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Bioaccumulation, inter-organ distribution, and retention of waterborne and dietary Am-241 in silver crucian carp [Text] / T. A. Zotina [et al.] // Toxicol Environ. Chem. - 2014. - Vol. 96, Is. 2. - P243-254, DOI 10.1080/02772248.2014.941368. - Cited References: 25 . - ISSN 0277-2248. - ISSN 1029-0486

РУБ Environmental Sciences + Toxicology
Рубрики:
YENISEI RIVER
   TELEOST FISH
   RADIONUCLIDES
   METALS
   AMERICIUM
   EXPOSURE
   ELEMENTS
   ASSIMILATION
   ELASMOBRANCH
   DEPURATION
Кл.слова (ненормированные):
Americium-241 -- assimilation -- Carassius auratus gibelio -- force-feeding
Аннотация: The bioaccumulation of actinide Am-241 from food and water in bodies of freshwater fish (Carassius auratus gibelio, silver crucian carp) has been investigated in laboratory experiments. Homogenized biomass of submerged macrophytes labeled with Am-241 was injected into the fish gullet. Internal organs and tissues of crucian carp could be ranked according to activity concentration of dietary Am-241 after depuration of the digestive tract as follows: liver > gonads > bones > muscles. Accumulation of waterborne Am-241 in internal organs and tissues of crucian carp mainly occurred via the digestive tract. While the concentration of Am-241 in liver of crucian carps decreased during depuration time, its concentration in bones increased indicating slower transfer of Am-241 to skeleton compared to muscles and liver. The retention of dietary Am-241 in the bodies of crucian carp reached 35%-46% of ingested Am-241: 20%-31% was retained in liver, 0.6%-0.8% in skeleton, and 1.4%-2.0% in muscles. The concentration factor of Am-241 from water was 0.4 for the whole body, 0.3 for liver, 0.01 for muscles, and 0.01 for skeleton. Trace amounts of Am-241 were recorded in viscera and muscles of a wild population of silver crucian carp inhabiting a radioactively contaminated part of the Yenisei River.

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Scopus
Держатели документа:
[Zotina, T. A.
Trofimova, E. A.
Dementyev, D. V.
Bolsunovsky, A. Y.] Inst Biophys SB RAS, Krasnoyarsk, Russia
ИБФ СО РАН : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Zotina, T.A.; Trofimova, E.A.; Dementyev, D.V.; Bolsunovsky, A.Y.

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Biocompatibility and resorption of intravenously administered polymer microparticles in tissues of internal organs of laboratory animals / E. Shishatskaya [et al.] // Journal of Biomaterials Science, Polymer Edition. - 2011. - Vol. 22, Is. 16. - P2185-2203, DOI 10.1163/092050610X537138 . - ISSN 0920-5063
Кл.слова (ненормированные):
14C products of polymer resorption -- intravenous administration -- microparticles -- Resorbable polyhydroxybutyrate -- tissues of internal organs -- 3-hydroxybutyric acid -- sup14/supC products of polymer resorption -- Adverse effect -- Drug-delivery systems -- Growth and development -- High molecular weight -- Initial molecular weight -- Initial values -- Internal organs -- Intravenous administration -- Laboratory animals -- Local response -- matrix -- Mean diameter -- Micro-particles -- Polymer degradation -- Polymer microparticles -- Preparation process -- Radioactivity level -- Residual content -- Resorbable -- Sustained-release -- Tail veins -- Wistar rat -- Animals -- Biocompatibility -- Degradation -- Histology -- Molecular weight -- Morphology -- Radiation -- Radioactivity -- Rats -- Tissue -- poly(3 hydroxybutyric acid) -- animal experiment -- animal tissue -- article -- biocompatibility -- concentration process -- controlled study -- degradation -- drug delivery system -- female -- gel permeation chromatography -- heart -- kidney parenchyma -- liver -- lung parenchyma -- molecular weight -- nonhuman -- organ culture -- priority journal -- radioactivity -- rat -- spleen -- Animals -- Animals, Laboratory -- Biocompatible Materials -- Drug Delivery Systems -- Female -- Infusions, Intravenous -- Materials Testing -- Microspheres -- Molecular Weight -- Particle Size -- Polymers -- Rats -- Rats, Wistar -- Tissue Distribution -- Animalia -- Rattus -- Rattus norvegicus
Аннотация: Specimens of 14C-labeled polymer of 3-hydroxybutyric acid, P(3-HB), with different initial molecular weights, were used to prepare microparticles, whose morphology was not influenced by the M w of the polymer. During the particle preparation process, P(3-HB) molecular weight decreased by 15-20%. Sterile microparticles (mean diameter 2.4 ?m) were injected into the tail veins of Wistar rats (5 mg/rat). The effects of the particles administered to rats were studied based on the general response of animals and local response of internal organ tissues and blood morphology; no adverse effects on growth and development of the animals or unfavorable changes in the structure of the tissues of internal organs were observed. Measurements of radioactivity in tissues showed that 14C concentrations are different in different organs, changing during the course of the experiment. The main targets for 14C-labeled microparticles were tissues of the liver, spleen, and kidneys. Comparison of radioactivity levels and residual contents of high-molecular-weight matrix in tissues suggested that the most rapid metabolism and degradation of P(3-HB) occurred in the liver and spleen. Gel-permeation chromatography showed that at 3 h after the microparticles were injected into the bloodstream, polymer degradation started in all examined organs, except the lungs; at 12 weeks, the M w of the polymer matrix was as low as 20-30% of its initial value. The presence of high-molecular-weight (undegraded) polymer in the tissues at 12 weeks after administration of the particles suggests that P(3-HB) is degraded in tissues of internal organs slowly and, hence, P(3-HB)-based microparticles can be used as sustained-release drug-delivery systems. В© 2011 VSP.

