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Каталог книг и продолжающихся изданий библиотеки Института биофизики СО РАН (1)

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Evaluation of antitumor activity of rubomycin deposited in absorbable polymeric microparticles / E. I. Shishatskaya [et al.] // Bulletin of Experimental Biology and Medicine. - 2008. - Vol. 145, Is. 3. - P358-361, DOI 10.1007/s10517-008-0091-9 . - ISSN 0007-4888
Кл.слова (ненормированные):
Absorbable polymers -- Ehrlich's ascitic carcinoma -- Microencapsulation -- Polyhydroxybutyrate -- Rubomycin -- poly(3 hydroxybutyric acid) -- polymer -- rubomycin -- animal cell -- animal experiment -- animal model -- antineoplastic activity -- article -- Bagg albino mouse -- cancer inhibition -- cancer mortality -- cancer survival -- controlled study -- drug delivery system -- Ehrlich ascites tumor -- microencapsulation -- mouse -- nonhuman -- polymerization -- survival rate -- tumor cell -- tumor volume -- Absorption -- Animals -- Antibiotics, Antineoplastic -- Carcinoma, Ehrlich Tumor -- Daunorubicin -- Hydroxybutyrates -- Mice -- Mice, Inbred BALB C -- Microspheres -- Polyesters -- Mus
Аннотация: An experimental dosage form of rubomycin is developed: the drug is incorporated in absorbable polymeric (polyhydroxybutyrate) matrix in the form of microparticles. Antitumor efficiency of this rubomycin dosage form was studied in laboratory mice with transplanted Ehrlich ascitic carcinoma. Rubomycin deposited in polymeric microparticles exhibited pronounced antitumor activity, inhibited the proliferative activity of Ehrlich ascitic carcinoma, and improved survival of mice with tumors. This dosage form of the drug can be used for local injections. В© Springer Science+Business Media, Inc. 2008.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Division of Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Siberian Federal University, Krasnoyarsk, Russian Federation
International Center for Studies of Critical Conditions, Presidium of Krasnoyarsk Research Center of Siberian Division of Russian Academy of Sciences, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.; Goreva, A.V.; Voinova, O.N.; Inzhevatkin, E.V.; Khlebopros, R.G.; Volova, T.G.

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Tissue response to the implantation of biodegradable polyhydroxyalkanoate sutures / E. I. Shishatskaya [et al.] // Journal of Materials Science: Materials in Medicine. - 2004. - Vol. 15, Is. 6. - P719-728, DOI 10.1023/B:JMSM.0000030215.49991.0d . - ISSN 0957-4530
Кл.слова (ненормированные):
Necrosis -- Polymeric implants -- Suppurative inflammation -- Tissue reaction -- Biodegradation -- Calcification (biochemistry) -- Cells -- Copolymers -- Implants (surgical) -- Silk -- Tissue -- Tumors -- Materials science -- acid phosphatase -- copolymer -- poly(3 hydroxybutyric acid) -- polyhydroxyalkanoic acid -- polyhydroxyvaleric acid -- unclassified drug -- animal experiment -- animal model -- article -- biodegradable implant -- blood vessel reactivity -- catgut -- controlled study -- enzyme activity -- female -- giant cell -- histochemistry -- inflammation -- macrophage -- nonhuman -- priority journal -- rat -- silk -- suture -- tensile strength -- tissue reaction -- tissue structure -- wound healing -- young modulus -- Absorbable Implants -- Animals -- Female -- Fibrosis -- Foreign-Body Reaction -- Hydroxybutyrates -- Muscle, Skeletal -- Polyesters -- Polymers -- Rats -- Rats, Wistar -- Sutures -- Treatment Outcome -- Wounds, Penetrating -- Animalia
Аннотация: Polyhydroxyalkanoate (PHA) sutures were implanted to test animals intramuscularly, and tissue reaction was investigated and compared with the reaction to silk and catgut. Tested monofilament sutures made of PHAs of two types polyhydroxybutyrate (PHB) and a copolymer of hydroxybutyrate and hydroxyvalerate (PHV) featured the strength necessary for the healing of muscle-fascial wounds. The reaction of tissues to polymeric implants was similar to their reaction to silk and was less pronounced than the reaction to catgut; it was expressed in a transient post-traumatic inflammation (up to four weeks) and the formation of a fibrous capsule less than 200 ?m thick, which became as thin as 4060 ?m after 16 weeks, in the course of reverse development. Macrophages and foreign-body giant cells with a high activity of acid phosphatase were actively involved in this process. PHB and PHB/PHV sutures implanted intramuscularly for an extended period (up to one year) did not cause any acute vascular reaction at the site of implantation or any adverse events, such as suppurative inflammation, necrosis, calcification of the fibrous capsule or malignant tumor formation. No statistically significant differences were revealed in the tissue response to polymer sutures of the two types. Capsules around silk and catgut sutures did not become significantly thinner.

