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Rubomycin microincapsulation with biodegradable polymer matrix / E. I. Shishatskaya // Antibiotiki i Khimioterapiya. - 2005. - Vol. 50, Is. 8-9. - С. 4-9 . - ISSN 0235-2990
Кл.слова (ненормированные):
Daunorubicin (rubomycin) -- Microspheres -- Polyhydroxybutirate -- antineoplastic antibiotic -- daunorubicin -- hydroxybutyric acid -- microsphere -- poly(3 hydroxybutyric acid) -- poly-beta-hydroxybutyrate -- polyester -- polymer -- article -- chemistry -- delayed release formulation -- electronics -- methodology -- microcapsule -- temperature -- Antibiotics, Antineoplastic -- Capsules -- Daunorubicin -- Delayed-Action Preparations -- Hydroxybutyrates -- Microspheres -- Miniaturization -- Polyesters -- Polymers -- Temperature
Аннотация: A procedure for preparation of microspheres from biodegradable linear polyether of microbiological origin (polyhydroxybutirate, PHB) with using the technology of solvent evaporation was developed considering a specific example of two- and three-component emulsions. The procedure provided permanent preparation of the microspheres of high quality. The influence of the procedure (emulsion type, dispersion process and medium temperature) on the yield of the microspheres, their structure and size was shown. The temperature had a significant impact on incorporation of the antitumor anthracycline antibiotic daunorubicin (rubomycin) to the polymer matrix. The microspheres with various levels of the drug load (29 and 90% of the initial content in the emulsion) were prepared and the kinetics of the in vitro rubomycin release was studied. The dynamics of the highly toxic rubomycin release from the microspheres was on the whole even with the curve profile reaching the plateau in 20-22 hours of the observation period. The rate of the rubomycin release to the medium depended on the value of the antibiotic incorporation and was maximum within the first two hours (3.3 and 13.0 mcg/mlВ·h) that corresponded to the release of 0.97 and 3.89 of the incorporated antibiotic. The average rate of rubomycin release during 300 hours was 0.81В·10-4 and 2.3В·10-4 mcg/mlВ·h. The release constituted respectively 3.9 and 13.11% of the antibiotic incorporated to the microspheres.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Branch of Russian Academy of Sciences, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.

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Laser image recording on detonation nanodiamond films [Text] / G. M. Mikheev [et al.] // Quantum Electron. - 2014. - Vol. 44, Is. 1. - P1-3, DOI 10.1070/QE2014v044n01ABEH015299. - Cited References: 34. - This work was supported by the Russian Foundation for Basic Research (Grant No. 13-02-96016 r_ural_ a) and the Presidium of the Ural Branch of the Russian Academy of Sciences (Project No. 12-C-1-1003). . - ISSN 1063-7818. - ISSN 1468-4799

РУБ Engineering, Electrical & Electronic + Physics, Applied
Рубрики:
THERMOCHEMICAL TECHNOLOGY
   DIAMOND FILMS
   NITROGEN
   CARBON
Кл.слова (ненормированные):
detonation nanodiamond -- films -- laser blackening -- Raman scattering -- luminescence -- image recording
Аннотация: A focused He - Ne laser beam is shown to cause local blackening of semitransparent detonation nanodiamond (DND) films at incident power densities above 600 W cm(-2). Data obtained with a Raman spectrometer and low-power 632.8-nm laser source indicate that the blackening is accompanied by a decrease in broadband background luminescence and emergence of sharp Raman peaks corresponding to the structures of nanodiamond and sp(2) carbon. The feasibility of image recording on DND films by a focused He - Ne laser beam is demonstrated.

WOS
Держатели документа:
[Mikheev, G. M.
Mikheev, K. G.
Mogileva, T. N.] Russian Acad Sci, Ural Branch, Inst Mech, Izhevsk 426067, Russia
[Puzyr, A. P.
Bondar, V. S.] Russian Acad Sci, Inst Biophys, Siberian Branch, Krasnoyarsk 660036, Russia
ИБФ СО РАН : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Mikheev, G.M.; Mikheev, K.G.; Mogileva, T.N.; Puzyr, A.P.; Bondar, V.S.; Russian Foundation for Basic Research [13-02-96016 r_ural_a]; Presidium of the Ural Branch of the Russian Academy of Sciences [12-C-1-1003]

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Laser processing of polymer constructs from poly(3-hydroxybutyrate) / T. G. Volova [et al.] // J. Biomater. Sci. Polym. Ed. - 2015. - Vol. 26, Is. 16. - P1210-1228, DOI 10.1080/09205063.2015.1082810 . - ISSN 0920-5063
Кл.слова (ненормированные):
biocompatibility -- biopolymers -- laser processing -- poly(3-hydroxybutyrate) -- polymer materials -- Biocompatibility -- Biomechanics -- Biopolymers -- Bone -- Cell culture -- Pulsed lasers -- Scaffolds (biology) -- Stem cells -- 3t3 mouse fibroblasts -- Bone marrow -- Bone regeneration -- Laser process -- Mesenchymal stem cell -- Poly-3-hydroxybutyrate -- Polymer materials -- Pulsed mode -- Laser materials processing
Аннотация: CO2 laser radiation was used to process poly(3-hydroxybutyrate) constructs - films and 3D pressed plates. Laser processing increased the biocompatibility of unperforated films treated with moderate uniform radiation, as estimated by the number and degree of adhesion of NIH 3T3 mouse fibroblast cells. The biocompatibility of perforated films modified in the pulsed mode did not change significantly. At the same time, pulsed laser processing of the 3D plates produced perforated scaffolds with improved mechanical properties and high biocompatibility with bone marrow-derived multipotent, mesenchymal stem cells, which show great promise for bone regeneration. © 2015 Taylor & Francis.

Scopus,
WOS
Держатели документа:
Institute of Biophysics of Siberian Branch of Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, Russian Federation
School of Fundamental Biology and Biotechnology, Siberian Federal University, 79 Svobodnyi Avenue, Krasnoyarsk, Russian Federation
School of Engineering Physics and Radio Electronics, Siberian Federal University, 79 Svobodnyi Avenue, Krasnoyarsk, Russian Federation
Special Design and Technological Bureau, Nauka Krasnoyarsk Scientific Centre of Siberian Branch, Russian Academy of Sciences, 53 Mir Avenue, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Volova, T. G.; Tarasevich, A. A.; Golubev, A. I.; Boyandin, A. N.; Shumilova, A. A.; Nikolaeva, E. D.; Shishatskaya, E. I.

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