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Effect of humic acid on absorption-release processes in the bottom sediments-Yenisei river water system as studied by dual-column ion chromatography and ?-ray spectrometry / L. G. Bondareva, O. P. Kalyakina, A. Ya. Bolsunovskii // Journal of Analytical Chemistry. - 2006. - Vol. 61, Is. 4. - P354-358, DOI 10.1134/S1061934806040101 . - ISSN 1061-9348
Кл.слова (ненормированные):
Absorption -- Chromatographic analysis -- Complexation -- Gamma ray spectrometers -- Radioisotopes -- ?-ray spectrometry -- Absorption-release processes -- Dual-column ion chromatography -- Humic acid -- Organic acids
Аннотация: The effect of humic acid on absorption-release processes in the bottom sediments-Yenisei river water system was studied by dual-column ion chromatography and ?-ray spectrometry. With the use of ion chromatography, it was found that processes related to the absorption of SO 42- and Cl- anions by a solid phase with the release of NO 3- , PO 43- , and F- to a liquid phase competed in the test systems as the concentration of water-soluble organic carbon (WSOC) was increased. Only the test anions were released in the systems without the introduction of an additional amount of WSOC as humic acid. With the use of ?-ray spectrometry, it was found that the release of 60Co, 152Eu, and 241Am radionuclides to the liquid phase in the systems with added humic acid began much earlier than in the system without the addition of humic acid. In this case, the amount of released radionuclides was greater than the amount of radioisotopes released in the system without the addition of humic acid: ?25% 241Am, ?3% 152Eu, and ?0.8% 60Co in the system with added humic acid or 0.8% 152Eu and <0.1% 60Co in the system without the addition of humic acid. The 241Am radionuclide was not determined in the system without the addition of humic acid. An increase in the concentration of WSOC in the experimental system of bottom sediments-Yenisei river water initiated the release of 60Co, 152Eu, and 241Am anthropogenic radionuclides from bottom sediments because of the formation of soluble complexes capable of migration. An increase in the concentration of WSOC had almost no effect on the release of 40K and 137Cs radionuclides. В© Pleiades Publishing, Inc., 2006.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation
Faculty of Chemistry, Krasnoyarsk State University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Bondareva, L.G.; Kalyakina, O.P.; Bolsunovskii, A.Ya.

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Evidence of the radioactive fallout in the center of asia (russia) following the fukushima nuclear accident / A. Bolsunovsky, D. Dementyev // Journal of Environmental Radioactivity. - 2011. - Vol. 102, Is. 11. - P1062-1064, DOI 10.1016/j.jenvrad.2011.06.007 . - ISSN 0265-931X
Кл.слова (ненормированные):
Environmental samples -- Fission product radionuclides -- Fukushima nuclear accident -- Radioactive fallout -- Russia -- Chernobyl accident -- Environmental sample -- Fallout radionuclides -- Global effects -- High velocity -- Nuclear accidents -- Radioactive contamination -- Russia -- Water samples -- Cesium -- Fallout -- Fission products -- Radioactivity -- Radioisotopes -- Nuclear reactor accidents -- cesium 137 -- iodine 131 -- rain -- atmospheric pollution -- cesium isotope -- fallout -- nuclear accident -- radioactive pollution -- radionuclide -- article -- environmental exposure -- gamma spectrometry -- nuclear accident -- radioactive contamination -- radioactive waste -- water analysis -- water contamination -- Cesium Radioisotopes -- Cities -- Humans -- Iodine Radioisotopes -- Japan -- Radiation Dosage -- Radiation Monitoring -- Radioactive Fallout -- Radioactive Hazard Release -- Radioactive Pollutants -- Risk Assessment -- Russia -- Time Factors -- Fukushima -- Honshu -- Japan -- Krasnoyarsk [Russian Federation] -- Russian Federation -- Tohoku
Аннотация: It was recently reported that radioactive fallout due to the Fukushima Nuclear Accident was detected in environmental samples collected in the USA and Greece, which are very far away from Japan. In April-May 2011, fallout radionuclides ( 134Cs, 137Cs, 131I) released in the Fukushima Nuclear Accident were detected in environmental samples at the city of Krasnoyarsk (Russia), situated in the center of Asia. Similar maximum levels of 131I and 137Cs/ 134Cs and 131I/ 137Cs ratios in water samples collected in Russia and Greece suggest the high-velocity movement of the radioactive contamination from the Fukushima Nuclear Accident and the global effects of this accident, similar to those caused by the Chernobyl accident. В© 2011 Elsevier Ltd.

Scopus
Держатели документа:
Radioecology Laboratory, Institute of Biophysics, Siberian Branch of Russian Academy of Sciences, Akademgorodok, 50-50, 660036 Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Bolsunovsky, A.; Dementyev, D.

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Bioavailability of 99Tc to a macrophyte of the Yenisei River / L. Bondareva, A. Bolsunovsky // Radioprotection. - 2009. - Vol. 44, Is. 5. - P71-76, DOI 10.1051/radiopro/20095019 . - ISSN 0033-8451
Аннотация: The experiments on accumulation of 99Tc by Elodea biomass showed that 99Tc activity concentration can reach 120 В± 6Bq/g, with the concentration factor for 99Tc 2700 В± 500 L/kg. In experiments on 99Tc release, over 504 h about 82% of the total 99Tc activity was released into the water from plant biomass; most of 99Tc was released within the first 192 h. Results of chemical fractionation of the biomass show that 99Tc contained in biomass was mainly concentrated in the exchangeable and the adsorbed fractions (83%). Thus, the data obtained using chemical fractionation of biomass confirmed the experimental data on 99Tc release, which suggested that most of the biomass-bound 99Tc was adsorbed on the biomass surface. 99Tc tightly bound to Elodea biomass (fractions of organics and mineral residue) constituted just 17% of the total 99Tc activity. Decreased illumination of Elodea shoots during the experiment did not cause any reduction in 99Tc activity concentration or concentration factor. Results of chemical fractionation of the biomass grown under lower illumination conditions show that the percentage of 99Tc tightly bound to Elodea biomass (fractions of organics and mineral residue) decreased while the 99Tc of the adsorbed fractions decreased. Our results and data reported by other authors suggest that some part of 99Tc activity can be bioavailable to living organisms and that the portion of bioavailable 99Tc can be determined by a number of factors. В© 2009 EDP Sciences.

