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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Barashkov V.A., Gitelzon I.I., Nefedov V.P., Trubachev I.N.
Заглавие : The dynamics of the amino acid composition of the medium in cultivating the isolated organs by controlled perfusion (Russian)
Место публикации : Byulleten Eksperimentalnoi Biologii i Meditsiny. - 1975. - Vol. 80, Is. 7. - С. 36-38. - ISSN 03659615 (ISSN)
Ключевые слова (''Своб.индексиров.''): amino acid--amino acid--dog--in vitro study--kidney--liver--sternum--theoretical study--animal--article--culture medium--metabolism--organ culture--organ preservation--perfusion--tissue preservation--kidney--liver--kidney perfusion--liver perfusion--tissue culture--amino acids--animal--culture media--dogs--english abstract--in vitro--organ culture--organ preservation--perfusion--tissue preservation--kidney--liver
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Barashkov V.A., Gitel'zon I.I., Nefedov V.P., Trubachev I.N.
Заглавие : Dynamics of amino acid composition of the medium in isolated organ culture by the controlled perfusion method
Место публикации : Bulletin of Experimental Biology and Medicine. - 1975. - Vol. 80, Is. 7. - С. 759-761. - ISSN 00074888 (ISSN)
Ключевые слова (''Своб.индексиров.''): amino acid--tissue culture medium--dog--in vitro study--organ culture--organ perfusion--theoretical study
Аннотация: The dynamics of the amino acid composition of the perfusion fluid was investigated during adequate perfusion of isolated dog organs (the thorax and a complex consisting of the thoracic organs, kidneys, and liver). The concentration of amino acids such as histidine, lysine, and alanine in the perfusion fluid 6 h after the beginning of perfusion of the organ complex was higher, whereas that of arginine, serine, aspartic acid, threonine with glutamine, isoleucine, proline, leucine, and valine was much lower than initially. In experiments on the isolated thorax the dynamics of the amino acid composition of the medium was studied during perfusion for 4 h. The concentration of alanine, lysine, and histidine in the medium increased, whereas those of serine, aspartic acid, isoleucine, tyrosine, and phenylalanine decreased.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Barashkov V.A., Gitel'zon I.I., Nefedov V.P., Trubachev I.N.
Заглавие : Dynamics of amino acid composition of the medium during culture of isolated liver and kidneys by the controlled perfusion method
Место публикации : Bulletin of Experimental Biology and Medicine. - 1976. - Vol. 80, Is. 11. - С. 1305-1307. - ISSN 00074888 (ISSN)
Ключевые слова (''Своб.индексиров.''): amino acid--dog--in vitro study--kidney perfusion--liver perfusion--theoretical study
Аннотация: The dynamics of the amino acid composition of the medium was investigated during perfusion of the dog liver and kidney for 6 h with a mixture of autogenous plasma and medium No.199 in the ratio of 2:3. During culture of the kidney for 6 h the histidine concentration in the medium increased by 2.2 times compared with initially, the concentration of glutamic acid by 1.7 times, and of alanine and lysine by 1.6 times, whereas the concentrations of arginine, serine, and aspartic acid fell by 3.3 times and those of glutamine with threonine by 2.5 times. During perfusion of the liver the concentration of glutamic acid rose by 2.9 times, of alanine by 2.3 times, cystine by 2.0 times, and glycine by 1.5 times. The concentration of tyrosine fell by half, and that of phenylalanine and serine by 1.4 times. The arginine concentration fell so quickly during perfusion of the liver that by the second hour after the beginning of perfusion no arginine could be found in the medium. The method of amino acid analysis during organ culture as described can be used as a method of developing and correcting culture media.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gitelzon I.I., Nefedov V.P., Mezhevikin V.V.
