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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Inzhevatkin E. V., Baron A. V., Maksimov N. G., Volkova M. B., Puzyr A. P., Bondar V. S.
Заглавие : EPR Spectrometric Estimation of the Distribution of Intravenously Injected Nanodiamonds in Mice
Колич.характеристики :7 с
Коллективы : Russian Foundation for Basic Research [16-04-00999]
Место публикации : Biol. Bull: PLEIADES PUBLISHING INC, 2019. - Vol. 46, Is. 3. - С. 277-283. - ISSN 1062-3590, DOI 10.1134/S1062359019020079. - ISSN 1608-3059(eISSN)
Примечания : Cited References:56. - This work was supported by the Russian Foundation for Basic Research, project no. 16-04-00999.
Предметные рубрики: DRUG-DELIVERY
DETONATION NANODIAMONDS
NANOMATERIALS
PARTICLES
Аннотация: The distribution in mice of intravenously injected modified nanodiamonds (MNDs) obtained by detonation synthesis was studied using electron paramagnetic resonance (EPR) spectrometry. It has been shown that 2.5 h after MND injection into the tail vein of mice, the nanoparticles accumulate mainly in the lungs and liver of animals; much smaller amounts of nanoparticles were found in the kidneys and heart. The presence of MNDs in the samples of blood, spleen, brain, and thigh muscles of mice was not detected within the sensitivity of the method used.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Pande S., Ranjan R., Kratasyuk V. A.
Заглавие : Is Body Mass Index a potential biomarker for anemia in obese adolescents?
Место публикации : J. Nutr. Intermediary Metab.: Elsevier Inc, 2019. - Vol. 15. - С. 1-2. - ISSN 23523859 (ISSN) , DOI 10.1016/j.jnim.2018.11.001
Ключевые слова (''Своб.индексиров.''): anemia--body mass index--hepcidin--leptin--obesity
Аннотация: The two paradoxical major health problems namely obesity and anemia are confirmed to affect millions around the world. Hepcidin, a protein synthesized in liver is a negative iron binding regulator. There is an affirmative relation between hepcidin and leptin levels and an inverse co-relation between hepcidin and iron status due to inflammation mediated by obesity in adolescents. So this implicates an alliance between anemia and obesity wherein weight reduction can be a powerful medium to improve iron absorption in obese adolescents. Also the Body Mass Index can serve as a preliminary non-invasive screening tool to identify potential adolescents prone to anemia. © 2018
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Inzhevatkin, Evgeny, Baron, Alexey, Maksimov, Nikolai, Volkova, Marina, Puzyr, Alexey, Ronzhin, Nikita, Bondar, Vladimir
Заглавие : Biodistribution of nanodiamonds in the body of mice using EPR spectrometry
Колич.характеристики :5 с
Коллективы : Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR) [16-04-00999]
Место публикации : IET Sci. Meas. Technol.: INST ENGINEERING TECHNOLOGY-IET, 2019. - Vol. 13, Is. 7. - С. 984-988. - ISSN 1751-8822, DOI 10.1049/iet-smt.2018.5594. - ISSN 1751-8830(eISSN)
Примечания : Cited References:32. - This work was supported by the Russian Foundation for Basic Research (project no. 16-04-00999).
Предметные рубрики: DRUG-DELIVERY
DETONATION NANODIAMONDS
NANOMATERIALS
DOXORUBICIN
Аннотация: In vitro experiments proved the usefulness of electron paramagnetic resonance (EPR) spectrometry for detecting detonation nanodiamonds (NDs) in samples of biomaterials (blood and homogenates of organs of mice). A characteristic EPR signal (g = 2.003, Delta H similar or equal to 10 G) was detected in biomaterials containing NDs, and its intensity linearly increased at nanoparticle concentrations of between 1.6 and 200 mu g/ml. In vivo experiments demonstrated that EPR spectrometry was effective for monitoring the inter-organ distribution of NDs intravenously injected to mice. In 2.5 h after the injection of NDs, the nanoparticles mainly accumulated in the lungs and liver of the animals - about 25 and 20%, respectively, of the initially injected NDs. The amounts of NDs accumulated in the heart and kidneys were considerably lower. Also, EPR spectrometry did not detect NDs in the blood, spleen, brain, and femoral muscles of mice. Ten days after injection, EPR spectrometry detected redistribution of NDs in mice. The amounts of nanoparticles decreased approximately by a factor of 3.5 in the lungs and increased almost by a factor of 3 in the liver; NDs were detected in the spleen. This study suggests ways to use EPR spectrometry to study the distribution, accumulation, and elimination of detonation NDs injected into laboratory animals.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Petrov, Klim A., Dudareva, Lyubov, V, Nokhsorov, Vasiliy V., Stoyanov, Kirill N., Makhutova, Olesia N.
