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1.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Tikhomirova N.A., Ushakova S.A., Tikhomirov A.A., Kalacheva G.S., Gros J.-B.
Заглавие : Possibility of Salicornia europaea use for the human liquid wastes inclusion into BLSS intrasystem mass exchange
Место публикации : Acta Astronautica. - 2008. - Vol. 63, Is. 7-10. - С. 1106-1110. - ISSN 00945765 (ISSN) , DOI 10.1016/j.actaastro.2008.01.003
Ключевые слова (''Своб.индексиров.''): blss--nacl turnover--salicornia europaea--space biology--acids--amides--arsenic compounds--biochemical engineering--biochemistry--biomass--cellulose--curing--drying--environmental engineering--fatty acids--garnets--health--human engineering--lipids--mineralogy--minerals--mining--nitrates--nitrogen--plants (botany)--polysaccharides--polyvinyl alcohols--renewable energy resources--silica--silicate minerals--sodium--sodium chloride--solutions--sugar (sucrose)--sugars--waste utilization--biochemical composition--biochemical substances--bioregenerative life support systems (blss)--component conditions--crude protein (cp)--dry weight (dw)--essential fatty acids--europaea--h igh concentrations--human urine--linoleic acid (la)--linolenic--lipid content--liquid wastes--mass exchanges--mineral compositions--nitrate nitrogen--nitrogen nutrition--non saturation--physico chemical processes--plant functions--plant lipids--reduced nitrogen--salicornia europaea--soluble sugars--wide spectrum--nonmetals--amides--arsenic--biochemistry--biomass--biotechnology--cellulose--curing--drying--fatty acids--lipids--nonmetals--plants--polysaccharides--sugars
Аннотация: One of the ways of solving the problem of the human liquid wastes utilization in bioregenerative life support systems (BLSS) can be the use of halophytic vegetable plant Salicornia europaea capable of accumulating sodium chloride in rather high concentrations. Since the most specific higher plant function in BLSS, which at present cannot be substituted by physicochemical processes, appears to be the biosynthesis of a wide spectrum of nutritive substances necessary for a human, the object of the given work was the investigation of the S. europaea productivity, biochemical and mineral composition when grown under close to optimal BLSS vegetative component conditions. As the use of human urine after its preliminary physicochemical processing is supposed to be the mineral solution basis for the S. europaea cultivation, it is necessary to clear up the effect of reduced nitrogen on plants growth. Ground research was carried out. Biochemical composition of the S. europaea edible part showed that crude protein was contained in the highest degree. At that the content of crude protein (24% per dry weight) and cellulose (4.7% per dry weight) was higher in the plants grown on solutions containing amide nitrogen in comparison with the plants grown on solutions with nitrate nitrogen (15.4%-3.1% correspondingly). The water-soluble sugar contents were not high in the S. europaea edible part and depending on the nitrogen nutrition form they amounted to 1.1% (amide nitrogen) and 1.5% (nitrate nitrogen). The polysaccharide number (except cellulose) was rather higher and varied from 7.7% to 8.2%. Although the lipid content in the S. europaea plants was relatively low (7% per dry weight), it was shown that the plant lipids are characterized by a high nonsaturation degree mainly due to alpha linolenic and linoleic acids. Nitrogen nutrition form did not significantly affect the S. europaea productivity, and dry edible biomass of one plant was 8.6 g. Sodium and its concentrations predominated in the plant mineral composition and amounted in average to 9% per dry weight. Thus the S. europaea being the vegetable plant it can be the source of several biochemical substances and essential fatty acids. The present work also considers the influence of nitrate and amide forms of nitrogen on S. europaea biochemical and mineral composition. В© 2008 Elsevier Ltd. All rights reserved.
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2.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Kudenko Y.A., Gribovskaya I.V., Zolotukhin I.G.
