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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Zotina T., Trofimova E., Dementyev D., Bolsunovsky A.
Заглавие : Transfer of americium-241 from food and water to organs and tissues of the crucian carp *
Место публикации : Radioprotection. - 2011. - Vol. 46, Is. 6 SUPPL. - С. S69-S73. - ISSN 00338451 (ISSN) , DOI 10.1051/radiopro/20116648s
Аннотация: The transfer of transuranium element americium-241 (241Am) from food and water to organs and tissues of freshwater fish (Carassius auratus gibelio, crucian carp) has been investigated in laboratory experiments. The fishes were fed with homogenized biomass of submerged macrophytes labeled with 241Am, through catheter. For the first two days after force-feeding, fishes excreted up to 80% of ingested americium, for four days - 98%. 241Am was registered in internal organs and tissues that had no direct contact with americium (liver, bones, muscles) as early as two days after the feeding and after eight days, when the digestive tract was depurated. Among internal organs, the highest activity concentration was recorded in the liver (up to 427 Bq/kg). Activity concentration in bones (19-31 Bq/kg) was several times higher than in muscles, indicating the affinity of americium to bone tissue. Assimilation of 241Am in organs and tissues of crucian carp from water occurred mainly via the digestive tract too. В© 2011 EDP Sciences.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Goreva A.V., Voinova O.N., Kalacheva G.S., Volova T.G.
Заглавие : Distribution and resorption of polymeric microparticles in visceral organs of laboratory animals after intravenous injection
Место публикации : Bulletin of Experimental Biology and Medicine. - 2009. - Vol. 148, Is. 5. - С. 789-793. - ISSN 00074888 (ISSN) , DOI 10.1007/s10517-010-0817-3
Ключевые слова (''Своб.индексиров.''): 14c--intravenous injection--microparticles--resorbable polyhydroxybutyrate--visceral tissues--carbon 14--microsphere--polyhydroxyaminobutyric acid--polymer--unclassified drug--animal experiment--animal tissue--article--biocompatibility--biodegradability--body growth--controlled drug release--controlled study--degradation kinetics--drug delivery system--drug dosage form--experimental animal--female--liver parenchyma--molecular weight--nonhuman--particle size--physical development--radioactivity--rat--spleen--tissue distribution--tissue structure--animals--animals, laboratory--carbon radioisotopes--female--injections, intravenous--particle size--polymers--rats--rats, wistar--tissue distribution--viscera--animalia
Аннотация: Microparticles obtained by using 14C-labeled resorbable hydroxyaminobutyric acid polymer were injected into the caudal vein of laboratory animals without negative aftereffects for their growth and development and without changes in the macro- and microstructure of organs and tissues. The distribution of microparticles in the viscera and the dynamics of accumulation of carbon-containing polymer degradation products in the viscera were studied. The main targets for the particles are liver tissues, as well as renal and splenic tissues. The polymeric matrix of the microparticles is most actively destroyed in the spleen and liver. The presence of high-molecular- weight polymeric matrix in organs indicates the integrity of microparticles and the possibility of long-term (up to 12 weeks) functioning of polymeric particles in vivo. В© 2009 Springer Science+Business Media, Inc.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Volova T.G., Popova T.G.
Заглавие : Study of biological properties of polyhydroxyalkanoates in a long-term experiment in vivo
Место публикации : Biomedical Engineering. - 2002. - Vol. 36, Is. 4. - С. 218-222. - ISSN 00063398 (ISSN) , DOI 10.1023/A:1021136203338
Ключевые слова (''Своб.индексиров.''): hemoglobin--polyhydroxyalkanoic acid--animal experiment--animal tissue--article--biocompatibility--biodegradability--biosynthesis--blood cell count--blood sampling--comparative study--controlled study--dna synthesis--elasticity--enzyme activity--enzyme mechanism--erythrocyte sedimentation rate--female--in vivo study--liver function--nonhuman--organ weight--rat--suture--animalia
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Volova T.G., Gitelson I.I.
