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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Pande, Shubhra, Ranjan, Rajeev, Ryazanova, Maria, Shuvaev, Anton N., Salmina, Alla B., Kratasyuk, Valentina A.
Заглавие : Buckwheat-enriched diet alleviates bisphenol A mediated oxidative stress via modulation of sirtuin 1 and antioxidant status in experimental rats
Колич.характеристики :8 с
Коллективы :
Ministry of Science and Higher Education of the Russian Federation [FSRZ-2020-0006]; Russian Ministry of Education, Post-Doctoral Program of Project "5-100" [M 2.2.3]
Место публикации : Food Chem.: ELSEVIER SCI LTD, 2022. - Vol. 373. - Ст.131507. - ISSN 0308-8146, DOI 10.1016/j.foodchem.2021.131507. - ISSN 1873-7072(eISSN)
Примечания : Cited References:36. - The research was supported by the Ministry of Science and Higher Education of the Russian Federation (Grant no. FSRZ-2020-0006) and Russian Ministry of Education, Post-Doctoral Program of Project "5-100" [Grant No. M 2.2.3]. Authors profusely thank R. Sabirzyanov and I.A. Denisov for the needful in the arrangement of ultrapure BPA.
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Аннотация: Present study investigated effect of dietary buckwheat in alleviating bisphenol A (BPA) mediated oxidative stress, concomitant sirtuin1 levels in serum, stomach, and liver of rats. Experimental group A and B ingested standard diet, C and D consumed buckwheat (30%); group A and C drank normal water, B and C had BPA contamination (10 mg L 1). Sirtuin1 mean B/A ratio nearing unity in all tissues reveals inertness of BPA towards sirtuin1. Dietary buckwheat improved sirtuin1 levels both in normal (mean C/A ratio of serum, 1.65; liver, 1.24; stomach, 1.78) and BPA fed state (mean D/B ratio of serum, 1.9; liver, 1.26; stomach, 1.75). Buckwheat augmented antioxidant status in BPA fed rats as seen in mean D/B ratio of serum (catalase, 2.4; glutathione reductase (GR), 1.33; Thiols, 1.2), liver (catalase, 2; GR, 2.5; Thiols, 1.36) and stomach (catalase, 1.31; GR, 1.5; Thiols, 1.33). Therefore, buckwheat counters BPA-led oxidative stress and modulates sirtuin1.
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