrease of production of these HUFA by river zoobenthos and thereby a diminishing of their supply for fish and next to humans. Copyright (c) 2015 John Wiley & Sons, Ltd.

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Держатели документа:
Russian Acad Sci, Inst Biophys, Siberian Branch, Krasnoyarsk 660036, Russia.
Siberian Fed Univ, Krasnoyarsk 660041, Russia.

Доп.точки доступа:
Gladyshev, M. I.; Sushchik, N. N.; Shulepina, S. P.; Ageev, A. V.; Dubovskaya, O. P.; Kolmakova, A. A.; Kalachova, G. S.; Siberian Federal University [6.1089.214/K]; Russian Federal Tasks of Fundamental Research [51.1.1]

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Role of essential fatty acids in trophometabolic interactions in the freshwater ecosystems (a review) / N. N. Sushchik // Zhurnal Obshchei Biologii. - 2008. - Vol. 69, Is. 4. - С. 299-316 . - ISSN 0044-4596
Кл.слова (ненормированные):
essential fatty acid -- fresh water -- animal -- article -- ecosystem -- fish -- food chain -- human -- metabolism -- phytoplankton -- zooplankton -- Animals -- Ecosystem -- Fatty Acids, Essential -- Fishes -- Food Chain -- Fresh Water -- Humans -- Phytoplankton -- Zooplankton -- algae -- Animalia -- Bacteria (microorganisms) -- Invertebrata -- Vertebrata
Аннотация: Polyunsaturated fatty acids (PUFA) of ?3 family are of crucial physiological importance for the most animals and they are an essential and deficient component of human nutrition. These compounds are most effectively synthesized by some groups of algae, hence, aquatic ecosystems are considered to be the main source of these PUFA for human nutrition. Factors controlling the content and distribution of ?3 PUFA in freshwater organisms of basic trophic levels and determined PUFA final production in freshwater ecosystems are considered in the review. PUFA biosynthesis is known to be tightly related to basic fatty acid metabolic pathways. Hence, fatty composition and the PUFA content of major freshwater hydrobiont groups, including bacteria, algae, invertebrates and vertebrates, and environmental and population age effects are described. The peculiarities of PUFA transfer between organisms of various trophic levels are discussed. The essential ?3 PUFA is one of the important parameter of food quality of aquatic consumers and they can determine the rate of energy and matter transfer between producers and primary consumers and, as a result, in a whole freshwater food chain. Analysis of PUFA content and its regulation in biomass of various fish populations indicates that freshwater ecosystems are of the same value in respect of PUFA sources as marine ecosystems. Despite the great practical importance, the studies focused on production and whole pools of ?3 PUFA in different freshwater ecosystems are still scarce and need to be continued.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Sushchik, N.N.

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10.

Reusable biochemical diagnosis systems based on nanodiamonds / V. S. Bondar [et al.] // Doklady Biochemistry and Biophysics. - 2013. - Vol. 448, Is. 1. - P55-58, DOI 10.1134/S160767291301016X . - ISSN 1607-6729
Кл.слова (ненормированные):
cholesterol -- diamond -- nanoparticle -- article -- bioassay -- blood -- chemical model -- chemistry -- glucose blood level -- human -- methodology -- Biological Assay -- Blood Glucose -- Cholesterol -- Diamond -- Humans -- Models, Chemical -- Nanoparticles

Scopus
Держатели документа:
Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, 660036, Russian Federation
Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Bondar, V.S.; Ronzhin, N.O.; Mamaeva, E.S.; Baron, A.V.; Gitelson, J.I.

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11.

Quality and Quantity of Biological Production in Water Bodies with Different Concentration of Phosphorus: Case Study of Eurasian Perch / M. I. Gladyshev // Dokl. Biochem. Biophys. - 2018. - Vol. 478, Is. 1. - P1-3, DOI 10.1134/S1607672918010015. - Cited References:15. - This work was supported by the project of the Russian Academy of Sciences no. II.2P/VI.51-1, the State task of the Ministry of Education and Science of the Russian Federation to the Siberian Federal University for research no. 6.1504.2017/PCh, and the Council for Grants of the President of the Russian Federation for State Support of Leading Scientific Schools (project no. NSh-9249.2016.5). . - ISSN 1607-6729. - ISSN 1608-3091