Заглавие : In vivo toxicological evaluation of polyhydroxyalkanoates.
Место публикации : Doklady Biological Sciences. - 2002. - Vol. 383, Is. 1-6. - С. 109-111. - ISSN 00124966 (ISSN)
Ключевые слова (''Своб.индексиров.''): alkane--animal--animal behavior--article--cytology--drug effect--erythrocyte sedimentation rate--female--heart--kidney--liver--lymphoid tissue--male--rat--spleen--wistar rat--alkanes--animals--behavior, animal--blood sedimentation--female--heart--kidney--liver--lymphoid tissue--male--rats--rats, wistar--spleen
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Eremeev A.V., Gitel'zon I.I., Setkov N.A., Volova T.G.
Заглавие : Cytotoxicity of polyhydroxyalkanoates in animal cell cultures.
Место публикации : Doklady Biological Sciences. - 2000. - Vol. 374, Is. 1-6. - С. 539-542. - ISSN 00124966 (ISSN)
Ключевые слова (''Своб.индексиров.''): dna--hydroxybutyric acid--poly(3 hydroxybutyrate) co (3 hydroxyvalerate)--poly(3 hydroxybutyric acid)--poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate)--poly-beta-hydroxybutyrate--polyester--rna--thymidine--uridine--animal--article--biosynthesis--cell division--cell strain 3t3--cell survival--cytology--drug effect--liver--liver cell--metabolism--mouse--vascular endothelium--3t3 cells--animals--cell division--cell survival--dna--endothelium, vascular--hepatocytes--hydroxybutyrates--liver--mice--polyesters--rna--thymidine--uridine
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E., Goreva A., Kalacheva G., Volova T.
Заглавие : Biocompatibility and resorption of intravenously administered polymer microparticles in tissues of internal organs of laboratory animals
Место публикации : Journal of Biomaterials Science, Polymer Edition. - 2011. - Vol. 22, Is. 16. - С. 2185-2203. - ISSN 09205063 (ISSN) , DOI 10.1163/092050610X537138
Ключевые слова (''Своб.индексиров.''): 14c products of polymer resorption--intravenous administration--microparticles--resorbable polyhydroxybutyrate--tissues of internal organs--3-hydroxybutyric acid--sup14/supc products of polymer resorption--adverse effect--drug-delivery systems--growth and development--high molecular weight--initial molecular weight--initial values--internal organs--intravenous administration--laboratory animals--local response--matrix--mean diameter--micro-particles--polymer degradation--polymer microparticles--preparation process--radioactivity level--residual content--resorbable--sustained-release--tail veins--wistar rat--animals--biocompatibility--degradation--histology--molecular weight--morphology--radiation--radioactivity--rats--tissue--poly(3 hydroxybutyric acid)--animal experiment--animal tissue--article--biocompatibility--concentration process--controlled study--degradation--drug delivery system--female--gel permeation chromatography--heart--kidney parenchyma--liver--lung parenchyma--molecular weight--nonhuman--organ culture--priority journal--radioactivity--rat--spleen--animals--animals, laboratory--biocompatible materials--drug delivery systems--female--infusions, intravenous--materials testing--microspheres--molecular weight--particle size--polymers--rats--rats, wistar--tissue distribution--animalia--rattus--rattus norvegicus
Аннотация: Specimens of 14C-labeled polymer of 3-hydroxybutyric acid, P(3-HB), with different initial molecular weights, were used to prepare microparticles, whose morphology was not influenced by the M w of the polymer. During the particle preparation process, P(3-HB) molecular weight decreased by 15-20%. Sterile microparticles (mean diameter 2.4 ?m) were injected into the tail veins of Wistar rats (5 mg/rat). The effects of the particles administered to rats were studied based on the general response of animals and local response of internal organ tissues and blood morphology; no adverse effects on growth and development of the animals or unfavorable changes in the structure of the tissues of internal organs were observed. Measurements of radioactivity in tissues showed that 14C concentrations are different in different organs, changing during the course of the experiment. The main targets for 14C-labeled microparticles were tissues of the liver, spleen, and kidneys. Comparison of radioactivity levels and residual contents of high-molecular-weight matrix in tissues suggested that the most rapid metabolism and degradation of P(3-HB) occurred in the liver and spleen. Gel-permeation chromatography showed that at 3 h after the microparticles were injected into the bloodstream, polymer degradation started in all examined organs, except the lungs; at 12 weeks, the M w of the polymer matrix was as low as 20-30% of its initial value. The presence of high-molecular-weight (undegraded) polymer in the tissues at 12 weeks after administration of the particles suggests that P(3-HB) is degraded in tissues of internal organs slowly and, hence, P(3-HB)-based microparticles can be used as sustained-release drug-delivery systems. В© 2011 VSP.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Barashkov V.A., Gitel'zon I.I., Nefedov V.P., Trubachev I.N.