Scopus
Держатели документа:
Institute of Biophysics, SB RAS, Akademgorodok, Krasnoyarsk 660036, Russian Federation
Siberian Federal University, Svobodnyi Avenue, Krasnoyarsk 660041, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.; Goreva, A.; Kalacheva, G.; Volova, T.

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Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma / E. V. Inzhevatkin, A. V. Baron, M. B. Volkova [et al.] // Bull. Exp. Biol. Med. - 2021. - Vol. 172, Is. 1. - P77-80, DOI 10.1007/s10517-021-05335-9. - Cited References:9 . - ISSN 0007-4888. - ISSN 1573-8221

РУБ Medicine, Research & Experimental

Кл.слова (ненормированные):
detonation synthesis nanodiamonds -- EPR-spectrometry -- intravenous -- administration -- biodistribution -- biochemical changes in blood plasma
Аннотация: Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values.

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Держатели документа:
Russian Acad Sci, Int Sci Ctr Extremal Organism State Res, Fed Res Ctr, Krasnoyarsk Sci Ctr,Siberian Div, Krasnoyarsk, Russia.
Russian Acad Sci, Fed Res Ctr, Inst Biophys, Krasnoyarsk Sci Ctr,Siberian Div, Krasnoyarsk, Russia.
Natl Res Univ, Moscow Inst Phys & Technol, Dolgoprudnyi, Moscow Region, Russia.
Russian Acad Sci, Fed Res Ctr, Inst Chem & Chem Technol, Krasnoyarsk Sci Ctr,Siberian Div, Krasnoyarsk, Russia.
Krasnoyarsk Reg Clin Ctr Matern & Child Protect, Krasnoyarsk, Russia.

Доп.точки доступа:
Inzhevatkin, E., V; Baron, A., V; Volkova, M. B.; Maksimov, N. G.; Golubenko, N. K.; Loshkareva, M., V; Puzyr', A. P.; Ronzhin, N. O.; Bondar, V. S.

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Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma / E. V. Inzhevatkin, A. V. Baron, M. B. Volkova [et al.] // Bull. Exp. Biol. Med. - 2021, DOI 10.1007/s10517-021-05335-9 . - Article in press. - ISSN 0007-4888
Кл.слова (ненормированные):
biochemical changes in blood plasma -- biodistribution -- detonation synthesis nanodiamonds -- EPR-spectrometry -- intravenous administration
Аннотация: Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.

Scopus
Держатели документа:
International Scientific Center of Extremal Organism State Research, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Institute of Biophysics, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russian Federation
Institute of Chemistry and Chemical Technology, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Krasnoyarsk Regional Clinical Center of Maternity and Child Protection, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Inzhevatkin, E. V.; Baron, A. V.; Volkova, M. B.; Maksimov, N. G.; Golubenko, N. K.; Loshkareva, M. V.; Puzyr’, A. P.; Ronzhin, N. O.; Bondar, V. S.

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Biodistribution of nanodiamonds in the body of mice using EPR spectrometry / E. Inzhevatkin [et al.] // IET Sci. Meas. Technol. - 2019. - Vol. 13, Is. 7. - P984-988, DOI 10.1049/iet-smt.2018.5594. - Cited References:32. - This work was supported by the Russian Foundation for Basic Research (project no. 16-04-00999). . - ISSN 1751-8822. - ISSN 1751-8830

РУБ Engineering, Electrical & Electronic
Рубрики:
DRUG-DELIVERY
   DETONATION NANODIAMONDS
   NANOMATERIALS
   DOXORUBICIN
Кл.слова (ненормированные):
blood -- biomedical materials -- kidney -- lung -- detonation -- diamond -- nanomedicine -- liver -- muscle -- cellular biophysics -- nanoparticles -- EPR -- imaging -- mice -- EPR spectrometry -- detonation NDs -- electron paramagnetic -- resonance spectrometry -- characteristic EPR signal -- initially injected -- NDs -- detonation -- femoral muscles -- blood -- spleen -- brain -- kidneys -- heart -- lungs -- liver -- biomaterials -- nanodiamonds -- organ homogenates -- nanoparticle concentrations -- inter-organ distribution -- time 2 -- 5 hour -- C
Аннотация: In vitro experiments proved the usefulness of electron paramagnetic resonance (EPR) spectrometry for detecting detonation nanodiamonds (NDs) in samples of biomaterials (blood and homogenates of organs of mice). A characteristic EPR signal (g = 2.003, Delta H similar or equal to 10 G) was detected in biomaterials containing NDs, and its intensity linearly increased at nanoparticle concentrations of between 1.6 and 200 mu g/ml. In vivo experiments demonstrated that EPR spectrometry was effective for monitoring the inter-organ distribution of NDs intravenously injected to mice. In 2.5 h after the injection of NDs, the nanoparticles mainly accumulated in the lungs and liver of the animals - about 25 and 20%, respectively, of the initially injected NDs. The amounts of NDs accumulated in the heart and kidneys were considerably lower. Also, EPR spectrometry did not detect NDs in the blood, spleen, brain, and femoral muscles of mice. Ten days after injection, EPR spectrometry detected redistribution of NDs in mice. The amounts of nanoparticles decreased approximately by a factor of 3.5 in the lungs and increased almost by a factor of 3 in the liver; NDs were detected in the spleen. This study suggests ways to use EPR spectrometry to study the distribution, accumulation, and elimination of detonation NDs injected into laboratory animals.

