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Evaluation of antitumor activity of rubomycin deposited in absorbable polymeric microparticles / E. I. Shishatskaya [et al.] // Bulletin of Experimental Biology and Medicine. - 2008. - Vol. 145, Is. 3. - P358-361, DOI 10.1007/s10517-008-0091-9 . - ISSN 0007-4888
Кл.слова (ненормированные):
Absorbable polymers -- Ehrlich's ascitic carcinoma -- Microencapsulation -- Polyhydroxybutyrate -- Rubomycin -- poly(3 hydroxybutyric acid) -- polymer -- rubomycin -- animal cell -- animal experiment -- animal model -- antineoplastic activity -- article -- Bagg albino mouse -- cancer inhibition -- cancer mortality -- cancer survival -- controlled study -- drug delivery system -- Ehrlich ascites tumor -- microencapsulation -- mouse -- nonhuman -- polymerization -- survival rate -- tumor cell -- tumor volume -- Absorption -- Animals -- Antibiotics, Antineoplastic -- Carcinoma, Ehrlich Tumor -- Daunorubicin -- Hydroxybutyrates -- Mice -- Mice, Inbred BALB C -- Microspheres -- Polyesters -- Mus
Аннотация: An experimental dosage form of rubomycin is developed: the drug is incorporated in absorbable polymeric (polyhydroxybutyrate) matrix in the form of microparticles. Antitumor efficiency of this rubomycin dosage form was studied in laboratory mice with transplanted Ehrlich ascitic carcinoma. Rubomycin deposited in polymeric microparticles exhibited pronounced antitumor activity, inhibited the proliferative activity of Ehrlich ascitic carcinoma, and improved survival of mice with tumors. This dosage form of the drug can be used for local injections. В© Springer Science+Business Media, Inc. 2008.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Division of Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Siberian Federal University, Krasnoyarsk, Russian Federation
International Center for Studies of Critical Conditions, Presidium of Krasnoyarsk Research Center of Siberian Division of Russian Academy of Sciences, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.; Goreva, A.V.; Voinova, O.N.; Inzhevatkin, E.V.; Khlebopros, R.G.; Volova, T.G.

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Microencapculation of daunorubicin with biodegradable polymer matrix / E. I. Shishatskaya // Antibiotiki i Khimioterapiya. - 2007. - Vol. 52, Is. 9-10. - С. 3-8 . - ISSN 0235-2990
Кл.слова (ненормированные):
Daunorubicin -- Microencapsulation -- Polymer matrix -- antineoplastic antibiotic -- daunorubicin -- polyester -- animal -- article -- Bagg albino mouse -- chemistry -- kinetics -- microcapsule -- mouse -- particle size -- Animals -- Antibiotics, Antineoplastic -- Capsules -- Daunorubicin -- Kinetics -- Mice -- Mice, Inbred BALB C -- Particle Size -- Polyesters -- Animalia
Аннотация: Procedure for microencapsulation providing stable formation of high quality microspheres was designed. Conditions for deposition of the anthracycline antibiotic daunorubicin to polymer matrix were developed and microsheres loaded with various quantities of the drug were prepared. The kinetics of the in vitro and in vivo release of daunorubicin from the microsheres was studied. The rate of the rubomycin release to the medium in vitro (balanced phosphate buffer at 37.8В°C) in a 300-hour experiment directly depended on the quantity of the incorporated drug and averaged 0.81 В· 10 -4 to 2.3 В· 10 -4 mcg/mlВ·h. The experiment on laboratory animals with intraperitoneal administration of the rubomycin microsperes showed that the drug remained in the blood and abdominal liquid for a long time (up to 10 days). Possible control of the quantity of the rubomycin encapsulation to the polymer matrix, no sharp efflux of the drug at the early stages of the observation and low rate of the drug release to the medium allowed to conclude that the use of the biodegradable polymer microsperes as carriers of the high toxic antibiotic providing its prolonged action was prospective.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.

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Rubomycin microincapsulation with biodegradable polymer matrix / E. I. Shishatskaya // Antibiotiki i Khimioterapiya. - 2005. - Vol. 50, Is. 8-9. - С. 4-9 . - ISSN 0235-2990
Кл.слова (ненормированные):
Daunorubicin (rubomycin) -- Microspheres -- Polyhydroxybutirate -- antineoplastic antibiotic -- daunorubicin -- hydroxybutyric acid -- microsphere -- poly(3 hydroxybutyric acid) -- poly-beta-hydroxybutyrate -- polyester -- polymer -- article -- chemistry -- delayed release formulation -- electronics -- methodology -- microcapsule -- temperature -- Antibiotics, Antineoplastic -- Capsules -- Daunorubicin -- Delayed-Action Preparations -- Hydroxybutyrates -- Microspheres -- Miniaturization -- Polyesters -- Polymers -- Temperature
Аннотация: A procedure for preparation of microspheres from biodegradable linear polyether of microbiological origin (polyhydroxybutirate, PHB) with using the technology of solvent evaporation was developed considering a specific example of two- and three-component emulsions. The procedure provided permanent preparation of the microspheres of high quality. The influence of the procedure (emulsion type, dispersion process and medium temperature) on the yield of the microspheres, their structure and size was shown. The temperature had a significant impact on incorporation of the antitumor anthracycline antibiotic daunorubicin (rubomycin) to the polymer matrix. The microspheres with various levels of the drug load (29 and 90% of the initial content in the emulsion) were prepared and the kinetics of the in vitro rubomycin release was studied. The dynamics of the highly toxic rubomycin release from the microspheres was on the whole even with the curve profile reaching the plateau in 20-22 hours of the observation period. The rate of the rubomycin release to the medium depended on the value of the antibiotic incorporation and was maximum within the first two hours (3.3 and 13.0 mcg/mlВ·h) that corresponded to the release of 0.97 and 3.89 of the incorporated antibiotic. The average rate of rubomycin release during 300 hours was 0.81В·10-4 and 2.3В·10-4 mcg/mlВ·h. The release constituted respectively 3.9 and 13.11% of the antibiotic incorporated to the microspheres.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Branch of Russian Academy of Sciences, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.

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