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THE ENTRY INTO S-PERIOD OF NUCLEI IN HETERODIKARYONS MODIFIED BY THE CYCLOHEXIMIDE [Текст] / N. A. SETKOV, V. N. KAZAKOV, T. V. ANDREEVA // TSITOLOGIYA. - 1991. - Vol. 33, Is. 12. - P. 73-78. - Cited References: 16 . - ISSN 0041-3771

РУБ Cell Biology
Рубрики:
NIH 3T3 CELLS
   DNA-SYNTHESIS
   RESTING CELLS
   C-MYC
   FUSION
   FIBROBLASTS
   EXPRESSION
   GENES
Аннотация: Serum-deprived (0.2%) resting NIH 3T3 mouse fibroblasts were fused with serum-stimulated (10%) proliferating cells to elucidate mechanisms of entering into S-period operating in the nuclei of the heterokaryons under the effect of cycloheximide - an inhibitor of protein synthesis. Using radioautography DNA synthesis was investigated in mono-, homo- and heterodikaryons. After short (0.5-3.0 h) depressing of protein synthesis, the nuclei of stimulated cells in heterokaryons were found to enter into S-period. Under these conditions no induction of DNA synthesis was found in the nuclei of resting cells in heterodikaryons. In other experiments, resting cells were under the effect of cycloheximide during 2-4 h before the fusion, that led to a great induction of DNA synthesis in the nuclei of these cells in heterodikaryons. The data obtained are consistent with the idea of fibroblast transition to the rest under the action of labile proteins-repressors.

WOS : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
SETKOV, N.A.; KAZAKOV, V.N.; ANDREEVA, T.V.

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HEPATOCYTES IN HETEROKARYONS DO NOT RETARD THE ENTRY OF STIMULATED FIBROBLAST NUCLEI INTO THE S-PERIOD [Текст] / N. A. SETKOV, V. N. KAZAKOV, T. V. ANDREYEVA // TSITOLOGIYA. - 1991. - Vol. 33, Is. 6. - P. 76-85. - Cited References: 39 . - ISSN 0041-3771

РУБ Cell Biology
Рубрики:
HUMAN-DIPLOID FIBROBLASTS
   LIVER PLASMA-MEMBRANES
   DNA-SYNTHESIS
   PRIMARY CULTURE
   MOUSE HEPATOCYTES
   CELLS INVITRO
   SENESCENT
   GROWTH
   INHIBIT
   PHASE
Аннотация: Serum-deprived (0.2 %) resting and serum-stimulated (10 %) proliferating NIH 3T3 mouse fibroblasts were fused with hepatocytes from intact, regenerating and embryonic mouse livers to elucidate mechanisms of liver cell proliferation, DNA synthesis being investigated in nuclei of heterokaryons and non-fused cells using radioautography. Hepatocytes in heterokaryons were found to have no inhibitory effect on the entry of stimulated fibroblast nuclei into the S-period, but on the contrary they were involved in DNA synthesis. In addition, the nuclei in heterokaryons mutually stimulated each other to enter the S-period. In their turn, the resting fibroblasts did not prevent the proliferating hepatocytes from the regenerating and embryonic livers to enter the S-period. Possible reasons of the absence of inhibitory effect of differentiated cells in heterokaryons are discussed. The data obtained enable us to conclude that the mechanism of proliferative process control in resting immortalized cells differs from that in differentiated cells where proliferation seems to be stopped without affecting the endogenous inhibitor postulated for the resting and ageing fibroblasts.

WOS : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
SETKOV, N.A.; KAZAKOV, V.N.; ANDREYEVA, T.V.

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Negative control of cell proliferation depend on protein synthesis in resting cells [Текст] / N. A. Setkov // Dokl. Akad. Nauk. - 1996. - Vol. 346, Is. 5. - P. 708-711. - Cited References: 15 . - ISSN 0869-5652

РУБ Multidisciplinary Sciences
Рубрики:
C-FOS
   SYNTHESIS INHIBITORS
   3T3 CELLS
   TRANSCRIPTIONAL ACTIVATION
   DNA-SYNTHESIS
   FIBROBLASTS
   NUCLEI
   FUSION
   MYC
   JUN

WOS : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Setkov, N.A.

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Inhibitors of protein biosynthesis can stimulate proliferation of mouse hepatocytes in vitro [Text] / N. A. Setkov, A. V. Eremeev // Biol. Bull. - 2003. - Vol. 30, Is. 3. - P. 212-219, DOI 10.1023/A:1023843409416. - Cited References: 43 . - ISSN 1062-3590

РУБ Biology
Рубрики:
TRANSFORMING-GROWTH-FACTOR
   RAT-LIVER REGENERATION
   FACTOR-BETA
   DNA-SYNTHESIS
   PRIMARY CULTURE
   PARTIAL-HEPATECTOMY
   EPITHELIAL-CELLS
   EXPRESSION
   MECHANISMS
   MODULATION
Аннотация: Hepatocyte proliferation in the liver regenerating after partial hepatectomy ceases when the organ is restored, and the mechanism of this phenomenon is still unclear. In the experiments on fusing hepatocytes from the reoenerated mouse liver (15 days after partial hepatectomy) with NIH 3T3 mouse fibroblasts, we revealed no DNA synthesis in the nuclei of stimulated fibroblasts in heterokaryons (in the presence of hepatocyte nuclei), whereas DNA synthesis in nonfused cells was undisturbed. In this work, our purpose was to find out whether the suppression of DNA synthesis in heterokaryons could be due to the appearance in hepatocytes of some endogenous factors having an inhibitory effect on proliferation. To this end, hepatocytes from the mouse liver regenerated after partial hepatectomy were treated with cycloheximide for 1-4 h and were then fused with stimulated fibroblasts. Such a short-term treatment of hepatocytes with cycloheximide proved to result in the loss of their ability to inhibit DNA synthesis in the nuclei of stimulated or quiescent fibroblasts in heterokaryons, but hepatocytes proper actively proliferated in the medium with a low serum content (0.2%). When the mice with the liver reoenerated after partial hepatectomy were treated with a single sublethal dose of cycloheximide (3 mg/kg), their hepatocytes taken two days after this treatment had no inhibitory effect. Puromycin, another inhibitor of protein synthesis, had the same effect on hepatocytes. These results may be interpreted as evidence that the final stage of liver regeneration after damage is controlled by the factors having a C C negative effect on cell proliferation.

WOS
Держатели документа:
Russian Acad Sci, Inst Biophys, Siberian Branch, Krasnoyarsk 660036, Russia
ИБФ СО РАН : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Setkov, N.A.; Eremeev, A.V.

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