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Distribution and resorption of polymeric microparticles in visceral organs of laboratory animals after intravenous injection / E. I. Shishatskaya [et al.] // Bulletin of Experimental Biology and Medicine. - 2009. - Vol. 148, Is. 5. - P789-793, DOI 10.1007/s10517-010-0817-3 . - ISSN 0007-4888
Кл.слова (ненормированные):
14C -- Intravenous injection -- Microparticles -- Resorbable polyhydroxybutyrate -- Visceral tissues -- carbon 14 -- microsphere -- polyhydroxyaminobutyric acid -- polymer -- unclassified drug -- animal experiment -- animal tissue -- article -- biocompatibility -- biodegradability -- body growth -- controlled drug release -- controlled study -- degradation kinetics -- drug delivery system -- drug dosage form -- experimental animal -- female -- liver parenchyma -- molecular weight -- nonhuman -- particle size -- physical development -- radioactivity -- rat -- spleen -- tissue distribution -- tissue structure -- Animals -- Animals, Laboratory -- Carbon Radioisotopes -- Female -- Injections, Intravenous -- Particle Size -- Polymers -- Rats -- Rats, Wistar -- Tissue Distribution -- Viscera -- Animalia
Аннотация: Microparticles obtained by using 14C-labeled resorbable hydroxyaminobutyric acid polymer were injected into the caudal vein of laboratory animals without negative aftereffects for their growth and development and without changes in the macro- and microstructure of organs and tissues. The distribution of microparticles in the viscera and the dynamics of accumulation of carbon-containing polymer degradation products in the viscera were studied. The main targets for the particles are liver tissues, as well as renal and splenic tissues. The polymeric matrix of the microparticles is most actively destroyed in the spleen and liver. The presence of high-molecular- weight polymeric matrix in organs indicates the integrity of microparticles and the possibility of long-term (up to 12 weeks) functioning of polymeric particles in vivo. В© 2009 Springer Science+Business Media, Inc.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Division of Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Institute of Basic Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.; Goreva, A.V.; Voinova, O.N.; Kalacheva, G.S.; Volova, T.G.

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Biocompatibility and resorption of intravenously administered polymer microparticles in tissues of internal organs of laboratory animals / E. Shishatskaya [et al.] // Journal of Biomaterials Science, Polymer Edition. - 2011. - Vol. 22, Is. 16. - P2185-2203, DOI 10.1163/092050610X537138 . - ISSN 0920-5063
Кл.слова (ненормированные):
14C products of polymer resorption -- intravenous administration -- microparticles -- Resorbable polyhydroxybutyrate -- tissues of internal organs -- 3-hydroxybutyric acid -- sup14/supC products of polymer resorption -- Adverse effect -- Drug-delivery systems -- Growth and development -- High molecular weight -- Initial molecular weight -- Initial values -- Internal organs -- Intravenous administration -- Laboratory animals -- Local response -- matrix -- Mean diameter -- Micro-particles -- Polymer degradation -- Polymer microparticles -- Preparation process -- Radioactivity level -- Residual content -- Resorbable -- Sustained-release -- Tail veins -- Wistar rat -- Animals -- Biocompatibility -- Degradation -- Histology -- Molecular weight -- Morphology -- Radiation -- Radioactivity -- Rats -- Tissue -- poly(3 hydroxybutyric acid) -- animal experiment -- animal tissue -- article -- biocompatibility -- concentration process -- controlled study -- degradation -- drug delivery system -- female -- gel permeation chromatography -- heart -- kidney parenchyma -- liver -- lung parenchyma -- molecular weight -- nonhuman -- organ culture -- priority journal -- radioactivity -- rat -- spleen -- Animals -- Animals, Laboratory -- Biocompatible Materials -- Drug Delivery Systems -- Female -- Infusions, Intravenous -- Materials Testing -- Microspheres -- Molecular Weight -- Particle Size -- Polymers -- Rats -- Rats, Wistar -- Tissue Distribution -- Animalia -- Rattus -- Rattus norvegicus
Аннотация: Specimens of 14C-labeled polymer of 3-hydroxybutyric acid, P(3-HB), with different initial molecular weights, were used to prepare microparticles, whose morphology was not influenced by the M w of the polymer. During the particle preparation process, P(3-HB) molecular weight decreased by 15-20%. Sterile microparticles (mean diameter 2.4 ?m) were injected into the tail veins of Wistar rats (5 mg/rat). The effects of the particles administered to rats were studied based on the general response of animals and local response of internal organ tissues and blood morphology; no adverse effects on growth and development of the animals or unfavorable changes in the structure of the tissues of internal organs were observed. Measurements of radioactivity in tissues showed that 14C concentrations are different in different organs, changing during the course of the experiment. The main targets for 14C-labeled microparticles were tissues of the liver, spleen, and kidneys. Comparison of radioactivity levels and residual contents of high-molecular-weight matrix in tissues suggested that the most rapid metabolism and degradation of P(3-HB) occurred in the liver and spleen. Gel-permeation chromatography showed that at 3 h after the microparticles were injected into the bloodstream, polymer degradation started in all examined organs, except the lungs; at 12 weeks, the M w of the polymer matrix was as low as 20-30% of its initial value. The presence of high-molecular-weight (undegraded) polymer in the tissues at 12 weeks after administration of the particles suggests that P(3-HB) is degraded in tissues of internal organs slowly and, hence, P(3-HB)-based microparticles can be used as sustained-release drug-delivery systems. В© 2011 VSP.

