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A hybrid PHB-hydroxyapatite composite for biomedical application: Production, in vitro and in vivo investigation / E. I. Shishatskaya, I. A. Khlusov, T. G. Volova // Journal of Biomaterials Science, Polymer Edition. - 2006. - Vol. 17, Is. 5. - P481-498, DOI 10.1163/156856206776986242 . - ISSN 0920-5063
Кл.слова (ненормированные):
Biocompatibility -- Hydroxyapatite (HA) -- PHB-hydroxyapatite composite -- Polyhydroxyalkanoate (PHA) -- Polyhydroxybutyrate (P(3HB)) -- Properties -- Biocompatibility -- Differential thermal analysis -- Electron microscopy -- Free energy -- Interfacial energy -- Physical properties -- Surface properties -- X ray analysis -- Biomedical application -- Physicochemical properties -- Polyhydroxyalkanoate (PHA) -- Polyhydroxybutyrate (PHB) -- Hydroxyapatite -- hydroxyapatite -- poly(3 hydroxybutyric acid) -- polymer -- biomaterial -- hydroxybutyric acid -- adhesion -- animal cell -- animal tissue -- article -- biomedicine -- bone marrow cell -- cell differentiation -- cell growth -- chemical structure -- composite material -- controlled study -- crystallization -- decomposition -- electron microscopy -- in vitro study -- in vivo study -- melting point -- mouse -- nonhuman -- ossification -- osteoblast -- physical chemistry -- priority journal -- rat -- strength -- structure analysis -- surface property -- synthesis -- temperature measurement -- thermal analysis -- tissue engineering -- wettability -- animal -- biomechanics -- bioremediation -- bone prosthesis -- cattle -- cell culture -- chemistry -- cytology -- differential scanning calorimetry -- drug effect -- human -- materials testing -- prostheses and orthoses -- scanning electron microscopy -- standard -- Wistar rat -- Murinae -- Animals -- Biocompatible Materials -- Biodegradation, Environmental -- Biomechanics -- Bone Substitutes -- Cattle -- Cells, Cultured -- Differential Thermal Analysis -- Durapatite -- Humans -- Hydroxybutyrates -- Materials Testing -- Microscopy, Electron, Scanning -- Osteoblasts -- Prostheses and Implants -- Rats -- Rats, Wistar -- Surface Properties
Аннотация: Samples of a hybrid composite of polyhydroxybutyrate (PHB), a biodegradable polyester, and hydroxyapatite (HA), with different PHB/HA ratios, have been prepared using mechanical-physical method. Electron microscopy, X-ray structure analysis and differential thermal analysis have been used to investigate the structure and physicochemical properties of the composite, depending on the PHB/HA ratio. The properties of the surface of the HA-loaded composite are significantly different from those of the pure polymer. As the HA percentage in the composite increases, free interface energy, the cohesive force, i.e., the strength of the adhesive bond between the composite surface and the water phase, and surface wettability increase. The HA percentage of the composite does not influence its melting temperature, but affects the temperature for the onset of decomposition: as the HA content increases from 0 to 10% (w/w), Td decreases from 260В°C to 225В°C. The degree of crystallinity of PHB/HA increases from 77% to 89% with an increase in the HA fraction from 10% to 50%. Functional properties of the composites have been investigated in vitro and in vivo. The best parameters of growth and differentiation of murine marrow osteoblasts are registered on PHB/HA samples containing 10% and 20% HA. In ectopic bone formation assay it has been proven that the hybrid PHB/HA composites can function as scaffolds and that bone tissue develops on their surface and in pores. В© VSP 2006.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 60036, Russian Federation
Tomsk State University, Tomsk 634021, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.; Khlusov, I.A.; Volova, T.G.

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Laser processing of polymer constructs from poly(3-hydroxybutyrate) / T. G. Volova [et al.] // J. Biomater. Sci. Polym. Ed. - 2015. - Vol. 26, Is. 16. - P1210-1228, DOI 10.1080/09205063.2015.1082810 . - ISSN 0920-5063
Кл.слова (ненормированные):
biocompatibility -- biopolymers -- laser processing -- poly(3-hydroxybutyrate) -- polymer materials -- Biocompatibility -- Biomechanics -- Biopolymers -- Bone -- Cell culture -- Pulsed lasers -- Scaffolds (biology) -- Stem cells -- 3t3 mouse fibroblasts -- Bone marrow -- Bone regeneration -- Laser process -- Mesenchymal stem cell -- Poly-3-hydroxybutyrate -- Polymer materials -- Pulsed mode -- Laser materials processing
Аннотация: CO2 laser radiation was used to process poly(3-hydroxybutyrate) constructs - films and 3D pressed plates. Laser processing increased the biocompatibility of unperforated films treated with moderate uniform radiation, as estimated by the number and degree of adhesion of NIH 3T3 mouse fibroblast cells. The biocompatibility of perforated films modified in the pulsed mode did not change significantly. At the same time, pulsed laser processing of the 3D plates produced perforated scaffolds with improved mechanical properties and high biocompatibility with bone marrow-derived multipotent, mesenchymal stem cells, which show great promise for bone regeneration. © 2015 Taylor & Francis.

