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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Goreva A.V., Voinova O.N., Kalacheva G.S., Volova T.G.
Заглавие : Distribution and resorption of polymeric microparticles in visceral organs of laboratory animals after intravenous injection
Место публикации : Bulletin of Experimental Biology and Medicine. - 2009. - Vol. 148, Is. 5. - С. 789-793. - ISSN 00074888 (ISSN) , DOI 10.1007/s10517-010-0817-3
Ключевые слова (''Своб.индексиров.''): 14c--intravenous injection--microparticles--resorbable polyhydroxybutyrate--visceral tissues--carbon 14--microsphere--polyhydroxyaminobutyric acid--polymer--unclassified drug--animal experiment--animal tissue--article--biocompatibility--biodegradability--body growth--controlled drug release--controlled study--degradation kinetics--drug delivery system--drug dosage form--experimental animal--female--liver parenchyma--molecular weight--nonhuman--particle size--physical development--radioactivity--rat--spleen--tissue distribution--tissue structure--animals--animals, laboratory--carbon radioisotopes--female--injections, intravenous--particle size--polymers--rats--rats, wistar--tissue distribution--viscera--animalia
Аннотация: Microparticles obtained by using 14C-labeled resorbable hydroxyaminobutyric acid polymer were injected into the caudal vein of laboratory animals without negative aftereffects for their growth and development and without changes in the macro- and microstructure of organs and tissues. The distribution of microparticles in the viscera and the dynamics of accumulation of carbon-containing polymer degradation products in the viscera were studied. The main targets for the particles are liver tissues, as well as renal and splenic tissues. The polymeric matrix of the microparticles is most actively destroyed in the spleen and liver. The presence of high-molecular- weight polymeric matrix in organs indicates the integrity of microparticles and the possibility of long-term (up to 12 weeks) functioning of polymeric particles in vivo. В© 2009 Springer Science+Business Media, Inc.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Voinova O.N., Goreva A.V., Mogilnaya O.A., Volova T.G.
Заглавие : Tissue reaction to intramuscular injection of resorbable polymer microparticles
Место публикации : Bulletin of Experimental Biology and Medicine. - 2007. - Vol. 144, Is. 6. - С. 786-790. - ISSN 00074888 (ISSN) , DOI 10.1007/s10517-007-0432-0
Ключевые слова (''Своб.индексиров.''): microencapsulation--polyhydroxybutyrate--resorbable polymers--tissue reaction--poly(3 hydroxybutyric acid)--polymer--animal experiment--animal tissue--article--cell infiltration--controlled study--drug delivery system--drug formulation--female--giant cell--inflammation--macrophage--microencapsulation--nonhuman--rat--tissue reaction--absorbable implants--animals--drug compounding--female--foreign-body reaction--injections, intramuscular--microspheres--polyesters--rats--rats, wistar
Аннотация: Tissue reaction to implantation of polymeric microparticles from resorbable polymer (polyhydroxybutyrate) is characterized by slight inflammatory reaction and pronounced progressive macrophage infiltration with the presence of mono-and multinuclear foreign body giant cells resorbing the polymeric matrix. No fibrous capsules were formed around the polymeric microparticles; neither necrosis nor other adverse morphological changes and tissue transformation in response to implantation of the PHB microparticles were recorded. The results indicate good prospects of using polyhydroxybutyrate for the construction of long-acting dosage forms as microparticles for intramuscular injection. В© Springer Science+Business Media, Inc. 2007.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Volova T.G., Puzyr A.P., Mogilnaya O.A., Efremov S.N.