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Держатели документа:
Russian Acad Sci, Siberian Branch, Inst Biophys, Fed Res Ctr,Krasnoyarsk Sci Ctr, Krasnoyarsk, Russia.
RAS, SB, Int Sci Ctr Studies Extreme States Organism, Fed Res Ctr,Krasnoyarsk Sci Ctr, Krasnoyarsk, Russia.
Siberian Fed Univ, Krasnoyarsk, Russia.
Russian Acad Sci, Siberian Branch, Inst Chem & Chem Technol, Fed Res Ctr,Krasnoyarsk Sci Ctr, Krasnoyarsk, Russia.

Доп.точки доступа:
Inzhevatkin, Evgeny; Baron, Alexey; Maksimov, Nikolai; Volkova, Marina; Puzyr, Alexey; Ronzhin, Nikita; Bondar, Vladimir; Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR) [16-04-00999]

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Biogenic Ferrihydrite Nanoparticles: Synthesis, Properties In Vitro and In Vivo Testing and the Concentration Effect / S. V. Stolyar, O. A. Kolenchukova, A. V. Boldyreva [et al.] // Biomedicines. - 2021. - Vol. 9, Is. 3. - Ст. 323, DOI 10.3390/biomedicines9030323. - Cited References:52. - This research was funded by the Russian Foundation for Basic Research, the Government of the Krasnoyarsk Territory and the Regional Science Foundation, grant number 20-416-242907. . - ISSN 2227-9059

РУБ Biochemistry & Molecular Biology + Medicine, Research & Experimental

Кл.слова (ненормированные):
ferrihydrite nanoparticles -- concentration effect -- microorganisms -- Klebsiella oxytoca -- neutrophilic granulocytes -- chemiluminescence -- toxicology
Аннотация: Biogenic ferrihydrite nanoparticles were synthesized as a result of the cultivation of Klebsiella oxytoca microorganisms. The distribution of nanoparticles in the body of laboratory animals and the physical properties of the nanoparticles were studied. The synthesized ferrihydrite nanoparticles are superparamagnetic at room temperature, and the characteristic blocking temperature is 23-25 K. The uncompensated moment of ferrihydrite particles was determined to be approximately 200 Bohr magnetons. In vitro testing of different concentrations of ferrihydrite nanoparticles for the functional activity of neutrophilic granulocytes by the chemiluminescence method showed an increase in the release of primary oxygen radicals by blood phagocytes when exposed to a minimum concentration and a decrease in secondary radicals when exposed to a maximum concentration. In vivo testing of ferrihydrite nanoparticles on Wister rats showed that a suspension of ferrihydrite nanoparticles has chronic toxicity, since it causes morphological changes in organs, mainly in the spleen, which are characterized by the accumulation of hemosiderin nanoparticles (stained blue according to Perls). Ferrihydrite can also directly or indirectly stimulate the proliferation and intracellular regeneration of hepatocytes. The partial detection of Perls-positive cells in the liver and kidneys can be explained by the rapid elimination from organs and the high dispersion of the nanomaterial. Thus, it is necessary to carry out studies of these processes at the systemic level, since the introduction of nanoparticles into the body is characterized by adaptive-proliferative processes, accompanied by the development of cell dystrophy and tension of the phagocytic system.

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Держатели документа:
RAS, Kirensky Inst Phys, Fed Res Ctr KSC SB, Krasnoyarsk 660036, Russia.
RAS, Krasnoyarsk Sci Ctr, Fed Res Ctr KSC SB, Krasnoyarsk 660036, Russia.
Siberian Fed Univ, Dept Biophys, Krasnoyarsk 660041, Russia.
RAS, Sci Res Inst Med Problems North, Fed Res Ctr KSC SB, Krasnoyarsk 660022, Russia.
RAS, Inst Biophys, Fed Res Ctr KSC SB, Krasnoyarsk 660036, Russia.

Доп.точки доступа:
Stolyar, Sergey V.; Kolenchukova, Oksana A.; Boldyreva, Anna V.; Kudryasheva, Nadezda S.; Gerasimova, Yulia V.; Krasikov, Alexandr A.; Yaroslavtsev, Roman N.; Bayukov, Oleg A.; Ladygina, Valentina P.; Birukova, Elena A.; Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR); Government of the Krasnoyarsk Territory; Regional Science Foundation [20-416-242907]

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Bioluminescent analysis of intensity of pathological oxidative processes in cells of perfused rat liver after hyperthermia / N. N. Remmel [et al.] // Bulletin of Experimental Biology and Medicine. - 2003. - Vol. 135, Is. 1. - P. 43-45, DOI 10.1023/A:1023489727703 . - ISSN 0007-4888
Кл.слова (ненормированные):
Bioluminescent analysis -- Controlled perfusion of isolated liver -- Hyperthermia oxidative stress -- thiobarbituric acid reactive substance -- animal experiment -- animal model -- animal tissue -- article -- bioluminescence -- concentration (parameters) -- controlled study -- correlation analysis -- female -- hyperthermia -- in vivo study -- lipid peroxidation -- liver metabolism -- liver perfusion -- male -- nonhuman -- oxidative stress -- oxygen consumption -- pathology -- rat -- thermal exposure -- Animals -- Female -- Hepatocytes -- Hyperthermia, Induced -- Liver -- Luminescent Measurements -- Male -- Oxidative Stress -- Perfusion -- Rats -- Animalia
Аннотация: We studied the possibility of evaluation of the intensity of pathological oxidative processes in rat liver using an integral bioluminescent test with controlled perfusion of the isolated organ. The test revealed a significant correlation between the level of TBA-reactive products and bioluminescence intensity.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russian Federation
Krasnoyarsk State University, Krasnoyarsk, Russian Federation
Intl. Res. Ctr. of Extreme States, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Remmel, N.N.; Kratasyuk, V.A.; Maznyak, O.M.; Inzhevatkin, E.V.; Nefedov, V.P.