РУБ Biochemistry & Molecular Biology + Biophysics
Рубрики:
POLYUNSATURATED FATTY-ACIDS
EPA
DHA
Аннотация: For the first time, the quantity of protectors of cardiovascular deceases-omega-3 polyunsaturated fatty acids, eicosapentaenoic (20:5n-3, EPA) and docosahexaenoic (22:6n-3, DHA), obtained through fish (Eurasian perch) catch in water bodies of different trophic status was determined. A formula was drawn to calculate the quantity of obtained EPA + DHA (kg km(-2) year(-1)) depending on the concentration of total phosphorus in water. It is found that the maximum quantity of EPA + DHA can be obtained by humans from fish caught in mesotrophic water bodies.

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Держатели документа:
Russian Acad Sci, Krasnoyarsk Res Ctr, Inst Biophys, Siberian Branch, Krasnoyarsk 660036, Russia.
Siberian Fed Univ, Krasnoyarsk 660041, Russia.

Доп.точки доступа:
Gladyshev, M. I.; Russian Academy of Sciences [II.2P/VI.51-1]; State task of the Ministry of Education and Science of the Russian Federation [6.1504.2017/PCh]; Council for Grants of the President of the Russian Federation for State Support of Leading Scientific Schools [NSh-9249.2016.5]

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12.

Production of purified polyhydroxyalkanoates (PHAs) for applications in contact with blood / V. I. Sevastianov [et al.] // Journal of Biomaterials Science, Polymer Edition. - 2003. - Vol. 14, Is. 10. - P1029-1042, DOI 10.1163/156856203769231547 . - ISSN 0920-5063
Кл.слова (ненормированные):
?-hydroxy acids -- Endotoxins -- Hemocompatibility -- Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) -- Polyhydroxyalkanoates (PHAs) -- Polyhydroxybutyrate (PHB) -- bacterium lipopolysaccharide -- carbon -- complement -- copolymer -- hydroxyacid -- long chain fatty acid -- poly(3 hydroxybutyric acid) -- polyhydroxyalkanoic acid -- valeric acid derivative -- adult -- article -- biofilm -- biotechnology -- blood analysis -- blood clotting -- blood compatibility -- cell function -- chemical analysis -- chemical composition -- complement activation -- concentration (parameters) -- controlled study -- gas chromatography -- hemostasis -- human -- human cell -- mass spectrometry -- micromorphology -- nonhuman -- priority journal -- purification -- quantitative analysis -- sampling -- synthesis -- thrombocyte adhesion -- Wautersia eutropha -- Biocompatible Materials -- Blood -- Blood Coagulation Tests -- Chromatography, Gas -- Complement Activation -- Cupriavidus necator -- Fatty Acids -- Humans -- Platelet Adhesiveness -- Polyesters -- Surface Properties
Аннотация: Samples of olyhydroxyalkanoates (PHAs), polyhydroxybutyrate (PHB) and copolymers poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) with 4 and 18 mol% hydroxyvalerate, synthesized by the bacteria Ralstonia eutropha B5786, were investigated. PHA films in contact with blood did not activate the hemostasis system at the level of cell response, but they did activate the coagulation system and the complement reaction. To detect biologically-active components in the PHAs, a detailed analysis of the composition of the polymers was conducted. Gas chromatography-mass spectrometry revealed long-chain fatty acids (FAs) in the tested PHAs. Their total concentration in the polymer ranged from tenths of mol% to 2-3 mol%, depending on the purification method. C16:0 constituted the largest proportion, up to 70%. Of the long-chain hydroxy acids, only ?-OH-C14:0 was detected and it did not exceed 0.06 mol%. The analysis of the hemocompatibility properties of the PHAs purified by a specialized procedure, including the quantitative and morphological estimation of platelets adherent to the surface of polymer films, the plasma recalcification time and complement activation studies, indicated that PHB and PHBV can be used in contact with blood. It has been found out that the lipopolysaccharides of bacteria producing PHAs, which contain mostly long-chain hydroxy acids, can be the factor activating the hemostasis systems. Thus, the technology of PHA purification must satisfy rather stringent specific requirements.