Заглавие : Tissue response to the implantation of biodegradable polyhydroxyalkanoate sutures
Место публикации : Journal of Materials Science: Materials in Medicine. - 2004. - Vol. 15, Is. 6. - С. 719-728. - ISSN 09574530 (ISSN) , DOI 10.1023/B:JMSM.0000030215.49991.0d
Ключевые слова (''Своб.индексиров.''): necrosis--polymeric implants--suppurative inflammation--tissue reaction--biodegradation--calcification (biochemistry)--cells--copolymers--implants (surgical)--silk--tissue--tumors--materials science--acid phosphatase--copolymer--poly(3 hydroxybutyric acid)--polyhydroxyalkanoic acid--polyhydroxyvaleric acid--unclassified drug--animal experiment--animal model--article--biodegradable implant--blood vessel reactivity--catgut--controlled study--enzyme activity--female--giant cell--histochemistry--inflammation--macrophage--nonhuman--priority journal--rat--silk--suture--tensile strength--tissue reaction--tissue structure--wound healing--young modulus--absorbable implants--animals--female--fibrosis--foreign-body reaction--hydroxybutyrates--muscle, skeletal--polyesters--polymers--rats--rats, wistar--sutures--treatment outcome--wounds, penetrating--animalia
Аннотация: Polyhydroxyalkanoate (PHA) sutures were implanted to test animals intramuscularly, and tissue reaction was investigated and compared with the reaction to silk and catgut. Tested monofilament sutures made of PHAs of two types polyhydroxybutyrate (PHB) and a copolymer of hydroxybutyrate and hydroxyvalerate (PHV) featured the strength necessary for the healing of muscle-fascial wounds. The reaction of tissues to polymeric implants was similar to their reaction to silk and was less pronounced than the reaction to catgut; it was expressed in a transient post-traumatic inflammation (up to four weeks) and the formation of a fibrous capsule less than 200 ?m thick, which became as thin as 4060 ?m after 16 weeks, in the course of reverse development. Macrophages and foreign-body giant cells with a high activity of acid phosphatase were actively involved in this process. PHB and PHB/PHV sutures implanted intramuscularly for an extended period (up to one year) did not cause any acute vascular reaction at the site of implantation or any adverse events, such as suppurative inflammation, necrosis, calcification of the fibrous capsule or malignant tumor formation. No statistically significant differences were revealed in the tissue response to polymer sutures of the two types. Capsules around silk and catgut sutures did not become significantly thinner.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Volova T.G., Efremov S.N., Puzyr' A.P., Mogil'Naya O.A.
Заглавие : Tissue response to biodegradable suture threads made of polyhydroxyalkanoates
Место публикации : Biomedical Engineering. - 2002. - Vol. 36, Is. 4. - С. 210-217. - ISSN 00063398 (ISSN) , DOI 10.1023/A:1021184119268
Ключевые слова (''Своб.индексиров.''): acid phosphatase--alkaline phosphatase--polyhydroxyalkanoic acid--animal experiment--animal tissue--article--biocompatibility--biodegradability--controlled study--elasticity--enzyme activity--enzyme mechanism--female--histochemistry--incision--nonhuman--physical chemistry--postoperative period--rat--rigidity--suture--thickness--tissue reaction--wound healing--animalia
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Volova T.G., Popova T.G.
Заглавие : Study of biological properties of polyhydroxyalkanoates in a long-term experiment in vivo
Место публикации : Biomedical Engineering. - 2002. - Vol. 36, Is. 4. - С. 218-222. - ISSN 00063398 (ISSN) , DOI 10.1023/A:1021136203338
Ключевые слова (''Своб.индексиров.''): hemoglobin--polyhydroxyalkanoic acid--animal experiment--animal tissue--article--biocompatibility--biodegradability--biosynthesis--blood cell count--blood sampling--comparative study--controlled study--dna synthesis--elasticity--enzyme activity--enzyme mechanism--erythrocyte sedimentation rate--female--in vivo study--liver function--nonhuman--organ weight--rat--suture--animalia
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Volova T.G., Gitelson I.I.
Заглавие : In vivo toxicological evaluation of polyhydroxyalkanoates.
Место публикации : Doklady Biological Sciences. - 2002. - Vol. 383, Is. 1-6. - С. 109-111. - ISSN 00124966 (ISSN)
Ключевые слова (''Своб.индексиров.''): alkane--animal--animal behavior--article--cytology--drug effect--erythrocyte sedimentation rate--female--heart--kidney--liver--lymphoid tissue--male--rat--spleen--wistar rat--alkanes--animals--behavior, animal--blood sedimentation--female--heart--kidney--liver--lymphoid tissue--male--rats--rats, wistar--spleen
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Volova T.G., Puzyr A.P., Mogil'naya O.A., Efremov S.N., Gitelson I.I.
Заглавие : Tissue morphogenesis under the conditions of implantation of polyhydroxybutyrate, a biodegradable polymer.
Место публикации : Doklady Biological Sciences. - 2002. - Vol. 383, Is. 1-6. - С. 123-126. - ISSN 00124966 (ISSN)
Ключевые слова (''Своб.индексиров.''): biomaterial--hydroxybutyric acid--polymer--animal--article--bioremediation--female--morphogenesis--rat--wistar rat--animals--biocompatible materials--biodegradation, environmental--female--hydroxybutyrates--morphogenesis--polymers--rats--rats, wistar
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Volova T.G., Efremova S.N., Puzyr S.P., Mogil'naya O.A.