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Bioluminescent analysis of intensity of pathological oxidative processes in cells of perfused rat liver after hyperthermia [Text] / N. N. Remmel [et al.] // Bull. Exp. Biol. Med. - 2003. - Vol. 135, Is. 1. - P. 43-45, DOI 10.1023/A:1023489727703. - Cited References: 15 . - ISSN 0007-4888

РУБ Medicine, Research & Experimental

Кл.слова (ненормированные):
bioluminescent analysis -- controlled perfusion of isolated liver -- hyperthermia -- oxidative stress
Аннотация: We studied the possibility of evaluation of the intensity of pathological oxidative processes in rat liver using an integral bioluminescent test with controlled perfusion of the isolated organ. The test revealed a significant correlation between the level of TBA-reactive products and bioluminescence intensity.

WOS
Держатели документа:
Russian Acad Sci, Siberian Div, Inst Biophys, Moscow 117901, Russia
Krasnoyarsk State Univ, Krasnoyarsk, Russia
Russian Acad Sci, Siberian Div, Presidium Krasnoyarsk Res Ctr, Int Res Ctr Extreme States, Moscow 117901, Russia
ИБФ СО РАН
МНЦ КНЦ СО РАН : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Remmel, N.N.; Kratasyuk, V.A.; Maznyak, O.M.; Inzhevatkin, E.V.; Nefedov, V.P.

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Buckwheat-enriched diet alleviates bisphenol A mediated oxidative stress via modulation of sirtuin 1 and antioxidant status in experimental rats / S. Pande, R. Ranjan, M. Ryazanova [et al.] // Food Chem. - 2022. - Vol. 373. - Ст. 131507, DOI 10.1016/j.foodchem.2021.131507. - Cited References:36. - The research was supported by the Ministry of Science and Higher Education of the Russian Federation (Grant no. FSRZ-2020-0006) and Russian Ministry of Education, Post-Doctoral Program of Project "5-100" [Grant No. M 2.2.3]. Authors profusely thank R. Sabirzyanov and I.A. Denisov for the needful in the arrangement of ultrapure BPA. . - ISSN 0308-8146. - ISSN 1873-7072

РУБ Chemistry, Applied + Food Science & Technology + Nutrition & Dietetics
Рубрики:
TRANSCRIPTION
   TOXICITY
   EXTRACT
   FIBER
Кл.слова (ненормированные):
Sirtuin1 -- Buckwheat -- Bisphenol A -- Dietary intervention -- Oxidative -- stress -- Male Wistar r a t s
Аннотация: Present study investigated effect of dietary buckwheat in alleviating bisphenol A (BPA) mediated oxidative stress, concomitant sirtuin1 levels in serum, stomach, and liver of rats. Experimental group A and B ingested standard diet, C and D consumed buckwheat (30%); group A and C drank normal water, B and C had BPA contamination (10 mg L 1). Sirtuin1 mean B/A ratio nearing unity in all tissues reveals inertness of BPA towards sirtuin1. Dietary buckwheat improved sirtuin1 levels both in normal (mean C/A ratio of serum, 1.65; liver, 1.24; stomach, 1.78) and BPA fed state (mean D/B ratio of serum, 1.9; liver, 1.26; stomach, 1.75). Buckwheat augmented antioxidant status in BPA fed rats as seen in mean D/B ratio of serum (catalase, 2.4; glutathione reductase (GR), 1.33; Thiols, 1.2), liver (catalase, 2; GR, 2.5; Thiols, 1.36) and stomach (catalase, 1.31; GR, 1.5; Thiols, 1.33). Therefore, buckwheat counters BPA-led oxidative stress and modulates sirtuin1.

WOS
Держатели документа:
Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Dept Biophys, Lab Bioluminescent Biotechnol, Svobodny Prospect 79, Krasnoyarsk 660041, Russia.
Krasnoyarsk State Med Univ, Res Inst Mol Med & Pathobiochem, P Zheleznyaka 1, Krasnoyarsk 660022, Russia.
Res Ctr Neurol, Lab Expt Brain Cytol, Moscow, Russia.
Fed Res Ctr, Inst Biophys SB RAS, Krasnoyarsk Sci Ctr SB RAS, Akad Gorodok 50-50, Krasnoyarsk 660036, Russia.

Доп.точки доступа:
Pande, Shubhra; Ranjan, Rajeev; Ryazanova, Maria; Shuvaev, Anton N.; Salmina, Alla B.; Kratasyuk, Valentina A.; Ministry of Science and Higher Education of the Russian Federation [FSRZ-2020-0006]; Russian Ministry of Education, Post-Doctoral Program of Project "5-100" [M 2.2.3]

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10.

Characteristics of oxygen transport through the surface of the isolated perfused rat liver / K. V. Shadrin [et al.] // Doklad. Biochem. Biophys. - 2015. - Vol. 464, Is. 1. - P298-300, DOI 10.1134/S1607672915050075 . - ISSN 1607-6729
Аннотация: It is shown that the transport of oxygen through the surface of the isolated perfused rat liver is an energy-dependent process that requires the energy of ATP hydrolysis. © 2015, Pleiades Publishing, Ltd.