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Держатели документа:
Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, 660036 Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Bondareva, L.; Bolsunovsky, A.

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Accumulation and release of 99Tc by a macrophyte of the Yenisei River (Elodea canadensis) in laboratory experiments / A. Bolsunovsky, L. Bondareva // Journal of Radioanalytical and Nuclear Chemistry. - 2008. - Vol. 277, Is. 3. - P631-636, DOI 10.1007/s10967-007-7148-5 . - ISSN 0236-5731
Кл.слова (ненормированные):
technetium 99m -- aquatic flora -- article -- biomass -- controlled study -- dry weight -- liquid scintillation counting -- macrophyte -- nonhuman -- radiation absorption -- radiation detection -- radiation dose fractionation -- radiation measurement -- radioactivity -- river -- water sampling
Аннотация: The study addresses 99Tc accumulation and release by Elodea canadensis, one of the abundant species of submerged plants in the Yenisei River. 99Tc in water samples of the "Elodea - Yenisei River water" model system and in the biomass fractions was measured using a liquid scintillation analyzer. Experiments on accumulation of 99Tc by Elodea showed that 99Tc activity concentration can reach 120В±6 Bq/g dry wt, with the concentration factor for 99Tc 2700В±500 l/kg dry wt. In experiments on 99Tc release, over 504 hours about 82% of the total 99Tc activity was released into the water from the plant; most of 99Tc was released within the first 192 hours. The data obtained using sequential chemical fractionation of biomass confirmed the experimental data on 99Tc release, which suggested that most of the biomass-bound 99Tc was adsorbed on the surface of Elodea. 99Tc tightly bound to biomass (fractions of organics and mineral residue) constituted just 17% of the total 99Tc activity. В© 2008 Akademiai Kiado, Budapest.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Bolsunovsky, A.; Bondareva, L.

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Accumulation and release of 241Am by a macrophyte of the Yenisei River (Elodea canadensis) / A. Bolsunovsky, T. Zotina, L. Bondareva // Journal of Environmental Radioactivity. - 2005. - Vol. 81, Is. 1. - P33-46, DOI 10.1016/j.jenvrad.2004.10.012 . - ISSN 0265-931X
Кл.слова (ненормированные):
241Am -- Accumulation -- Laboratory experiments -- Release -- Submerged plant Elodea canadensis -- Yenisei River -- Activation analysis -- Biomass -- Concentration (process) -- Effluents -- Plutonium -- Rivers -- Aquatic plants -- Elodea plant -- Macrophytes -- Radioactive contamination -- Transuranium elements -- americium 241 -- river water -- americium -- americium nitrate -- bioaccumulation -- biological uptake -- macrophyte -- pollutant source -- radioactive pollution -- river water -- submerged vegetation -- article -- biomass -- concentration (parameters) -- environmental factor -- fractionation -- laboratory -- macrophyte -- radioactivity -- river -- sampling -- adsorption -- chemistry -- Hydrocharitaceae -- methodology -- physiology -- plant -- radiation exposure -- radiation monitoring -- Russian Federation -- sediment -- soil pollutant -- time -- tissue distribution -- water pollutant -- Eastern Hemisphere -- Eurasia -- Russian Federation -- World -- Yenisei River -- Elodea canadensis -- Adsorption -- Americium -- Biomass -- Chemical Fractionation -- Geologic Sediments -- Hydrocharitaceae -- Plant Shoots -- Radiation Monitoring -- Rivers -- Russia -- Soil Pollutants, Radioactive -- Time Factors -- Tissue Distribution -- Water Pollutants, Radioactive
Аннотация: The source of radioactive contamination of the Yenisei River floodplain, including contamination with transuranic elements, is the Mining-and-Chemical Combine of the Russian Ministry of Atomic Energy, which has for many years been producing weapons-grade plutonium. Transuranic elements have been detected not only in the soil and sediment of the river but also in the biomass of aquatic plants. This work is an investigation of accumulation and release of 241Am by a submerged macrophyte of the Yenisei River (Elodea canadensis) in laboratory experiments. In 2000-2003, laboratory experiments were carried out with biomass of E. canadensis Mich. and filtered river water. The samples were collected from the Yenisei River upstream of the discharge of the Combine's radioactive effluent. The experiments showed that 241Am is accumulated by Elodea biomass: the activity concentration of 241Am can reach 3280 В± 240 Bq/g, with the concentration factor for 241Am 16 600 В± 2200 l/kg. Results of chemical fractionation have proved that in the course of 241Am accumulation by Elodea biomass, 241Am tightly bound to biomass increases from 11% to 27% of the total 241Am in the biomass. Release of 241Am from the decaying Elodea biomass has been evaluated experimentally. By the end of the experiment (lasting up to 127 days), the Elodea plants had lost up to 65% of their initial 241Am activity and the rate of 241Am release into the water environment reached 23 Bq/day. В© 2004 Elsevier Ltd. All rights reserved.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Bolsunovsky, A.; Zotina, T.; Bondareva, L.