Заглавие : Tissue response to biodegradable suture threads made of polyoxyalkanoates
Место публикации : Meditsinskaya Tekhnika. - 2002. - Is. 4. - С. 23-29. - ISSN 00258075 (ISSN)
Ключевые слова (''Своб.индексиров.''): biocompatibility--biodegradation--implants (surgical)--materials testing--organic polymers--polyoxyalkanoates--suture threads--biomaterials--biomaterial--polymer--animal--article--bioremediation--female--metabolism--rat--suture--wistar rat--animals--biocompatible materials--biodegradation, environmental--female--polymers--rats--rats, wistar--sutures
Аннотация: The paper presents data on the materials and methods of obtaining suture threads based on of the polymer batty acid derivatives (polyoxyalkanoates). Results of the study of tissue response to biodegradable polyoxyalkanoate suture threads in the postoperative period are analyzed. These suture threads have been shown to have the required strength and meet a number of other requirements for currently available materials.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E.I., Volova T.G., Popova T.G.
Заглавие : Study of the biological properties of polyoxyalkanoates in the in vivo chronic experiment
Место публикации : Meditsinskaya Tekhnika. - 2002. - Is. 4. - С. 29-33. - ISSN 00258075 (ISSN)
Ключевые слова (''Своб.индексиров.''): biomaterial--polymer--animal--article--bioremediation--comparative study--female--metabolism--rat--suture--wistar rat--animals--biocompatible materials--biodegradation, environmental--female--polymers--rats--rats, wistar--sutures--biocompatibility--immunology--implants (surgical)--materials testing--organic polymers--polyoxyalkanoates--rat models--suture threads--biomaterials
Аннотация: Chronic experiments on mature Wistar rats studied the biological properties of suture threads from two types of polyoxyalkanoates (POA), such as polyoxybutyrate (POB) and the copolymer of POB and polyoxyvalerate (POV) (POB/POV) as compared to the conventional surgical material (silk and catgut). The physiological and biochemical parameters that reflect the status of the animals, including their behavior, height and development, the weight of the body and viscera, the morphology of peripheral blood, the biochemical parameters of blood, the activity of some enzymes, as well as histological findings of the viscera, and lymphoid tissue responses were assessed. POA was found to produce no negative effect on the physiological, biochemical, and functional characteristics of the animals irrespective of the duration of contact with the internal medium of the body and of the chemical composition of a material.
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10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E., Goreva A., Kalacheva G., Volova T.
Заглавие : Biocompatibility and resorption of intravenously administered polymer microparticles in tissues of internal organs of laboratory animals
Место публикации : Journal of Biomaterials Science, Polymer Edition. - 2011. - Vol. 22, Is. 16. - С. 2185-2203. - ISSN 09205063 (ISSN) , DOI 10.1163/092050610X537138
Ключевые слова (''Своб.индексиров.''): 14c products of polymer resorption--intravenous administration--microparticles--resorbable polyhydroxybutyrate--tissues of internal organs--3-hydroxybutyric acid--sup14/supc products of polymer resorption--adverse effect--drug-delivery systems--growth and development--high molecular weight--initial molecular weight--initial values--internal organs--intravenous administration--laboratory animals--local response--matrix--mean diameter--micro-particles--polymer degradation--polymer microparticles--preparation process--radioactivity level--residual content--resorbable--sustained-release--tail veins--wistar rat--animals--biocompatibility--degradation--histology--molecular weight--morphology--radiation--radioactivity--rats--tissue--poly(3 hydroxybutyric acid)--animal experiment--animal tissue--article--biocompatibility--concentration process--controlled study--degradation--drug delivery system--female--gel permeation chromatography--heart--kidney parenchyma--liver--lung parenchyma--molecular weight--nonhuman--organ culture--priority journal--radioactivity--rat--spleen--animals--animals, laboratory--biocompatible materials--drug delivery systems--female--infusions, intravenous--materials testing--microspheres--molecular weight--particle size--polymers--rats--rats, wistar--tissue distribution--animalia--rattus--rattus norvegicus
Аннотация: Specimens of 14C-labeled polymer of 3-hydroxybutyric acid, P(3-HB), with different initial molecular weights, were used to prepare microparticles, whose morphology was not influenced by the M w of the polymer. During the particle preparation process, P(3-HB) molecular weight decreased by 15-20%. Sterile microparticles (mean diameter 2.4 ?m) were injected into the tail veins of Wistar rats (5 mg/rat). The effects of the particles administered to rats were studied based on the general response of animals and local response of internal organ tissues and blood morphology; no adverse effects on growth and development of the animals or unfavorable changes in the structure of the tissues of internal organs were observed. Measurements of radioactivity in tissues showed that 14C concentrations are different in different organs, changing during the course of the experiment. The main targets for 14C-labeled microparticles were tissues of the liver, spleen, and kidneys. Comparison of radioactivity levels and residual contents of high-molecular-weight matrix in tissues suggested that the most rapid metabolism and degradation of P(3-HB) occurred in the liver and spleen. Gel-permeation chromatography showed that at 3 h after the microparticles were injected into the bloodstream, polymer degradation started in all examined organs, except the lungs; at 12 weeks, the M w of the polymer matrix was as low as 20-30% of its initial value. The presence of high-molecular-weight (undegraded) polymer in the tissues at 12 weeks after administration of the particles suggests that P(3-HB) is degraded in tissues of internal organs slowly and, hence, P(3-HB)-based microparticles can be used as sustained-release drug-delivery systems. В© 2011 VSP.
