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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Semyonov, Denis A., Eltsov, Ilia, V, Nechipurenko, Yury D.
Заглавие : A New Bias Site for Epigenetic Modifications: How Non-Canonical GC Base Pairs Favor Mechanochemical Cleavage of DNA
Колич.характеристики :8 с
Коллективы : program of the Presidium of the Russian Academy of Sciences for Molecular and Cellular Biology; Program of Fundamental Research for State Academies for years 2013-2020 [01201363818]; Russian Ministry of Science and High Education [05.604.21.0234, RFMEFI60419X0234]
Место публикации : Bioessays: WILEY, 2020. - Vol.: 42, Issue: 11. - Ст.2000051. - ISSN 0265-9247, DOI 10.1002/bies.202000051. - ISSN 1521-1878(eISSN)
Примечания : Cited References:55. - The authors thank Dr. Dmitry M. Graifer, Prof. Vladimir A. Reznikov, and Dr. Anastasia Anashkina, for useful discussion. The authors thank the Prof. D. R. Forsdyke whose advice on improving the style of the manuscript was very useful. This work was supported by the program of the Presidium of the Russian Academy of Sciences for Molecular and Cellular Biology and the Program of Fundamental Research for State Academies for years 2013-2020, project no. 01201363818. The work was supported by the Russian Ministry of Science and High Education (grant #05.604.21.0234, unique number RFMEFI60419X0234)
Предметные рубрики: NUCLEIC-ACIDS
CYTOSINE
MUTAGENESIS
N-4-METHOXYCYTOSINE
Аннотация: Properties of non-canonical GC base pairs and their relations with mechanochemical cleavage of DNA are analyzed. A hypothesis of the involvement of the transient GC wobble base pairs both in the mechanisms of the mechanochemical cleavage of DNA and epigenetic mechanisms involving of 5-methylcytosine, is proposed. The hypothesis explains the increase in the frequency of the breaks of the sugar-phosphate backbone of DNA after cytosines, the asymmetric character of these breaks, and an increase in break frequency in CpG after cytosine methylation. As an alternative hypothesis, probable implication of GC(+)Hoogsteen base pairs is considered, which now exemplify the best-studied non-canonical GC base pairs in the DNA double helix. Also see the video abstract here https://youtu.be/EUunVWL0ptw.
WOS,
Файл:  доступ к статье - 0
https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202000051
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