Заглавие : Fatty Acid Content and Composition of the Yakutian Horses and Their Main Food Source: Living in Extreme Winter Conditions
Колич.характеристики :15 с
Коллективы : Russian FederationRussian Federation [51.1.1]; Ministry of Science and Higher Education of the Russian Federation; Ministry of Education and Science of RussiaMinistry of Education and Science, Russian Federation [FSRG-2020-0019]
Место публикации : Biomolecules: MDPI, 2020. - Vol. 10, Is. 2. - Ст.315. - ISSN 2218-273X(eISSN), DOI 10.3390/biom10020315
Примечания : Cited References:62. - This research was funded by the State Assignment within the framework of the fundamental research program of the Russian Federation, topic No. 51.1.1; the Government Assignment given by the Ministry of Science and Higher Education of the Russian Federation to Siberian Federal University in 2020 (Project "Biologically active substances in trophic chains of aquatic ecosystems as essential components of human diet and markers for fisheries resource conservation"; the state task of the Ministry of Education and Science of Russia (FSRG-2020-0019).
Предметные рубрики: MEMBRANE-LIPIDS
MEAT QUALITY
TEMPERATURE
CARCASS
GROWTH
Аннотация: For the first time, seasonal changes in the content of total lipids (TLs) and phospholipids (PLs) were studied in fodder plants growing in Central Yakutia-a perennial cereal, smooth brome (Bromopsis inermis L.), and an annual cereal, common oat (Avena sativa L.). Both species have concentrated TLs and PLs in autumn under cold hardening. In addition, a significant increase in the content of fatty acids (FAs) of B. inermis was observed during the autumn decrease in temperature. The Yakutian horses, which fed on cereals enriched with nutrients preserved by natural cold (green cryo-fodder), accumulated significant amounts of 18:2n-6 and 18:3n-3, the total content of which in cereals was 75% of the total FA content. We found differences in the distribution of these two FAs in different tissues of the horses. Thus, liver was rich in 18:2n-6, while muscle and adipose tissues accumulated mainly 18:3n-3. Such a distribution may indicate different roles of these FAs in the metabolism of the horses. According to FA content, meat of the Yakutian horses is a valuable dietary product.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Petrov K. A., Dudareva L. V., Nokhsorov V. V., Stoyanov K. N., Makhutova O. N.
Заглавие : Fatty acid content and composition of the yakutian horses and their main food source: living in extreme winter conditions
Место публикации : Biomolecules: MDPI AG, 2020. - Vol. 10, Is. 2. - Ст.315. - ISSN 2218273X (ISSN), DOI 10.3390/biom10020315
Аннотация: For the first time, seasonal changes in the content of total lipids (TLs) and phospholipids (PLs) were studied in fodder plants growing in Central Yakutia—a perennial cereal, smooth brome (Bromopsis inermis L.), and an annual cereal, common oat (Avena sativa L.). Both species have concentrated TLs and PLs in autumn under cold hardening. In addition, a significant increase in the content of fatty acids (FAs) of B. inermis was observed during the autumn decrease in temperature. The Yakutian horses, which fed on cereals enriched with nutrients preserved by natural cold (green cryo-fodder), accumulated significant amounts of 18:2n-6 and 18:3n-3, the total content of which in cereals was 75% of the total FA content. We found differences in the distribution of these two FAs in different tissues of the horses. Thus, liver was rich in 18:2n-6, while muscle and adipose tissues accumulated mainly 18:3n-3. Such a distribution may indicate different roles of these FAs in the metabolism of the horses. According to FA content, meat of the Yakutian horses is a valuable dietary product. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Setkov N.A., Eremeev A.V.