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11.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gladyshev M.I., Lepskaya E.V., Sushchik N.N., Makhutova O.N., Kalachova G.S., Malyshevskaya K.K., Markevich G.N.
Заглавие : Comparison of Polyunsaturated Fatty Acids Content in Filets of Anadromous and Landlocked Sockeye Salmon Oncorhynchus Nerka
Место публикации : Journal of Food Science. - 2012. - Vol. 77, Is. 12. - С. C1307-C1310. - ISSN 00221147 (ISSN) , DOI 10.1111/j.1750-3841.2012.02998.x
Ключевые слова (''Своб.индексиров.''): kokanee salmon--polyunsaturated fatty acids--sockeye salmon--docosahexaenoic acid--icosapentaenoic acid--animal--article--body weight--classification--comparative study--female--male--phylogeny--russian federation--salmon--animals--body weight--docosahexaenoic acids--eicosapentaenoic acid--female--male--phylogeny--russia--salmon--oncorhynchus nerka
Аннотация: Abstract: Fatty acid composition and content of 2 forms of sockeye salmon Oncorhynchus nerka from lakes in Kamchatka Peninsula (Russia) were compared. One form of sockeye salmon was anadromous ("marine"), that is, adult fish migrated in ocean to feed and grow and than return in the lake to breed. Fish of another form, kokanee, never migrate in the ocean. Per cent levels of the main indicators of nutritive value, eicosapentaenoic acid (EPA, 20:5n-3), and docosahexaenoic acid (DHA, 22:6n-3), were significantly higher in the landlocked O. nerka. However, concentrations of EPA and DHA per wet weight of filets were higher in the marine form, because of the relatively higher content of sum of fatty acids in their muscle tissue. As concluded, fish fed in marine environment had higher contents of long-chain n-3 fatty acids per wet weight than fish of the same species, fed in fresh waters. In general, both the anadromous sockeye salmon and the landlocked kokanee salmon can be recommended for human diet as a valuable product concerning contents of EPA and DHA. В© 2012 Institute of Food TechnologistsВ®.
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12.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gladyshev M.I., Sushchik N.N., Makhutova O.N., Kalachova G.S., Malyshevskaya K.K.
Заглавие : Differences in fatty acid composition of food and tissues of grayling from the Yenisei River
Место публикации : Doklady Biochemistry and Biophysics. - 2012. - Vol. 445, Is. 1. - С. 194-196. - ISSN 16076729 (ISSN) , DOI 10.1134/S1607672912040035
Ключевые слова (''Своб.индексиров.''): fatty acid--animal--article--female--fish--food analysis--male--metabolism--animals--fatty acids--female--fishes--food analysis--male
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13.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gladyshev M.I., Kharitonov A.Y., Popova O.N., Sushchik N.N., Makhutova O.N., Kalacheva G.S.
Заглавие : Quantitative estimation of dragonfly role in transfer of essential polyunsaturated fatty acids from aquatic to terrestrial ecosystems
Место публикации : Doklady Biochemistry and Biophysics. - 2011. - Vol. 438, Is. 1. - С. 141-143. - ISSN 16076729 (ISSN) , DOI 10.1134/S1607672911030094
Ключевые слова (''Своб.индексиров.''): unsaturated fatty acid--animal--article--chemistry--ecosystem--female--insect--male--animals--ecosystem--fatty acids, unsaturated--female--insects--male--anisoptera (dragonflies)
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14.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gladyshev M.I., Lepskaya E.V., Sushchik N.N., Makhutova O.N., Kalacheva G.S.