Заглавие : Physical-chemical treatment of wastes: A way to close turnover of elements in LSS
Колич.характеристики :5 с
Место публикации : Acta Astronaut.: PERGAMON-ELSEVIER SCIENCE LTD, 2000. - Vol. 46, Is. 9. - P585-589. - ISSN 0094-5765, DOI 10.1016/S0094-5765(00)00007-2
Примечания : Cited References: 14
Аннотация: Man-plants-physical-chemical unit system designed For space stations or terrestrial ecohabitats to close steady-state mineral, water and gas exchange is proposed. The physical-chemical unit is to mineralize all inedible plant wastes and physiological human wastes (feces, urine, gray water) by electromagnetically activated hydrogen peroxide in an oxidation reactor. The final product is a mineralized solution containing all elements balanced for plants' requirements. The solution has been successfully used in experiments to grow wheat, beans and radish. The solution was reusable: the evaporated moisture was replenished by the phytotron condensate. Sodium salination of plants was precluded by evaporating reactor-mineralized urine to sodium saturation concentration to crystallize out NaCl which can be used as food for the crew. The remaining mineralized product was brought back for nutrition of plants. The gas composition of the reactor comprises O(2), N(2), CO(2), NH(3), H(2). At the reactor's output hydrogen and oxygen were catalyzed into water, NH(3) was converted in a water trap into NH(4) and used for nutrition of plants. A special accessory at the reactor's output may produce hydrogen peroxide from intrasystem water and gas which makes possible to close gas loops between LSS components. (C) 2000 Elsevier Science ttd. All rights reserved.
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3.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Volova T., Zhila N., Kiselev E., Shishatskaya E.
Заглавие : A study of synthesis and properties of poly-3-hydroxybutyrate/diethylene glycol copolymers
Место публикации : Biotechnol. Prog.: John Wiley and Sons Inc., 2016. - Vol. 32, Is. 4. - С. 1017-1028. - ISSN 87567938 (ISSN) , DOI 10.1002/btpr.2267
Ключевые слова (''Своб.индексиров.''): biocompatibility--biosynthesis--molecular weight--physicochemical and mechanical properties--poly(3-hydroxybutyrate)/diethylene glycol copolymers--biochemistry--biocompatibility--biosynthesis--cell culture--cell membranes--cells--cytology--fatty acids--glycols--molecular weight--american institute of chemical engineers--biological properties--chemical compositions--cytoplasmic membrane--degree of saturations--physico-chemical and mechanical properties--physiological effects--poly-3-hydroxybutyrate--biomechanics
Аннотация: This study investigates synthesis of poly(3-hydroxybutyrate)/diethylene glycol copolymers (P3HB/DEG) by Cupriavidus eutrophus B-10646 cells as related to DEG concentration in the medium and the time when it is added to the culture of cells synthesizing P3HB. The study determines the limits of physiological effect of DEG on C. eutrophus cells, showing that at DEG concentrations above 30 g/L, it inhibits cell growth, decreasing cell concentration and total P3HB/DEG yield and inducing an increase in the degree of saturation of fatty acids in lipids of cell cytoplasmic membrane. A series of copolymers containing different molar fractions of DEG (between 0.13 and 3.0 mol%) have been synthesized and their physicochemical, physical/mechanical, and biological properties have been investigated as related to the chemical composition and proportions of DEG monomers of the polymers. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:1017–1028, 2016. © 2016 American Institute of Chemical Engineers
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4.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Vanyukov V., Mikheev G., Mogileva T., Puzyr A., Bondar V., Lyashenko D., Chuvilin A.
Заглавие : Saturable absorption in detonation nanodiamond dispersions
Место публикации : J. Nanophoton.: SPIE, 2017. - Vol. 11, Is. 3. - ISSN 19342608 (ISSN) , DOI 10.1117/1.JNP.11.032506
Ключевые слова (''Своб.индексиров.''): modelocking--nanodiamonds--nanomaterials--nonlinear optics--saturable absorption--carbon--chains--dispersion (waves)--electromagnetic wave absorption--laser excitation--laser pulses--light--light absorption--locks (fasteners)--nanostructured materials--nonlinear optics--ultrafast lasers--ultrashort pulses--yarn--aqueous dispersions--detonation nanodiamond--light-induced--modelocking--nano-diamond particles--non-linear parameters--saturable absorption--z-scan experiment--nanodiamonds
Аннотация: We report on a saturable absorption in aqueous dispersions of nanodiamonds with femtosecond laser pulse excitation at a wavelength of 795 nm. The open aperture Z-scan experiments reveal that in a wide range of nanodiamond particle sizes and concentrations, a lightinduced increase of transmittance occurs. The transmittance increase originates from the saturation of light absorption and is associated with a light absorption at 1.5 eV by graphite and dimer chains (Pandey dimer chains). The obtained key nonlinear parameters of nanodiamond dispersions are compared with those of graphene and carbon nanotubes, which are widely used for the mode-locking. © 2017 Society of Photo-Optical Instrumentation Engineers (SPIE).