Scopus
Держатели документа:
Inst. Biophys. Siberian Br. Russ. A., Akademgorodok, Krasnoyarsk 660036, Russia, Russian Federation
Terr. Pathological Anatomy Bureau, Partisan Zheleznyak St. 1, Krasnoyarsk 660049, Russia, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.; Volova, T.G.; Puzyr, A.P.; Mogilnaya, O.A.; Efremov, S.N.

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Population dynamics in modeling tumor growth / V. A. Slepkov, V. G. Sukhovolsky, R. G. Khlebopros // Biophysics. - 2007. - Vol. 52, Is. 4. - P426-431, DOI 10.1134/S0006350907040136 . - ISSN 0006-3509
Кл.слова (ненормированные):
Angiogenesis -- Local cellular interaction -- Modeling -- Tumor growth
Аннотация: A new approach based on local interaction between cancer and tissue cells is applied to the problem of the onset and growth of solid tumors in homogeneous tissues and effects associated with dramatic changes in tumor growth after crossing the boundary between different tissues. The characteristic sizes and growth rates of spherical tumors, the points of the beginning and the end of spherical growth, and further development of complex structures from the spherical ones (rough interface between the tumor and the host tissue, elongate outgrowths, dendritic structures, and metastases) are inferred assuming that the reproduction rate of a population of cancer cells is a nonmonotonous function of their local concentration and thus of the local curvature of the tumor surface. The growth behavior changes dramatically when the tumor crosses a boundary between two tissues. В© 2007 Pleiades Publishing, Inc.

Scopus
Держатели документа:
Nikolaev Institute of Inorganic Chemistry, Siberian Division, Russian Academy of Sciences, Novosibirsk 630090, Russian Federation
International Center for Critical States Research, Siberian Division, Russian Academy of Sciences, Krasnoyarsk, Akademgorodok 660036, Russian Federation
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Krasnoyarsk, Akademgorodok 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Slepkov, V.A.; Sukhovolsky, V.G.; Khlebopros, R.G.

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Modeling the growth and morphogenesis of malignant tumors / V. A. Slepkov, V. G. Sukhovol'skii, R. G. Khlebopros // Doklady Biochemistry and Biophysics. - 2006. - Vol. 411, Is. 1. - P342-345, DOI 10.1134/S1607672906060056 . - ISSN 1607-6729
Кл.слова (ненормированные):
animal -- article -- biological model -- cancer invasion -- cell proliferation -- computer simulation -- human -- morphogenesis -- neoplasm -- pathology -- pathophysiology -- Animals -- Cell Proliferation -- Computer Simulation -- Humans -- Models, Biological -- Morphogenesis -- Neoplasm Invasiveness -- Neoplasms

Scopus
Держатели документа:
Nikolaev Institute of Inorganic Chemistry, Siberian Division, Russian Academy of Sciences, Novosibirsk, 630090, Russian Federation
International Research Center for Extreme Body States, Presidium of the Krasnoyarsk Research Center, Siberian Division, Akademogorogok, Krasnoyarsk, 660036, Russian Federation
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Slepkov, V.A.; Sukhovol'skii, V.G.; Khlebopros, R.G.

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