Заглавие : Inhibitors of protein biosynthesis can stimulate proliferation of mouse hepatocytes in vitro
Колич.характеристики :8 с
Место публикации : Biol. Bull: MAIK NAUKA/INTERPERIODICA, 2003. - Vol. 30, Is. 3. - P212-219. - ISSN 1062-3590, DOI 10.1023/A:1023843409416
Примечания : Cited References: 43
Предметные рубрики: TRANSFORMING-GROWTH-FACTOR
RAT-LIVER REGENERATION
FACTOR-BETA
DNA-SYNTHESIS
PRIMARY CULTURE
PARTIAL-HEPATECTOMY
EPITHELIAL-CELLS
EXPRESSION
MECHANISMS
MODULATION
Аннотация: Hepatocyte proliferation in the liver regenerating after partial hepatectomy ceases when the organ is restored, and the mechanism of this phenomenon is still unclear. In the experiments on fusing hepatocytes from the reoenerated mouse liver (15 days after partial hepatectomy) with NIH 3T3 mouse fibroblasts, we revealed no DNA synthesis in the nuclei of stimulated fibroblasts in heterokaryons (in the presence of hepatocyte nuclei), whereas DNA synthesis in nonfused cells was undisturbed. In this work, our purpose was to find out whether the suppression of DNA synthesis in heterokaryons could be due to the appearance in hepatocytes of some endogenous factors having an inhibitory effect on proliferation. To this end, hepatocytes from the mouse liver regenerated after partial hepatectomy were treated with cycloheximide for 1-4 h and were then fused with stimulated fibroblasts. Such a short-term treatment of hepatocytes with cycloheximide proved to result in the loss of their ability to inhibit DNA synthesis in the nuclei of stimulated or quiescent fibroblasts in heterokaryons, but hepatocytes proper actively proliferated in the medium with a low serum content (0.2%). When the mice with the liver reoenerated after partial hepatectomy were treated with a single sublethal dose of cycloheximide (3 mg/kg), their hepatocytes taken two days after this treatment had no inhibitory effect. Puromycin, another inhibitor of protein synthesis, had the same effect on hepatocytes. These results may be interpreted as evidence that the final stage of liver regeneration after damage is controlled by the factors having a C C negative effect on cell proliferation.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Vinokurov A.P., Eremeev A.V., Setkov N.A.
Заглавие : Dobutamine prevents experimental postintoxication liver cirrhosis in mice
Колич.характеристики :4 с
Место публикации : Bull. Exp. Biol. Med.: CONSULTANTS BUREAU, 2002. - Vol. 134, Is. 1. - P43-46. - ISSN 0007-4888, DOI 10.1023/A:1020604621142
Примечания : Cited References: 14
Предметные рубрики: GROWTH-FACTOR-BETA
HEPATIC-FIBROSIS
RAT HEPATOCYTES
NOREPINEPHRINE
INJURY
CELLS
Ключевые слова (''Своб.индексиров.''): hepatocytes--dobutamine--proliferation--liver cirrhosis
Аннотация: Various chronic inflammatory and necrotic processes in the liver parenchyma are accompanied by pathological morphofunctional changes, which are associated with hepatocyte death and, hyperplasia of the connective tissue. Regeneration of the liver parenchyma should include not only prevention of fibrosis, but also stimulation of hepatocyte proliferation. The adrenoceptor agonist dobutamine stimulated proliferative activity of cultured hepatocytes and prevented the development of postintoxication liver cirrhosis in mice produced by chronic poisoning with CCl4.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Remmel N.N., Kratasyuk V.A., Maznyak O.M., Inzhevatkin E.V., Nefedov V.P.
Заглавие : Bioluminescent analysis of intensity of pathological oxidative processes in cells of perfused rat liver after hyperthermia
Колич.характеристики :3 с
Место публикации : Bull. Exp. Biol. Med.: CONSULTANTS BUREAU, 2003. - Vol. 135, Is. 1. - P43-45. - ISSN 0007-4888, DOI 10.1023/A:1023489727703
Примечания : Cited References: 15
Ключевые слова (''Своб.индексиров.''): bioluminescent analysis--controlled perfusion of isolated liver--hyperthermia--oxidative stress
Аннотация: We studied the possibility of evaluation of the intensity of pathological oxidative processes in rat liver using an integral bioluminescent test with controlled perfusion of the isolated organ. The test revealed a significant correlation between the level of TBA-reactive products and bioluminescence intensity.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shadrin K. V., Morgulis I. I., Pahomova V. G., Rupenko A. P., Khlebopros R. G.
Заглавие : Characteristics of oxygen transport through the surface of the isolated perfused rat liver
Место публикации : Doklad. Biochem. Biophys. - 2015. - Vol. 464, Is. 1. - С. 298-300. - ISSN 16076729 (ISSN) , DOI 10.1134/S1607672915050075
Аннотация: It is shown that the transport of oxygen through the surface of the isolated perfused rat liver is an energy-dependent process that requires the energy of ATP hydrolysis. © 2015, Pleiades Publishing, Ltd.