Заглавие : Dynamics of amino acid composition of the medium during culture of isolated liver and kidneys by the controlled perfusion method
Место публикации : Bulletin of Experimental Biology and Medicine. - 1976. - Vol. 80, Is. 11. - С. 1305-1307. - ISSN 00074888 (ISSN)
Ключевые слова (''Своб.индексиров.''): amino acid--dog--in vitro study--kidney perfusion--liver perfusion--theoretical study
Аннотация: The dynamics of the amino acid composition of the medium was investigated during perfusion of the dog liver and kidney for 6 h with a mixture of autogenous plasma and medium No.199 in the ratio of 2:3. During culture of the kidney for 6 h the histidine concentration in the medium increased by 2.2 times compared with initially, the concentration of glutamic acid by 1.7 times, and of alanine and lysine by 1.6 times, whereas the concentrations of arginine, serine, and aspartic acid fell by 3.3 times and those of glutamine with threonine by 2.5 times. During perfusion of the liver the concentration of glutamic acid rose by 2.9 times, of alanine by 2.3 times, cystine by 2.0 times, and glycine by 1.5 times. The concentration of tyrosine fell by half, and that of phenylalanine and serine by 1.4 times. The arginine concentration fell so quickly during perfusion of the liver that by the second hour after the beginning of perfusion no arginine could be found in the medium. The method of amino acid analysis during organ culture as described can be used as a method of developing and correcting culture media.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Barashkov V.A., Gitel'zon I.I., Nefedov V.P., Trubachev I.N.
Заглавие : Dynamics of amino acid composition of the medium in isolated organ culture by the controlled perfusion method
Место публикации : Bulletin of Experimental Biology and Medicine. - 1975. - Vol. 80, Is. 7. - С. 759-761. - ISSN 00074888 (ISSN)
Ключевые слова (''Своб.индексиров.''): amino acid--tissue culture medium--dog--in vitro study--organ culture--organ perfusion--theoretical study
Аннотация: The dynamics of the amino acid composition of the perfusion fluid was investigated during adequate perfusion of isolated dog organs (the thorax and a complex consisting of the thoracic organs, kidneys, and liver). The concentration of amino acids such as histidine, lysine, and alanine in the perfusion fluid 6 h after the beginning of perfusion of the organ complex was higher, whereas that of arginine, serine, aspartic acid, threonine with glutamine, isoleucine, proline, leucine, and valine was much lower than initially. In experiments on the isolated thorax the dynamics of the amino acid composition of the medium was studied during perfusion for 4 h. The concentration of alanine, lysine, and histidine in the medium increased, whereas those of serine, aspartic acid, isoleucine, tyrosine, and phenylalanine decreased.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Markelova N.M., Shishatskaya E.I., Vinnik Y.S., Cherdantsev D.V., Beletskiy I.I., Kuznetsov M.N., Zykova L.D.