Заглавие : Effect of hypoxemia on erythropoietic activity of perfused organs
Место публикации : Byulleten Eksperimentalnoi Biologii i Meditsiny. - 1977. - Vol. 84, Is. 7. - С. 23-24. - ISSN 03659615 (ISSN)
Ключевые слова (''Своб.индексиров.''): animal--bone marrow--cell proliferation--erythropoiesis--histology--hypoxemia--injury--mammal--perfusion fluid--theoretical study--article--dog--kidney--liver--metabolism--perfusion--spleen--sternum--erythropoietin--animal--anoxemia--dogs--english abstract--erythropoietin--kidney--liver--perfusion--spleen--sternum
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : NEFEDOV V.P., MAKAROV V.P., TASHENOV E.K., KRIZHANOVSKAYA E.V., KAZAKOV V.N., RUPENKO A.P., GITELZON I.I.
Заглавие : EVALUATION OF THE ERYTHROPOIETIN-PRODUCING FUNCTION OF THE KIDNEY AND LIVER DURING CONTROLLED PERFUSION
Колич.характеристики :3 с
Место публикации : Bull. Exp. Biol. Med.: PLENUM PUBL CORP, 1986. - Vol. 102, Is. 10. - P1340-1342. - ISSN 0007-4888, DOI 10.1007/BF00851040
Примечания : Cited References: 14
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : NEFEDOV V.P., MAKAROV V.P., TASHENOV E.K., KRIZHANOVSKAYA E.V., KAZAKOV V.N., RUPENKO A.P., GITELZON I.I.
Заглавие : EVALUATION OF THE ERYTHROPOIETIN-PRODUCING FUNCTION OF THE KIDNEY AND LIVER DURING CONTROLLED PERFUSION
Колич.характеристики :3 с
Место публикации : Bull. Exp. Biol. Med.: PLENUM PUBL CORP, 1986. - Vol. 102, Is. 10. - С. 1340-1342. - ISSN 0007-4888, DOI 10.1007/BF00851040
Примечания : Cited References: 14
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : NEFEDOV V.P., TASHENOV E.K., RUPENKO A.P., ALEXEEV P.V., GITELZON I.I.
Заглавие : ESTIMATE OF KIDNEY AND LIVER CONTRIBUTIONS TO THE BALANCE OF ERYTHROPOIETIN
Колич.характеристики :4 с
Место публикации : DOKLADY AKADEMII NAUK SSSR: MEZHDUNARODNAYA KNIGA, 1988. - Vol. 301, Is. 5. - P1261-1264. - ISSN 0002-3264
Примечания : Cited References: 10
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : NEFEDOV V.P., TASHENOV E.K., RUPENKO A.P., ALEXEEV P.V., GITELZON I.I.
Заглавие : ESTIMATE OF KIDNEY AND LIVER CONTRIBUTIONS TO THE BALANCE OF ERYTHROPOIETIN
Колич.характеристики :4 с
Место публикации : DOKLADY AKADEMII NAUK SSSR: MEZHDUNARODNAYA KNIGA, 1988. - Vol. 301, Is. 5. - С. 1261-1264. - ISSN 0002-3264
Примечания : Cited References: 10
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : SETKOV N.A., KAZAKOV V.N., ANDREYEVA T.V.
Заглавие : HEPATOCYTES IN HETEROKARYONS DO NOT RETARD THE ENTRY OF STIMULATED FIBROBLAST NUCLEI INTO THE S-PERIOD
Колич.характеристики :10 с
Место публикации : TSITOLOGIYA: MEZHDUNARODNAYA KNIGA, 1991. - Vol. 33, Is. 6. - P76-85. - ISSN 0041-3771
Примечания : Cited References: 39
Предметные рубрики: HUMAN-DIPLOID FIBROBLASTS
LIVER PLASMA-MEMBRANES
DNA-SYNTHESIS
PRIMARY CULTURE
MOUSE HEPATOCYTES
CELLS INVITRO
SENESCENT
GROWTH
INHIBIT
PHASE
Аннотация: Serum-deprived (0.2 %) resting and serum-stimulated (10 %) proliferating NIH 3T3 mouse fibroblasts were fused with hepatocytes from intact, regenerating and embryonic mouse livers to elucidate mechanisms of liver cell proliferation, DNA synthesis being investigated in nuclei of heterokaryons and non-fused cells using radioautography. Hepatocytes in heterokaryons were found to have no inhibitory effect on the entry of stimulated fibroblast nuclei into the S-period, but on the contrary they were involved in DNA synthesis. In addition, the nuclei in heterokaryons mutually stimulated each other to enter the S-period. In their turn, the resting fibroblasts did not prevent the proliferating hepatocytes from the regenerating and embryonic livers to enter the S-period. Possible reasons of the absence of inhibitory effect of differentiated cells in heterokaryons are discussed. The data obtained enable us to conclude that the mechanism of proliferative process control in resting immortalized cells differs from that in differentiated cells where proliferation seems to be stopped without affecting the endogenous inhibitor postulated for the resting and ageing fibroblasts.