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5.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Aleksandrova Y. V., Zotina T. A., Gaevsky N. A.
Заглавие : Effect of the level of irradiance on growth and content of photosynthetic pigments of Canadian Elodea (Elodea Canadensis) in model system “Water-Bottom Sediments”
Место публикации : J. Sib. Fed. Univ. - Biol.: Siberian Federal University, 2020. - Vol. 13, Is. 2. - С. 188-196. - ISSN 19971389 (ISSN), DOI 10.17516/1997-1389-0317
Аннотация: Bioassays based on aquatic plants are a convenient tool for studying the quality of bottom sediments. One of the stages in the development of a bioassay is the selection of optimal growth conditions for indicator plants in a model test system. Response of indicator physiological endpoints of Canadian waterweed (Elodea canadensis) to light flux density was investigated to determine optimal irradiance level in a “water - sediment” model system, proposed previously for contact bioassay of natural bulk bottom sediments. Based on the response of shoot and root growth (length and weight), and concentration and ratio of photosynthetic pigments (chl. a, chl. b, and carotenoids) of Elodea to the change of light flux density, no limitation or inhibition of growth and photosynthesis of Elodea was revealed at light flux density from 56 to 143 µmol quanta • m-2 • s-1. Hence, the level of irradiance within this range can be recommended for use in the experimental system proposed for bioassay of bulk bottom sediments using E. canadensis as an indicator. © Siberian Federal University. All rights reserved
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6.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Lagutkin D., Semyonov D., Yegorov Y. E., Lavrinenko I., Generalov E., Zaitceva A. Y., Matveeva O., Nechipurenko Y. D.
Заглавие : Positive feedback between acidosis and hypoxia during the transition of COVID-19 to a severe form of the disease
Колич.характеристики :1 с
Место публикации : FEBS Open Bio: WILEY, 2021. - Vol. 11. - С. 450-450. - ISSN 2211-5463
Примечания : Cited References:0
Аннотация: SARS­CoV­2 virus causes disease that has several distinctive characteristics compared to diseases caused by other viruses. We have put forward a hypothesis that relates COVID­19 pathogenesis with acidosis, which frequently characterizes severe cases of this disease. It has been shown that hypoxia and acidosis affect the progression of severe COVID­19 at various physiological levels such as organs, tissues, and cells. The physiological effects of acidosis and hypoxia range from the level of compensatory capabilities of the whole organism to the functioning of a single hemoglobin molecule. In our work, we consider several mechanisms that link the damaging factors of COVID­19 with acidosis. These mechanisms reveal step­by­step processes with a pronounced positive feedback. In accordance with the well­ known Bohr effect, a decrease in blood pH leads to a drop in blood oxygen saturation. At the same time, this drop in saturation contributes to the further development of acidosis. This indicates a depletion of the body's compensatory capabilities to regulate acidosis and leads to deterioration of the patient's condition. In addition, a decrease in pH can cause conformational changes in the viral S­protein, followed by changes in ability of some antibodies to recognize the virus. This might lead to the decrease in antibodies affinity and avidity, negatively affecting virus clearance. Low levels of pH and hypoxia in blood and tissues can induce a pro­inflammatory innate response even in the absence of antigen stimulation. Therefore, hypoxia and acidosis can lead to a restructuring of the immune system and multidirectional pro­ and anti­inflammatory responses, which often, instead of recovery, lead to the disease aggravation.
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7.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Nechipurenko Y. D., Semyonov D. A., Lavrinenko I. A., Lagutkin D. A., Generalov E. A., Zaitceva A. Y., Matveeva O. V., Yegorov Y. E.