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10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gladyshev, Michail I., Makhutova, Olesia N., Gubanenko, Galina A., Rechkina, Ekaterina A., Kalachova, Galina S., Sushchik, Nadezhda N.
Заглавие : Livers of terrestrial production animals as a source of long-chain polyunsaturated fatty acids for humans: An alternative to fish?
Колич.характеристики :5 с
Место публикации : Eur. J. Lipid Sci. Technol.: WILEY-BLACKWELL, 2015. - Vol. 117, Is. 9. - С. 1417-1421. - ISSN 1438-7697, DOI 10.1002/ejlt.201400449. - ISSN 1438-9312(eISSN)
Примечания : Cited References:41
Предметные рубрики: CARDIOVASCULAR-DISEASE
DOCOSAHEXAENOIC ACID
MUSCLE-TISSUE
MEAT
Ключевые слова (''Своб.индексиров.''): beef liver--chicken liver--essential fatty acids--pork liver
Аннотация: Long-chain polyunsaturated n-3 fatty acids (LC-PUFA), including eicosapentaenoic (EPA), and docosahexaenoic (DHA) are an essential part of human diets, but their main source, the wild fish catch, is limited. Terrestrial production animals, such as cattle, pigs, and chicken, can synthesize these compounds from the plant-derived precursor -linolenic acid, and the synthesis occurs mainly in liver. We estimated the putative contribution of liver products to the LC-PUFA supply in human nutrition, as an alternative to fish. We measured EPA and DHA contents in raw and cooked livers of the animals. Calculations of global production of EPA and DHA in the livers of these animals were done. Mean contents of LC-PUFA in raw livers of chicken, pigs, and cattle were comparable with those in some fish. Culinary treatments of the liver did not result in a decrease of EPA and DHA contents. Global production of EPA and DHA in animals' livers was estimated as approximate to 410(6)kg/year, while the global EPA+DHA supply through the wild fish catch is known to be 18010(6)kg/year. Thus, liver of production animals is an additional source of LC-PUFA for human nutrition, rather than an alternative to fish. Practical applications: Consumption of food with a high PUFA content and a low n-6/n-3 ratio is recommended for humans to prevent cardiovascular disease and psychiatric disorders. We found that cooked pork and beef liver is a valuable source of n-3 LC-PUFA in human nutrition. In contrast, cooked chicken liver had too high of a n-6/n-3 ratio and, thereby, had a lower nutritive value concerning n-3 LC-PUFA. An estimate has been made of the putative contribution of liver products of terrestrial animals to the LC-PUFA supply as alternative to fish in human nutrition.
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11.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Pande S., Ranjan R., Shuvaev A. N., Malinovskaya N. A., Ryazanova M., Salmina A. B., Kolenchukova O. A., Kratasyuk V. A.
Заглавие : Dietary buckwheat enhances sirtuin1 without calorie restriction
Место публикации : J. Cereal Sci.: Academic Press, 2020. - Vol. 94. - Ст.103004. - ISSN 07335210 (ISSN), DOI 10.1016/j.jcs.2020.103004
Аннотация: In the present investigation, the role of dietary intervention in male Wistar rats (n = 8, 3 groups) was studied to observe absolute sirtuin 1 (SIRT1) levels (expressed as ng mg?1 total protein) in serum, stomach, liver, and kidney. Dietary buckwheat at 30% (w/w) level of incorporation in the standard diet (Buckwheat Enriched Diet, BED) improved SIRT1 with values 0.933 ± 0.05, 210 ± 7, 63.26 ± 4, and 69.89 ± 3 in serum, stomach, liver, and kidney respectively when compared to the respective control values of 0.536 ± 0.03, 156 ± 23.3, 31.07 ± 2 and 47.11 ± 4. Moreover, BED though isocaloric to CR diet, led to weight gain (g) by 63.11 ± 3.8, ca. 10%, and 40% higher than control (56.27 ± 5.6) and CR (45.05 ± 4.1) diet groups. A marked rise in Feed Efficiency Ratio (FER) by ca. 37% while a 30% decrease in Feed Conversion Ratio (FCR) was observed for the BED group which supports unexpected weight gain in rats post-dietary intervention. The results justify the superior nutritional profile of buckwheat laden with essential nutrients, essential proteins, and bioactives. In contrast, Calorie Restriction (CR) resulted in a decline of the total protein content in circulation by 19%, while reduction of total protein in stomach, liver, and kidney was estimated to be 95%, 35.2%, and 27% respectively though SIRT1 values were comparatively the highest in all the samples studied. A 30-fold enhancement of SIRT1 in stomach post CR is presumed to counter enhanced stress in gastric tissues. Therefore, mild to moderate expression of SIRT1 may confer beneficial effects such as delayed aging and stress resistance but exceedingly high SIRT1 may evoke increased oxidative stress. © 2020 Elsevier Ltd
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12.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Inzhevatkin E. V., Baron A. V., Volkova M. B., Maksimov N. G., Golubenko N. K., Loshkareva M. V., Puzyr’ A. P., Ronzhin N. O., Bondar V. S.