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Microparticles prepared from biodegradable polyhydroxyalkanoates as matrix for encapsulation of cytostatic drug / A. V. Murueva [et al.] // Journal of Materials Science: Materials in Medicine. - 2013. - Vol. 24, Is. 8. - P1905-1915, DOI 10.1007/s10856-013-4941-2 . - ISSN 0957-4530
Кл.слова (ненормированные):
3-hydroxybutyric acid -- Average diameter -- Cell attachments -- Chemical compositions -- Mass concentration -- Mouse-fibroblasts -- Polyhydroxyalkanoates -- Solvent evaporation techniques -- Biocompatibility -- Cell culture -- Cells -- Loading -- 3 hydroxybutyric acid -- 3 hydroxyhexanoic acid -- 4 hydroxybutyric acid -- 4',6 diamidino 2 phenylindole -- DNA -- doxorubicin -- nanoparticle -- polyhydroxyalkanoic acid -- polymer -- polystyrene -- solvent -- unclassified drug -- animal cell -- article -- biocompatibility -- biodegradability -- cell adhesion -- cell proliferation -- cell strain 3T3 -- cell viability -- chemical composition -- chemical structure -- controlled study -- cytotoxicity -- drug efficacy -- drug release -- electrophoretic mobility -- encapsulation -- evaporation -- fibroblast -- in vitro study -- nonhuman -- particle size -- priority journal -- stain -- study -- surface charge -- zeta potential
Аннотация: Microparticles made from degradable polyhydroxyalkanoates of different chemical compositions a homopolymer of 3-hydroxybutyric acid, copolymers of 3-hydroxybutyric and 4-hydroxybutyric acids (P3HB/4HB), 3-hydroxybutyric and 3-hydroxyvaleric acids (P3HB/3HV), 3-hydroxybutyric and 3-hydroxyhexanoic acids (P3HB/3HHx) were prepared using the solvent evaporation technique, from double emulsions. The study addresses the influence of the chemical compositions on the size and ?-potential of microparticles. P3HB microparticles loaded with doxorubicin have been prepared and investigated. Their average diameter and ?-potential have been found to be dependent upon the level of loading (1, 5, and 10 % of the polymer mass). Investigation of the in vitro drug release behavior showed that the total drug released from the microparticle into the medium increased with mass concentration of the drug. In this study mouse fibroblast NIH 3T3 cells were cultivated on PHA microparticles, and results of using fluorescent DAPI DNA stain, and MTT assay showed that microparticles prepared from PHAs of different chemical compositions did not exhibit cytotoxicity to cells cultured on them and proved to be highly biocompatible. Cell attachment and proliferation on PHA microparticles were similar to those on polystyrene. The cytostatic drug encapsulated in P3HB/3HV microparticles has been proven to be effective against HeLa tumor cells. В© 2013 Springer Science+Business Media New York.

Scopus
Держатели документа:
Institute of Biophysics, SB RAS, Akademgorodok 50, Krasnoyarsk 660036, Russian Federation
Institute of Modern Biology and Biotechnology, Siberian Federal University, Svobodny Av. 79, Krasnoyarsk 660041, Russian Federation
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States
Engineering Systems Division, Massachusetts Institute of Technology, Cambridge, MA 02139, United States
Health Sciences Technology Division, Massachusetts Institute of Technology, Cambridge, MA 02139, United States : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Murueva, A.V.; Shishatskaya, E.I.; Kuzmina, A.M.; Volova, T.G.; Sinskey, A.J.

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Distribution and resorption of polymeric microparticles in visceral organs of laboratory animals after intravenous injection / E. I. Shishatskaya [et al.] // Bulletin of Experimental Biology and Medicine. - 2009. - Vol. 148, Is. 5. - P789-793, DOI 10.1007/s10517-010-0817-3 . - ISSN 0007-4888
Кл.слова (ненормированные):
14C -- Intravenous injection -- Microparticles -- Resorbable polyhydroxybutyrate -- Visceral tissues -- carbon 14 -- microsphere -- polyhydroxyaminobutyric acid -- polymer -- unclassified drug -- animal experiment -- animal tissue -- article -- biocompatibility -- biodegradability -- body growth -- controlled drug release -- controlled study -- degradation kinetics -- drug delivery system -- drug dosage form -- experimental animal -- female -- liver parenchyma -- molecular weight -- nonhuman -- particle size -- physical development -- radioactivity -- rat -- spleen -- tissue distribution -- tissue structure -- Animals -- Animals, Laboratory -- Carbon Radioisotopes -- Female -- Injections, Intravenous -- Particle Size -- Polymers -- Rats -- Rats, Wistar -- Tissue Distribution -- Viscera -- Animalia
Аннотация: Microparticles obtained by using 14C-labeled resorbable hydroxyaminobutyric acid polymer were injected into the caudal vein of laboratory animals without negative aftereffects for their growth and development and without changes in the macro- and microstructure of organs and tissues. The distribution of microparticles in the viscera and the dynamics of accumulation of carbon-containing polymer degradation products in the viscera were studied. The main targets for the particles are liver tissues, as well as renal and splenic tissues. The polymeric matrix of the microparticles is most actively destroyed in the spleen and liver. The presence of high-molecular- weight polymeric matrix in organs indicates the integrity of microparticles and the possibility of long-term (up to 12 weeks) functioning of polymeric particles in vivo. В© 2009 Springer Science+Business Media, Inc.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Division of Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Institute of Basic Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.; Goreva, A.V.; Voinova, O.N.; Kalacheva, G.S.; Volova, T.G.

