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Biodistribution of nanodiamonds in the body of mice using EPR spectrometry / E. Inzhevatkin [et al.] // IET Sci. Meas. Technol. - 2019. - Vol. 13, Is. 7. - P984-988, DOI 10.1049/iet-smt.2018.5594. - Cited References:32. - This work was supported by the Russian Foundation for Basic Research (project no. 16-04-00999). . - ISSN 1751-8822. - ISSN 1751-8830

РУБ Engineering, Electrical & Electronic
Рубрики:
DRUG-DELIVERY
   DETONATION NANODIAMONDS
   NANOMATERIALS
   DOXORUBICIN
Кл.слова (ненормированные):
blood -- biomedical materials -- kidney -- lung -- detonation -- diamond -- nanomedicine -- liver -- muscle -- cellular biophysics -- nanoparticles -- EPR -- imaging -- mice -- EPR spectrometry -- detonation NDs -- electron paramagnetic -- resonance spectrometry -- characteristic EPR signal -- initially injected -- NDs -- detonation -- femoral muscles -- blood -- spleen -- brain -- kidneys -- heart -- lungs -- liver -- biomaterials -- nanodiamonds -- organ homogenates -- nanoparticle concentrations -- inter-organ distribution -- time 2 -- 5 hour -- C
Аннотация: In vitro experiments proved the usefulness of electron paramagnetic resonance (EPR) spectrometry for detecting detonation nanodiamonds (NDs) in samples of biomaterials (blood and homogenates of organs of mice). A characteristic EPR signal (g = 2.003, Delta H similar or equal to 10 G) was detected in biomaterials containing NDs, and its intensity linearly increased at nanoparticle concentrations of between 1.6 and 200 mu g/ml. In vivo experiments demonstrated that EPR spectrometry was effective for monitoring the inter-organ distribution of NDs intravenously injected to mice. In 2.5 h after the injection of NDs, the nanoparticles mainly accumulated in the lungs and liver of the animals - about 25 and 20%, respectively, of the initially injected NDs. The amounts of NDs accumulated in the heart and kidneys were considerably lower. Also, EPR spectrometry did not detect NDs in the blood, spleen, brain, and femoral muscles of mice. Ten days after injection, EPR spectrometry detected redistribution of NDs in mice. The amounts of nanoparticles decreased approximately by a factor of 3.5 in the lungs and increased almost by a factor of 3 in the liver; NDs were detected in the spleen. This study suggests ways to use EPR spectrometry to study the distribution, accumulation, and elimination of detonation NDs injected into laboratory animals.

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Держатели документа:
Russian Acad Sci, Siberian Branch, Inst Biophys, Fed Res Ctr,Krasnoyarsk Sci Ctr, Krasnoyarsk, Russia.
RAS, SB, Int Sci Ctr Studies Extreme States Organism, Fed Res Ctr,Krasnoyarsk Sci Ctr, Krasnoyarsk, Russia.
Siberian Fed Univ, Krasnoyarsk, Russia.
Russian Acad Sci, Siberian Branch, Inst Chem & Chem Technol, Fed Res Ctr,Krasnoyarsk Sci Ctr, Krasnoyarsk, Russia.

Доп.точки доступа:
Inzhevatkin, Evgeny; Baron, Alexey; Maksimov, Nikolai; Volkova, Marina; Puzyr, Alexey; Ronzhin, Nikita; Bondar, Vladimir; Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR) [16-04-00999]

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Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma / E. V. Inzhevatkin, A. V. Baron, M. B. Volkova [et al.] // Bull. Exp. Biol. Med. - 2021, DOI 10.1007/s10517-021-05335-9 . - Article in press. - ISSN 0007-4888
Кл.слова (ненормированные):
biochemical changes in blood plasma -- biodistribution -- detonation synthesis nanodiamonds -- EPR-spectrometry -- intravenous administration
Аннотация: Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.

Scopus
Держатели документа:
International Scientific Center of Extremal Organism State Research, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Institute of Biophysics, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russian Federation
Institute of Chemistry and Chemical Technology, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Krasnoyarsk Regional Clinical Center of Maternity and Child Protection, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Inzhevatkin, E. V.; Baron, A. V.; Volkova, M. B.; Maksimov, N. G.; Golubenko, N. K.; Loshkareva, M. V.; Puzyr’, A. P.; Ronzhin, N. O.; Bondar, V. S.

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Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma / E. V. Inzhevatkin, A. V. Baron, M. B. Volkova [et al.] // Bull. Exp. Biol. Med. - 2021. - Vol. 172, Is. 1. - P77-80, DOI 10.1007/s10517-021-05335-9. - Cited References:9 . - ISSN 0007-4888. - ISSN 1573-8221

РУБ Medicine, Research & Experimental

Кл.слова (ненормированные):
detonation synthesis nanodiamonds -- EPR-spectrometry -- intravenous -- administration -- biodistribution -- biochemical changes in blood plasma
Аннотация: Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values.

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Держатели документа:
Russian Acad Sci, Int Sci Ctr Extremal Organism State Res, Fed Res Ctr, Krasnoyarsk Sci Ctr,Siberian Div, Krasnoyarsk, Russia.
Russian Acad Sci, Fed Res Ctr, Inst Biophys, Krasnoyarsk Sci Ctr,Siberian Div, Krasnoyarsk, Russia.
Natl Res Univ, Moscow Inst Phys & Technol, Dolgoprudnyi, Moscow Region, Russia.
Russian Acad Sci, Fed Res Ctr, Inst Chem & Chem Technol, Krasnoyarsk Sci Ctr,Siberian Div, Krasnoyarsk, Russia.
Krasnoyarsk Reg Clin Ctr Matern & Child Protect, Krasnoyarsk, Russia.

Доп.точки доступа:
Inzhevatkin, E., V; Baron, A., V; Volkova, M. B.; Maksimov, N. G.; Golubenko, N. K.; Loshkareva, M., V; Puzyr', A. P.; Ronzhin, N. O.; Bondar, V. S.

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