Заглавие : Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma
Место публикации : Bull. Exp. Biol. Med.: Springer, 2021. - Article in press. - ISSN 00074888 (ISSN), DOI 10.1007/s10517-021-05335-9
Аннотация: Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.
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13.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Makhutova, Olesia N., Stoyanov, Kirill N.
Заглавие : Fatty acid content and composition in tissues of Baikal grayling (Thymallus baicalensis), with a special focus on DHA synthesis
Колич.характеристики :19 с
Коллективы : Russian Foundation for Basic Research (RFBR)Russian Foundation for Basic Research (RFBR) [20-04-00594]; Russian FederationRussian Federation [51.1.1]; Ministry of Science and Higher Education of the Russian Federation [FSRZ-2020-0006]
Место публикации : Aquac. Int.: SPRINGER, 2021. - Article in press. - ISSN 0967-6120, DOI 10.1007/s10499-021-00755-w. - ISSN 1573-143X(eISSN)
Примечания : Cited References:75. - The research was funded by a grant from the Russian Foundation for Basic Research (RFBR) N 20-04-00594, by the state assignment within the framework of the Basic Research Program of the Russian Federation (topic no. 51.1.1) and the state assignment of the Ministry of Science and Higher Education of the Russian Federation to Siberian Federal University in 2020 (Project no. FSRZ-2020-0006 "Biologically active substances in environmental, biotechnological and medical systems").
Предметные рубрики: COD GADUS-MORHUA
DOCOSAHEXAENOIC ACID
SEASONAL DYNAMICS
FISH
Аннотация: Long-chain polyunsaturated fatty acids of n-3 family (n-3 LC PUFAs) are physiologically essential compounds required for normal growth and development of animals, including humans. The ability of fish species to synthesize n-3 LC PUFAs varies significantly across different trophic levels. We have studied fatty acid (FA) content (mg/g of wet weight) and level (% of total FAs) in the brain, liver, heart, intestine, female and male gonads, muscle, and adipose tissues of commercially important wild freshwater Baikal grayling. Additionally, FA content and level of Baikal grayling juveniles have been studied. In all tissues of Baikal grayling, some LC PUFAs, namely, 24:5n-3 and 24:6n-3 (C24 PUFAs), have been found. These FAs are the intermediate products in the synthesis of docosahexaenoic acid (DHA, 22:6n-3) by the Sprecher pathway. The levels of C24 PUFAs in tissues differed significantly: the highest levels of C24 PUFAs were found in adipose tissue and the lowest values in the gonads of females, liver, brain, and head of juveniles. According to the dynamics of DHA and C24 PUFAs, the maximum rate of DHA synthesis is achieved in brain of Baikal grayling, while the lowest rate of DHA synthesis probably occurs in adipose tissue. Although all studied tissues had differences in the number of FAs and their levels, 16:0, 18:1n-9, 16:1n-7, 20:5n-3, and DHA dominated. Male gonads contained an extremely high level of furan FAs - presumably beneficial substances for human health. Additionally, the nutritional value of the tissues of Baikal grayling as a source of n-3 LC PUFAs for humans has been estimated.
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14.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Inzhevatkin, E., V, Baron, A., V, Volkova M. B., Maksimov N. G., Golubenko N. K., Loshkareva, M., V, Puzyr' A. P., Ronzhin N. O., Bondar V. S.
Заглавие : Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma
Колич.характеристики :4 с
Место публикации : Bull. Exp. Biol. Med.: SPRINGER, 2021. - Vol. 172, Is. 1. - С. 77-80. - ISSN 0007-4888, DOI 10.1007/s10517-021-05335-9. - ISSN 1573-8221(eISSN)
Примечания : Cited References:9
Аннотация: Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values.