Заглавие : In vitro justification of using endobiliary stents made of polyhydroxyalkanoates
Место публикации : Macromolecular Symposia. - 2008. - Vol. 269, Is. 1. - С. 82-91. - ISSN 10221360 (ISSN) , DOI 10.1002/masy.200850910
Ключевые слова (''Своб.индексиров.''): bioresorbable materials--endobiliary stents--mechanical jaundice (mj)--phas--abs resins--biopolymers--biotechnology--body fluids--experiments--free radical polymerization--liver--polymers--prosthetics--silicon--surgery--turbulent flow--abdominal cavities--bile ducts--biliary--biological properties--bioresorbable materials--blood analyses--endobiliary stents--endoprosthesis--experimental groups--experimental models--in vitro--inflammatory reactions--macroscopic changes--mechanical jaundice (mj)--minimally invasive--negative controls--phas--polyhydroxyalkanoates--positive control groups--radical surgeries--reconstructive surgeries--suture materials--biological materials
Аннотация: Treatment of patients with mechanical jaundice (MJ) has been one of the topical problems of current medicine. The fraction of patients having MJ of oncologic character that can undergo radical surgery does not exceed 25-30%. A way out of such situation is to use minimally invasive endobiliary interventions, the main type of which is endoprosthesis replacement of bile duct lumens. The aim of the work was to study the biological properties of the experimental models of polymer stents made of PHA for endobiliary prosthetics and to investigate the biological properties of PHA suture material for forming of biliary-enteric anastomoses (cholecystoduodenostomy). Experiments were performed on 20 adult mongrel dogs, weighing 10-12 kg. The animals were divided to three groups: the negative control group (intact animals); the positive control group (the animals with implanted endobiliary silicon stents); and the experimental group (the animals with the PHA stents). The animals were monitored for 100 days. The clinical blood analysis was made before the operation, on day 7, 30, 60 and 100 days. During autopsy the presence of exudate, commissural process in the free abdominal cavity and subhepatic spatium, the appearance of choledoch where the prosthesis was located, as well as the appearance of cholecystoenterostomy, liver and duodenum. We did not found any signs of inflammation, cicatrical changes were estimated in the free abdominal cavity and subhepatic spatium. All implanted PHA stents were at their initial places of implantation. After the end of the experiment inflammatory reaction and anastomositis were absent. Macroscopic changes of liver and duodenum were also not detected. Liver function did not have any pathological deviations. These positive results give grounds to conclude that application of PHA as endobiliary stents in reconstructive surgery of bile passages and as suture material is a promising technology. Copyright В© 2008 WILEY-VCH Verlag GmbH & Co. KGaA.
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10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gitelzon I.I., Nefedov V.P., Mezhevikin V.V.
Заглавие : Effect of hypoxemia on erythropoietic activity of perfused organs
Место публикации : Byulleten Eksperimentalnoi Biologii i Meditsiny. - 1977. - Vol. 84, Is. 7. - С. 23-24. - ISSN 03659615 (ISSN)
Ключевые слова (''Своб.индексиров.''): animal--bone marrow--cell proliferation--erythropoiesis--histology--hypoxemia--injury--mammal--perfusion fluid--theoretical study--article--dog--kidney--liver--metabolism--perfusion--spleen--sternum--erythropoietin--animal--anoxemia--dogs--english abstract--erythropoietin--kidney--liver--perfusion--spleen--sternum
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11.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Barashkov V.A., Gitelzon I.I., Nefedov V.P., Trubachev I.N.