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Microbial polymers as a degradable carrier for pesticide delivery / O. N. Voinova [et al.] // Applied Biochemistry and Microbiology. - 2009. - Vol. 45, Is. 4. - P384-388, DOI 10.1134/S0003683809040061 . - ISSN 0003-6838
Аннотация: The possibility of use of polyhydroxyalkanoates (PHAs), biodegradable microbial polyesters, as a carrier for pesticides (?-hexachlorcyclohexane and lindane) for targeted and controlled delivery of these compounds to soil was investigated. The kinetics of polymer degradation and the dynamics of pesticide release from the extended-release formulations was studied. It is shown that pesticides embedded in a degradable polymer (PHA) carrier are released gradually and slowly, without surges, as the polymer is degraded by the soil micro-flora. The microbial soil component actively responded to the addition of the polymer as an additional nutrient substrate: the latter was degraded and then utilized. The rate of the pesticide release to the soil can be regulated by varying the polymer-pesticide ratio. В© 2009 Pleiades Publishing, Ltd.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Branch Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation
Siberian Federal University, Krasnoyarsk, 660041, Russian Federation
Institute of Forestry, Siberian Branch Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Voinova, O.N.; Kalacheva, G.S.; Grodnitskaya, I.D.; Volova, T.G.

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A Temperature Dependence of the Intra- and Extracellular Fatty-Acid Composition of Green Algae and Cyanobacterium / N. N. Sushchik [et al.] // Russian Journal of Plant Physiology. - 2003. - Vol. 50, Is. 3. - P374-380, DOI 10.1023/A:1023830405898 . - ISSN 1021-4437
Кл.слова (ненормированные):
Cyanobacterium -- Fatty acids -- Green algae -- Lipids -- Secretion -- algae -- Bacteria (microorganisms) -- Botryococcus braunii -- Chlorella vulgaris -- Chlorophyta -- Eukaryota -- Prokaryota -- Spirulina -- Spirulina platensis
Аннотация: The effect of ambient temperature on the composition of intracellular fatty acids and the release of free fatty acids (FFA) into a medium by cyanobacterium Spirulina platensis and eukaryotic microalgae, Chlorella vulgaris and Botryococcus braunii, was studied using their batch cultures. It was found that all the species studied, regardless of their taxonomic status, responded to the temperature regime by similar changes in their intracellular fatty acid composition: the relative content of more unsaturated fatty acids decreased with the elevation of temperature. At the same time, in the prokaryote, this temperature shift blocked, first of all, the elongation of 16: 0 to 18:0 and then their further desaturation. In eukaryotes, the change in the desaturation of dienoic to trienoic fatty acids was the most pronounced process. The ratio of dienoic to trienoic fatty acids remained almost unchanged in S. platensis. The relative content of extracellular unsaturated FFA increased in the prokaryotic organism S. platensis at a higher temperature. But no significant changes in the composition of extracellular unsaturated FFA were detected in eukaryotic algae upon temperature elevation.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Sushchik, N.N.; Kalacheva, G.S.; Zhila, N.O.; Gladyshev, M.I.; Volova, T.G.

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10.

Biocompatibility and resorption of intravenously administered polymer microparticles in tissues of internal organs of laboratory animals / E. Shishatskaya [et al.] // Journal of Biomaterials Science, Polymer Edition. - 2011. - Vol. 22, Is. 16. - P2185-2203, DOI 10.1163/092050610X537138 . - ISSN 0920-5063
Кл.слова (ненормированные):
14C products of polymer resorption -- intravenous administration -- microparticles -- Resorbable polyhydroxybutyrate -- tissues of internal organs -- 3-hydroxybutyric acid -- sup14/supC products of polymer resorption -- Adverse effect -- Drug-delivery systems -- Growth and development -- High molecular weight -- Initial molecular weight -- Initial values -- Internal organs -- Intravenous administration -- Laboratory animals -- Local response -- matrix -- Mean diameter -- Micro-particles -- Polymer degradation -- Polymer microparticles -- Preparation process -- Radioactivity level -- Residual content -- Resorbable -- Sustained-release -- Tail veins -- Wistar rat -- Animals -- Biocompatibility -- Degradation -- Histology -- Molecular weight -- Morphology -- Radiation -- Radioactivity -- Rats -- Tissue -- poly(3 hydroxybutyric acid) -- animal experiment -- animal tissue -- article -- biocompatibility -- concentration process -- controlled study -- degradation -- drug delivery system -- female -- gel permeation chromatography -- heart -- kidney parenchyma -- liver -- lung parenchyma -- molecular weight -- nonhuman -- organ culture -- priority journal -- radioactivity -- rat -- spleen -- Animals -- Animals, Laboratory -- Biocompatible Materials -- Drug Delivery Systems -- Female -- Infusions, Intravenous -- Materials Testing -- Microspheres -- Molecular Weight -- Particle Size -- Polymers -- Rats -- Rats, Wistar -- Tissue Distribution -- Animalia -- Rattus -- Rattus norvegicus
Аннотация: Specimens of 14C-labeled polymer of 3-hydroxybutyric acid, P(3-HB), with different initial molecular weights, were used to prepare microparticles, whose morphology was not influenced by the M w of the polymer. During the particle preparation process, P(3-HB) molecular weight decreased by 15-20%. Sterile microparticles (mean diameter 2.4 ?m) were injected into the tail veins of Wistar rats (5 mg/rat). The effects of the particles administered to rats were studied based on the general response of animals and local response of internal organ tissues and blood morphology; no adverse effects on growth and development of the animals or unfavorable changes in the structure of the tissues of internal organs were observed. Measurements of radioactivity in tissues showed that 14C concentrations are different in different organs, changing during the course of the experiment. The main targets for 14C-labeled microparticles were tissues of the liver, spleen, and kidneys. Comparison of radioactivity levels and residual contents of high-molecular-weight matrix in tissues suggested that the most rapid metabolism and degradation of P(3-HB) occurred in the liver and spleen. Gel-permeation chromatography showed that at 3 h after the microparticles were injected into the bloodstream, polymer degradation started in all examined organs, except the lungs; at 12 weeks, the M w of the polymer matrix was as low as 20-30% of its initial value. The presence of high-molecular-weight (undegraded) polymer in the tissues at 12 weeks after administration of the particles suggests that P(3-HB) is degraded in tissues of internal organs slowly and, hence, P(3-HB)-based microparticles can be used as sustained-release drug-delivery systems. В© 2011 VSP.