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15.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Zotina T. A., Anishchenko, O., V, Trofimova E. A., Dementiev, D., V
Заглавие : Comparative Assessment of the Content of Transition Metals (Cu, Zn, Mn, Pb, and Cd) and Radiocesium (Cs-137) in Pike (Esox lucius) and Burbot (Lota lota) of the Yenisei River
Колич.характеристики :9 с
Коллективы : Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR) [18-44-240003]; Government of Krasnoyarsk krai; Krasnoyarsk Regional Fund for Support of Scientific and Technical Activity [20-44-240004]
Место публикации : Contemp. Probl. Ecol.: MAIK NAUKA/INTERPERIODICA/SPRINGER, 2022. - Vol. 15, Is. 1. - С. 91-99. - ISSN 1995-4255, DOI 10.1134/S1995425522010115. - ISSN 1995-4263(eISSN)
Примечания : Cited References:36. - This work was supported by the Russian Foundation for Basic Research, grant no. 18-44-240003, and the Government of Krasnoyarsk krai, together with the Krasnoyarsk Regional Fund for Support of Scientific and Technical Activity, grant no. 20-44-240004.
Предметные рубрики: FRESH-WATER FISH
NORTHERN PIKE
HEAVY-METALS
BRAMA L.
FOOD-WEB
SIZE
Аннотация: The trophic position of fish is one of the most important factors controlling the accumulation of potentially toxic elements and compounds in fish tissues, primarily via the spectrum of fish nutrition. In this study, the content of potentially toxic transition metals (Cu, Zn, Mn, Pb, and Cd) and radiocesium (Cs-137) in the edible tissues (muscles and liver) of two representatives of the fish-eating ichthyofauna of the Yenisei River, northern pike (Esox lucius) and burbot (Lota lota), have been comparatively studied relatively to the size of the fish. A significant decrease in the content of radiocesium and zinc in the muscles of pike and zinc in the liver of pike with an increase in body size has been recorded in juvenile pikes with a body weight (W) of less than 0.35 kg. For larger sexually mature pikes, no significant size dependences of the accumulation of metals in tissues are found. A positive correlation is found between the content of Cs-137, Cu, Zn, and Mn in muscles and the size of burbot in the W range from 0.42 to 1.62 kg. The tissues of burbots and pikes of the same size significantly (p 0.05) differ in the concentration of metals in their tissues: concentrations of Zn and Mn are 1.6-2.2 times higher in the muscle of burbot; the concentration of Pb is 1.8 times higher in muscle of pike; Cu is twice as high in the liver of burbot; and Zn and Mn are 4.7 and 1.6 times higher in the liver of pike, respectively. These differences may be due to the different food spectra of pike and burbot. Concentrations of Cu, Zn, and Mn in the liver of pike are 3-7 times higher than in muscle; the concentration of Cu in the liver of burbot is 5 times higher than in muscle. Pb and Cd tend to be higher in liver than muscle for both fish species. Despite the revealed size dependences, the concentrations of potentially toxic metals and radiocesium in the muscles and liver of fish are below the permissible concentrations for food. These results can be used to assess environmental risks for the population consuming fish, as well as to plan for the long-term environmental monitoring of rivers using representatives of piscivorous fish.
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16.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Pande, Shubhra, Ranjan, Rajeev, Ryazanova, Maria, Shuvaev, Anton N., Salmina, Alla B., Kratasyuk, Valentina A.
Заглавие : Buckwheat-enriched diet alleviates bisphenol A mediated oxidative stress via modulation of sirtuin 1 and antioxidant status in experimental rats
Колич.характеристики :8 с
Коллективы : Ministry of Science and Higher Education of the Russian Federation [FSRZ-2020-0006]; Russian Ministry of Education, Post-Doctoral Program of Project "5-100" [M 2.2.3]
Место публикации : Food Chem.: ELSEVIER SCI LTD, 2022. - Vol. 373. - Ст.131507. - ISSN 0308-8146, DOI 10.1016/j.foodchem.2021.131507. - ISSN 1873-7072(eISSN)
Примечания : Cited References:36. - The research was supported by the Ministry of Science and Higher Education of the Russian Federation (Grant no. FSRZ-2020-0006) and Russian Ministry of Education, Post-Doctoral Program of Project "5-100" [Grant No. M 2.2.3]. Authors profusely thank R. Sabirzyanov and I.A. Denisov for the needful in the arrangement of ultrapure BPA.