Заглавие : Differences in fatty acid composition between smolts of Sockeye Salmon and adults migrated from sea to lake for spawning
Место публикации : Doklady Biochemistry and Biophysics. - 2010. - Vol. 430, Is. 1. - С. 29-32. - ISSN 16076729 (ISSN) , DOI 10.1134/S1607672910010096
Ключевые слова (''Своб.индексиров.''): fatty acid--fresh water--sea water--animal--article--chemistry--cytology--female--male--metabolism--muscle--physiology--population migration--reproduction--salmon--sea--animal migration--animals--fatty acids--female--fresh water--male--muscles--oceans and seas--reproduction--salmon--seawater--oncorhynchus nerka
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15.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Sushchik N.N., Gladyshev M.I., Kalachova G.S., Makhutova O.N., Ageev A.V.
Заглавие : Comparison of seasonal dynamics of the essential PUFA contents in benthic invertebrates and grayling Thymallus arcticus in the Yenisei river
Место публикации : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. - 2006. - Vol. 145, Is. 3-4. - С. 278-287. - ISSN 10964959 (ISSN) , DOI 10.1016/j.cbpb.2006.05.014
Ключевые слова (''Своб.индексиров.''): benthic invertebrates--grayling--polyunsaturated fatty acids--riverine food web--essential fatty acid--long chain fatty acid--polyunsaturated fatty acid--amphipoda--animal tissue--annelid worm--article--benthos--chironomidae--comparative study--controlled study--dominant inheritance--ecosystem--evolution--fatty acid analysis--female--fish--fly--invertebrate--larva--male--metabolic regulation--nonhuman--nutrient dynamics--priority journal--river--seasonal variation--statistical significance--thymallus arcticus--animals--fatty acids, unsaturated--food chain--gastrointestinal contents--invertebrates--muscles--rivers--russia--salmonidae--seasons--amphipoda--chironomidae--diptera--gammaridae--invertebrata--oligochaeta (metazoa)--thymallus arcticus--trichoptera
Аннотация: Seasonal dynamics of contents of essential polyunsaturated fatty acids (PUFA) in dominant groups of benthic invertebrates: gammarids (Gammaridae, Amphipoda), oligochaetes (Oligochaeta), chironomid larvae (Chironomidae, Diptera) and caddisfly larvae (Trichoptera), and dominant benthivorous fish, Siberian grayling Thymallus arcticus, have been studied in ecosystem of the large Siberian river. During the year of the study most benthic invertebrate taxa showed significant variations in the contents of both C-18 and long chain C-20-22 PUFAs. In contrast, the fish, which consumed the zoobenthos, had no significant seasonal variations in long chain PUFAs' contents. Thereby, the fish, as organisms of relatively higher evolution level than invertebrates, was supposed to have more strict metabolic control of long chain PUFAs' contents. Evidence was obtained that the studied fish species, grayling, may be capable to convert dietary EPA into DHA. В© 2006 Elsevier Inc. All rights reserved.
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16.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Volkova E.N., Zadereev E.S.
Заглавие : Effect of methyl farnesoate on the change of the reproduction mode in Moina macrocopa (Cladocera)
Место публикации : Doklady Biochemistry and Biophysics. - 2012. - Vol. 447, Is. 1. - С. 282-285. - ISSN 16076729 (ISSN) , DOI 10.1134/S1607672912050158
Ключевые слова (''Своб.индексиров.''): farnesoic acid methyl ester--unsaturated fatty acid--animal--article--cladocera--drug effect--female--parthenogenesis--physiology--reproduction--animals--cladocera--fatty acids, unsaturated--female--parthenogenesis--reproduction
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17.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Zadereev E.S., Prokopkin I.G.
Заглавие : Role of diapause in coexistence of zooplankton species: Model analysis
Место публикации : Doklady Biological Sciences. - 2007. - Vol. 412, Is. 1. - С. 73-75. - ISSN 00124966 (ISSN) , DOI 10.1134/S0012496607010243
Ключевые слова (''Своб.индексиров.''): animal--article--biological model--cladocera--ecosystem--female--growth, development and aging--oocyte--physiology--population dynamics--reproduction--zooplankton--animals--cladocera--ecosystem--female--models, biological--ovum--population dynamics--reproduction--zooplankton
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18.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Zadereev E.S., Gubanov V.G., Egorov I.V.
