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Evaluation of antitumor activity of rubomycin deposited in absorbable polymeric microparticles / E. I. Shishatskaya [et al.] // Bulletin of Experimental Biology and Medicine. - 2008. - Vol. 145, Is. 3. - P358-361, DOI 10.1007/s10517-008-0091-9 . - ISSN 0007-4888
Кл.слова (ненормированные):
Absorbable polymers -- Ehrlich's ascitic carcinoma -- Microencapsulation -- Polyhydroxybutyrate -- Rubomycin -- poly(3 hydroxybutyric acid) -- polymer -- rubomycin -- animal cell -- animal experiment -- animal model -- antineoplastic activity -- article -- Bagg albino mouse -- cancer inhibition -- cancer mortality -- cancer survival -- controlled study -- drug delivery system -- Ehrlich ascites tumor -- microencapsulation -- mouse -- nonhuman -- polymerization -- survival rate -- tumor cell -- tumor volume -- Absorption -- Animals -- Antibiotics, Antineoplastic -- Carcinoma, Ehrlich Tumor -- Daunorubicin -- Hydroxybutyrates -- Mice -- Mice, Inbred BALB C -- Microspheres -- Polyesters -- Mus
Аннотация: An experimental dosage form of rubomycin is developed: the drug is incorporated in absorbable polymeric (polyhydroxybutyrate) matrix in the form of microparticles. Antitumor efficiency of this rubomycin dosage form was studied in laboratory mice with transplanted Ehrlich ascitic carcinoma. Rubomycin deposited in polymeric microparticles exhibited pronounced antitumor activity, inhibited the proliferative activity of Ehrlich ascitic carcinoma, and improved survival of mice with tumors. This dosage form of the drug can be used for local injections. В© Springer Science+Business Media, Inc. 2008.

Scopus
Держатели документа:
Institute of Biophysics, Siberian Division of Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Siberian Federal University, Krasnoyarsk, Russian Federation
International Center for Studies of Critical Conditions, Presidium of Krasnoyarsk Research Center of Siberian Division of Russian Academy of Sciences, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Shishatskaya, E.I.; Goreva, A.V.; Voinova, O.N.; Inzhevatkin, E.V.; Khlebopros, R.G.; Volova, T.G.

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In vitro justification of using endobiliary stents made of polyhydroxyalkanoates / N. M. Markelova [et al.] // Macromolecular Symposia. - 2008. - Vol. 269, Is. 1. - P82-91, DOI 10.1002/masy.200850910 . - ISSN 1022-1360
Кл.слова (ненормированные):
Bioresorbable materials -- Endobiliary stents -- Mechanical jaundice (MJ) -- PHAs -- ABS resins -- Biopolymers -- Biotechnology -- Body fluids -- Experiments -- Free radical polymerization -- Liver -- Polymers -- Prosthetics -- Silicon -- Surgery -- Turbulent flow -- Abdominal cavities -- Bile ducts -- Biliary -- Biological properties -- Bioresorbable materials -- Blood analyses -- Endobiliary stents -- Endoprosthesis -- Experimental groups -- Experimental models -- In vitro -- Inflammatory reactions -- Macroscopic changes -- Mechanical jaundice (MJ) -- Minimally invasive -- Negative controls -- PHAs -- Polyhydroxyalkanoates -- Positive control groups -- Radical surgeries -- Reconstructive surgeries -- Suture materials -- Biological materials
Аннотация: Treatment of patients with mechanical jaundice (MJ) has been one of the topical problems of current medicine. The fraction of patients having MJ of oncologic character that can undergo radical surgery does not exceed 25-30%. A way out of such situation is to use minimally invasive endobiliary interventions, the main type of which is endoprosthesis replacement of bile duct lumens. The aim of the work was to study the biological properties of the experimental models of polymer stents made of PHA for endobiliary prosthetics and to investigate the biological properties of PHA suture material for forming of biliary-enteric anastomoses (cholecystoduodenostomy). Experiments were performed on 20 adult mongrel dogs, weighing 10-12 kg. The animals were divided to three groups: the negative control group (intact animals); the positive control group (the animals with implanted endobiliary silicon stents); and the experimental group (the animals with the PHA stents). The animals were monitored for 100 days. The clinical blood analysis was made before the operation, on day 7, 30, 60 and 100 days. During autopsy the presence of exudate, commissural process in the free abdominal cavity and subhepatic spatium, the appearance of choledoch where the prosthesis was located, as well as the appearance of cholecystoenterostomy, liver and duodenum. We did not found any signs of inflammation, cicatrical changes were estimated in the free abdominal cavity and subhepatic spatium. All implanted PHA stents were at their initial places of implantation. After the end of the experiment inflammatory reaction and anastomositis were absent. Macroscopic changes of liver and duodenum were also not detected. Liver function did not have any pathological deviations. These positive results give grounds to conclude that application of PHA as endobiliary stents in reconstructive surgery of bile passages and as suture material is a promising technology. Copyright В© 2008 WILEY-VCH Verlag GmbH & Co. KGaA.

