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Каталог книг и продолжающихся изданий библиотеки Института биофизики СО РАН
Иностранные журналы библиотеки Института биофизики СО РАН
Отечественные журналы библиотеки Института биофизики СО РАН
Каталог диссертаций ИБФ СО РАН
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1.


   
    Results of biomedical investigations of PHB and PHB/PHV fibers / T. Volova [et al.] // Biochemical Engineering Journal. - 2003. - Vol. 16, Is. 2. - P125-133, DOI 10.1016/S1369-703X(03)00038-X . - ISSN 1369-703X
Кл.слова (ненормированные):
Biocompatibility -- Fibers -- Implants -- Poly-3-hydroxybutyrate (PHB) -- Poly-3-hydroxybutyrate-co-poly-3-hydroxyvalerate (PHB/PHV) -- Polyhydroxyalkanoates (PHAs) -- Tissue reaction -- Bacteriology -- Calcification (biochemistry) -- Copolymers -- Flammability -- Tissue -- Tissue response -- Biomedical engineering -- acid phosphatase -- poly(3 hydroxybutyric acid) -- poly(3 hydroxybutyric acid) co poly(3 hydroxyvaleric acid) -- polyhydroxyalkanoic acid -- suture material -- unclassified drug -- animal experiment -- article -- bacterial metabolism -- biochemistry -- biocompatibility -- biomedicine -- calcification -- catgut -- correlation analysis -- dose time effect relation -- enzyme activity -- fascia -- fiber -- foreign body -- functional assessment -- giant cell -- implantation -- in vivo study -- inflammation -- intermethod comparison -- macrophage -- materials testing -- multinuclear cell -- muscle injury -- necrosis -- nonhuman -- parameter -- phagocytosis -- physiology -- postoperative period -- priority journal -- process monitoring -- ralstonia eutropha b 5786 -- scar formation -- silk -- strength -- suture -- synthesis -- tissue reaction -- Wautersia eutropha -- wound healing -- Animalia -- Ralstonia -- Wautersia eutropha
Аннотация: The paper presents the results of biomedical investigations of sutures made of polyhydroxyalkanoates (PHAs) of two types (poly-3-hydroxybutyrate (PHB) and poly-3-hydroxybutyrate-co-poly-3-hydroxyvalerate (PHB/PHV)), synthesized by the bacteria Ralstonia eutropha B 5786 in the experiment on test animals in vivo, in comparison with silk and catgut sutures. PHB and PHB/PHV (PHBV) implants produced no adverse effect on physiological, biochemical and functional parameters of the animals during the post-surgery period. The tested PHA sutures featured the necessary strength throughout the healing period of the muscle-fascial cuts. The reaction of tissues to the implantation of PHB and PHB/PHV fibers fitted into the usual scheme characteristic of the wound process and of the reaction to a foreign-body invasion. This reaction and the reaction of tissues to silk had the similar nature and period of inflammation, but it was much less pronounced than the reaction to catgut. The tissue response to the implantation of PHAs consisted in a short-duration (up to 2 weeks) post-traumatic inflammation and the formation of a fibrous capsule less than 200 ?m thick during weeks 4-8, which in 4-6 months was reduced to 40-60 ?m in the course of reverse development. There were no adverse changes, such as suppurative inflammation, necrosis, calcification, and malignization of the cicatrice, at the site of implantation of PHA filaments, unlike in the cases with silk and catgut. In the case of PHA implantation there was a typical prolonged (throughout the post-surgery monitoring period) pronounced macrophagal stage with a large number of macrophages present. The macrophages were of the phagocytic type and multinucleate giant foreign cells, with a high activity of acid phosphomonoesterase that correlated with the activity of the enzyme in blood. Throughout the period of monitoring no differences in the tissue response to the implantation of the polymer filaments of two PHA types were recorded. В© 2003 Elsevier Science B.V. All rights reserved.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 60036, Russian Federation
Inst. Transplantology Artif. Organs, Russian Ministry of Health, Shchukinskaya 1, 123182 Moscow, Russian Federation
Terr. Pathological Anatomy Bureau, Partisan Zheleznyak St. 1, Krasnoyarsk 660049, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Volova, T.; Shishatskaya, E.; Sevastianov, V.; Efremov, S.; Mogilnaya, O.