Scopus
Держатели документа:
Institute of Biophysics, SB RAS, Akademgorodok, Krasnoyarsk 660036, Russian Federation
Siberian Federal University, Svobodnyi Avenue, Krasnoyarsk 660041, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.; Goreva, A.; Kalacheva, G.; Volova, T.

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11.

An estimate of the rate of 241Am release from the biomass of aquatic plants of the Enisei river / A. Y. Bolsunovskij, T. A. Zotina, L. G. Bondareva // Doklady Akademii Nauk. - 2003. - Vol. 392, Is. 4. - С. 560-563 . - ISSN 0869-5652
Кл.слова (ненормированные):
Americium -- Aquaculture -- Biomass -- Contamination -- Ecology -- Radioisotopes -- River pollution -- Am release rate -- Americium 241 -- Elodea canadensis -- Enisei river -- Fontinalis antipyretica -- Radioecology -- Biological radiation effects
Аннотация: In the lab experiments (2000-2003) the biomass of Elodea canadelis (water thyme) and Fontinalis antipyretica (water moss) plants was used. The plants were exposed in filtered Enisei water with radionuclide additive in the form of 241Am(NO3)3 solution. The activity (A) was measured with gamma-spectrometer ("Canberra", USA) with ultra-pure germanium detector. The main A release in aqueous medium is observed after long stabilization stage caused by the plant necrosis. Elodea plants in 127 days lost up to 65% of initial A, and moss biomass - 35% in 373 days.

Scopus
Держатели документа:
Inst. Biofiziki SO RAN, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Bolsunovskij, A.Y.; Zotina, T.A.; Bondareva, L.G.

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12.

Individual-based model of the reproduction cycle of Moina macrocopa (Crustacea: Cladocera) / E. S. Zadereev [et al.] // Ecological Modelling. - 2003. - Vol. 162, Is. 1-2. - P15-31, DOI 10.1016/S0304-3800(02)00348-4 . - ISSN 0304-3800
Кл.слова (ненормированные):
Change of reproduction mode -- Cladocera -- Individual-based model -- Metabolic by-products -- ecological modeling -- individual-based model -- reproductive cycle -- Animalia -- Cladocera -- Crustacea -- Moina macrocopa
Аннотация: An individual-based model of cyclic development of Cladocera populations was developed on the basis of experimental data. The model takes into account the following processes describing the development of an individual animal: maturation, transition into other reproductive classes, selection of the reproduction mode (parthenogenetic or gamogenetic), release of parthenogenetic progeny and death. The model assumes that switching from asexual to sexual reproduction is controlled by the concentration of food and metabolic by-products of the animal population. Verification of the model by independent experiments demonstrated that (1) during population growth, metabolic by-products build up in the medium, and (2) the effect of metabolic by-products on gamogenesis induction depends on concentration. The hypothesis that the effect of regulating reproductive switching factors should synchronise the development of population with the change of environmental conditions in order to ensure production of the maximum number of diapausing eggs was tested. It is shown that combination of regulating reproductive switching factors maximises the production of diapausing eggs. В© 2002 Elsevier Science B.V. All rights reserved.

Scopus
Держатели документа:
Institute of Biophysics, Akademgorodok, 660036 Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Zadereev, E.S.; Prokopkin, I.G.; Gubanov, V.G.; Gubanov, M.V.

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13.

Infochemical-mediated trophic interactions between the rotifer Brachionus calyciflorus and its food algae / A. M. Verschoor, Y. S. Zadereev, W. M. Mooij // Limnology and Oceanography. - 2007. - Vol. 52, Is. 5. - P2109-2119 . - ISSN 0024-3590
Кл.слова (ненормированные):
alga -- aquatic ecosystem -- assimilation efficiency -- experimental study -- feeding behavior -- food web -- freshwater environment -- ingestion rate -- trophic interaction -- algae -- Brachionus calyciflorus -- Rotifera -- Scenedesmus -- Scenedesmus obliquus
Аннотация: We studied how chemicals obtained as filtrates from algal monocultures (algal chemicals) and from rotifer cultures with or without algae (rotifer chemicals) affected feeding rates of the rotifer Brachionus calyciflorus on its food algae, both directly and indirectly (through chemical-induced changes in algal morphology). Algal chemicals had a strong stimulating effect on the feeding rate of B. calyciflorus, but these effects were counteracted by rotifer chemicals. In functional response experiments, rotifer chemicals lowered maximum ingestion rates and had strong effects on assimilation rates and assimilation efficiencies of B. calyciflorus, probably due to the release of unspecific (auto)toxic metabolites. Furthermore, rotifer chemicals induced colony formation in the food alga Scenedesmus obliquus. Above the optimum particle size for ingestion by B. calyciflorus, larger algal colony sizes increased the food-handling time, thus lowering ingestion and assimilation rates. Through their effects on trophic interactions, infochemicals may play a role in structuring and the functioning of aquatic food webs. В© 2007, by the American Society of Limnology and Oceanography, Inc.