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10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Eremeev A.V., Setkov N.A.
Заглавие : DNA synthesis in heterokaryons obtained by fusion of hepatocytes from a regenerating mouse liver and NIH 3T3 fibroblasts
Место публикации : Doklady Biological Sciences. - 2000. - Vol. 372, Is. 1-6. - P329-332. - ISSN 00124966 (ISSN)
Ключевые слова (''Своб.индексиров.''): dna--thymidine--animal--article--biosynthesis--cell division--cell fusion--cell strain 3t3--cytology--hybrid cell--kinetics--liver cell--liver regeneration--metabolism--mouse--3t3 cells--animals--cell division--cell fusion--dna--hepatocytes--hybrid cells--kinetics--liver regeneration--mice--thymidine
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11.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Eremeev A.V., Gitel'zon I.I., Setkov N.A., Volova T.G.
Заглавие : Cytotoxicity of polyhydroxyalkanoates in animal cell cultures.
Место публикации : Doklady Biological Sciences. - 2000. - Vol. 374, Is. 1-6. - С. 539-542. - ISSN 00124966 (ISSN)
Ключевые слова (''Своб.индексиров.''): dna--hydroxybutyric acid--poly(3 hydroxybutyrate) co (3 hydroxyvalerate)--poly(3 hydroxybutyric acid)--poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate)--poly-beta-hydroxybutyrate--polyester--rna--thymidine--uridine--animal--article--biosynthesis--cell division--cell strain 3t3--cell survival--cytology--drug effect--liver--liver cell--metabolism--mouse--vascular endothelium--3t3 cells--animals--cell division--cell survival--dna--endothelium, vascular--hepatocytes--hydroxybutyrates--liver--mice--polyesters--rna--thymidine--uridine
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12.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Vinokurov A.P., Eremeev A.V., Setkov N.A.
Заглавие : Dobutamine prevents experimental postintoxication liver cirrhosis in mice
Место публикации : Bulletin of Experimental Biology and Medicine. - 2002. - Vol. 134, Is. 1. - P43-46. - ISSN 00074888 (ISSN) , DOI 10.1023/A:1020604621142
Ключевые слова (''Своб.индексиров.''): dobutamine--hepatocytes--liver cirrhosis--proliferation--adrenergic receptor stimulating agent--alpha 1 adrenergic receptor stimulating agent--beta 1 adrenergic receptor stimulating agent--beta 2 adrenergic receptor stimulating agent--carbon tetrachloride--catecholamine derivative--dobutamine--epidermal growth factor--animal cell--animal experiment--animal model--animal tissue--article--cell activity--cell culture--cell death--cell proliferation--cell stimulation--chronic hepatitis--connective tissue--controlled study--disease association--drug effect--drug potency--experimental test--female--liver cell--liver cirrhosis--liver fibrosis--liver hyperplasia--liver necrosis--liver parenchyma--liver regeneration--liver toxicity--morphology--mouse--nonhuman--toxicity testing--adrenergic beta-agonists--animals--carbon tetrachloride--cell division--dobutamine--dose-response relationship, drug--female--hepatocytes--liver--liver cirrhosis--mice--mice, inbred balb c--animalia
Аннотация: Various chronic inflammatory and necrotic processes in the liver parenchyma are accompanied by pathological morphofunctional changes, which are associated with hepatocyte death and hyperplasia of the connective tissue. Regeneration of the liver parenchyma should include not only prevention of fibrosis, but also stimulation of hepatocyte prolifearation. The adrenoceptor agonist dobutamine stimulated proliferative activity of cultured hepatocytes and prevented the development of postintoxication liver cirrhosis in mice produced by chronic poisoning with CCl4.