Scopus,
WOS
Держатели документа:
Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, Russian Federation
Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, Russian Federation
Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Shadrin, K. V.; Morgulis, I. I.; Pahomova, V. G.; Rupenko, A. P.; Khlebopros, R. G.

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11.

Comparative Assessment of the Content of Transition Metals (Cu, Zn, Mn, Pb, and Cd) and Radiocesium (Cs-137) in Pike (Esox lucius) and Burbot (Lota lota) of the Yenisei River / T. A. Zotina, O. V. Anishchenko, E. A. Trofimova, D. V. Dementiev // Contemp. Probl. Ecol. - 2022. - Vol. 15, Is. 1. - P91-99, DOI 10.1134/S1995425522010115. - Cited References:36. - This work was supported by the Russian Foundation for Basic Research, grant no. 18-44-240003, and the Government of Krasnoyarsk krai, together with the Krasnoyarsk Regional Fund for Support of Scientific and Technical Activity, grant no. 20-44-240004. . - ISSN 1995-4255. - ISSN 1995-4263

РУБ Ecology
Рубрики:
FRESH-WATER FISH
   NORTHERN PIKE
   HEAVY-METALS
   BRAMA L.
   FOOD-WEB
   SIZE
Кл.слова (ненормированные):
piscivorous fish -- toxic metals -- body length -- body weight -- size effect
Аннотация: The trophic position of fish is one of the most important factors controlling the accumulation of potentially toxic elements and compounds in fish tissues, primarily via the spectrum of fish nutrition. In this study, the content of potentially toxic transition metals (Cu, Zn, Mn, Pb, and Cd) and radiocesium (Cs-137) in the edible tissues (muscles and liver) of two representatives of the fish-eating ichthyofauna of the Yenisei River, northern pike (Esox lucius) and burbot (Lota lota), have been comparatively studied relatively to the size of the fish. A significant decrease in the content of radiocesium and zinc in the muscles of pike and zinc in the liver of pike with an increase in body size has been recorded in juvenile pikes with a body weight (W) of less than 0.35 kg. For larger sexually mature pikes, no significant size dependences of the accumulation of metals in tissues are found. A positive correlation is found between the content of Cs-137, Cu, Zn, and Mn in muscles and the size of burbot in the W range from 0.42 to 1.62 kg. The tissues of burbots and pikes of the same size significantly (p < 0.05) differ in the concentration of metals in their tissues: concentrations of Zn and Mn are 1.6-2.2 times higher in the muscle of burbot; the concentration of Pb is 1.8 times higher in muscle of pike; Cu is twice as high in the liver of burbot; and Zn and Mn are 4.7 and 1.6 times higher in the liver of pike, respectively. These differences may be due to the different food spectra of pike and burbot. Concentrations of Cu, Zn, and Mn in the liver of pike are 3-7 times higher than in muscle; the concentration of Cu in the liver of burbot is 5 times higher than in muscle. Pb and Cd tend to be higher in liver than muscle for both fish species. Despite the revealed size dependences, the concentrations of potentially toxic metals and radiocesium in the muscles and liver of fish are below the permissible concentrations for food. These results can be used to assess environmental risks for the population consuming fish, as well as to plan for the long-term environmental monitoring of rivers using representatives of piscivorous fish.

WOS
Держатели документа:
Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Inst Biophys, 50 Akademgorodok, Krasnoyarsk 660036, Russia.
Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Krasnoyarsk 660036, Russia.

Доп.точки доступа:
Zotina, T. A.; Anishchenko, O., V; Trofimova, E. A.; Dementiev, D., V; Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR) [18-44-240003]; Government of Krasnoyarsk krai; Krasnoyarsk Regional Fund for Support of Scientific and Technical Activity [20-44-240004]

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12.

Cytotoxicity of polyhydroxyalkanoates in animal cell cultures. / E. I. Shishatskaya [et al.] // Doklady Biological Sciences. - 2000. - Vol. 374, Is. 1-6. - P539-542 . - ISSN 0012-4966
Кл.слова (ненормированные):
DNA -- hydroxybutyric acid -- poly(3 hydroxybutyrate) co (3 hydroxyvalerate) -- poly(3 hydroxybutyric acid) -- poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate) -- poly-beta-hydroxybutyrate -- polyester -- RNA -- thymidine -- uridine -- animal -- article -- biosynthesis -- cell division -- cell strain 3T3 -- cell survival -- cytology -- drug effect -- liver -- liver cell -- metabolism -- mouse -- vascular endothelium -- 3T3 Cells -- Animals -- Cell Division -- Cell Survival -- DNA -- Endothelium, Vascular -- Hepatocytes -- Hydroxybutyrates -- Liver -- Mice -- Polyesters -- RNA -- Thymidine -- Uridine

Scopus
Держатели документа:
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Krasnoyarsk, Russia. : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.; Eremeev, A.V.; Gitel'zon, I.I.; Setkov, N.A.; Volova, T.G.

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13.