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2.


   
    Population model for malignant tumor and organism interaction / V. A. Slepkov, V. G. Sukhovol'skiy, R. G. Khlebopros // Doklady Biological Sciences. - 2010. - Vol. 430, Is. 1. - P17-19, DOI 10.1134/S0012496610010060 . - ISSN 0012-4966
Кл.слова (ненормированные):
article -- biological model -- cancer invasion -- human -- neoplasm -- pathophysiology -- Humans -- Models, Biological -- Neoplasm Invasiveness -- Neoplasms

Scopus
Держатели документа:
Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent'eva 3, Novosibirsk 630090, Russian Federation
Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk 630036, Russian Federation
International Scientific Center for Studies of Extreme States, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok 50, Krasnoyarsk 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Slepkov, V.A.; Sukhovol'skiy, V.G.; Khlebopros, R.G.

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3.


   
    Modeling the growth and morphogenesis of malignant tumors / V. A. Slepkov, V. G. Sukhovol'skii, R. G. Khlebopros // Doklady Biochemistry and Biophysics. - 2006. - Vol. 411, Is. 1. - P342-345, DOI 10.1134/S1607672906060056 . - ISSN 1607-6729
Кл.слова (ненормированные):
animal -- article -- biological model -- cancer invasion -- cell proliferation -- computer simulation -- human -- morphogenesis -- neoplasm -- pathology -- pathophysiology -- Animals -- Cell Proliferation -- Computer Simulation -- Humans -- Models, Biological -- Morphogenesis -- Neoplasm Invasiveness -- Neoplasms

Scopus
Держатели документа:
Nikolaev Institute of Inorganic Chemistry, Siberian Division, Russian Academy of Sciences, Novosibirsk, 630090, Russian Federation
International Research Center for Extreme Body States, Presidium of the Krasnoyarsk Research Center, Siberian Division, Akademogorogok, Krasnoyarsk, 660036, Russian Federation
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Slepkov, V.A.; Sukhovol'skii, V.G.; Khlebopros, R.G.

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4.


   
    Results of biomedical investigations of PHB and PHB/PHV fibers [Text] / T. . Volova [et al.] // Biochem. Eng. J. - 2003. - Vol. 16, Is. 2. - P. 125-133, DOI 10.1016/S1369-703X(03)00038-X. - Cited References: 20 . - ISSN 1369-703X
РУБ Biotechnology & Applied Microbiology + Engineering, Chemical
Рубрики:
POLYHYDROXYALKANOATES
   POLYESTERS
   POLYMERS
Кл.слова (ненормированные):
polyhydroxyalkanoates (PHAs) -- poly-3-hydroxybutyrate (PHB) -- poly-3-hydroxybutyrate-co-poly-3-hydroxyvalerate (PHB/PHV) -- fibers -- implants -- biocompatibility -- tissue reaction
Аннотация: The paper presents the results of biomedical investigations of sutures made of polyhydroxyalkanoates (PHAs) of two types (poly-3-hydroxybutyrate (PHB) and poly-3-hydroxybutyrate-co-poly-3-hydroxyvalerate (PHB/PHV)), synthesized by the bacteria Ralstonia eutropha B 5786 in the experiment on test animals in vivo, in comparison with silk and catgut sutures. PHB and PHB/PHV (PHBV) implants produced no adverse effect on physiological, biochemical and functional parameters of the animals during the post-surgery period. The tested PHA sutures featured the necessary strength throughout the healing period of the muscle-fascial cuts. The reaction of tissues to the implantation of PHB and PHB/PHV fibers fitted into the usual scheme characteristic of the wound process and of the reaction to a foreign-body invasion. This reaction and the reaction of tissues to silk had the similar nature and period of inflammation, but it was much less pronounced than the reaction to catgut. The tissue response to the implantation of PHAs consisted in a short-duration (up to 2 weeks) post-traumatic inflammation and the formation of a fibrous capsule less than 200 mum thick during weeks 4-8, which in 4-6 months was reduced to 40-60 mum in the course of reverse development. There were no adverse changes, such as suppurative inflammation, necrosis, calcification, and malignization of the cicatrice, at the site of implantation of PHA filaments, unlike in the cases with silk and catgut. In the case of PHA implantation there was a typical prolonged (throughout the post-surgery monitoring period) pronounced macrophagal stage with a large number of macrophages present. The macrophages were of the phagocytic type and multinucleate giant foreign cells, with a high activity of acid phosphomonoesterase that correlated with the activity of the enzyme in blood. Throughout the period of monitoring no differences in the tissue response to the implantation of the polymer filaments of two PHA types were recorded. (C) 2003 Elsevier Science B.V. All rights reserved.