Scopus
Держатели документа:
Inst. of Transplantol. Artif. Organs, Russian Ministry of Health, Shchukinskaya 1, 123182 Moscow, Russian Federation
Inst. of Biophys. of Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Sevastianov, V.I.; Perova, N.V.; Shishatskaya, E.I.; Kalacheva, G.S.; Volova, T.G.

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13.

Production of EPA and DHA in aquatic ecosystems and their transfer to the land / M. I. Gladyshev, N. N. Sushchik, O. N. Makhutova // Prostaglandins and Other Lipid Mediators. - 2013, DOI 10.1016/j.prostaglandins.2013.03.002 . - ISSN 1098-8823
Кл.слова (ненормированные):
Aquatic ecosystems -- Docosahexaenoic acid -- Eicosapentaenoic acid -- Trophic transfer efficiency
Аннотация: Most omnivorous animals, including humans, have to some degree relied on physiologically important polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from food. Only some taxa of microalgae, rather than higher plants can synthesize de novo high amounts of EPA and DHA. Once synthesized by microalgae, PUFA are transferred through trophic chain to organisms of higher levels. Thus, aquatic ecosystems play the unique role in the Biosphere as the principal source of EPA and DHA for most omnivorous animals, including inhabitants of terrestrial ecosystems. PUFA are transferred from aquatic to terrestrial ecosystems through riparian predators, drift of carrion and seaweeds, emergence of amphibiotic insects, and water birds. The essential PUFA are transferred through trophic chains with about twice higher efficiency than bulk carbon. Thereby, PUFA are accumulated, rather than diluted in biomass of organisms of higher trophic levels, e.g., in fish. Mankind is faced with a severe deficiency of EPA and DHA in diet. Although additional sources of PUFA supply for humans, such as aquaculture, biotechnology of microorganisms and transgenic terrestrial oil-seed producing plants are developed, natural fish production of aquatic ecosystems will remain one of the main sources of EPA and DHA for humans. Aquatic ecosystems have to be protected from anthropogenic impacts, such as eutrophication, pollution and warming, which reduce PUFA production. В© 2013 Elsevier Inc. All rights reserved.

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Держатели документа:
Institute of Biophysics of Siberian Branch of Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036, Russia
Siberian Federal University, Svobodny av. 79, Krasnoyarsk 660041, Russia : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Gladyshev, M.I.; Sushchik, N.N.; Makhutova, O.N.

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14.

Production of EPA and DHA in aquatic ecosystems and their transfer to the land [Text] / M. I. Gladyshev, N. N. Sushchik, O. N. Makhutova // Prostaglandins Other Lipid Mediat. - 2013. - Vol. 107. - P117-126, DOI 10.1016/j.prostaglandins.2013.03.002. - Cited References: 129. - This work was supported by grants of Russian Foundation for Basic Research (RFBR) No. 11-04-00168 and No. 12-05-00298, and also by the project B-15 of Siberian Federal University, carried out according to Federal Tasks of Ministry of Education and Science of Russian Federation. We are grateful to two anonymous reviewers for their helpful comments to improve the manuscript. . - 10. - ISSN 1098-8823

РУБ Biochemistry & Molecular Biology + Cell Biology
Рубрики:
POLYUNSATURATED FATTY-ACIDS
   FRESH-WATER FISH
   EICOSAPENTAENOIC ACID
   DOCOSAHEXAENOIC ACID
   YENISEI RIVER
   BIOTECHNOLOGICAL PRODUCTION
   ARBUSCULAR MYCORRHIZAL
   CAENORHABDITIS-ELEGANS
   MICROBIAL COMMUNITY
   THYMALLUS-ARCTICUS
Кл.слова (ненормированные):
Eicosapentaenoic acid -- Docosahexaenoic acid -- Aquatic ecosystems -- Trophic transfer efficiency
Аннотация: Most omnivorous animals, including humans, have to some degree relied on physiologically important polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from food. Only some taxa of microalgae, rather than higher plants can synthesize de novo high amounts of EPA and DHA. Once synthesized by microalgae, PUFA are transferred through trophic chain to organisms of higher levels. Thus, aquatic ecosystems play the unique role in the Biosphere as the principal source of EPA and DHA for most omnivorous animals, including inhabitants of terrestrial ecosystems. PUFA are transferred from aquatic to terrestrial ecosystems through riparian predators, drift of carrion and seaweeds, emergence of amphibiotic insects, and water birds. The essential PUFA are transferred through trophic chains with about twice higher efficiency than bulk carbon. Thereby, PUFA are accumulated, rather than diluted in biomass of organisms of higher trophic levels, e.g., in fish. Mankind is faced with a severe deficiency of EPA and DHA in diet. Although additional sources of PUFA supply for humans, such as aquaculture, biotechnology of microorganisms and transgenic terrestrial oil-seed producing plants are developed, natural fish production of aquatic ecosystems will remain one of the main sources of EPA and DHA for humans. Aquatic ecosystems have to be protected from anthropogenic impacts, such as eutrophication, pollution and warming, which reduce PUFA production. (C) 2013 Elsevier Inc. All rights reserved.