Dietary buckwheat enhances sirtuin1 without calorie restriction / S. Pande, R. Ranjan, A. N. Shuvaev [et al.] // J. Cereal Sci. - 2020. - Vol. 94. - Ст. 103004, DOI 10.1016/j.jcs.2020.103004 . - ISSN 0733-5210
Кл.слова (ненормированные):
Calorie restriction -- Dietary buckwheat -- Male wistar rats -- SIRT1 expression
Аннотация: In the present investigation, the role of dietary intervention in male Wistar rats (n = 8, 3 groups) was studied to observe absolute sirtuin 1 (SIRT1) levels (expressed as ng mg?1 total protein) in serum, stomach, liver, and kidney. Dietary buckwheat at 30% (w/w) level of incorporation in the standard diet (Buckwheat Enriched Diet, BED) improved SIRT1 with values 0.933 ± 0.05, 210 ± 7, 63.26 ± 4, and 69.89 ± 3 in serum, stomach, liver, and kidney respectively when compared to the respective control values of 0.536 ± 0.03, 156 ± 23.3, 31.07 ± 2 and 47.11 ± 4. Moreover, BED though isocaloric to CR diet, led to weight gain (g) by 63.11 ± 3.8, ca. 10%, and 40% higher than control (56.27 ± 5.6) and CR (45.05 ± 4.1) diet groups. A marked rise in Feed Efficiency Ratio (FER) by ca. 37% while a 30% decrease in Feed Conversion Ratio (FCR) was observed for the BED group which supports unexpected weight gain in rats post-dietary intervention. The results justify the superior nutritional profile of buckwheat laden with essential nutrients, essential proteins, and bioactives. In contrast, Calorie Restriction (CR) resulted in a decline of the total protein content in circulation by 19%, while reduction of total protein in stomach, liver, and kidney was estimated to be 95%, 35.2%, and 27% respectively though SIRT1 values were comparatively the highest in all the samples studied. A 30-fold enhancement of SIRT1 in stomach post CR is presumed to counter enhanced stress in gastric tissues. Therefore, mild to moderate expression of SIRT1 may confer beneficial effects such as delayed aging and stress resistance but exceedingly high SIRT1 may evoke increased oxidative stress. © 2020 Elsevier Ltd

Scopus
Держатели документа:
Laboratory of Bioluminescent Biotechnologies, Department of Biophysics, Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Svobodny Prospect 79, Krasnoyarsk, 660041, Russian Federation
Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University Named After Prof. V.F. Voino-Yasenetsky, P. Zheleznyaka 1, Krasnoyarsk, 660022, Russian Federation
Department of Biochemistry, Medical, Pharmaceutical & Toxicological Chemistry, Krasnoyarsk State Medical University Named After Prof. V.F. Voino-Yasenetsky, P. Zheleznyaka 1, Krasnoyarsk, 660022, Russian Federation
Scientific Research Institute of Medical Problems of the North, P. Zheleznyaka 3g, Krasnoyarsk, 660022, Russian Federation
Institute of Biophysics SB RAS, Federal Research Center ‘Krasnoyarsk Science Center SB RAS’, Akademgorodok 50/50, Krasnoyarsk, 660036, Russian Federation

Доп.точки доступа:
Pande, S.; Ranjan, R.; Shuvaev, A. N.; Malinovskaya, N. A.; Ryazanova, M.; Salmina, A. B.; Kolenchukova, O. A.; Kratasyuk, V. A.

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14.

Dietary buckwheat enhances sirtuin1 without calorie restriction / S. Pande, R. Ranjan, A. N. Shuvaev [et al.] // J. Cereal Sci. - 2020. - Vol. 94. - Ст. 103004, DOI 10.1016/j.jcs.2020.103004. - Cited References:22. - This work was supported by the Russian Foundation for Basic Research (RFBR) [Grant No. 16-06-00-439] and by the Russian Ministry of Education, Post-Doctoral Program of Project "5-100" [Grant No. M 2.2.3]. . - ISSN 0733-5210. - ISSN 1095-9963

РУБ Food Science & Technology
Рубрики:
LIFE-SPAN
   STRESS
   FLOUR
   RATS
Кл.слова (ненормированные):
Dietary buckwheat -- SIRT1 expression -- Calorie restriction -- Male wistar -- rats
Аннотация: In the present investigation, the role of dietary intervention in male Wistar rats (n = 8, 3 groups) was studied to observe absolute sirtuin 1 (SIRT1) levels (expressed as ng mg(-1) total protein) in serum, stomach, liver, and kidney. Dietary buckwheat at 30% (w/w) level of incorporation in the standard diet (Buckwheat Enriched Diet, BED) improved SIRT1 with values 0.933 +/- 0.05, 210 +/- 7, 63.26 +/- 4, and 69.89 +/- 3 in serum, stomach, liver, and kidney respectively when compared to the respective control values of 0.536 +/- 0.03, 156 +/- 23.3, 31.07 +/- 2 and 47.11 +/- 4. Moreover, BED though isocaloric to CR diet, led to weight gain (g) by 63.11 +/- 3.8, ca. 10%, and 40% higher than control (56.27 +/- 5.6) and CR (45.05 +/- 4.1) diet groups. A marked rise in Feed Efficiency Ratio (FER) by ca. 37% while a 30% decrease in Feed Conversion Ratio (FCR) was observed for the BED group which supports unexpected weight gain in rats post-dietary intervention. The results justify the superior nutritional profile of buckwheat laden with essential nutrients, essential proteins, and bioactives. In contrast, Calorie Restriction (CR) resulted in a decline of the total protein content in circulation by 19%, while reduction of total protein in stomach, liver, and kidney was estimated to be 95%, 35.2%, and 27% respectively though SIRT1 values were comparatively the highest in all the samples studied. A 30-fold enhancement of SIRT1 in stomach post CR is presumed to counter enhanced stress in gastric tissues. Therefore, mild to moderate expression of SIRT1 may confer beneficial effects such as delayed aging and stress resistance but exceedingly high SIRT1 may evoke increased oxidative stress.