WOS
Держатели документа:
Russian Acad Sci, Siberian Branch, Inst Biophys, Akademgorodok, Krasnoyarsk 60036, Russia
Russian Minist Hlth, Inst Transplantol Artificial Organs, Moscow 123182, Russia
Territorial Pathol Anat Bur, Krasnoyarsk 660049, Russia
ИБФ СО РАН : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Volova, T...; Shishatskaya, E...; Sevastianov, V...; Efremov, S...; Mogilnaya, O...

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5.


   
    Comparison of fatty acid composition in major lipid classes of the dominant benthic invertebrates of the Yenisei river [Text] / N. N. Sushchik [et al.] // Comp. Biochem. Physiol. B-Biochem. Mol. Biol. - 2003. - Vol. 134, Is. 1. - P. 111-122, DOI 10.1016/S1096-4959(02)00191-4. - Cited References: 30 . - ISSN 1096-4959
РУБ Biochemistry & Molecular Biology + Zoology
Рубрики:
LAKE-ERKEN
   BIOMARKERS
   BACTERIA
   MARKERS
   DIET
   FISH
   N-3
Кл.слова (ненормированные):
fatty acids -- triacylglycerols -- polar lipids -- gammarids -- aquatic larvae of insects
Аннотация: The composition and content of fatty acids (FAs) in total lipids, triacylglycerols (TAG) and polar lipids (PL) in dominant groups of benthic invertebrates: gammarids (Gammaridae, Amphipoda), chironomid larvae (Chironomidae, Diptera), caddisfly larvae (Trichoptera) and mayfly larvae (Ephemeroptera) were studied in the Yenisei river. For the first time data on the FA composition of species belonging to Trichoptera (Insecta) are presented. The groups of aquatic insect larvae and gammarids weakly differed in total content of essential polyunsaturated fatty acids (PUFAs). Hence, the strong invasion of gammarids which occurred in the last decades in the Yenisei river should not result in a decrease in potential yield of essential PUFA in the ecosystem and corresponding decrease in food resource quality for fish in respect to PUFA content. Significant differences in biomarker FAs in TAG were found which correlated to specific food sources. Different levels of long-chain PUFA in PL of the invertebrates are discussed in relation to the genetic ability of particular taxa to form these FAs. (C) 2002 Elsevier Science Inc. All rights reserved.

WOS
Держатели документа:
Russian Acad Sci, Inst Biophys, Siberian Branch, Krasnoyarsk 660036, Russia
Krasnoyarsk State Univ, Krasnoyarsk 660041, Russia
ИБФ СО РАН : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Sushchik, N.N.; Gladyshev, M.I.; Moskvichova, A.V.; Makhutova, O.N.; Kalachova, G.S.

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6.