Заглавие : The role of acidosis in the pathogenesis of severe forms of COVID-19
Место публикации : Biology: MDPI, 2021. - Vol. 10, Is. 9. - Ст.852. - ISSN 20797737 (ISSN), DOI 10.3390/biology10090852
Аннотация: COVID-19 has specific characteristics that distinguish this disease from many other infec-tions. We suggest that the pathogenesis of severe forms of COVID-19 can be associated with acidosis. This review article discusses several mechanisms potentially linking the damaging effects of COVID-19 with acidosis and shows the existence of a vicious cycle between the development of hypoxia and acidosis in COVID-19 patients. At the early stages of the disease, inflammation, difficulty in gas exchange in the lungs and thrombosis collectively contribute to the onset of acidosis. In accordance with the Verigo-Bohr effect, a decrease in blood pH leads to a decrease in oxygen saturation, which contributes to the exacerbation of acidosis and results in a deterioration of the patient’s condition. A decrease in pH can also cause conformational changes in the S-protein of the virus and thus lead to a decrease in the affinity and avidity of protective antibodies. Hypoxia and acidosis lead to dysregu-lation of the immune system and multidirectional pro-and anti-inflammatory reactions, resulting in the development of a “cytokine storm”. In this review, we highlight the potential importance of supporting normal blood pH as an approach to COVID-19 therapy. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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8.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Nechipurenko, Yury D., Semyonov, Denis A., Lavrinenko, Igor A., Lagutkin, Denis A., Generalov, Evgenii A., Zaitceva, Anna Y., Matveeva, Olga, V, Yegorov, Yegor E.
Заглавие : The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19
Колич.характеристики :15 с
Коллективы : Presidium of the Russian Academy of Sciences for Molecular and Cellular Biology; Program of Fundamental Research for State Academies for years 2013-2020 [01201363818]
Место публикации : Biology-Basel: MDPI, 2021. - Vol. 10, Is. 9. - Ст.852. - ISSN 2079-7737(eISSN), DOI 10.3390/biology10090852
Примечания : Cited References:86. - This research was funded by the Presidium of the Russian Academy of Sciences for Molecular and Cellular Biology and the Program of Fundamental Research for State Academies for years 2013-2020, project no. 01201363818.
Предметные рубрики: RESPIRATORY-ACIDOSIS
LACTATE
COAGULATION
GLYCOLYSIS
SECRETION
Аннотация: Simple Summary Recently, several studies have shown that acidosis, which is increased acidity in the blood and other body tissues, is often associated with severe COVID-19. In this article, we look at the mechanisms and consequences of acidosis that can lead to an exacerbation of COVID-19. We want to draw the attention of readers to the threshold values of such disease characteristics as hypoxia and acidosis, which are associated with a sharp deterioration in the patient's condition. Hypoxia and acidosis mutually reinforce each other according to the principle of a vicious cycle (that is, they are involved in a system of positive feedbacks). Elevated blood lactate (lactic acid) levels are associated with poor clinical outcomes in COVID patients. As a practical recommendation, we propose to pay more attention to the prevention of acidosis, including in the early stages of the disease, when the adjustment of homeostasis requires less effort and is less risky. COVID-19 has specific characteristics that distinguish this disease from many other infections. We suggest that the pathogenesis of severe forms of COVID-19 can be associated with acidosis. This review article discusses several mechanisms potentially linking the damaging effects of COVID-19 with acidosis and shows the existence of a vicious cycle between the development of hypoxia and acidosis in COVID-19 patients. At the early stages of the disease, inflammation, difficulty in gas exchange in the lungs and thrombosis collectively contribute to the onset of acidosis. In accordance with the Verigo-Bohr effect, a decrease in blood pH leads to a decrease in oxygen saturation, which contributes to the exacerbation of acidosis and results in a deterioration of the patient's condition. A decrease in pH can also cause conformational changes in the S-protein of the virus and thus lead to a decrease in the affinity and avidity of protective antibodies. Hypoxia and acidosis lead to dysregulation of the immune system and multidirectional pro- and anti-inflammatory reactions, resulting in the development of a "cytokine storm". In this review, we highlight the potential importance of supporting normal blood pH as an approach to COVID-19 therapy.
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