Предметные рубрики: TRANSCRIPTION
TOXICITY
EXTRACT
FIBER
Аннотация: Present study investigated effect of dietary buckwheat in alleviating bisphenol A (BPA) mediated oxidative stress, concomitant sirtuin1 levels in serum, stomach, and liver of rats. Experimental group A and B ingested standard diet, C and D consumed buckwheat (30%); group A and C drank normal water, B and C had BPA contamination (10 mg L 1). Sirtuin1 mean B/A ratio nearing unity in all tissues reveals inertness of BPA towards sirtuin1. Dietary buckwheat improved sirtuin1 levels both in normal (mean C/A ratio of serum, 1.65; liver, 1.24; stomach, 1.78) and BPA fed state (mean D/B ratio of serum, 1.9; liver, 1.26; stomach, 1.75). Buckwheat augmented antioxidant status in BPA fed rats as seen in mean D/B ratio of serum (catalase, 2.4; glutathione reductase (GR), 1.33; Thiols, 1.2), liver (catalase, 2; GR, 2.5; Thiols, 1.36) and stomach (catalase, 1.31; GR, 1.5; Thiols, 1.33). Therefore, buckwheat counters BPA-led oxidative stress and modulates sirtuin1.
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17.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Petrov K. A., Makhutova O. N., Gladyshev M. I.
Заглавие : Fatty Acid Composition of Yakut Horse Tissues
Место публикации : Doklad. Biochem. Biophys.: Pleiades Publishing, 2020. - Vol. 492, Is. 1. - С. 105-107. - ISSN 16076729 (ISSN), DOI 10.1134/S1607672920030047
Аннотация: Abstract: We compared the composition and content of fatty acids (FAs) in the liver, muscles, and subcutaneous fat of Yakut horses inhabiting extreme environment in the Cryolithozone. Essential linoleic and alpha-linolenic acids, supplied to horses with their food, were accumulated in different tissues. Linoleic acid was accumulated in the liver but alpha-linolenic acid was accumulated in muscle and subcutaneous fat. Such a distribution indicates different roles of these fatty acids in the metabolism of horses. Yakut horse meat is a valuable dietary product owing to its fatty acid composition and content. © 2020, Pleiades Publishing, Ltd.
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18.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Pande, Shubhra, Ranjan, Rajeev, Shuvaev, Anton N., Malinovskaya, Natalia A., Ryazanova, Maria, Salmina, Alla B., Kolenchukova, Oksana A., Kratasyuk, Valentina A.
Заглавие : Dietary buckwheat enhances sirtuin1 without calorie restriction
Колич.характеристики :6 с
Коллективы : Russian Foundation for Basic Research (RFBR)Russian Foundation for Basic Research (RFBR) [16-06-00-439]; Russian Ministry of EducationMinistry of Education and Science, Russian Federation [M 2.2.3]
Место публикации : J. Cereal Sci.: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2020. - Vol. 94. - Ст.103004. - ISSN 0733-5210, DOI 10.1016/j.jcs.2020.103004. - ISSN 1095-9963(eISSN)
Примечания : Cited References:22. - This work was supported by the Russian Foundation for Basic Research (RFBR) [Grant No. 16-06-00-439] and by the Russian Ministry of Education, Post-Doctoral Program of Project "5-100" [Grant No. M 2.2.3].
Предметные рубрики: LIFE-SPAN
STRESS
FLOUR
RATS
Аннотация: In the present investigation, the role of dietary intervention in male Wistar rats (n = 8, 3 groups) was studied to observe absolute sirtuin 1 (SIRT1) levels (expressed as ng mg(-1) total protein) in serum, stomach, liver, and kidney. Dietary buckwheat at 30% (w/w) level of incorporation in the standard diet (Buckwheat Enriched Diet, BED) improved SIRT1 with values 0.933 +/- 0.05, 210 +/- 7, 63.26 +/- 4, and 69.89 +/- 3 in serum, stomach, liver, and kidney respectively when compared to the respective control values of 0.536 +/- 0.03, 156 +/- 23.3, 31.07 +/- 2 and 47.11 +/- 4. Moreover, BED though isocaloric to CR diet, led to weight gain (g) by 63.11 +/- 3.8, ca. 10%, and 40% higher than control (56.27 +/- 5.6) and CR (45.05 +/- 4.1) diet groups. A marked rise in Feed Efficiency Ratio (FER) by ca. 37% while a 30% decrease in Feed Conversion Ratio (FCR) was observed for the BED group which supports unexpected weight gain in rats post-dietary intervention. The results justify the superior nutritional profile of buckwheat laden with essential nutrients, essential proteins, and bioactives. In contrast, Calorie Restriction (CR) resulted in a decline of the total protein content in circulation by 19%, while reduction of total protein in stomach, liver, and kidney was estimated to be 95%, 35.2%, and 27% respectively though SIRT1 values were comparatively the highest in all the samples studied. A 30-fold enhancement of SIRT1 in stomach post CR is presumed to counter enhanced stress in gastric tissues. Therefore, mild to moderate expression of SIRT1 may confer beneficial effects such as delayed aging and stress resistance but exceedingly high SIRT1 may evoke increased oxidative stress.