Scopus
Держатели документа:
Netherlands Institute of Ecology (NIOO-KNAW), Centre for Limnology, Rijksstraatweg 6, 3631 AC Nieuwersluis, Netherlands
Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, 660036 Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Verschoor, A.M.; Zadereev, Y.S.; Mooij, W.M.

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14.

Increase of atmospheric CO2: Response patterns on a simple terrestrial man-made ecosystem / L. A. Somova, N. S. Pechurkin, T. I. Pisman // Advances in Space Research. - 2003. - Vol. 31, Is. 7. - P1731-1735, DOI 10.1016/S0273-1177(03)80019-4 . - ISSN 0273-1177
Кл.слова (ненормированные):
Carbon dioxide -- Earth atmosphere -- Ecosystems -- Environmental impact -- Mathematical models -- Microorganisms -- Plants (botany) -- Soils -- Man-made ecosystems -- Space research -- biosphere -- carbon dioxide enrichment -- terrestrial ecosystem -- carbon dioxide -- nitrogen -- phosphorus -- article -- atmosphere -- biological model -- chemistry -- dose response -- drug effect -- ecosystem -- growth, development and aging -- metabolism -- microbiology -- microclimate -- plant root -- wheat -- Atmosphere -- Carbon Dioxide -- Dose-Response Relationship, Drug -- Ecosystem -- Environment, Controlled -- Models, Biological -- Nitrogen -- Phosphorus -- Plant Roots -- Soil Microbiology -- Triticum
Аннотация: Simple models of terrestrial ecosystems with a limited number of components are an efficient tool to study the main laws of functioning of populations, including microbial ones, and their communities, as components of natural ecosystems, under variable environmental conditions. Among other factors are the increase of carbon dioxide in the atmosphere and limitation of plants' growth by biogenic elements. The main types of ecosystems' responses to changes in environmental conditions (a change in CO2 concentration) have been demonstrated in a "plants - rhizospheric microorganisms - artificial soil" simple experimental system. The mathematical model of interactions between plants and microorganisms under normal and elevated atmospheric CO2 and limitation by nutrients (nitrogen and phosphorus) yielded a qualitative agreement between calculated and experimental values of limiting substances concentrations and release rates of exudates. В© 2003 COSPAR. Published by Elsevier Science Ltd. All rights reserved.

Scopus
Держатели документа:
Institute of Biophysics, Russian Academy of Sciences, Siberian Branch, Krasnoyarsk 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Somova, L.A.; Pechurkin, N.S.; Pisman, T.I.

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15.

Microencapculation of daunorubicin with biodegradable polymer matrix / E. I. Shishatskaya // Antibiotiki i Khimioterapiya. - 2007. - Vol. 52, Is. 9-10. - С. 3-8 . - ISSN 0235-2990
Кл.слова (ненормированные):
Daunorubicin -- Microencapsulation -- Polymer matrix -- antineoplastic antibiotic -- daunorubicin -- polyester -- animal -- article -- Bagg albino mouse -- chemistry -- kinetics -- microcapsule -- mouse -- particle size -- Animals -- Antibiotics, Antineoplastic -- Capsules -- Daunorubicin -- Kinetics -- Mice -- Mice, Inbred BALB C -- Particle Size -- Polyesters -- Animalia
Аннотация: Procedure for microencapsulation providing stable formation of high quality microspheres was designed. Conditions for deposition of the anthracycline antibiotic daunorubicin to polymer matrix were developed and microsheres loaded with various quantities of the drug were prepared. The kinetics of the in vitro and in vivo release of daunorubicin from the microsheres was studied. The rate of the rubomycin release to the medium in vitro (balanced phosphate buffer at 37.8В°C) in a 300-hour experiment directly depended on the quantity of the incorporated drug and averaged 0.81 В· 10 -4 to 2.3 В· 10 -4 mcg/mlВ·h. The experiment on laboratory animals with intraperitoneal administration of the rubomycin microsperes showed that the drug remained in the blood and abdominal liquid for a long time (up to 10 days). Possible control of the quantity of the rubomycin encapsulation to the polymer matrix, no sharp efflux of the drug at the early stages of the observation and low rate of the drug release to the medium allowed to conclude that the use of the biodegradable polymer microsperes as carriers of the high toxic antibiotic providing its prolonged action was prospective.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.

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16.

