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Biocompatibility and resorption of intravenously administered polymer microparticles in tissues of internal organs of laboratory animals / E. Shishatskaya [et al.] // Journal of Biomaterials Science, Polymer Edition. - 2011. - Vol. 22, Is. 16. - P2185-2203, DOI 10.1163/092050610X537138 . - ISSN 0920-5063
Кл.слова (ненормированные):
14C products of polymer resorption -- intravenous administration -- microparticles -- Resorbable polyhydroxybutyrate -- tissues of internal organs -- 3-hydroxybutyric acid -- sup14/supC products of polymer resorption -- Adverse effect -- Drug-delivery systems -- Growth and development -- High molecular weight -- Initial molecular weight -- Initial values -- Internal organs -- Intravenous administration -- Laboratory animals -- Local response -- matrix -- Mean diameter -- Micro-particles -- Polymer degradation -- Polymer microparticles -- Preparation process -- Radioactivity level -- Residual content -- Resorbable -- Sustained-release -- Tail veins -- Wistar rat -- Animals -- Biocompatibility -- Degradation -- Histology -- Molecular weight -- Morphology -- Radiation -- Radioactivity -- Rats -- Tissue -- poly(3 hydroxybutyric acid) -- animal experiment -- animal tissue -- article -- biocompatibility -- concentration process -- controlled study -- degradation -- drug delivery system -- female -- gel permeation chromatography -- heart -- kidney parenchyma -- liver -- lung parenchyma -- molecular weight -- nonhuman -- organ culture -- priority journal -- radioactivity -- rat -- spleen -- Animals -- Animals, Laboratory -- Biocompatible Materials -- Drug Delivery Systems -- Female -- Infusions, Intravenous -- Materials Testing -- Microspheres -- Molecular Weight -- Particle Size -- Polymers -- Rats -- Rats, Wistar -- Tissue Distribution -- Animalia -- Rattus -- Rattus norvegicus
Аннотация: Specimens of 14C-labeled polymer of 3-hydroxybutyric acid, P(3-HB), with different initial molecular weights, were used to prepare microparticles, whose morphology was not influenced by the M w of the polymer. During the particle preparation process, P(3-HB) molecular weight decreased by 15-20%. Sterile microparticles (mean diameter 2.4 ?m) were injected into the tail veins of Wistar rats (5 mg/rat). The effects of the particles administered to rats were studied based on the general response of animals and local response of internal organ tissues and blood morphology; no adverse effects on growth and development of the animals or unfavorable changes in the structure of the tissues of internal organs were observed. Measurements of radioactivity in tissues showed that 14C concentrations are different in different organs, changing during the course of the experiment. The main targets for 14C-labeled microparticles were tissues of the liver, spleen, and kidneys. Comparison of radioactivity levels and residual contents of high-molecular-weight matrix in tissues suggested that the most rapid metabolism and degradation of P(3-HB) occurred in the liver and spleen. Gel-permeation chromatography showed that at 3 h after the microparticles were injected into the bloodstream, polymer degradation started in all examined organs, except the lungs; at 12 weeks, the M w of the polymer matrix was as low as 20-30% of its initial value. The presence of high-molecular-weight (undegraded) polymer in the tissues at 12 weeks after administration of the particles suggests that P(3-HB) is degraded in tissues of internal organs slowly and, hence, P(3-HB)-based microparticles can be used as sustained-release drug-delivery systems. В© 2011 VSP.

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Держатели документа:
Institute of Biophysics, SB RAS, Akademgorodok, Krasnoyarsk 660036, Russian Federation
Siberian Federal University, Svobodnyi Avenue, Krasnoyarsk 660041, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.; Goreva, A.; Kalacheva, G.; Volova, T.

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EPR Spectrometric Estimation of the Distribution of Intravenously Injected Nanodiamonds in Mice / E. V. Inzhevatkin [et al.] // Biol. Bull. - 2019. - Vol. 46, Is. 3. - P277-283, DOI 10.1134/S1062359019020079. - Cited References:56. - This work was supported by the Russian Foundation for Basic Research, project no. 16-04-00999. . - ISSN 1062-3590. - ISSN 1608-3059

РУБ Biology
Рубрики:
DRUG-DELIVERY
   DETONATION NANODIAMONDS
   NANOMATERIALS
   PARTICLES
Аннотация: The distribution in mice of intravenously injected modified nanodiamonds (MNDs) obtained by detonation synthesis was studied using electron paramagnetic resonance (EPR) spectrometry. It has been shown that 2.5 h after MND injection into the tail vein of mice, the nanoparticles accumulate mainly in the lungs and liver of animals; much smaller amounts of nanoparticles were found in the kidneys and heart. The presence of MNDs in the samples of blood, spleen, brain, and thigh muscles of mice was not detected within the sensitivity of the method used.