Заглавие : The influence of food concentration and "water of aggregation" on the reproductive parameters of Moina macrocopa (Crustacea: Cladocera) females
Место публикации : Zhurnal Obshchei Biologii. - 1998. - Vol. 59, Is. 1. - С. 55-57. - ISSN 00444596 (ISSN)
Аннотация: Combined influence of "water of aggregation" and food concentration on the reproductive parameters of Moina macrocopa females was investigated. In all experiments the influence of population density was associated with the effect of "water of aggregation" prepared earlier by keeping dense population (200 ?g/ml) of M. macrocopa. It was shown that life-span of M. macrocopa females in "water of aggregation" was not dependent on food concentration; under conditions of all tested food concentration it was less than in case of control clean water. There was no difference in proportion of males produced in "water of aggregation" and in control though more males were born under conditions of higher food concentration. In general "water of aggregation" causes a specific acceleration of female life history: the life-span and the period between clutches decrease, the amount of neonates in last clutches increases while the chance of male production at the beginning of reproduction period becames greater. The "water of aggregation" could also causes the formation of ephipial eggs instead of the first partenogenetic clutch. It seems that life strategy under conditions of very high mortality associated with "water of aggregation" is aimed to maximum realization of individual capacities in short period of time.
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19.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Remmel N.N., Kratasyuk V.A., Maznyak O.M., Inzhevatkin E.V., Nefedov V.P.
Заглавие : Bioluminescent analysis of intensity of pathological oxidative processes in cells of perfused rat liver after hyperthermia
Место публикации : Bulletin of Experimental Biology and Medicine. - 2003. - Vol. 135, Is. 1. - P43-45. - ISSN 00074888 (ISSN) , DOI 10.1023/A:1023489727703
Ключевые слова (''Своб.индексиров.''): bioluminescent analysis--controlled perfusion of isolated liver--hyperthermia oxidative stress--thiobarbituric acid reactive substance--animal experiment--animal model--animal tissue--article--bioluminescence--concentration (parameters)--controlled study--correlation analysis--female--hyperthermia--in vivo study--lipid peroxidation--liver metabolism--liver perfusion--male--nonhuman--oxidative stress--oxygen consumption--pathology--rat--thermal exposure--animals--female--hepatocytes--hyperthermia, induced--liver--luminescent measurements--male--oxidative stress--perfusion--rats--animalia
Аннотация: We studied the possibility of evaluation of the intensity of pathological oxidative processes in rat liver using an integral bioluminescent test with controlled perfusion of the isolated organ. The test revealed a significant correlation between the level of TBA-reactive products and bioluminescence intensity.
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20.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Vinokurov A.P., Eremeev A.V., Setkov N.A.
Заглавие : Dobutamine prevents experimental postintoxication liver cirrhosis in mice
Место публикации : Bulletin of Experimental Biology and Medicine. - 2002. - Vol. 134, Is. 1. - P43-46. - ISSN 00074888 (ISSN) , DOI 10.1023/A:1020604621142
Ключевые слова (''Своб.индексиров.''): dobutamine--hepatocytes--liver cirrhosis--proliferation--adrenergic receptor stimulating agent--alpha 1 adrenergic receptor stimulating agent--beta 1 adrenergic receptor stimulating agent--beta 2 adrenergic receptor stimulating agent--carbon tetrachloride--catecholamine derivative--dobutamine--epidermal growth factor--animal cell--animal experiment--animal model--animal tissue--article--cell activity--cell culture--cell death--cell proliferation--cell stimulation--chronic hepatitis--connective tissue--controlled study--disease association--drug effect--drug potency--experimental test--female--liver cell--liver cirrhosis--liver fibrosis--liver hyperplasia--liver necrosis--liver parenchyma--liver regeneration--liver toxicity--morphology--mouse--nonhuman--toxicity testing--adrenergic beta-agonists--animals--carbon tetrachloride--cell division--dobutamine--dose-response relationship, drug--female--hepatocytes--liver--liver cirrhosis--mice--mice, inbred balb c--animalia
Аннотация: Various chronic inflammatory and necrotic processes in the liver parenchyma are accompanied by pathological morphofunctional changes, which are associated with hepatocyte death and hyperplasia of the connective tissue. Regeneration of the liver parenchyma should include not only prevention of fibrosis, but also stimulation of hepatocyte prolifearation. The adrenoceptor agonist dobutamine stimulated proliferative activity of cultured hepatocytes and prevented the development of postintoxication liver cirrhosis in mice produced by chronic poisoning with CCl4.
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