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13.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Vinokurov A.P., Eremeev A.V., Setkov N.A.
Заглавие : Dobutamine prevents experimental postintoxication liver cirrhosis in mice
Колич.характеристики :4 с
Место публикации : Bull. Exp. Biol. Med.: CONSULTANTS BUREAU, 2002. - Vol. 134, Is. 1. - P43-46. - ISSN 0007-4888, DOI 10.1023/A:1020604621142
Примечания : Cited References: 14
Предметные рубрики: GROWTH-FACTOR-BETA
HEPATIC-FIBROSIS
RAT HEPATOCYTES
NOREPINEPHRINE
INJURY
CELLS
Ключевые слова (''Своб.индексиров.''): hepatocytes--dobutamine--proliferation--liver cirrhosis
Аннотация: Various chronic inflammatory and necrotic processes in the liver parenchyma are accompanied by pathological morphofunctional changes, which are associated with hepatocyte death and, hyperplasia of the connective tissue. Regeneration of the liver parenchyma should include not only prevention of fibrosis, but also stimulation of hepatocyte proliferation. The adrenoceptor agonist dobutamine stimulated proliferative activity of cultured hepatocytes and prevented the development of postintoxication liver cirrhosis in mice produced by chronic poisoning with CCl4.
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14.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Volova T.G., Popova T.G.
Заглавие : Study of biological properties of polyhydroxyalkanoates in a long-term experiment in vivo
Место публикации : Biomedical Engineering. - 2002. - Vol. 36, Is. 4. - С. 218-222. - ISSN 00063398 (ISSN) , DOI 10.1023/A:1021136203338
Ключевые слова (''Своб.индексиров.''): hemoglobin--polyhydroxyalkanoic acid--animal experiment--animal tissue--article--biocompatibility--biodegradability--biosynthesis--blood cell count--blood sampling--comparative study--controlled study--dna synthesis--elasticity--enzyme activity--enzyme mechanism--erythrocyte sedimentation rate--female--in vivo study--liver function--nonhuman--organ weight--rat--suture--animalia
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15.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Volova T.G., Gitelson I.I.
Заглавие : In vivo toxicological evaluation of polyhydroxyalkanoates.
Место публикации : Doklady Biological Sciences. - 2002. - Vol. 383, Is. 1-6. - С. 109-111. - ISSN 00124966 (ISSN)
Ключевые слова (''Своб.индексиров.''): alkane--animal--animal behavior--article--cytology--drug effect--erythrocyte sedimentation rate--female--heart--kidney--liver--lymphoid tissue--male--rat--spleen--wistar rat--alkanes--animals--behavior, animal--blood sedimentation--female--heart--kidney--liver--lymphoid tissue--male--rats--rats, wistar--spleen
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16.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Remmel N.N., Kratasyuk V.A., Maznyak O.M., Inzhevatkin E.V., Nefedov V.P.
Заглавие : Bioluminescent analysis of intensity of pathological oxidative processes in cells of perfused rat liver after hyperthermia
Колич.характеристики :3 с
Место публикации : Bull. Exp. Biol. Med.: CONSULTANTS BUREAU, 2003. - Vol. 135, Is. 1. - P43-45. - ISSN 0007-4888, DOI 10.1023/A:1023489727703
Примечания : Cited References: 15
Ключевые слова (''Своб.индексиров.''): bioluminescent analysis--controlled perfusion of isolated liver--hyperthermia--oxidative stress
Аннотация: We studied the possibility of evaluation of the intensity of pathological oxidative processes in rat liver using an integral bioluminescent test with controlled perfusion of the isolated organ. The test revealed a significant correlation between the level of TBA-reactive products and bioluminescence intensity.