Scopus
Держатели документа:
Krasnoyarsk State Medical Academy, Partizana Zheleznyaka Street, 1, 660022, Krasnoyarsk, Russian Federation
Institute of Biophysics, SB, RAS, Akademgorodok, 660036, Krasnoyarsk, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Markelova, N.M.; Shishatskaya, E.I.; Vinnik, Y.S.; Cherdantsev, D.V.; Beletskiy, I.I.; Kuznetsov, M.N.; Zykova, L.D.

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A glucose-utilizing strain, cupriavidus euthrophus B-10646: Growth kinetics, characterization and synthesis of multicomponent PHAs / T. Volova [et al.] // PLoS ONE. - 2014. - Vol. 9, Is. 2, DOI 10.1371/journal.pone.0087551 . - ISSN 1932-6203
Кл.слова (ненормированные):
3 hydroxybutyrate 3 hydroxyhexanoate 3 hydroxyvalerate copolymer -- 3 hydroxybutyrate 4 hydroxybutyrate 3 hydroxyvalerate copolymer -- copolymer -- gamma butyrolactone -- glucose -- hexanoic acid -- poly(3 hydroxybutyric acid) -- polyhydroxyalkanoic acid -- polystyrene -- propionic acid -- unclassified drug -- valeric acid -- animal cell -- article -- bacterial growth -- bacterium culture -- cell adhesion -- cell proliferation -- crystal structure -- culture optimization -- Cupriavidus -- Cupriavidus euthrophus -- decomposition -- elasticity -- film -- glucose utilization -- kinetics -- mechanics -- melting point -- mouse -- nonhuman -- nucleotide sequence -- physical chemistry -- polymerization -- strength -- synthesis
Аннотация: This study investigates kinetic and production parameters of a glucose-utilizing bacterial strain, C. eutrophus B-10646, and its ability to synthesize PHA terpolymers. Optimization of a number of parameters of bacterial culture (cell concentration in the inoculum, physiological activity of the inoculum, determined by the initial intracellular polymer content, and glucose concentration in the culture medium during cultivation) provided cell concentrations and PHA yields reaching 110 g/L and 80%, respectively, under two-stage batch culture conditions. Addition of precursor substrates (valerate, hexanoate, propionate, ?-butyrolactone) to the culture medium enabled synthesis of PHA terpolymers, P(3HB/3HV/4HB) and P(3HB/ 3HV/3HHx), with different composition and different molar fractions of 3HB, 3HV, 4HB, and 3HHx. Different types of PHA terpolymers synthesized by C. eutrophus B-10646 were used to prepare films, whose physicochemical and physical-mechanical properties were investigated. The properties of PHA terpolymers were significantly different from those of the P3HB homopolymer: they had much lower degrees of crystallinity and lower melting points and thermal decomposition temperatures, with the difference between these temperatures remaining practically unchanged. Films prepared from all PHA terpolymers had higher mechanical strength and elasticity than P3HB films. In spite of dissimilar surface structures, all films prepared from PHA terpolymers facilitated attachment and proliferation of mouse fibroblast NIH 3T3 cells more effectively than polystyrene and the highly crystalline P3HB. Copyright: © 2014 Volova et al.

Scopus
Держатели документа:
Institute of Biophysics of Siberian Branch of Russian Academy of Sciences, Krasnoyarsk, Russian Federation
Siberian Federal University, Krasnoyarsk, Russian Federation
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, Moscow, Russian Federation : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Volova, T.; Kiselev, E.; Vinogradova, O.; Nikolaeva, E.; Chistyakov, A.; Sukovatiy, A.; Shishatskaya, E.