Rubomycin microincapsulation with biodegradable polymer matrix / E. I. Shishatskaya // Antibiotiki i Khimioterapiya. - 2005. - Vol. 50, Is. 8-9. - С. 4-9 . - ISSN 0235-2990
Кл.слова (ненормированные):
Daunorubicin (rubomycin) -- Microspheres -- Polyhydroxybutirate -- antineoplastic antibiotic -- daunorubicin -- hydroxybutyric acid -- microsphere -- poly(3 hydroxybutyric acid) -- poly-beta-hydroxybutyrate -- polyester -- polymer -- article -- chemistry -- delayed release formulation -- electronics -- methodology -- microcapsule -- temperature -- Antibiotics, Antineoplastic -- Capsules -- Daunorubicin -- Delayed-Action Preparations -- Hydroxybutyrates -- Microspheres -- Miniaturization -- Polyesters -- Polymers -- Temperature
Аннотация: A procedure for preparation of microspheres from biodegradable linear polyether of microbiological origin (polyhydroxybutirate, PHB) with using the technology of solvent evaporation was developed considering a specific example of two- and three-component emulsions. The procedure provided permanent preparation of the microspheres of high quality. The influence of the procedure (emulsion type, dispersion process and medium temperature) on the yield of the microspheres, their structure and size was shown. The temperature had a significant impact on incorporation of the antitumor anthracycline antibiotic daunorubicin (rubomycin) to the polymer matrix. The microspheres with various levels of the drug load (29 and 90% of the initial content in the emulsion) were prepared and the kinetics of the in vitro rubomycin release was studied. The dynamics of the highly toxic rubomycin release from the microspheres was on the whole even with the curve profile reaching the plateau in 20-22 hours of the observation period. The rate of the rubomycin release to the medium depended on the value of the antibiotic incorporation and was maximum within the first two hours (3.3 and 13.0 mcg/mlВ·h) that corresponded to the release of 0.97 and 3.89 of the incorporated antibiotic. The average rate of rubomycin release during 300 hours was 0.81В·10-4 and 2.3В·10-4 mcg/mlВ·h. The release constituted respectively 3.9 and 13.11% of the antibiotic incorporated to the microspheres.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Branch of Russian Academy of Sciences, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.

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17.

Characterization of polymeric microparticles based on resorbable polyesters of oxyalkanoic acids as a platform for deposition and delivery of drugs / A. V. Goreva [et al.] // Polym. Sci. Ser. A. - 2012. - Vol. 54, Is. 2. - P94-105, DOI 10.1134/S0965545X12020022. - Cited References: 33. - This work was supported by the program for Support of Leading Scientific Schools of the Russian Federation (project no. 11.G34.31.0013.2010, Biotechnology of New Biomaterials) and the program of integrated studies of the Presidium of the Siberian Branch, Russian Academy of Sciences (project no. 93). . - 12. - ISSN 0965-545X

РУБ Polymer Science
Рубрики:
IN-VITRO RELEASE
   POLYHYDROXYBUTYRATE MICROSPHERES
   BLENDS
   RIFAMPICIN
   BIOCOMPATIBILITY
   DEGRADATION
   FORMULATION
   COMPOSITE
   CARRIERS
   MODEL
Аннотация: The effect of the preparation technique (chemical composition of a polymer, type and method of emulsion mixing, and molecular mass of a drug) on the yield, structure, and size of microparticles obtained from resorbable polyesters of microbiological origin, polyhydroxyalkanoates, is studied. It is found that the concentration of the polymer solution and the method of emulsion mixing are the most significant factors affecting the diameter of microparticles based on polyhydroxyalkanoates; the surface structure of particles depends to a higher extent on the chemical composition of the polymer. The family of microparticles from 100-200 nm to 50-70 mu m in diameter is synthesized. It is shown that the rate of drug release from microparticles in vitro into the medium is higher in the case of 3-hydroxybutyrate copolymers with 3-hydroxyvalerate than in the case of the homopolymer of 3-hydroxybutyrate. This parameter increases with the content of 3-hydroxyvalerate units in the copolymer and the porosity and mass fraction of the drug in particles with a decrease in their sizes. For in vitro systems containing a phosphate buffer, variation in the preparation parameters makes it possible to obtain microparticles with various characteristics suitable for deposition of drugs. For microparticles obtained from polyhydroxyalkanoates and having different diameters, the mathematical description of the kinetics of drug release from the polymer matrix is provided.

Держатели документа:
[Goreva, A. V.
Shishatskaya, E. I.
Volova, T. G.] Russian Acad Sci, Siberian Branch, Inst Biophys, Krasnoyarsk 660036, Russia
[Shishatskaya, E. I.
Volova, T. G.] Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Krasnoyarsk 660041, Russia
[Goreva, A. V.
Sinskey, A. J.] MIT, Cambridge, MA 02139 USA : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Goreva, A.V.; Shishatskaya, E.I.; Volova, T.G.; Sinskey, A.J.

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18.

Effect of humic acid on absorption-release processes in the bottom sediments-Yenisei river water system as studied by dual-column ion chromatography and gamma-ray spectrometry [Text] / L. G. Bondareva, O. P. Kalyakina, A. Y. Bolsunovskii // J. Anal. Chem. - 2006. - Vol. 61, Is. 4. - P354-358, DOI 10.1134/S1061934806040101. - Cited References: 11 . - 5. - ISSN 1061-9348

РУБ Chemistry, Analytical

Аннотация: The effect of humic acid on absorption-release processes in the bottom sediments-Yenisei river water system was studied by dual-column ion chromatography and gamma-ray spectrometry. With the use of ion chromatography, it was found that processes related to the absorption of SO42- and Cl- anions by a solid phase with the release of NO3-, PO43-, and F- to a liquid phase competed in the test systems as the concentration of water-soluble organic carbon (WSOC) was increased. Only the test anions were released in the systems without the introduction of an additional amount of WSOC as humic acid. With the use of gamma-ray spectrometry, it was found that the release of Co-60, Eu-152, and Am-241 radionuclides to the liquid phase in the systems with added humic acid began much earlier than in the system without the addition of humic acid. In this case, the amount of released radionuclides was greater than the amount of radioisotopes released in the system without the addition of humic acid: similar to 25% Am-241, similar to 3% Eu-152, and similar to 0.8% Co-60 in the system with added humic acid or 0.8% Eu-152 and 0.1% Co-60 in the system without the addition of humic acid. The Am-241 radionuclide was not determined in the system without the addition of humic acid. An increase in the concentration of WSOC in the experimental system of bottom sediments-Yenisei river water initiated the release of Co-60, Eu-152, and Am-241 anthropogenic radionuclides from bottom sediments because of the formation of soluble complexes capable of migration. An increase in the concentration of WSOC had almost no effect on the release of K-40 and Cs-137 radionuclides.