WOS,
Scopus
Держатели документа:
[Gladyshev, Michail I.
Sushchik, Nadezhda N.
Makhutova, Olesia N.] Russian Acad Sci, Inst Biophys, Siberian Branch, Krasnoyarsk 660036, Russia
[Gladyshev, Michail I.
Sushchik, Nadezhda N.] Siberian Fed Univ, Krasnoyarsk 660041, Russia
ИБФ СО РАН : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Gladyshev, M.I.; Sushchik, N.N.; Makhutova, O.N.; Russian Foundation for Basic Research (RFBR) [11-04-00168, 12-05-00298]; project B-15 of Siberian Federal University

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15.

Population model for malignant tumor and organism interaction / V. A. Slepkov, V. G. Sukhovol'skiy, R. G. Khlebopros // Doklady Biological Sciences. - 2010. - Vol. 430, Is. 1. - P17-19, DOI 10.1134/S0012496610010060 . - ISSN 0012-4966
Кл.слова (ненормированные):
article -- biological model -- cancer invasion -- human -- neoplasm -- pathophysiology -- Humans -- Models, Biological -- Neoplasm Invasiveness -- Neoplasms

Scopus
Держатели документа:
Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent'eva 3, Novosibirsk 630090, Russian Federation
Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk 630036, Russian Federation
International Scientific Center for Studies of Extreme States, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok 50, Krasnoyarsk 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Slepkov, V.A.; Sukhovol'skiy, V.G.; Khlebopros, R.G.

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16.

Pesticides: formulants, distribution pathways and effects on human health-a review / V. P. Kalyabina, E. N. Esimbekova, K. V. Kopylova, V. A. Kratasyuk // Toxicol. Rep. - 2021. - Vol. 8. - P1179-1192, DOI 10.1016/j.toxrep.2021.06.004. - Cited References:211. - The research was funding by the Government of Krasnoyarsk Territory, Krasnoyarsk Regional Fund of Science and Russian Foundation for Basic Research (project No 20-44-242001). . - ISSN 2214-7500

РУБ Toxicology
Рубрики:
GLYPHOSATE-BASED HERBICIDES
ENDOCRINE-DISRUPTING CHEMICALS
IN-VITRO
Кл.слова (ненормированные):
Pesticides -- Agricultural crops -- Health consequences -- Formulants -- Risk -- assessment
Аннотация: Pesticides are commonly used in agriculture to enhance crop production and control pests. Therefore, pesticide residues can persist in the environment and agricultural crops. Although modern formulations are relatively safe to non-target species, numerous theoretical and experimental data demonstrate that pesticide residues can produce long-term negative effects on the health of humans and animals and stability of ecosystems. Of particular interest are molecular mechanisms that mediate the start of a cascade of adverse effects. This is a review of the latest literature data on the effects and consequences of contamination of agricultural crops by pesticide residues. In addition, we address the issue of implicit risks associated with pesticide formulations. The effects of pesticides are considered in the context of the Adverse Outcome Pathway concept.

WOS
Держатели документа:
Siberian Fed Univ, 79 Svobodny Prospect, Krasnoyarsk 660041, Russia.
RAS, SB, Inst Biophys, 50-50 Akademgorodok, Krasnoyarsk 660036, Russia.