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Держатели документа:
Institute of Biophysics of Siberian Branch of Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, Russian Federation
School of Fundamental Biology and Biotechnology, Siberian Federal University, 79 Svobodnyi Avenue, Krasnoyarsk, Russian Federation
School of Engineering Physics and Radio Electronics, Siberian Federal University, 79 Svobodnyi Avenue, Krasnoyarsk, Russian Federation
Special Design and Technological Bureau, Nauka Krasnoyarsk Scientific Centre of Siberian Branch, Russian Academy of Sciences, 53 Mir Avenue, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Volova, T. G.; Tarasevich, A. A.; Golubev, A. I.; Boyandin, A. N.; Shumilova, A. A.; Nikolaeva, E. D.; Shishatskaya, E. I.

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Synthesis of P(3HB-co-3HHx) copolymers containing high molar fraction of 3-hydroxyhexanoate monomer by Cupriavidus eutrophus B10646 / T. G. Volova [et al.] // J. Chem. Technol. Biotechnol. - 2016. - Vol. 91, Is. 2. - P416-425, DOI 10.1002/jctb.4592 . - ISSN 0268-2575
Кл.слова (ненормированные):
Growth kinetics -- Physicochemical and mechanical properties -- Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) -- Wild-type strain Cupriavidus eutrophus B10646 -- Biomaterials -- Biomechanics -- Chemical industry -- Cultivation -- Growth kinetics -- Mechanical properties -- Organic compounds -- Polymers -- Sodium -- 3-Hydroxyhexanoate -- Bacterial strains -- Cultivation conditions -- Kinetic properties -- Physico-chemical and mechanical properties -- Physiological range -- Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) -- Wild-type strain -- Strain
Аннотация: BACKGROUND: P(3HB-co-3HHx) copolymers are very promising biomaterials. The main challenge in the production of these polymers is to simultaneously achieve high cell biomass; high P(3HB-co-3HHx) content; and high molar fraction of 3HHx in P(3HB-co-3HHx). The most common approach to production of these copolymers is the use of recombinant bacterial strains. The purpose of this study was to optimize the process of production of P(3HB-co-3HHx) copolymers containing high molar fractions of 3HHx by using the wild-type strain Cupriavidus eutrophus B10646. RESULTS: Kinetic properties of C. eutrophus B10646 were studied during cultivation of the cells on substrates necessary for P(3HB-co-3HHx) synthesis: glucose, nitrogen, sodium hexanoate, and sodium acrylate. The physiological ranges of their effects were determined experimentally, and C. eutrophus B10646 was grown in culture media with different dosages of these substrates. P(3HB-co-3HHx) copolymers with different molar fractions of 3HHx, including high ones (12 to 68%), were synthesized, and their physicochemical and mechanical properties were investigated. CONCLUSION: For the first time, cultivation conditions of Cupriavidus eutrophus B10646 enabled production of high biomass yields (5-6gL-1) and high content of the polymer (60-75%) that contained high 3HHx molar fraction. By varying the 3HB/3HHx ratio, one can change physicochemical and mechanical properties of P(3HB-co-3HHx) copolymers. © 2014 Society of Chemical Industry © 2016 Society of Chemical Industry.

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WOS
Держатели документа:
Institute of Biophysics SB RAS, Akademgorodok 50, Krasnoyarsk, Russian Federation
Siberian Federal University, 79 Svobodny pr, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Volova, T. G.; Syrvacheva, D. A.; Zhila, N. O.; Sukovatiy, A. G.

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A study of synthesis and properties of poly-3-hydroxybutyrate/diethylene glycol copolymers / T. Volova [et al.] // Biotechnol. Prog. - 2016. - Vol. 32, Is. 4. - P1017-1028, DOI 10.1002/btpr.2267 . - ISSN 8756-7938
Кл.слова (ненормированные):
biocompatibility -- biosynthesis -- molecular weight -- physicochemical and mechanical properties -- poly(3-hydroxybutyrate)/diethylene glycol copolymers -- Biochemistry -- Biocompatibility -- Biosynthesis -- Cell culture -- Cell membranes -- Cells -- Cytology -- Fatty acids -- Glycols -- Molecular weight -- American Institute of Chemical Engineers -- Biological properties -- Chemical compositions -- Cytoplasmic membrane -- Degree of saturations -- Physico-chemical and mechanical properties -- Physiological effects -- Poly-3-hydroxybutyrate -- Biomechanics
Аннотация: This study investigates synthesis of poly(3-hydroxybutyrate)/diethylene glycol copolymers (P3HB/DEG) by Cupriavidus eutrophus B-10646 cells as related to DEG concentration in the medium and the time when it is added to the culture of cells synthesizing P3HB. The study determines the limits of physiological effect of DEG on C. eutrophus cells, showing that at DEG concentrations above 30 g/L, it inhibits cell growth, decreasing cell concentration and total P3HB/DEG yield and inducing an increase in the degree of saturation of fatty acids in lipids of cell cytoplasmic membrane. A series of copolymers containing different molar fractions of DEG (between 0.13 and 3.0 mol%) have been synthesized and their physicochemical, physical/mechanical, and biological properties have been investigated as related to the chemical composition and proportions of DEG monomers of the polymers. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:1017–1028, 2016. © 2016 American Institute of Chemical Engineers

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Держатели документа:
Inst. of Biophysics SB RAS, Akademgorodok 50, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Volova, T.; Zhila, N.; Kiselev, E.; Shishatskaya, E.