Заглавие : The dynamics of the amino acid composition of the medium in cultivating the isolated organs by controlled perfusion (Russian)
Место публикации : Byulleten Eksperimentalnoi Biologii i Meditsiny. - 1975. - Vol. 80, Is. 7. - С. 36-38. - ISSN 03659615 (ISSN)
Ключевые слова (''Своб.индексиров.''): amino acid--amino acid--dog--in vitro study--kidney--liver--sternum--theoretical study--animal--article--culture medium--metabolism--organ culture--organ preservation--perfusion--tissue preservation--kidney--liver--kidney perfusion--liver perfusion--tissue culture--amino acids--animal--culture media--dogs--english abstract--in vitro--organ culture--organ preservation--perfusion--tissue preservation--kidney--liver
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12.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Mogilnaya O.A., Puzyr A.P., Baron A.V., Bondar V.S.
Заглавие : Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with Nanodiamonds
Колич.характеристики :5 с
Коллективы :
Место публикации : Nanoscale Res. Lett.: SPRINGER, 2010. - Vol. 5, Is. 5. - С. 908-912. - ISSN 1931-7573, DOI 10.1007/s11671-010-9571-8
Примечания : Cited References: 23. - The study was financially supported by the Russian Foundation for Basic Research (RFBR) (Grant No. 06-0490234) and the RAS Presidium (Program No. 27, Project No. 64).
Предметные рубрики: B-1
MYCOTOXINS
ADSORPTION
Ключевые слова (''Своб.индексиров.''): nanodiamonds--aflatoxin b(1)--detoxification--adsorbent
Аннотация: Hematological parameters and the state of liver cells of rats were examined in vivo after the animals received aflatoxin B(1) (AfB(1)) alone and together with modified nanodiamonds (MND) synthesized by detonation. The rats that had received the MND hydrosol had elevated leukocyte levels, mainly due to higher granulocyte counts and somewhat increased monocyte counts compared to control rats. Hematological parameters of the rats that had received AfB(1) alone differed from those of the control rats in another way: total white blood cell counts were significantly lower due to the decreased lymphocyte counts. In rats that had consumed AfB(1) with the MND hydrosol, changes in hematological parameters were less pronounced than in rats that had consumed either AfB(1) or MND. Electron microscopy showed that hepatocytes of the rats that had received the MND hydrosol or AfB(1) with the MND hydrosol contained elevated levels of lipid inclusions and lysosomes. Hyperplasia of the smooth endoplasmic reticulum (EPR) was revealed in liver specimens of the rats that had received AfB(1). Results of the study suggest the conclusion about mutual mitigation of the effects of nanoparticles and the mycotoxin on rats blood and liver cells after AfB(1) has adsorbed on MND.
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13.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : NEFEDOV V.P., TASHENOV E.K., RUPENKO A.P., ALEXEEV P.V., GITELZON I.I.
Заглавие : ESTIMATE OF KIDNEY AND LIVER CONTRIBUTIONS TO THE BALANCE OF ERYTHROPOIETIN
Колич.характеристики :4 с
Место публикации : DOKLADY AKADEMII NAUK SSSR: MEZHDUNARODNAYA KNIGA, 1988. - Vol. 301, Is. 5. - С. 1261-1264. - ISSN 0002-3264
Примечания : Cited References: 10
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14.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : NEFEDOV V.P., MAKAROV V.P., TASHENOV E.K., KRIZHANOVSKAYA E.V., KAZAKOV V.N., RUPENKO A.P., GITELZON I.I.
Заглавие : EVALUATION OF THE ERYTHROPOIETIN-PRODUCING FUNCTION OF THE KIDNEY AND LIVER DURING CONTROLLED PERFUSION
Колич.характеристики :3 с
Место публикации : Bull. Exp. Biol. Med.: PLENUM PUBL CORP, 1986. - Vol. 102, Is. 10. - С. 1340-1342. - ISSN 0007-4888, DOI 10.1007/BF00851040
Примечания : Cited References: 14
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15.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Zotina T.A., Trofimova E.A., Dementyev D.V., Bolsunovsky A.Y.