Доп.точки доступа:
Kalyabina, Valeriya P.; Esimbekova, Elena N.; Kopylova, Kseniya, V; Kratasyuk, Valentina A.; Esimbekova, Elena; Kalyabina, Valeriya; Kopylova, Kseniya; Government of Krasnoyarsk Territory, Krasnoyarsk Regional Fund of Science; Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR) [20-44-242001]

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17.

Pesticides: formulants, distribution pathways and effects on human health – a review / V. P. Kalyabina, E. N. Esimbekova, K. V. Kopylova, V. A. Kratasyuk // Toxicol. Rep. - 2021. - Vol. 8. - P1179-1192, DOI 10.1016/j.toxrep.2021.06.004 . - ISSN 2214-7500
Кл.слова (ненормированные):
Agricultural crops -- Formulants -- Health consequences -- Pesticides -- Risk assessment
Аннотация: Pesticides are commonly used in agriculture to enhance crop production and control pests. Therefore, pesticide residues can persist in the environment and agricultural crops. Although modern formulations are relatively safe to non-target species, numerous theoretical and experimental data demonstrate that pesticide residues can produce long-term negative effects on the health of humans and animals and stability of ecosystems. Of particular interest are molecular mechanisms that mediate the start of a cascade of adverse effects. This is a review of the latest literature data on the effects and consequences of contamination of agricultural crops by pesticide residues. In addition, we address the issue of implicit risks associated with pesticide formulations. The effects of pesticides are considered in the context of the Adverse Outcome Pathway concept. © 2021 The Author(s)

Scopus
Держатели документа:
Siberian Federal University, 79 Svobodny Prospect, Krasnoyarsk, 660041, Russian Federation
Institute of Biophysics SB RAS, 50/50 Akademgorodok, Krasnoyarsk, 660036, Russian Federation

Доп.точки доступа:
Kalyabina, V. P.; Esimbekova, E. N.; Kopylova, K. V.; Kratasyuk, V. A.

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18.

Perspectives of different type biological life support systems (BLSS) usage in space missions / S. I. Bartsev [et al.] // Acta Astronautica. - 1996. - Vol. 39, Is. 8. - P617-622, DOI 10.1016/S0094-5765(97)00012-X . - ISSN 0094-5765
Кл.слова (ненормированные):
article -- bacterium -- comparative study -- construction work and architectural phenomena -- environmental planning -- green alga -- human -- instrumentation -- mathematics -- microclimate -- moon -- plant -- quality of life -- space flight -- standard -- weightlessness -- Algae, Green -- Bacteria -- Ecological Systems, Closed -- Environment Design -- Environment, Controlled -- Facility Design and Construction -- Humans -- Life Support Systems -- Mathematics -- Moon -- Plants -- Quality of Life -- Space Flight -- Weightlessness -- Biology -- Life support systems (spacecraft) -- Spreadsheets -- Biological life support systems (BLSS) -- Lunar missions
Аннотация: In the paper an attempt is made to combine three important criteria of LSS comparison: minimum mass, maximum safety and maximum quality of life. Well-known types of BLSS were considered: with higher plant, higher plants and mushrooms, microalgae, and hydrogen-oxidizing bacteria. These BLSSs were compared in terms of "integrated" mass for the case of a vegetarian diet and a "normal" one (with animal proteins and fats). It was shown that the BLSS with higher plants and incineration of wastes becomes the best when the exploitation period is more than 1 yr. The dependence of higher plants' LSS structure on operation time was found. Comparison of BLSSs in terms of integral reliability (this criterion includes mass and quality of life criteria) for a lunar base scenario showed that BLSSs with higher plants are advantageous in reliability and comfort. This comparison was made for achieved level of technology of closing and for perspective one. В© 1997 Elsevier Science Ltd.

Scopus
Держатели документа:
Biophys. Inst. of SB RAS, Krasnoyarsk, 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Bartsev, S.I.; Gitelson, J.I.; Lisovsky, G.M.; Mezhevikin, V.V.; Okhonin, V.A.

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19.

