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Prolonged effects of nanodiamonds conjugated with corticosteroids / C. Kyu Rhee, A. E. Burov, A. P. Puzyr, V. S. Bondar // Appl Surf Sci. - 2021. - Vol. 551. - Ст. 149334, DOI 10.1016/j.apsusc.2021.149334 . - ISSN 0169-4332
Кл.слова (ненормированные):
Corticosteroids -- Delivery system -- Detonation nanodiamonds -- Modification -- Prolonged release -- Adsorption -- Controlled drug delivery -- Detonation -- Drug products -- Sodium compounds -- Suspensions (fluids) -- Targeted drug delivery -- Anti-inflammatory drugs -- Antineoplastic agents -- Aqueous suspensions -- Carrier for deliveries -- Detonation nanodiamonds -- Dexamethasone sodium phosphate -- Langmuir and freundlich adsorption -- Physical adsorption -- Nanodiamonds
Аннотация: The application of detonation nanodiamonds (DNDs) in delivery systems has been demonstrated many times for a variety of substances, including anti-inflammatory drugs, antibiotics, antineoplastic agents, vitamins etc. The applicability of detonation nanodiamonds as a carrier for delivery of corticosteroids is investigated in this study. Commercial DNDs were modified to obtain particles with high colloidal stability in aqueous suspensions. Physical adsorption was then used to conjugate the DNDs with methylprednisolone sodium succinate and dexamethasone sodium phosphate. The experimental adsorption isotherms were fit with Langmuir and Freundlich adsorption models. The results of in vitro release study demonstrated an explicit prolonged effect of DNDs, due to which a sustained release of the adsorbed drugs was provided. © 2021 Elsevier B.V.

Scopus
Держатели документа:
Korea Atomic Energy Research Institute, Daejeon, 34057, South Korea
Federal Research Center for Information and Computational Technologies, Krasnoyarsk, 660049, Russian Federation
Institute of Biophysics SB RAS, Federal Research Center “Krasnoyarsk Science Center SB RAS”, Krasnoyarsk, 660036, Russian Federation

Доп.точки доступа:
Kyu Rhee, C.; Burov, A. E.; Puzyr, A. P.; Bondar, V. S.

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Prolonged effects of nanodiamonds conjugated with corticosteroids / C. K. Rhee, A. E. Burov, A. P. Puzyr, V. S. Bondar // Appl. Surf. Sci. - 2021. - Vol. 551: 16th International Symposium on Novel and Nano Materials (ISNNM) (NOV 03-06, 2020, Jeju, SOUTH KOREA). - Ст. 149334, DOI 10.1016/j.apsusc.2021.149334. - Cited References:26. - The authors are grateful to Daewha Alloytech Co., Ltd (Republic of Korea) for financial support of the research. . - ISSN 0169-4332. - ISSN 1873-5584

РУБ Chemistry, Physical + Materials Science, Coatings & Films + Physics,
Рубрики:
BIOMEDICAL APPLICATIONS
SURFACE MODIFICATION
Кл.слова (ненормированные):
Detonation nanodiamonds -- Modification -- Corticosteroids -- Delivery system -- Prolonged release
Аннотация: The application of detonation nanodiamonds (DNDs) in delivery systems has been demonstrated many times for a variety of substances, including anti-inflammatory drugs, antibiotics, antineoplastic agents, vitamins etc. The applicability of detonation nanodiamonds as a carrier for delivery of corticosteroids is investigated in this study. Commercial DNDs were modified to obtain particles with high colloidal stability in aqueous suspensions. Physical adsorption was then used to conjugate the DNDs with methylprednisolone sodium succinate and dexamethasone sodium phosphate. The experimental adsorption isotherms were fit with Langmuir and Freundlich adsorption models. The results of in vitro release study demonstrated an explicit prolonged effect of DNDs, due to which a sustained release of the adsorbed drugs was provided.

WOS
Держатели документа:
Korea Atom Energy Res Inst, Daejeon 34057, South Korea.
Fed Res Ctr Informat & Computat Technol, Krasnoyarsk 660049, Russia.
Krasnoyarsk Sci Ctr SB RAS, Inst Biophys SB RAS, Fed Res Ctr, Krasnoyarsk 660036, Russia.

Доп.точки доступа:
Rhee, Chang Kyu; Burov, Andrey E.; Puzyr, Alexey P.; Bondar, Vladimir S.; Daewha Alloytech Co., Ltd (Republic of Korea)

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