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Porous 3D implants of degradable poly-3-hydroxybutyrate used to enhance regeneration of rat cranial defect / A. A. Shumilova [et al.] // J. Biomed. Mater. Res. Part A. - 2017. - Vol. 105, Is. 2. - P566-577, DOI 10.1002/jbm.a.35933. - Cited References:53. - Contract grant sponsor: The state budget allocated to the fundamental research at the Russian Academy of Sciences; contract grant number: 01201351505 . - ISSN 1549-3296. - ISSN 1552-4965

РУБ Engineering, Biomedical + Materials Science, Biomaterials
Рубрики:
BONE TISSUE REGENERATION
   CRITICAL SIZE DEFECT
   IN-VITRO
   CALVARIAL
Кл.слова (ненормированные):
3D implants -- poly-3-hydroxybutyrate -- MSC differentiation -- grafts for -- osteogenesis -- regeneration of defect cranial
Аннотация: The study describes preparation and testing of porous 3D implants of natural degradable polymer of 3-hydroxybutyric acid P(3HB) for regeneration of bone tissue defects. The ability of the P(3HB) implants to favor attachment and facilitate proliferation and directed differentiation of mesenchymal stem cells (MSCs) was studied in the culture of MSCs isolated from bone marrow and adipose tissue. Tissue-engineered hybrid systems (grafts) constructed using P(3HB) and P(3HB) in combination with osteoblasts were used in experiments on laboratory animals (n=48) with bone defect model. The defect model (5 mm in diameter) was created in the rat parietal bone, and filling of the defect by the new bone tissue was monitored in the groups of animals with P(3HB) implants, with commercial material, and without implants (negative control). Computed tomography (CT) and histologic examination showed that after 120 days, in the group with the osteoblast-seeded P(3HB) implants, the defect was completely closed; in the group with the cell-free P(3HB) implants, the remaining defect was no more than 10% of the initial one (0.5 mm); in both the negative and positive controls, the size of the defect was about 1.0-1.2 mm. These results suggest that P(3HB) has good potential as osteoplastic material for reconstructive osteogenesis. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 566-577, 2017.

WOS,
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Держатели документа:
Siberian Fed Univ, 79 Svobodnyi Ave, Krasnoyarsk 660041, Russia.
Russian Acad Sci, Siberian Branch, Inst Biophys, Krasnoyarsk 660036, Russia.
VF Voino Yasenetsky Krasnoyarsk State Med Univ, 1 Partizan Zheleznyak St, Krasnoyarsk 660022, Russia.

Доп.точки доступа:
Shumilova, A. A.; Myltygashev, M. P.; Kirichenko, A. K.; Nikolaeva, E. D.; Volova, T. G.; Shishatskaya, E. I.; Russian Academy of Sciences [01201351505]

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