Multiple antibiotic resistance of heterotrophic bacteria in the littoral zone of Lake Shira as an indicator of human impact on the ecosystem / T. I. Lobova [et al.] // Microbiological Research. - 2008. - Vol. 163, Is. 2. - P152-160, DOI 10.1016/j.micres.2006.03.014 . - ISSN 0944-5013
Кл.слова (ненормированные):
Antibiotic resistance -- Aquatic ecosystems -- Heterotrophic bacteria -- Human impact -- Monitoring -- Antibiotics -- Bacteria -- Ecosystems -- Environmental impact -- Mammals -- Antibiotic resistance -- Aquatic ecosystems -- Heterotrophic bacteria -- Materials -- antiinfective agent -- fresh water -- allochthony -- anthropogenic effect -- antibiotic resistance -- bacterium -- concentration (composition) -- heterotrophy -- intertidal environment -- monitoring -- recreational facility -- spring (season) -- summer -- animal -- article -- bacterial count -- bacterium -- drug effect -- ecosystem -- environmental monitoring -- heterotrophy -- human -- isolation and purification -- methodology -- microbiological examination -- microbiology -- multidrug resistance -- Russian Federation -- season -- Animals -- Anti-Bacterial Agents -- Bacteria -- Colony Count, Microbial -- Drug Resistance, Multiple, Bacterial -- Ecosystem -- Environmental Monitoring -- Fresh Water -- Heterotrophic Processes -- Humans -- Microbial Sensitivity Tests -- Russia -- Seasons -- Eurasia -- Khakassia -- Lake Shira -- Russian Federation -- Animalia -- Bacteria (microorganisms)
Аннотация: Resistance to Ampicillin and Kanamycin displayed by heterotrophic bacteria isolated in Summer and in Spring from the littoral and the central parts of Lake Shira (a therapeutic lake in the Khakasia Republic, Russia) has been investigated. It has been found that in Summer, human and animal microflora featuring multiple antibiotic resistance (to Ampicillin and Kanamycin) predominates in all the studied stations of the littoral zone of the lake. In Spring, concentrations of bacteria featuring multiple antibiotic resistance decrease significantly and bacteria sensitive to antibiotics predominate in the lake. Emergence of multiple antibiotic resistance in bacteria of Lake Shira is caused by the input of allochthonous bacteria into the lake; this feature of heterotrophic bacteria of Lake Shira can be used to monitor the impact on the ecosystem made by health resorts. В© 2006 Elsevier GmbH. All rights reserved.

Scopus
Держатели документа:
LTD Territory-oriented information systems, Institute of Computational Modeling, Russian Academy of Sciences, Akademgorodok 50, Krasnoyarsk 660036, Russian Federation
Institute of Biophysics, Russian Academy of Sciences, Siberian Branch, Akademgorodok 50, 660036, Russian Federation
Center of Hygiene and Epidemiology in Krasnoyarsk Region, Sopochnaya 38, Russian Federation
Krasnoyarsk Scientific Centre, Akademgorodok 50, Krasnoyarsk, 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Lobova, T.I.; Barkhatov, Y.V.; Salamatina, O.V.; Popova, L.Yu.

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20.

Modeling the growth and morphogenesis of malignant tumors / V. A. Slepkov, V. G. Sukhovol'skii, R. G. Khlebopros // Doklady Biochemistry and Biophysics. - 2006. - Vol. 411, Is. 1. - P342-345, DOI 10.1134/S1607672906060056 . - ISSN 1607-6729
Кл.слова (ненормированные):
animal -- article -- biological model -- cancer invasion -- cell proliferation -- computer simulation -- human -- morphogenesis -- neoplasm -- pathology -- pathophysiology -- Animals -- Cell Proliferation -- Computer Simulation -- Humans -- Models, Biological -- Morphogenesis -- Neoplasm Invasiveness -- Neoplasms

Scopus
Держатели документа:
Nikolaev Institute of Inorganic Chemistry, Siberian Division, Russian Academy of Sciences, Novosibirsk, 630090, Russian Federation
International Research Center for Extreme Body States, Presidium of the Krasnoyarsk Research Center, Siberian Division, Akademogorogok, Krasnoyarsk, 660036, Russian Federation
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Slepkov, V.A.; Sukhovol'skii, V.G.; Khlebopros, R.G.

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