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19.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Petrov K. A., Makhutova O. N., Gladyshev M. I.
Заглавие : Fatty Acid Composition of Yakut Horse Tissues
Колич.характеристики :3 с
Коллективы : Russian FederationRussian Federation [51.1.1]; Ministry of Science and Higher Education of the Russian Federation [FSRZ-2020-0006]
Место публикации : Dokl. Biochem. Biophys.: MAIK NAUKA/INTERPERIODICA/SPRINGER, 2020. - Vol. 492, Is. 1. - С. 105-107. - ISSN 1607-6729, DOI 10.1134/S1607672920030047. - ISSN 1608-3091(eISSN)
Примечания : Cited References:8. - This study was supported by the state assignment within the framework of the Basic Research Program of the Russian Federation (topic no. 51.1.1) and the state assignment of the Ministry of Science and Higher Education of the Russian Federation to Siberian Federal University in 2020 (Project no. FSRZ-2020-0006 "Biologically active substances in environmental, biotechnological and medical systems").
Предметные рубрики: MEAT
Аннотация: We compared the composition and content of fatty acids (FAs) in the liver, muscles, and subcutaneous fat of Yakut horses inhabiting extreme environment in the Cryolithozone. Essential linoleic and alpha-linolenic acids, supplied to horses with their food, were accumulated in different tissues. Linoleic acid was accumulated in the liver but alpha-linolenic acid was accumulated in muscle and subcutaneous fat. Such a distribution indicates different roles of these fatty acids in the metabolism of horses. Yakut horse meat is a valuable dietary product owing to its fatty acid composition and content.
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20.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Makhutova O. N., Stoyanov K. N.
Заглавие : Fatty acid content and composition in tissues of Baikal grayling (Thymallus baicalensis), with a special focus on DHA synthesis
Место публикации : Aquac. Int.: Springer Science and Business Media Deutschland GmbH, 2021. - Article in press. - ISSN 09676120 (ISSN), DOI 10.1007/s10499-021-00755-w
Аннотация: Long-chain polyunsaturated fatty acids of n-3 family (n-3 LC PUFAs) are physiologically essential compounds required for normal growth and development of animals, including humans. The ability of fish species to synthesize n-3 LC PUFAs varies significantly across different trophic levels. We have studied fatty acid (FA) content (mg/g of wet weight) and level (% of total FAs) in the brain, liver, heart, intestine, female and male gonads, muscle, and adipose tissues of commercially important wild freshwater Baikal grayling. Additionally, FA content and level of Baikal grayling juveniles have been studied. In all tissues of Baikal grayling, some LC PUFAs, namely, 24:5n-3 and 24:6n-3 (C24 PUFAs), have been found. These FAs are the intermediate products in the synthesis of docosahexaenoic acid (DHA, 22:6n-3) by the Sprecher pathway. The levels of C24 PUFAs in tissues differed significantly: the highest levels of C24 PUFAs were found in adipose tissue and the lowest values in the gonads of females, liver, brain, and head of juveniles. According to the dynamics of DHA and C24 PUFAs, the maximum rate of DHA synthesis is achieved in brain of Baikal grayling, while the lowest rate of DHA synthesis probably occurs in adipose tissue. Although all studied tissues had differences in the number of FAs and their levels, 16:0, 18:1n-9, 16:1n-7, 20:5n-3, and DHA dominated. Male gonads contained an extremely high level of furan FAs — presumably beneficial substances for human health. Additionally, the nutritional value of the tissues of Baikal grayling as a source of n-3 LC PUFAs for humans has been estimated. © 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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