Заглавие : Bioaccumulation, inter-organ distribution, and retention of waterborne and dietary Am-241 in silver crucian carp
Колич.характеристики :12 с
Место публикации : Toxicol Environ. Chem.: TAYLOR & FRANCIS LTD, 2014. - Vol. 96, Is. 2. - С. 243-254. - ISSN 0277-2248, DOI 10.1080/02772248.2014.941368. - ISSN 1029-0486
Примечания : Cited References: 25
Предметные рубрики: YENISEI RIVER
TELEOST FISH
RADIONUCLIDES
METALS
AMERICIUM
EXPOSURE
ELEMENTS
ASSIMILATION
ELASMOBRANCH
DEPURATION
Ключевые слова (''Своб.индексиров.''): americium-241--assimilation--carassius auratus gibelio--force-feeding
Аннотация: The bioaccumulation of actinide Am-241 from food and water in bodies of freshwater fish (Carassius auratus gibelio, silver crucian carp) has been investigated in laboratory experiments. Homogenized biomass of submerged macrophytes labeled with Am-241 was injected into the fish gullet. Internal organs and tissues of crucian carp could be ranked according to activity concentration of dietary Am-241 after depuration of the digestive tract as follows: liver gonads bones muscles. Accumulation of waterborne Am-241 in internal organs and tissues of crucian carp mainly occurred via the digestive tract. While the concentration of Am-241 in liver of crucian carps decreased during depuration time, its concentration in bones increased indicating slower transfer of Am-241 to skeleton compared to muscles and liver. The retention of dietary Am-241 in the bodies of crucian carp reached 35%-46% of ingested Am-241: 20%-31% was retained in liver, 0.6%-0.8% in skeleton, and 1.4%-2.0% in muscles. The concentration factor of Am-241 from water was 0.4 for the whole body, 0.3 for liver, 0.01 for muscles, and 0.01 for skeleton. Trace amounts of Am-241 were recorded in viscera and muscles of a wild population of silver crucian carp inhabiting a radioactively contaminated part of the Yenisei River.
WOS,
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16.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Remmel N.N., Kratasyuk V.A., Maznyak O.M., Inzhevatkin E.V., Nefedov V.P.
Заглавие : Bioluminescent analysis of intensity of pathological oxidative processes in cells of perfused rat liver after hyperthermia
Место публикации : Bulletin of Experimental Biology and Medicine. - 2003. - Vol. 135, Is. 1. - P43-45. - ISSN 00074888 (ISSN) , DOI 10.1023/A:1023489727703
Ключевые слова (''Своб.индексиров.''): bioluminescent analysis--controlled perfusion of isolated liver--hyperthermia oxidative stress--thiobarbituric acid reactive substance--animal experiment--animal model--animal tissue--article--bioluminescence--concentration (parameters)--controlled study--correlation analysis--female--hyperthermia--in vivo study--lipid peroxidation--liver metabolism--liver perfusion--male--nonhuman--oxidative stress--oxygen consumption--pathology--rat--thermal exposure--animals--female--hepatocytes--hyperthermia, induced--liver--luminescent measurements--male--oxidative stress--perfusion--rats--animalia
Аннотация: We studied the possibility of evaluation of the intensity of pathological oxidative processes in rat liver using an integral bioluminescent test with controlled perfusion of the isolated organ. The test revealed a significant correlation between the level of TBA-reactive products and bioluminescence intensity.
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17.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Remmel N.N., Titova N.M., Kratasyuk V.A.
Заглавие : Oxidative stress monitoring in biological samples by bioluminescent method
Место публикации : Bulletin of Experimental Biology and Medicine. - 2003. - Vol. 136, Is. 2. - P209-211. - ISSN 00074888 (ISSN) , DOI 10.1023/A:1026347830283
Ключевые слова (''Своб.индексиров.''): bioluminescent analysis--lipid peroxidation--malonic dialdehyde--oxidative stress--malonaldehyde--animal tissue--article--bioluminescence--brain tissue--controlled study--fluorescence--freeze drying--kidney parenchyma--lipid peroxidation--liver--male--monitoring--nonhuman--oxidative stress--photobacterium phosphoreum--rat--serum--animals--bacteria--biological assay--lipid peroxidation--luminescent measurements--malondialdehyde--oxidative stress--photobacterium--rats--tissue extracts--animalia--negibacteria--photobacterium--photobacterium phosphoreum
Аннотация: The integral bioluminescent biotest with lyophilized fluorescent bacteria was used for monitoring of LPO processes in tissue extracts and serum of rats exposed to stress. A relationship between the content of MDA (LPO indicator) and fluorescence of bacteria was observed in all biological samples.