Scopus
Держатели документа:
Institute of Biophysics, SB RAS, Akademgorodok, Krasnoyarsk 660036, Russian Federation
Siberian Federal University, Svobodnyi Avenue, Krasnoyarsk 660041, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.; Goreva, A.; Kalacheva, G.; Volova, T.

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Study of the efficiency of doxorubicin deposited in microparticles from resorbable bioplastotaneв„ў on laboratory animals with Ehrlich's solid carcinoma / E. I. Shishatskaya, A. V. Goreva, A. M. Kuzmina // Bulletin of Experimental Biology and Medicine. - 2013. - Vol. 154, Is. 6. - P773-777, DOI 10.1007/s10517-013-2053-0 . - ISSN 0007-4888
Кл.слова (ненормированные):
Bioplastotane -- controlled drug delivery systems -- Ehrlich's carcinoma -- microparticles -- resorbable polymers -- doxorubicin -- drug carrier -- animal experiment -- animal model -- animal tissue -- antineoplastic activity -- article -- cancer inhibition -- controlled study -- drug delivery device -- drug delivery system -- drug dosage form comparison -- drug efficacy -- drug mechanism -- Ehrlich ascites tumor -- encapsulation -- leukocyte count -- mouse -- multiple cycle treatment -- nonhuman -- oncological parameters -- tumor volume -- tumor weight -- Animalia -- Mus
Аннотация: Antitumor efficiency of an experimental form of an experimental form of anthracyclin antibiotic (doxorubicin), resorbable microparticles from Bioplastotaneв„ў, was studied on laboratory mice with transplanted Ehrlich's solid carcinoma. Use of the experimental form of the cytostatic in polymeric microparticles from resorbable Bioplastotaneв„ў in animals with solid tumor led to inhibition of the cancerous process, comparable to that in response to intravenous free doxorubicin, but without negative effects on the blood system. В© 2013 Springer Science+Business Media New York.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Division, Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Siberian Federal University, Institute of Basic Biology and Biotechnology, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.; Goreva, A.V.; Kuzmina, A.M.