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17.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Setkov N.A., Eremeev A.V.
Заглавие : Inhibitors of protein biosynthesis can stimulate proliferation of mouse hepatocytes in vitro
Колич.характеристики :8 с
Место публикации : Biol. Bull: MAIK NAUKA/INTERPERIODICA, 2003. - Vol. 30, Is. 3. - P212-219. - ISSN 1062-3590, DOI 10.1023/A:1023843409416
Примечания : Cited References: 43
Предметные рубрики: TRANSFORMING-GROWTH-FACTOR
RAT-LIVER REGENERATION
FACTOR-BETA
DNA-SYNTHESIS
PRIMARY CULTURE
PARTIAL-HEPATECTOMY
EPITHELIAL-CELLS
EXPRESSION
MECHANISMS
MODULATION
Аннотация: Hepatocyte proliferation in the liver regenerating after partial hepatectomy ceases when the organ is restored, and the mechanism of this phenomenon is still unclear. In the experiments on fusing hepatocytes from the reoenerated mouse liver (15 days after partial hepatectomy) with NIH 3T3 mouse fibroblasts, we revealed no DNA synthesis in the nuclei of stimulated fibroblasts in heterokaryons (in the presence of hepatocyte nuclei), whereas DNA synthesis in nonfused cells was undisturbed. In this work, our purpose was to find out whether the suppression of DNA synthesis in heterokaryons could be due to the appearance in hepatocytes of some endogenous factors having an inhibitory effect on proliferation. To this end, hepatocytes from the mouse liver regenerated after partial hepatectomy were treated with cycloheximide for 1-4 h and were then fused with stimulated fibroblasts. Such a short-term treatment of hepatocytes with cycloheximide proved to result in the loss of their ability to inhibit DNA synthesis in the nuclei of stimulated or quiescent fibroblasts in heterokaryons, but hepatocytes proper actively proliferated in the medium with a low serum content (0.2%). When the mice with the liver reoenerated after partial hepatectomy were treated with a single sublethal dose of cycloheximide (3 mg/kg), their hepatocytes taken two days after this treatment had no inhibitory effect. Puromycin, another inhibitor of protein synthesis, had the same effect on hepatocytes. These results may be interpreted as evidence that the final stage of liver regeneration after damage is controlled by the factors having a C C negative effect on cell proliferation.
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18.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Remmel N.N., Kratasyuk V.A., Maznyak O.M., Inzhevatkin E.V., Nefedov V.P.
Заглавие : Bioluminescent analysis of intensity of pathological oxidative processes in cells of perfused rat liver after hyperthermia
Место публикации : Bulletin of Experimental Biology and Medicine. - 2003. - Vol. 135, Is. 1. - P43-45. - ISSN 00074888 (ISSN) , DOI 10.1023/A:1023489727703
Ключевые слова (''Своб.индексиров.''): bioluminescent analysis--controlled perfusion of isolated liver--hyperthermia oxidative stress--thiobarbituric acid reactive substance--animal experiment--animal model--animal tissue--article--bioluminescence--concentration (parameters)--controlled study--correlation analysis--female--hyperthermia--in vivo study--lipid peroxidation--liver metabolism--liver perfusion--male--nonhuman--oxidative stress--oxygen consumption--pathology--rat--thermal exposure--animals--female--hepatocytes--hyperthermia, induced--liver--luminescent measurements--male--oxidative stress--perfusion--rats--animalia
Аннотация: We studied the possibility of evaluation of the intensity of pathological oxidative processes in rat liver using an integral bioluminescent test with controlled perfusion of the isolated organ. The test revealed a significant correlation between the level of TBA-reactive products and bioluminescence intensity.
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19.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Remmel N.N., Titova N.M., Kratasyuk V.A.