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18.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Vinokurov A.P., Eremeev A.V., Setkov N.A.
Заглавие : Dobutamine prevents experimental postintoxication liver cirrhosis in mice
Место публикации : Bulletin of Experimental Biology and Medicine. - 2002. - Vol. 134, Is. 1. - P43-46. - ISSN 00074888 (ISSN) , DOI 10.1023/A:1020604621142
Ключевые слова (''Своб.индексиров.''): dobutamine--hepatocytes--liver cirrhosis--proliferation--adrenergic receptor stimulating agent--alpha 1 adrenergic receptor stimulating agent--beta 1 adrenergic receptor stimulating agent--beta 2 adrenergic receptor stimulating agent--carbon tetrachloride--catecholamine derivative--dobutamine--epidermal growth factor--animal cell--animal experiment--animal model--animal tissue--article--cell activity--cell culture--cell death--cell proliferation--cell stimulation--chronic hepatitis--connective tissue--controlled study--disease association--drug effect--drug potency--experimental test--female--liver cell--liver cirrhosis--liver fibrosis--liver hyperplasia--liver necrosis--liver parenchyma--liver regeneration--liver toxicity--morphology--mouse--nonhuman--toxicity testing--adrenergic beta-agonists--animals--carbon tetrachloride--cell division--dobutamine--dose-response relationship, drug--female--hepatocytes--liver--liver cirrhosis--mice--mice, inbred balb c--animalia
Аннотация: Various chronic inflammatory and necrotic processes in the liver parenchyma are accompanied by pathological morphofunctional changes, which are associated with hepatocyte death and hyperplasia of the connective tissue. Regeneration of the liver parenchyma should include not only prevention of fibrosis, but also stimulation of hepatocyte prolifearation. The adrenoceptor agonist dobutamine stimulated proliferative activity of cultured hepatocytes and prevented the development of postintoxication liver cirrhosis in mice produced by chronic poisoning with CCl4.
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19.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Eremeev A.V., Setkov N.A.
Заглавие : DNA synthesis in heterokaryons obtained by fusion of hepatocytes from a regenerating mouse liver and NIH 3T3 fibroblasts
Место публикации : Doklady Biological Sciences. - 2000. - Vol. 372, Is. 1-6. - P329-332. - ISSN 00124966 (ISSN)
Ключевые слова (''Своб.индексиров.''): dna--thymidine--animal--article--biosynthesis--cell division--cell fusion--cell strain 3t3--cytology--hybrid cell--kinetics--liver cell--liver regeneration--metabolism--mouse--3t3 cells--animals--cell division--cell fusion--dna--hepatocytes--hybrid cells--kinetics--liver regeneration--mice--thymidine
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20.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : NEFEDOV V.P., MAKAROV V.P., TASHENOV E.K., KRIZHANOVSKAYA E.V., KAZAKOV V.N., RUPENKO A.P., GITELZON I.I.
Заглавие : EVALUATION OF THE ERYTHROPOIETIN-PRODUCING FUNCTION OF THE KIDNEY AND LIVER DURING CONTROLLED PERFUSION
Колич.характеристики :3 с
Место публикации : Bull. Exp. Biol. Med.: PLENUM PUBL CORP, 1986. - Vol. 102, Is. 10. - P1340-1342. - ISSN 0007-4888, DOI 10.1007/BF00851040
Примечания : Cited References: 14
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