Держатели документа:
Russian Acad Sci, Siberian Div, Inst Biophys, Krasnoyarsk 660036, Russia
Krasnoyarsk State Univ, Fac Chem, Krasnoyarsk 660041, Russia : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Bondareva, L.G.; Kalyakina, O.P.; Bolsunovskii, A.Y.

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19.

Degradable Polyhydroxyalkanoates as Herbicide Carriers [Text] / S. V. Prudnikova [et al.] // J. Polym. Environ. - 2013. - Vol. 21, Is. 3. - P675-682, DOI 10.1007/s10924-012-0561-z. - Cited References: 31. - We thank Dr. Christopher Brigham for critical review of the manuscript prior to submission. The study was supported by the project initiated by the Government of the Russian Federation for governmental support of scientific research conducted under the guidance of leading scientists at Russian institutions of higher learning (Agreement No. 11.G34.31.0013). . - 8. - ISSN 1566-2543

РУБ Engineering, Environmental + Polymer Science
Рубрики:
CONTROLLED-RELEASE
   SOIL
   BIODEGRADATION
   POLYESTERS
   PESTICIDE
   POLY(3-HYDROXYBUTYRATE-CO-3-HYDROXYVALERATE)
   MICROSPHERES
   BACTERIA
Кл.слова (ненормированные):
Herbicide -- Haloxyfop-P-methyl -- Zellek Super -- Sustained-release formulations -- Polyhydroxyalkanoates -- Plant growth suppression
Аннотация: The biodegradable polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) has been used to design experimental sustained-release formulations of the herbicide Zellek Super in the form of films and microgranules. The kinetics of polymer degradation and the dynamics of herbicide release show that the rate and extent of herbicide release from the polymer matrix into the soil depends on the geometry of the carrier and the proportion of the pesticide loaded into it (polymer/pesticide mass ratio). Experiments with the creeping bentgrass (Agrostis stolonifera L.) show that the formulations of the herbicide Zellek Super constructed as microgranules and films can be successfully used to suppress the growth of grasses. This study is the first to demonstrate that biodegradable polyhydroxyalkanoates can be used effectively to construct environmentally friendly sustained-release PHA-herbicide systems that can be placed into the soil together with seeds.

Держатели документа:
[Prudnikova, S. V.
Sinskey, A. J.] Siberian Fed Univ, Krasnoyarsk 660041, Russia
[Boyandin, A. N.
Kalacheva, G. S.] Russian Acad Sci, Inst Biophys, Siberian Branch, Krasnoyarsk 660036, Russia
[Sinskey, A. J.] MIT, Cambridge, MA 02139 USA : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Prudnikova, S.V.; Boyandin, A.N.; Kalacheva, G.S.; Sinskey, A.J.; Government of the Russian Federation [11.G34.31.0013]

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20.

The role of volatile metabolites in microbial communities of the LSS higher plant link / L. S. Tirranen, I. I. Gitelson // Advances in Space Research. - 2006. - Vol. 38, Is. 6. - P1227-1232, DOI 10.1016/j.asr.2006.02.038 . - ISSN 0273-1177
Кл.слова (ненормированные):
Inhibiting, bactericidal, stimulating effect -- Microbial interaction -- Type of interaction -- Volatile and non-volatile metabolites -- Growth kinetics -- Microbiology -- Microorganisms -- Plants (botany) -- Sensitivity analysis -- Toxic materials -- Inhibiting, bactericidal, stimulating effect -- Microbial interaction -- Type of interaction -- Volatile and non-volatile metabolites -- Metabolites
Аннотация: The paper addresses the possibility of controlling the microbial community composition through metabolites produced by microbes. The comparative analysis of experimental data has shown that volatile metabolites make a much greater contribution to the microbial interactions than nonvolatile ones. It has been found that interaction of microorganisms via the volatiles they release occurs frequently and is typical of a number of microorganisms. Volatile metabolites released by microorganisms produce an inhibitory, sometimes bactericidal, effect on the vital functions of bacteria. The stimulating action occurs 6-8 times less frequently. The range of action on the growth of the test cultures and the range of sensitivity to the effect of volatile metabolites of the study microbes have been found to be individual. Comparative cluster analysis of the ranges of action of 100 study cultures has shown that in the investigated set of microorganism species interaction was performed via a set of volatiles of an inhibiting action (82) and of a stimulating action (52). It has been found that release of volatile metabolites by the studied microorganisms depends upon the culture age, concentrations of components of the nutrient medium, and volatile by-products released by other microorganisms. This production can be increased or decreased by the action of volatile metabolites of other microbes. This is related to strain features and culture age. The prospects of using these regulating metabolites depend on the "range", specificity and safety for other members of the microbial community in insufficient concentrations. Volatiles produced by plants and microorganisms as well as by other components of the system - humans and processing equipment installed inside the closed ecosystem - could influence the formation not only of the microbial community but also of the gas composition of the system's atmosphere, through which they could affect the state of the plants. Specially performed experiments have shown that volatile metabolites of microorganisms can accumulate in their habitat, dissolve in the atmospheric water, and maintain their biological activity for days. It has been determined that volatile metabolites of some microorganisms are toxic for plants. Growth of seedling roots is inhibited more than growth of stems. В© 2006 COSPAR.

Scopus
Держатели документа:
Institute of Biophysics SB RAS, Akademgorodok, 660036 Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Tirranen, L.S.; Gitelson, I.I.

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