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Вид документа : Статья из журнала
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Автор(ы) : Pande, Shubhra, Kratasyuk, Valentina A., Medvedeva, Nadezhda N., Kolenchukova, Oxana A., Salmina, Alla B.
Заглавие : Nutritional biomarkers: Current view and future perspectives
Колич.характеристики :15 с
Коллективы : Russian Foundation for Basic Research [16-06-00-439]; Russian Ministry of Education [M 2.2.3]; Russian Foundation for Basic Research; Krasnoyarsk Regional Fund for Scientific and Technical Activity Support [16-44-242126]
Место публикации : Crit. Rev. Food Sci. Nutr.: TAYLOR & FRANCIS INC, 2018. - Vol. 58, Is. 18. - С. 3055-3069. - ISSN 1040-8398, DOI 10.1080/10408398.2017.1350136. - ISSN 1549-7852(eISSN)
Примечания : Cited References:163. - The research was partially supported by the Russian Foundation for Basic Research [Grant No 16-06-00-439], the Russian Ministry of Education, Post-Doctoral Program of Project "5-100" [Grant No. M 2.2.3] and the Russian Foundation for Basic Research in collaboration with Krasnoyarsk Regional Fund for Scientific and Technical Activity Support [project No 16-44-242126].
Предметные рубрики: PROMOTES CELL-SURVIVAL
FATTY-ACID OXIDATION
CALORIE RESTRICTION
Ключевые слова (''Своб.индексиров.''): sirtuins--nad--biomarker--proteomics--calorie restriction--longitivity
Аннотация: There is a poor relationship between nutrient intake and existing nutritional biomarkers due to variety of factors affecting their sensitivity and specificity. To explore the impact of nutrients at molecular level and devising a sensitive biomarker, proteomics is a central technology with sirtuins as one of the most promising nutritional biomarker. Sirtuins (seven mammalian sirtuins reported so far) have been reported to perform protein deacetylases and ADP-ribosyltransferases activity. It is distributed in different cellular compartments thereby controlling several metabolic processes. Sirtuins are oxidized nicotinamide adenine dinucleotide dependent, which implicates a direct effect of the metabolic state of the cell on its activity. Calorie restriction upregulates the mammalian sirtuin protein levels in variety of tissues and organs where it acts upon both histone and nonhistone substrates. Sirtuin senses nutrient availability and impacts gluconeogenesis, glycolysis, and insulin sensitivity. It deacetylates and inhibits the nuclear receptor that activates fat synthesis and adipogenesis in the body, leading to fat loss and bringing favorable cellular and health changes. Sirtuins mediates intracellular response that promotes cell survival, DNA damage repair thereby increasing the cell longitivity. The activation of sirtuins brings a wide spectrum of other health benefits and its activity levels are indicative of nutritional status as well as disease progression in cancer, inflammation, obesity, cardiovascular diseases, and viral infections. There are several foods that activate sirtuin activity and offer significant health benefits by their consumption.
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