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Держатели документа:
Russian Acad Sci, Int Sci Ctr Studies Extreme States Organism, Fed Res Ctr, Krasnoyarsk Sci Ctr,Siberian Branch, Akademgorodok 50, Krasnoyarsk 660036, Russia.
Russian Acad Sci, Siberian Branch, Inst Biophys, Fed Res Ctr,Krasnoyarsk Sci Ctr, Akademgorodok 50-50, Krasnoyarsk 660036, Russia.
Siberian Fed Univ, Pr Svobodnyi 79, Krasnoyarsk 660041, Russia.
Russian Acad Sci, Inst Chem & Chem Technol, Fed Res Ctr, Krasnoyarsk Sci Ctr,Siberian Branch, Akademgorodok 50-24, Krasnoyarsk 660036, Russia.

Доп.точки доступа:
Inzhevatkin, E. V.; Baron, A. V.; Maksimov, N. G.; Volkova, M. B.; Puzyr, A. P.; Bondar, V. S.; Russian Foundation for Basic Research [16-04-00999]

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Biodistribution of nanodiamonds in the body of mice using EPR spectrometry / E. Inzhevatkin [et al.] // IET Sci. Meas. Technol. - 2019. - Vol. 13, Is. 7. - P984-988, DOI 10.1049/iet-smt.2018.5594. - Cited References:32. - This work was supported by the Russian Foundation for Basic Research (project no. 16-04-00999). . - ISSN 1751-8822. - ISSN 1751-8830

РУБ Engineering, Electrical & Electronic
Рубрики:
DRUG-DELIVERY
   DETONATION NANODIAMONDS
   NANOMATERIALS
   DOXORUBICIN
Кл.слова (ненормированные):
blood -- biomedical materials -- kidney -- lung -- detonation -- diamond -- nanomedicine -- liver -- muscle -- cellular biophysics -- nanoparticles -- EPR -- imaging -- mice -- EPR spectrometry -- detonation NDs -- electron paramagnetic -- resonance spectrometry -- characteristic EPR signal -- initially injected -- NDs -- detonation -- femoral muscles -- blood -- spleen -- brain -- kidneys -- heart -- lungs -- liver -- biomaterials -- nanodiamonds -- organ homogenates -- nanoparticle concentrations -- inter-organ distribution -- time 2 -- 5 hour -- C
Аннотация: In vitro experiments proved the usefulness of electron paramagnetic resonance (EPR) spectrometry for detecting detonation nanodiamonds (NDs) in samples of biomaterials (blood and homogenates of organs of mice). A characteristic EPR signal (g = 2.003, Delta H similar or equal to 10 G) was detected in biomaterials containing NDs, and its intensity linearly increased at nanoparticle concentrations of between 1.6 and 200 mu g/ml. In vivo experiments demonstrated that EPR spectrometry was effective for monitoring the inter-organ distribution of NDs intravenously injected to mice. In 2.5 h after the injection of NDs, the nanoparticles mainly accumulated in the lungs and liver of the animals - about 25 and 20%, respectively, of the initially injected NDs. The amounts of NDs accumulated in the heart and kidneys were considerably lower. Also, EPR spectrometry did not detect NDs in the blood, spleen, brain, and femoral muscles of mice. Ten days after injection, EPR spectrometry detected redistribution of NDs in mice. The amounts of nanoparticles decreased approximately by a factor of 3.5 in the lungs and increased almost by a factor of 3 in the liver; NDs were detected in the spleen. This study suggests ways to use EPR spectrometry to study the distribution, accumulation, and elimination of detonation NDs injected into laboratory animals.

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Держатели документа:
Russian Acad Sci, Siberian Branch, Inst Biophys, Fed Res Ctr,Krasnoyarsk Sci Ctr, Krasnoyarsk, Russia.
RAS, SB, Int Sci Ctr Studies Extreme States Organism, Fed Res Ctr,Krasnoyarsk Sci Ctr, Krasnoyarsk, Russia.
Siberian Fed Univ, Krasnoyarsk, Russia.
Russian Acad Sci, Siberian Branch, Inst Chem & Chem Technol, Fed Res Ctr,Krasnoyarsk Sci Ctr, Krasnoyarsk, Russia.