Заглавие : Oxidative stress monitoring in biological samples by bioluminescent method
Место публикации : Bulletin of Experimental Biology and Medicine. - 2003. - Vol. 136, Is. 2. - P209-211. - ISSN 00074888 (ISSN) , DOI 10.1023/A:1026347830283
Ключевые слова (''Своб.индексиров.''): bioluminescent analysis--lipid peroxidation--malonic dialdehyde--oxidative stress--malonaldehyde--animal tissue--article--bioluminescence--brain tissue--controlled study--fluorescence--freeze drying--kidney parenchyma--lipid peroxidation--liver--male--monitoring--nonhuman--oxidative stress--photobacterium phosphoreum--rat--serum--animals--bacteria--biological assay--lipid peroxidation--luminescent measurements--malondialdehyde--oxidative stress--photobacterium--rats--tissue extracts--animalia--negibacteria--photobacterium--photobacterium phosphoreum
Аннотация: The integral bioluminescent biotest with lyophilized fluorescent bacteria was used for monitoring of LPO processes in tissue extracts and serum of rats exposed to stress. A relationship between the content of MDA (LPO indicator) and fluorescence of bacteria was observed in all biological samples.
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20.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Markelova N.M., Shishatskaya E.I., Vinnik Y.S., Cherdantsev D.V., Beletskiy I.I., Kuznetsov M.N., Zykova L.D.
Заглавие : In vitro justification of using endobiliary stents made of polyhydroxyalkanoates
Место публикации : Macromolecular Symposia. - 2008. - Vol. 269, Is. 1. - С. 82-91. - ISSN 10221360 (ISSN) , DOI 10.1002/masy.200850910
Ключевые слова (''Своб.индексиров.''): bioresorbable materials--endobiliary stents--mechanical jaundice (mj)--phas--abs resins--biopolymers--biotechnology--body fluids--experiments--free radical polymerization--liver--polymers--prosthetics--silicon--surgery--turbulent flow--abdominal cavities--bile ducts--biliary--biological properties--bioresorbable materials--blood analyses--endobiliary stents--endoprosthesis--experimental groups--experimental models--in vitro--inflammatory reactions--macroscopic changes--mechanical jaundice (mj)--minimally invasive--negative controls--phas--polyhydroxyalkanoates--positive control groups--radical surgeries--reconstructive surgeries--suture materials--biological materials
Аннотация: Treatment of patients with mechanical jaundice (MJ) has been one of the topical problems of current medicine. The fraction of patients having MJ of oncologic character that can undergo radical surgery does not exceed 25-30%. A way out of such situation is to use minimally invasive endobiliary interventions, the main type of which is endoprosthesis replacement of bile duct lumens. The aim of the work was to study the biological properties of the experimental models of polymer stents made of PHA for endobiliary prosthetics and to investigate the biological properties of PHA suture material for forming of biliary-enteric anastomoses (cholecystoduodenostomy). Experiments were performed on 20 adult mongrel dogs, weighing 10-12 kg. The animals were divided to three groups: the negative control group (intact animals); the positive control group (the animals with implanted endobiliary silicon stents); and the experimental group (the animals with the PHA stents). The animals were monitored for 100 days. The clinical blood analysis was made before the operation, on day 7, 30, 60 and 100 days. During autopsy the presence of exudate, commissural process in the free abdominal cavity and subhepatic spatium, the appearance of choledoch where the prosthesis was located, as well as the appearance of cholecystoenterostomy, liver and duodenum. We did not found any signs of inflammation, cicatrical changes were estimated in the free abdominal cavity and subhepatic spatium. All implanted PHA stents were at their initial places of implantation. After the end of the experiment inflammatory reaction and anastomositis were absent. Macroscopic changes of liver and duodenum were also not detected. Liver function did not have any pathological deviations. These positive results give grounds to conclude that application of PHA as endobiliary stents in reconstructive surgery of bile passages and as suture material is a promising technology. Copyright В© 2008 WILEY-VCH Verlag GmbH & Co. KGaA.
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