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Production of porous films based on biodegradable polyesters by the casting solution technique using a co-soluble porogen (Camphor) / A. N. Boyandin, L. M. Dvoinina, A. G. Sukovatyi, A. A. Sukhanova // Polym. - 2020. - Vol. 12, Is. 9. - Ст. 1950. - P1-12, DOI 10.3390/polym12091950 . - ISSN 2073-4360
Кл.слова (ненормированные):
Biopolymers -- Camphor -- Co-soluble porogen -- Polycaprolactone -- Polyesters -- Polyhydroxybutyrate -- Porosity -- Biocompatibility -- Biodegradable polymers -- Biomechanics -- Camphor -- Cell adhesion -- Cell culture -- Cell engineering -- Cells -- Porosity -- Scaffolds (biology) -- 3t3 mouse fibroblasts -- Biocompatibility testing -- Biodegradable polyesters -- Biological properties -- Cellular engineering -- Intermediate structures -- Poly3-hydroxybutyrate (PHB) -- Water vapor transmission rate -- Polymer films
Аннотация: Porous films have been prepared from degradable polymers—poly-3-hydroxybutyrate (PHB), poly-?-caprolactone (PCL) and a blend of these polymers (1:3)—by adding porogen (camphor) to the polymer solution at 10%, 30% or 50% of the total mass of the polymer and porogen, and leaching it out afterwards. After the rinse, camphor content in films decreased to about 0.025%. The structure, physical/mechanical and biological properties of the films were investigated as dependent on their composition and porosity, which varied depending on the amount of camphor added. The surface of PHB films was porous, the PCL films were relatively smooth, and the PHB/PCL films had an intermediate structure. The addition of camphor increased the thickness (from 35 to 45 µm, from 40 to 80 µm and from 20 to 65 µm for PHB, PCL and PHB/PCL, respectively) and porosity (from 4.2(±3.6)% to 50.0(±12.8)%, from 6.4(±5.5)% to 54.5(±6.0)% and from 4.9(±4.8)% to 51.5(±5.8)%, respectively) of the films. The introduction (and removal) of 10% camphor into the PHB and PHB/PCL films led to an approximately twofold increase in the polar component of the free surface energy (from 5.4 ± 0.38 to 11.8 ± 1.33 and from 2.7 ± 0.13 to 5.2 ± 0.09 mN/m, respectively) but in other cases, on the contrary, a decrease in this indicator was registered. The increase of camphor addition from 0% to 50% gradually impaired mechanical properties of the films: so, Young’s modulus decreased from 3.6 to 1.8 GPa, from 0.30 to 0.12 GPa and from 0.50 to 0.20 GPa for PHB, PCL and PHB/PCL, respectively. At the same time, the water vapor transmission rate considerably increased from 197.37 ± 23.62 to 934.03 ± 114.34 g/m2 /d for PHB films; from 1027.99 ± 154.10 to 7014.62 ± 280.81 g/m2 /d for PCL films; and from 715.47 ± 50.08 to 4239.09 ± 275.54 g/m2 /d for PHB/PCL films. Results of biocompatibility testing in the culture of NIH 3T3 mouse fibroblast cells showed that for the most of experimental samples cell adhesion and proliferation were comparable or superior to the corresponding parameters on the initial nonporous films. The best results were obtained for PHB films where at Day 3 of the experiment the registered cell density for experimental samples arrived at 2.66(±0.26) ? 105 cells/cm2 versus 1.29(±0.33) ? 105 cells/cm2 in the control. So, the proposed method can be used to construct highly porous cell scaffolds for cellular engineering. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Scopus
Держатели документа:
Reshetnev Siberian State University of Science & Technology, 31 Krasnoyarsky Rabochy Av., Krasnoyarsk, 660037, Russian Federation
Institute of Biophysics of Siberian Branch of Russian Academy of Sciences, Federal Research Center “Krasnoyarsk Science Center SB RAS”, 50/50 Akademgorodok, Krasnoyarsk, 660036, Russian Federation
Siberian Federal University, 79 Svobodnyi Av., Krasnoyarsk, 660041, Russian Federation

Доп.точки доступа:
Boyandin, A. N.; Dvoinina, L. M.; Sukovatyi, A. G.; Sukhanova, A. A.

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