   
    Experimental effects of large-bodied Daphnia, fish and zebra mussels on cladoceran community and size structure [Text] / I. Feniova [et al.] // J. Plankton Res. - 2015. - Vol. 37, Is. 3. - P611-625, DOI 10.1093/plankt/fbv022. - Cited References:66. - This research was supported by the Polish National Science Centre (2012/05/B/N28/02684). The work also was supported by grants of Belorussian Foundation for Basic Research ((sic)12P-98), Russian Foundation for Basic Research (14-04-00087), Siberian Federal University project, carried out according to Federal Tasks of Ministry of Education and Science of Russian Federation (6.1089.214/K) and by Russian Federal Tasks of Fundamental Research (51.1.1). . - ISSN 0142-7873. - ISSN 1464-3774
РУБ Marine & Freshwater Biology + Oceanography
Рубрики:
FRESH-WATER ZOOPLANKTON
   POLYUNSATURATED FATTY-ACIDS
   LAKE-ERIE
Кл.слова (ненормированные):
alien species -- large- and small-bodied cladocerans -- invasion mechanisms -- PUFA -- C:N:P ratios
Аннотация: Understanding the factors that regulate the abundance, size structure and community structure of cladocerans is an important goal of aquatic ecologists. While both top-down and bottom-up factors help to structure cladoceran communities, there may be interactions between these factors. We conducted a mesocosm study to determine how alien large-bodied Daphnia, zebra mussels and fish affected cladoceran community and size structure. We found that large-bodied Daphnia reduced algal resources and the fecundity of smaller bodied cladocerans. Fish removed the large-bodied Daphnia magna from the mesocosms and shifted the cladoceran community to a smaller body size. Fish also appeared to promote increases in cladoceran diversity through the coexistence of several smaller bodied taxa. In contrast, zebra mussels increased cyanobacteria and helped to promote the success of the alien Daphnia, but reduced the biomass of small-bodied cladocerans. Zebra mussels reduced the carbon (C):phosphorus (P) ratio of the phytoplankton in the mesocosms which may have favored the relatively P-limited Daphnia. Combined, our results highlight the complex interactions of multiple factors that help to regulate cladoceran community and size structure.

WOS,
Scopus
Держатели документа:
Russian Acad Sci, AN Severtsov Inst Ecol & Evolut, Moscow 119071, Russia.
Univ Warsaw, Biol & Chem Res Ctr, Inst Zool, Dept Hydrobiol, PL-02089 Warsaw, Poland.
Russian Acad Sci, Inst Biophys, Siberian Branch, Krasnoyarsk 660036, Russia.
Siberian Fed Univ, Krasnoyarsk 660041, Russia.
Polish Acad Sci, M Nencki Inst Expt Biol, PL-02093 Warsaw, Poland.
Natl Acad Sci Belarus, Sci & Pract Ctr Bioresources, Minsk 220072, Byelarus.
Oklahoma State Univ, Dept Integrat Biol, Stillwater, OK 74078 USA.

Доп.точки доступа:
Feniova, Irina; Dawidowicz, Piotr; Gladyshev, Michail I.; Kostrzewska-Szlakowska, Iwona; Rzepecki, Marek; Razlutskij, Vladimir; Sushchik, Nadezda N.; Majsak, Natalia; Dzialowski, Andrew R.; Polish National Science Centre [2012/05/B/N28/02684]; Belorussian Foundation for Basic Research [(sic)12P-98]; Russian Foundation for Basic Research [14-04-00087]; Siberian Federal University project; Russian Federal Tasks of Fundamental Research [51.1.1]

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7.