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Detection of nanodiamonds in biological samples by EPR spectrometry / E. V. Inzhevatkin [et al.] // Doklad. Biochem. Biophys. - 2017. - Vol. 477, Is. 1. - P394-397, DOI 10.1134/S1607672917060138 . - ISSN 1607-6729
Аннотация: In model experiments in vitro, the applicability of the EPR spectrometry method for the detection of modified nanodiamonds (MNDs) in blood and homogenates of mouse organs has been established. A characteristic signal (g = 2.003, ?H ? 10 G) is observed in the samples of biomaterials containing MNDs, the intensity of which increases linearly with the concentration of nanoparticles in the range of 1.6–200 ?g MNDs per 1 mL of the sample. The EPR method in biomaterials reveals the presence of intrinsic paramagnetic centers, signals from which are superimposed on the signal from the MNDs. However, the intensity of these signals is small, which makes it possible to register the MNDs using EPR spectrometry with the necessary accuracy. The data obtained open up the prospects of using the EPR method for studies of the interorgan distribution, accumulation, and elimination of MNDs during their intravenous injection into experimental animals. © 2017, Pleiades Publishing, Ltd.

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Держатели документа:
International Scientific Center for Studies of Extreme States of Organism, Federal Research Center “Krasnoyarsk Scientific Center,” Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Institute of Biophysics, Federal Research Center “Krasnoyarsk Scientific Center”, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Siberian Federal University, Krasnoyarsk, Russian Federation
Institute of Chemistry and Chemical Technology, Federal Research Center “Krasnoyarsk Scientific Center,” Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Inzhevatkin, E. V.; Baron, A. V.; Maksimov, N. G.; Volkova, M. B.; Puzyr, A. P.; Bondar, V. S.

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Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma / E. V. Inzhevatkin, A. V. Baron, M. B. Volkova [et al.] // Bull. Exp. Biol. Med. - 2021, DOI 10.1007/s10517-021-05335-9 . - Article in press. - ISSN 0007-4888
Кл.слова (ненормированные):
biochemical changes in blood plasma -- biodistribution -- detonation synthesis nanodiamonds -- EPR-spectrometry -- intravenous administration
Аннотация: Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.

Scopus
Держатели документа:
International Scientific Center of Extremal Organism State Research, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Institute of Biophysics, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russian Federation
Institute of Chemistry and Chemical Technology, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Krasnoyarsk Regional Clinical Center of Maternity and Child Protection, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Inzhevatkin, E. V.; Baron, A. V.; Volkova, M. B.; Maksimov, N. G.; Golubenko, N. K.; Loshkareva, M. V.; Puzyr’, A. P.; Ronzhin, N. O.; Bondar, V. S.

Найти похожие

Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma / E. V. Inzhevatkin, A. V. Baron, M. B. Volkova [et al.] // Bull. Exp. Biol. Med. - 2021. - Vol. 172, Is. 1. - P77-80, DOI 10.1007/s10517-021-05335-9. - Cited References:9 . - ISSN 0007-4888. - ISSN 1573-8221

РУБ Medicine, Research & Experimental

Кл.слова (ненормированные):
detonation synthesis nanodiamonds -- EPR-spectrometry -- intravenous -- administration -- biodistribution -- biochemical changes in blood plasma
Аннотация: Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values.

WOS
Держатели документа:
Russian Acad Sci, Int Sci Ctr Extremal Organism State Res, Fed Res Ctr, Krasnoyarsk Sci Ctr,Siberian Div, Krasnoyarsk, Russia.
Russian Acad Sci, Fed Res Ctr, Inst Biophys, Krasnoyarsk Sci Ctr,Siberian Div, Krasnoyarsk, Russia.
Natl Res Univ, Moscow Inst Phys & Technol, Dolgoprudnyi, Moscow Region, Russia.
Russian Acad Sci, Fed Res Ctr, Inst Chem & Chem Technol, Krasnoyarsk Sci Ctr,Siberian Div, Krasnoyarsk, Russia.
Krasnoyarsk Reg Clin Ctr Matern & Child Protect, Krasnoyarsk, Russia.

Доп.точки доступа:
Inzhevatkin, E., V; Baron, A., V; Volkova, M. B.; Maksimov, N. G.; Golubenko, N. K.; Loshkareva, M., V; Puzyr', A. P.; Ronzhin, N. O.; Bondar, V. S.

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