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Pre-biotic stage of life origin under non-photo synthetic conditions [Text] / S. I. Bartsev, V. V. Mezhevikin ; ed. SI Bartse // SPACE LIFE SCIENCES: CLOSED ECOLOGICAL SYSTEMS: EARTH AND SPACE APPLICATIONS. Ser. ADVANCES IN SPACE RESEARCH : PERGAMON-ELSEVIER SCIENCE LTD, 2005. - Vol. 35: Workshop on Closed Ecological Systems (JUL, 2004, Paris, FRANCE), Is. 9. - P. 1643-1647, DOI 10.1016/j.asr.2005.04.072. - Cited References: 14 . - ISBN 0273-1177

РУБ Engineering, Aerospace + Astronomy & Astrophysics + Ecology + Geosciences, Multidisciplinary + Meteorology & Atmospheric Sciences

Кл.слова (ненормированные):
life origin -- pre-biotic autocatalytic system -- phase-separated autocatalytic particles -- multivariate oligomeric autocatalyst
Аннотация: Spontaneous assembling of a simplest bacterial cell even if all necessary molecules are present in a solution seems to be extremely rare event and from the scientific standpoint has to be considered as impossible. Therefore, a predecessor of a living cell has to be very simple for providing its self-assembling and at the same time it should be able of progressive increase in complexity. Now phase-separated particles, first of all micelles, are put forward as possible predecessors of living cell. According to the offered working concept only phase-separated particles possessing autocatalytic properties can be considered as predecessors of living cells. The first stage of evolution of these phase-separated autocatalytic systems is the appearance of pre-biotic metabolism providing synthesis of amphiphiles for formation of capsules of these systems. This synthesis is maintained by the energy of a base reaction being a component of a planet-chemical cycle. Catalytic system providing functioning of pre-biotic metabolism is based on multivariate oligomeric autocatalyst, which reproduces itself from monomers, penetrating the particles from the outside. Since the autocatalyst realizes random polymerization then a collection of other oligomers possessing different catalytic functions is produced. In the paper the functioning of multivariate oligomeric autocatalyst in flow reactor is analyzed. (c) 2005 Published by Elsevier Ltd on behalf of COSPAR.

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Держатели документа:
Russian Acad Sci, Siberian Branch, Inst Biophys, Lab Theoret Biophys, Krasnoyarsk 660036, Russia
ИБФ СО РАН : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Bartsev, S.I.; Mezhevikin, V.V.; Bartse, SI \ed.\

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A novel method of fabricating polymer tubes using the casting solution technique / A. N. Boyandin, A. A. Sukhanova, V. V. Orlova, A. I. Volchek // Mater Lett. - 2021. - Vol. 282. - Ст. 128833, DOI 10.1016/j.matlet.2020.128833 . - ISSN 0167-577X
Кл.слова (ненормированные):
Biopolymers -- Polyesters -- Polyhydroxyalkanoates -- Polylactide -- Polymeric tube -- Tube template -- Fabrication -- Polyesters -- Ring opening polymerization -- Silicones -- Casting solutions -- Hydroxyvalerate -- Inner diameters -- Microbial polyesters -- Poly-3-hydroxybutyrate -- Poly-L-lactide -- Solution casting -- Solvent vapors -- Tubes (components)
Аннотация: A procedure has been developed to fabricate polymer tubes using solution casting inside template tubes. Polyester solution placed inside the vertically fixed template evaporated forming a hollow tube on the inner walls of the template. Silicone tubes used as the templates were permeable to solvent vapors and had relatively low adhesion to materials of the fabricated tubes, enabling their effortless removal. Parameters of the polymer tubes were determined by a type of the polymer, its concentration in the solution, and the inner diameter of the template. In the first method, a clamp was placed on the lower end of the template tube. A thickness of the new tube walls gradually increased from the open to the clamped end of the template tube. In another method viscous polymer solution without clamping was used; in this case, a polymeric bulkhead was formed in the middle of the tube. Two microbial polyesters, poly-3-hydroxybutyrate and poly-3-hydroxybutyrate-co-3-hydroxyvalerate, and also synthetic poly-L-lactide were used as model polymers. © 2020 Elsevier B.V.

Scopus
Держатели документа:
Reshetnev Siberian State University of Science and Technology, 31 Krasnoyarsky Rabochy Av., Krasnoyarsk, 660037, Russian Federation
Institute of Biophysics of the Siberian Branch of the Russian Academy of Sciences, Federal Research Center “Krasnoyarsk Science Center SB RAS”, 50/50 Akademgorodok, Krasnoyarsk, 660036, Russian Federation
Siberian Federal University, 79 Svobodnyi Av., Krasnoyarsk, 660041, Russian Federation

Доп.точки доступа:
Boyandin, A. N.; Sukhanova, A. A.; Orlova, V. V.; Volchek, A. I.

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