   
    Content of polyunsaturated fatty acids essential for fish nutrition in zoobenthos species / O. N. Makhutova [et al.] // Freshwater Sci. - 2016. - Vol. 35, Is. 4. - P1222-1234, DOI 10.1086/688760 . - ISSN 2161-9549
Кл.слова (ненормированные):
Fatty acids -- Fish -- Food quality -- Invasion -- Invertebrates -- Bryozoa -- Coleoptera -- Crustacea -- Dytiscus -- Ephemeroptera -- Gammaridae -- Hirudinea -- Insecta -- Invertebrata -- Mollusca -- Plumatella emarginata -- Polychaeta -- Trichoptera -- Turbellaria
Аннотация: Content of eicosapentaenoic acid (EPA, 20 : 5n-3) and docosahexaenoic acid (DHA, 22 : 6n-3) and the n-3/n-6 ratio are important indicators of nutritive value of aquatic invertebrates as food for fish. We studied fatty acid (FA) content and composition of 68 zoobenthic species. Benthic invertebrates differed significantly in their contents of EPA and DHA and n-3/n-6 ratios. The most valuable food for fish were Insecta, especially Ephemeroptera and Trichoptera, Gammaridae, and Turbellaria (Dendrocaelopsis sp.). The invertebrates of low food quality for fish were Hirudinea, Mollusca, Oligochaeta, Bryozoa (Plumatella emarginata), and Coleoptera (Dytiscus lapponicus). Our data suggest that the recent and ongoing global replacement of native species, mainly Insecta, by invaders, mostly represented by Mollusca, Crustacea, Polychaeta, Oligochaeta, Bryozoa, and Hirudinea, probably will reduce the nutritive value of food sources for benthivorous fish. In addition, some of the taxa studied have peculiar FAs, which may be useful as their markers in trophic webs. Thus, 20 : 1n-13, 20 : 2n-6, 22 : 5n-3, and 22 : 6n-3 are likely to be considered markers of Mollusca, Hirudinea, Turbellaria, and Gammaridae, respectively, for tracing food webs in freshwater ecosystems. © 2016 by The Society for Freshwater Science.

Scopus,
Смотреть статью
Держатели документа:
Institute of Biophysics, Siberian Branch of Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, Russian Federation
Siberian Federal University, Svobodny Av. 79, Krasnoyarsk, Russian Federation
Institute of Problems of Development of the North, Siberian Branch of Russian Academy of Sciences, Malygina Str., Tyumen, Russian Federation
Institute of Biology, Komi Scientific Center, Ural Division, Russian Academy of Science, 28 Kommunisticheskaya Str., Syktyvkar, Russian Federation
Institute for Biology of Inland Waters, Russian Academy of Science, Borok, Russian Federation

Доп.точки доступа:
Makhutova, O. N.; Shulepina, S. P.; Sharapova, T. A.; Dubovskaya, O. P.; Sushchik, N. N.; Baturina, M. A.; Pryanichnikova, E. G.; Kalachova, G. S.; Gladyshev, M. I.

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8.


   
    FOXC1-Mediated Effects of miR-204-5p on Melanoma Cell Proliferation / I. Y. Dubovtseva, M. B. Aksenenko, E. D. Nikolaeva [et al.] // Mol. Biol. - 2021. - Vol. 55, Is. 4. - P610-617, DOI 10.1134/S0026893321020199. - Cited References:24 . - ISSN 0026-8933. - ISSN 1608-3245
РУБ Biochemistry & Molecular Biology
Рубрики:
FOXC1
Кл.слова (ненормированные):
FOXC1 -- miR-204-5p -- melanoma -- BRO -- SK-MEL-2 -- siRNA -- miRNA -- dormant cancer -- cells
Аннотация: MicroRNAs epigenetically regulate physiological and pathological processes. Previously, we found that miR-204-5p is expressed at low levels in melanoma cells, and an increase in its level leads to a change in proliferation, migration, and invasion of these cancer cells. Now, using bioinformatics analysis, it has been shown that the target of miR-204-5p is FOXC1 transcription factor, which is implicated in carcinogenesis. Using the luciferase reporter assay, it was found that miR-204-5p suppresses expression of the FOXC1 gene by binding to its 3' non-coding region. Transfection of small interfering RNA (siRNA) targeting FOXC1 into melanoma cells caused a decrease in miR-204-5p levels, which is consistent with the generally accepted concept of feedback regulation of miRNA expression by target genes. According to the results of the MTT test and fluorescence microscopy, the proliferation level of melanoma cells under the influence of siRNA to FOXC1 decreased 72 h after transfection. Changes in the ratio of cells by cell cycle phase were analyzed using flow cytometry. Regulatory relationships between FOXC1 and miR-204-5p, and an inhibitory effect of FOXC1 knockdown on melanoma cell proliferation were revealed. Based on the results, it can be assumed that miR-204-5p regulates proliferation of melanoma cells by affecting FOXC1 expression.