Доп.точки доступа:
Inzhevatkin, Evgeny; Baron, Alexey; Maksimov, Nikolai; Volkova, Marina; Puzyr, Alexey; Ronzhin, Nikita; Bondar, Vladimir; Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR) [16-04-00999]

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The role of acidosis in the pathogenesis of severe forms of COVID-19 / Y. D. Nechipurenko, D. A. Semyonov, I. A. Lavrinenko [et al.] // Biology. - 2021. - Vol. 10, Is. 9. - Ст. 852, DOI 10.3390/biology10090852 . - ISSN 2079-7737
Кл.слова (ненормированные):
Acidosis -- Bohr effect -- COVID-19 -- Hypoxia -- Lactate -- PH -- SARS-CoV-2 -- Saturation
Аннотация: COVID-19 has specific characteristics that distinguish this disease from many other infec-tions. We suggest that the pathogenesis of severe forms of COVID-19 can be associated with acidosis. This review article discusses several mechanisms potentially linking the damaging effects of COVID-19 with acidosis and shows the existence of a vicious cycle between the development of hypoxia and acidosis in COVID-19 patients. At the early stages of the disease, inflammation, difficulty in gas exchange in the lungs and thrombosis collectively contribute to the onset of acidosis. In accordance with the Verigo-Bohr effect, a decrease in blood pH leads to a decrease in oxygen saturation, which contributes to the exacerbation of acidosis and results in a deterioration of the patient’s condition. A decrease in pH can also cause conformational changes in the S-protein of the virus and thus lead to a decrease in the affinity and avidity of protective antibodies. Hypoxia and acidosis lead to dysregu-lation of the immune system and multidirectional pro-and anti-inflammatory reactions, resulting in the development of a “cytokine storm”. In this review, we highlight the potential importance of supporting normal blood pH as an approach to COVID-19 therapy. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Scopus
Держатели документа:
Laboratory DNA-Protein Recognition, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russian Federation
Institute of Molecular Medicine and Pathobiochemistry, Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russian Federation
Institute of Biophysics Siberian Branch of Russian Academy of Sciences, Krasnoyarsk, 660036, Russian Federation
Department of Human and Animal Physiology, Faculty of Medicine and Biology, Voronezh State University, Voronezh, 394018, Russian Federation
Department of Biological and Medical Physics, Moscow Institute of Physics and Technology, Moscow Region, Dolgoprudny, 141701, Russian Federation
Department of Biophysics, Faculty of Physics, Lomonosov Moscow State University, Moscow, 119991, Russian Federation
Laboratory of Medical Analytical Methods and Devices, Institute for Analytical Instrumentation of the Russian Academy of Sciences, St. Petersburg, 198095, Russian Federation
Sendai Viralytics LLC, Acton, MA 117261, United States
Laboratory of Cellular Bases for the Development of Malignant Diseases, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russian Federation

Доп.точки доступа:
Nechipurenko, Y. D.; Semyonov, D. A.; Lavrinenko, I. A.; Lagutkin, D. A.; Generalov, E. A.; Zaitceva, A. Y.; Matveeva, O. V.; Yegorov, Y. E.

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The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19 / Y. D. Nechipurenko, D. A. Semyonov, I. A. Lavrinenko [et al.] // Biology-Basel. - 2021. - Vol. 10, Is. 9. - Ст. 852, DOI 10.3390/biology10090852. - Cited References:86. - This research was funded by the Presidium of the Russian Academy of Sciences for Molecular and Cellular Biology and the Program of Fundamental Research for State Academies for years 2013-2020, project no. 01201363818. . - ISSN 2079-7737

РУБ Biology
Рубрики:
RESPIRATORY-ACIDOSIS
   LACTATE
   COAGULATION
   GLYCOLYSIS
   SECRETION
Кл.слова (ненормированные):
SARS-CoV-2 -- COVID-19 -- acidosis -- hypoxia -- saturation -- Bohr effect -- lactate -- pH
Аннотация: Simple Summary Recently, several studies have shown that acidosis, which is increased acidity in the blood and other body tissues, is often associated with severe COVID-19. In this article, we look at the mechanisms and consequences of acidosis that can lead to an exacerbation of COVID-19. We want to draw the attention of readers to the threshold values of such disease characteristics as hypoxia and acidosis, which are associated with a sharp deterioration in the patient's condition. Hypoxia and acidosis mutually reinforce each other according to the principle of a vicious cycle (that is, they are involved in a system of positive feedbacks). Elevated blood lactate (lactic acid) levels are associated with poor clinical outcomes in COVID patients. As a practical recommendation, we propose to pay more attention to the prevention of acidosis, including in the early stages of the disease, when the adjustment of homeostasis requires less effort and is less risky. COVID-19 has specific characteristics that distinguish this disease from many other infections. We suggest that the pathogenesis of severe forms of COVID-19 can be associated with acidosis. This review article discusses several mechanisms potentially linking the damaging effects of COVID-19 with acidosis and shows the existence of a vicious cycle between the development of hypoxia and acidosis in COVID-19 patients. At the early stages of the disease, inflammation, difficulty in gas exchange in the lungs and thrombosis collectively contribute to the onset of acidosis. In accordance with the Verigo-Bohr effect, a decrease in blood pH leads to a decrease in oxygen saturation, which contributes to the exacerbation of acidosis and results in a deterioration of the patient's condition. A decrease in pH can also cause conformational changes in the S-protein of the virus and thus lead to a decrease in the affinity and avidity of protective antibodies. Hypoxia and acidosis lead to dysregulation of the immune system and multidirectional pro- and anti-inflammatory reactions, resulting in the development of a "cytokine storm". In this review, we highlight the potential importance of supporting normal blood pH as an approach to COVID-19 therapy.