WOS
Держатели документа:
Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Dept Biophys, Lab Bioluminescent Biotechnol, Svobodny Prospect 79, Krasnoyarsk 660041, Russia.
Krasnoyarsk State Med Univ, Res Inst Mol Med & Pathobiochem, P Zheleznyaka 1, Krasnoyarsk 660022, Russia.
Krasnoyarsk State Med Univ, Dept Biochem Med Pharmaceut & Toxicol Chem, P Zheleznyaka 1, Krasnoyarsk 660022, Russia.
Sci Res Inst Med Problems North, P Zheleznyaka 3g, Krasnoyarsk 660022, Russia.
Fed Res Ctr Krasnoyarsk Sci Ctr SB RAS, Inst Biophys SB RAS, Akademgorodok 50-50, Krasnoyarsk 660036, Russia.

Доп.точки доступа:
Pande, Shubhra; Ranjan, Rajeev; Shuvaev, Anton N.; Malinovskaya, Natalia A.; Ryazanova, Maria; Salmina, Alla B.; Kolenchukova, Oksana A.; Kratasyuk, Valentina A.; Russian Foundation for Basic Research (RFBR)Russian Foundation for Basic Research (RFBR) [16-06-00-439]; Russian Ministry of EducationMinistry of Education and Science, Russian Federation [M 2.2.3]

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15.

Distribution and resorption of polymeric microparticles in visceral organs of laboratory animals after intravenous injection / E. I. Shishatskaya [et al.] // Bulletin of Experimental Biology and Medicine. - 2009. - Vol. 148, Is. 5. - P789-793, DOI 10.1007/s10517-010-0817-3 . - ISSN 0007-4888
Кл.слова (ненормированные):
14C -- Intravenous injection -- Microparticles -- Resorbable polyhydroxybutyrate -- Visceral tissues -- carbon 14 -- microsphere -- polyhydroxyaminobutyric acid -- polymer -- unclassified drug -- animal experiment -- animal tissue -- article -- biocompatibility -- biodegradability -- body growth -- controlled drug release -- controlled study -- degradation kinetics -- drug delivery system -- drug dosage form -- experimental animal -- female -- liver parenchyma -- molecular weight -- nonhuman -- particle size -- physical development -- radioactivity -- rat -- spleen -- tissue distribution -- tissue structure -- Animals -- Animals, Laboratory -- Carbon Radioisotopes -- Female -- Injections, Intravenous -- Particle Size -- Polymers -- Rats -- Rats, Wistar -- Tissue Distribution -- Viscera -- Animalia
Аннотация: Microparticles obtained by using 14C-labeled resorbable hydroxyaminobutyric acid polymer were injected into the caudal vein of laboratory animals without negative aftereffects for their growth and development and without changes in the macro- and microstructure of organs and tissues. The distribution of microparticles in the viscera and the dynamics of accumulation of carbon-containing polymer degradation products in the viscera were studied. The main targets for the particles are liver tissues, as well as renal and splenic tissues. The polymeric matrix of the microparticles is most actively destroyed in the spleen and liver. The presence of high-molecular- weight polymeric matrix in organs indicates the integrity of microparticles and the possibility of long-term (up to 12 weeks) functioning of polymeric particles in vivo. В© 2009 Springer Science+Business Media, Inc.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Division of Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Institute of Basic Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.; Goreva, A.V.; Voinova, O.N.; Kalacheva, G.S.; Volova, T.G.

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16.

DNA synthesis in heterokaryons obtained by fusion of hepatocytes from a regenerating mouse liver and NIH 3T3 fibroblasts / A. V. Eremeev, N. A. Setkov // Doklady Biological Sciences. - 2000. - Vol. 372, Is. 1-6. - P. 329-332 . - ISSN 0012-4966
Кл.слова (ненормированные):
DNA -- thymidine -- animal -- article -- biosynthesis -- cell division -- cell fusion -- cell strain 3T3 -- cytology -- hybrid cell -- kinetics -- liver cell -- liver regeneration -- metabolism -- mouse -- 3T3 Cells -- Animals -- Cell Division -- Cell Fusion -- DNA -- Hepatocytes -- Hybrid Cells -- Kinetics -- Liver Regeneration -- Mice -- Thymidine

Scopus
Держатели документа:
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Krasnoyarsk, Russia. : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Eremeev, A.V.; Setkov, N.A.

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17.

Dobutamine prevents experimental postintoxication liver cirrhosis in mice [Text] / A. P. Vinokurov, A. V. Eremeev, N. A. Setkov // Bull. Exp. Biol. Med. - 2002. - Vol. 134, Is. 1. - P. 43-46, DOI 10.1023/A:1020604621142. - Cited References: 14 . - ISSN 0007-4888

РУБ Medicine, Research & Experimental
Рубрики:
GROWTH-FACTOR-BETA
   HEPATIC-FIBROSIS
   RAT HEPATOCYTES
   NOREPINEPHRINE
   INJURY
   CELLS
Кл.слова (ненормированные):
hepatocytes -- dobutamine -- proliferation -- liver cirrhosis
Аннотация: Various chronic inflammatory and necrotic processes in the liver parenchyma are accompanied by pathological morphofunctional changes, which are associated with hepatocyte death and, hyperplasia of the connective tissue. Regeneration of the liver parenchyma should include not only prevention of fibrosis, but also stimulation of hepatocyte proliferation. The adrenoceptor agonist dobutamine stimulated proliferative activity of cultured hepatocytes and prevented the development of postintoxication liver cirrhosis in mice produced by chronic poisoning with CCl4.

WOS
Держатели документа:
Krasnoyarsk State Med Acad, Dept Gen Surg, Krasnoyarsk, Russia
Russian Acad Sci, Inst Biophys, Siberian Div, Krasnoyarsk, Russia
ИБФ СО РАН : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Vinokurov, A.P.; Eremeev, A.V.; Setkov, N.A.