WOS
Держатели документа:
Voino Yasenetsky Krasnoyarsk State Med Univ, Minist Hlth Russian Federat, Krasnoyarsk 660022, Russia.
RAS, Biophys Inst, Siberian Branch, Div Fed Res Ctr,Krasnoyarsk Sci Ctr, Krasnoyarsk 660022, Russia.
Russian Acad Sci, Siberian Branch, Res Inst Med Problems North, Krasnoyarsk 660022, Russia.

Доп.точки доступа:
Dubovtseva, I. Yu; Aksenenko, M. B.; Nikolaeva, E. D.; Averchuk, A. S.; Moshev, A., V; Savchenko, A. A.; Markova, S., V; Ruksha, T. G.

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9.


   
    FOXC1-Mediated Effects of miR-204-5p on Melanoma Cell Proliferation / I. Y. Dubovtseva, M. B. Aksenenko, E. D. Nikolaeva [и др.] // Mol Biol (Mosk). - 2021. - Vol. 55, Is. 4. - С. 667-675, DOI 10.31857/S0026898421030058 . - ISSN 0026-8984
Кл.слова (ненормированные):
BRO -- dormant cancer cells -- FOXC1 -- melanoma -- miR-204-5p -- miRNA -- siRNA -- SK-MEL-2 -- forkhead transcription factor -- FOXC1 protein, human -- microRNA -- MIRN204 microRNA, human -- cell motion -- cell proliferation -- genetics -- human -- melanoma -- tumor cell line -- Cell Line, Tumor -- Cell Movement -- Cell Proliferation -- Forkhead Transcription Factors -- Humans -- Melanoma -- MicroRNAs
Аннотация: MicroRNAs epigenetically regulate physiological and pathological processes. Previously, we found that miR-204-5p is expressed at low levels in melanoma cells, and an increase in its level leads to a change in proliferation, migration, and invasion of these cancer cells. Now, using bioinformatics analysis, it has been shown that the target of miR-204-5p is FOXC1 transcription factor, which is implicated in carcinogenesis. Using the luciferase reporter assay, it was found that miR-204-5p suppresses expression of the FOXC1 gene by binding to its 3' non-coding region. Transfection of small interfering RNA (siRNA) targeting FOXC1 into melanoma cells caused a decrease in miR-204-5p levels, which is consistent with the generally accepted concept of feedback regulation of miRNA expression by target genes. According to the results of the MTT test and fluorescence microscopy, the proliferation level of melanoma cells under the influence of siRNA to FOXC1 decreased 72 h after transfection. Changes in the ratio of cells by cell cycle phase were analyzed using flow cytometry. Regulatory relationships between FOXC1 and miR-204-5p, and an inhibitory effect of FOXC1 knockdown on melanoma cell proliferation were revealed. Based on the results, it can be assumed that miR-204-5p regulates proliferation of melanoma cells by affecting FOXC1 expression.

Scopus
Держатели документа:
Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, 660022, Russian Federation
Siberian Branch of the Russian Academy of Sciences, Research Institute for Medical Problems in the North, Krasnoyarsk, 660022, Russian Federation
Biophysics Institute of the Siberian Branch of the RAS - Division of Federal Research Center "Krasnoyarsk Scientific Center of the Siberian Branch of the RAS", Krasnoyarsk, 660022, Russian Federation

Доп.точки доступа:
Dubovtseva, I. Y.; Aksenenko, M. B.; Nikolaeva, E. D.; Averchuk, A. S.; Moshev, A. V.; Savchenko, A. A.; Markova, S. V.; Ruksha, T. G.

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