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Держатели документа:
Russian Acad Sci, Engelhardt Inst Mol Biol, Lab DNA Prot Recognit, Moscow 119991, Russia.
Voyno Yasenetsky Krasnoyarsk State Med Univ, Inst Mol Med & Pathobiochem, Krasnoyarsk 660022, Russia.
Russian Acad Sci, Inst Biophys, Siberian Branch, Krasnoyarsk 660036, Russia.
Voronezh State Univ, Fac Med & Biol, Dept Human & Anim Physiol, Voronezh 394018, Russia.
Moscow Inst Phys & Technol, Dept Biol & Med Phys, Dolgoprudnyi 141701, Russia.
Lomonosov Moscow State Univ, Fac Phys, Dept Biophys, Moscow 119991, Russia.
Russian Acad Sci, Lab Med Analyt Methods & Devices, Inst Analyt Instrumentat, St Petersburg 198095, Russia.
Sendai Viralyt LLC, Acton, MA USA.
Russian Acad Sci, Engelhardt Inst Mol Biol, Lab Cellular Bases Dev Malignant Dis, Moscow 119991, Russia.

Доп.точки доступа:
Nechipurenko, Yury D.; Semyonov, Denis A.; Lavrinenko, Igor A.; Lagutkin, Denis A.; Generalov, Evgenii A.; Zaitceva, Anna Y.; Matveeva, Olga, V; Yegorov, Yegor E.; Lagutkin, Denis; Presidium of the Russian Academy of Sciences for Molecular and Cellular Biology; Program of Fundamental Research for State Academies for years 2013-2020 [01201363818]

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Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma / E. V. Inzhevatkin, A. V. Baron, M. B. Volkova [et al.] // Bull. Exp. Biol. Med. - 2021, DOI 10.1007/s10517-021-05335-9 . - Article in press. - ISSN 0007-4888
Кл.слова (ненормированные):
biochemical changes in blood plasma -- biodistribution -- detonation synthesis nanodiamonds -- EPR-spectrometry -- intravenous administration
Аннотация: Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.

Scopus
Держатели документа:
International Scientific Center of Extremal Organism State Research, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Institute of Biophysics, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russian Federation
Institute of Chemistry and Chemical Technology, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Krasnoyarsk Regional Clinical Center of Maternity and Child Protection, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Inzhevatkin, E. V.; Baron, A. V.; Volkova, M. B.; Maksimov, N. G.; Golubenko, N. K.; Loshkareva, M. V.; Puzyr’, A. P.; Ronzhin, N. O.; Bondar, V. S.

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Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma / E. V. Inzhevatkin, A. V. Baron, M. B. Volkova [et al.] // Bull. Exp. Biol. Med. - 2021. - Vol. 172, Is. 1. - P77-80, DOI 10.1007/s10517-021-05335-9. - Cited References:9 . - ISSN 0007-4888. - ISSN 1573-8221

РУБ Medicine, Research & Experimental

Кл.слова (ненормированные):
detonation synthesis nanodiamonds -- EPR-spectrometry -- intravenous -- administration -- biodistribution -- biochemical changes in blood plasma
Аннотация: Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values.

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Держатели документа:
Russian Acad Sci, Int Sci Ctr Extremal Organism State Res, Fed Res Ctr, Krasnoyarsk Sci Ctr,Siberian Div, Krasnoyarsk, Russia.
Russian Acad Sci, Fed Res Ctr, Inst Biophys, Krasnoyarsk Sci Ctr,Siberian Div, Krasnoyarsk, Russia.
Natl Res Univ, Moscow Inst Phys & Technol, Dolgoprudnyi, Moscow Region, Russia.
Russian Acad Sci, Fed Res Ctr, Inst Chem & Chem Technol, Krasnoyarsk Sci Ctr,Siberian Div, Krasnoyarsk, Russia.
Krasnoyarsk Reg Clin Ctr Matern & Child Protect, Krasnoyarsk, Russia.

Доп.точки доступа:
Inzhevatkin, E., V; Baron, A., V; Volkova, M. B.; Maksimov, N. G.; Golubenko, N. K.; Loshkareva, M., V; Puzyr', A. P.; Ronzhin, N. O.; Bondar, V. S.

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