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18.

Dobutamine prevents experimental postintoxication liver cirrhosis in mice / A. P. Vinokurov, A. V. Eremeev, N. A. Setkov // Bulletin of Experimental Biology and Medicine. - 2002. - Vol. 134, Is. 1. - P. 43-46, DOI 10.1023/A:1020604621142 . - ISSN 0007-4888
Кл.слова (ненормированные):
Dobutamine -- Hepatocytes -- Liver cirrhosis -- Proliferation -- adrenergic receptor stimulating agent -- alpha 1 adrenergic receptor stimulating agent -- beta 1 adrenergic receptor stimulating agent -- beta 2 adrenergic receptor stimulating agent -- carbon tetrachloride -- catecholamine derivative -- dobutamine -- epidermal growth factor -- animal cell -- animal experiment -- animal model -- animal tissue -- article -- cell activity -- cell culture -- cell death -- cell proliferation -- cell stimulation -- chronic hepatitis -- connective tissue -- controlled study -- disease association -- drug effect -- drug potency -- experimental test -- female -- liver cell -- liver cirrhosis -- liver fibrosis -- liver hyperplasia -- liver necrosis -- liver parenchyma -- liver regeneration -- liver toxicity -- morphology -- mouse -- nonhuman -- toxicity testing -- Adrenergic beta-Agonists -- Animals -- Carbon Tetrachloride -- Cell Division -- Dobutamine -- Dose-Response Relationship, Drug -- Female -- Hepatocytes -- Liver -- Liver Cirrhosis -- Mice -- Mice, Inbred BALB C -- Animalia
Аннотация: Various chronic inflammatory and necrotic processes in the liver parenchyma are accompanied by pathological morphofunctional changes, which are associated with hepatocyte death and hyperplasia of the connective tissue. Regeneration of the liver parenchyma should include not only prevention of fibrosis, but also stimulation of hepatocyte prolifearation. The adrenoceptor agonist dobutamine stimulated proliferative activity of cultured hepatocytes and prevented the development of postintoxication liver cirrhosis in mice produced by chronic poisoning with CCl4.

Scopus
Держатели документа:
Department of General Surgery, Krasnoyarsk State Medical Academy, Krasnoyarsk, Russian Federation
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Vinokurov, A.P.; Eremeev, A.V.; Setkov, N.A.

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19.

Dynamics of amino acid composition of the medium during culture of isolated liver and kidneys by the controlled perfusion method / V. A. Barashkov [et al.] // Bulletin of Experimental Biology and Medicine. - 1976. - Vol. 80, Is. 11. - P1305-1307 . - ISSN 0007-4888
Кл.слова (ненормированные):
amino acid -- dog -- in vitro study -- kidney perfusion -- liver perfusion -- theoretical study
Аннотация: The dynamics of the amino acid composition of the medium was investigated during perfusion of the dog liver and kidney for 6 h with a mixture of autogenous plasma and medium No.199 in the ratio of 2:3. During culture of the kidney for 6 h the histidine concentration in the medium increased by 2.2 times compared with initially, the concentration of glutamic acid by 1.7 times, and of alanine and lysine by 1.6 times, whereas the concentrations of arginine, serine, and aspartic acid fell by 3.3 times and those of glutamine with threonine by 2.5 times. During perfusion of the liver the concentration of glutamic acid rose by 2.9 times, of alanine by 2.3 times, cystine by 2.0 times, and glycine by 1.5 times. The concentration of tyrosine fell by half, and that of phenylalanine and serine by 1.4 times. The arginine concentration fell so quickly during perfusion of the liver that by the second hour after the beginning of perfusion no arginine could be found in the medium. The method of amino acid analysis during organ culture as described can be used as a method of developing and correcting culture media.

Scopus
Держатели документа:
Siberian Div., Dept. Biophys., L.V. Kirenskii Inst. Phys., Acad. Sci. USSR, Krasnoyarsk, Russia : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Barashkov, V.A.; Gitel'zon, I.I.; Nefedov, V.P.; Trubachev, I.N.

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20.

Dynamics of amino acid composition of the medium in isolated organ culture by the controlled perfusion method / V. A. Barashkov [et al.] // Bulletin of Experimental Biology and Medicine. - 1975. - Vol. 80, Is. 7. - P759-761 . - ISSN 0007-4888
Кл.слова (ненормированные):
amino acid -- tissue culture medium -- dog -- in vitro study -- organ culture -- organ perfusion -- theoretical study
Аннотация: The dynamics of the amino acid composition of the perfusion fluid was investigated during adequate perfusion of isolated dog organs (the thorax and a complex consisting of the thoracic organs, kidneys, and liver). The concentration of amino acids such as histidine, lysine, and alanine in the perfusion fluid 6 h after the beginning of perfusion of the organ complex was higher, whereas that of arginine, serine, aspartic acid, threonine with glutamine, isoleucine, proline, leucine, and valine was much lower than initially. In experiments on the isolated thorax the dynamics of the amino acid composition of the medium was studied during perfusion for 4 h. The concentration of alanine, lysine, and histidine in the medium increased, whereas those of serine, aspartic acid, isoleucine, tyrosine, and phenylalanine decreased.

Scopus
Держатели документа:
Siberian Div., Dept. Biophys., L.V. Kirenskii Inst. Phys., Acad. Sci. USSR, Krasnoyarsk, Russia : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Barashkov, V.A.; Gitel'zon, I.I.; Nefedov, V.P.; Trubachev, I.N.

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