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Characterization of polymeric microparticles based on resorbable polyesters of oxyalkanoic acids as a platform for deposition and delivery of drugs / A. V. Goreva [et al.] // Polym. Sci. Ser. A. - 2012. - Vol. 54, Is. 2. - P94-105, DOI 10.1134/S0965545X12020022. - Cited References: 33. - This work was supported by the program for Support of Leading Scientific Schools of the Russian Federation (project no. 11.G34.31.0013.2010, Biotechnology of New Biomaterials) and the program of integrated studies of the Presidium of the Siberian Branch, Russian Academy of Sciences (project no. 93). . - 12. - ISSN 0965-545X

РУБ Polymer Science
Рубрики:
IN-VITRO RELEASE
   POLYHYDROXYBUTYRATE MICROSPHERES
   BLENDS
   RIFAMPICIN
   BIOCOMPATIBILITY
   DEGRADATION
   FORMULATION
   COMPOSITE
   CARRIERS
   MODEL
Аннотация: The effect of the preparation technique (chemical composition of a polymer, type and method of emulsion mixing, and molecular mass of a drug) on the yield, structure, and size of microparticles obtained from resorbable polyesters of microbiological origin, polyhydroxyalkanoates, is studied. It is found that the concentration of the polymer solution and the method of emulsion mixing are the most significant factors affecting the diameter of microparticles based on polyhydroxyalkanoates; the surface structure of particles depends to a higher extent on the chemical composition of the polymer. The family of microparticles from 100-200 nm to 50-70 mu m in diameter is synthesized. It is shown that the rate of drug release from microparticles in vitro into the medium is higher in the case of 3-hydroxybutyrate copolymers with 3-hydroxyvalerate than in the case of the homopolymer of 3-hydroxybutyrate. This parameter increases with the content of 3-hydroxyvalerate units in the copolymer and the porosity and mass fraction of the drug in particles with a decrease in their sizes. For in vitro systems containing a phosphate buffer, variation in the preparation parameters makes it possible to obtain microparticles with various characteristics suitable for deposition of drugs. For microparticles obtained from polyhydroxyalkanoates and having different diameters, the mathematical description of the kinetics of drug release from the polymer matrix is provided.

Держатели документа:
[Goreva, A. V.
Shishatskaya, E. I.
Volova, T. G.] Russian Acad Sci, Siberian Branch, Inst Biophys, Krasnoyarsk 660036, Russia
[Shishatskaya, E. I.
Volova, T. G.] Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Krasnoyarsk 660041, Russia
[Goreva, A. V.
Sinskey, A. J.] MIT, Cambridge, MA 02139 USA : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Goreva, A.V.; Shishatskaya, E.I.; Volova, T.G.; Sinskey, A.J.

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ELECTRON EXCITED-STATES IN BIOLUMINESCENCE [Текст] / N. S. KUDRYASHEVA [и др.] // DOKLADY AKADEMII NAUK SSSR. - 1991. - Vol. 321, Is. 4. - С. 837-841. - Cited References: 15 . - 5. - ISSN 0002-3264

РУБ Multidisciplinary Sciences
Рубрики:
MODEL

Держатели документа:
LY KARPOV PHYS CHEM RES INST,MOSCOW,USSR : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
KUDRYASHEVA, N.S.; BELOBROV, P.I.; KRATASYUK, V.A.; SHIGORIN, D.N.

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The carbon cycle in a bioregenerative life support system with a soil-like substrate [Text] / Y. L. Gurevich [et al.] // Acta Astronaut. - 2008. - Vol. 63: 16th IAA Humans in Space Symposium (MAY 20-24, 2007, Beijing, PEOPLES R CHINA), Is. 07.10.2013. - P1043-1048, DOI 10.1016/j.actaastro.2008.03.009. - Cited References: 28 . - 6. - ISSN 0094-5765

РУБ Engineering, Aerospace
Рубрики:
ECOSYSTEM
PLANTS
MODEL
Кл.слова (ненормированные):
life support system -- soil-like substrate -- carbon cycle -- mass-flow model
Аннотация: A mass-flow model of carbon cycle in a bioregenerative life support system (BLSS) including Resource, Plant Growth, Food Processing, Human, Waste Processing, and Waste Storage Modules was developed. A human received food from Plant Growth and Resource Modules. Plants were assumed to be growing on the soil-like substrate (SLS). Another function of SLS was balancing the carbon cycle. The input of BLSS was set to 81 g of carbon per day along with food from the Resource Module. To balance the carbon cycle an equal arnount of carbon was removed from BLSS along with urine, feces, plant wastes, and SLS. A mass flow of carbon cycle was used to simulate the effect of light intensity on the basic parameters of the Plant Growth Module. It was calculated that the stationary dry mass of SLS increases from 10 to 35 kg m(-2) with increase canopy-level daily photosynthetic photon flux (PPF) from 34 to 178 mol m(-2) d(-1). On the contrary dry mass of SLS needed to provide one person with plant food is not dependent on light intensity. (C) 2008 Elsevier Ltd. All rights reserved.

Держатели документа:
[Gurevich, Yu. L.
Manukovsky, N. S.
Kovalev, V. S.
Degermendzy, A. G.] Russian Acad Sci, Inst Biophys, Siberian Branch, Krasnoyarsk 660036, Russia
[Hu, Dawei
Liu, Hong] Beijing Univ Aeronaut & Astronaut, Dept Bioengn, Beijing 100083, Peoples R China
[Hue, EnZhu] Beijing Univ Aeronaut & Astronaut, Dept Environm Engn, Beijing 100083, Peoples R China : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
Gurevich, Y.L.; Manukovsky, N.S.; Kovalev, V.S.; Degermendzy, A.G.; Hu, D.W.; Hue, E.Z.; Liu, H...

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Protein biosensor based on Schottky barrier nanowire field effect transistor / T. E. Smolyarova, L. V. Shanidze, A. V. Lukyanenko [et al.] // Talanta. - 2022. - Vol. 239. - Ст. 123092, DOI 10.1016/j.talanta.2021.123092. - Cited References:44. - The reported study was funded by RFBR according to the research project N? 20-32-90134. The authors thank RFBR, Krasnoyarsk Terri-tory and Krasnoyarsk Regional Fund of Science (projects nos. 20-42-243007 and 20-42-240013) and the Government of the Russian Feder-ation, Mega Grant for the Creation of Competitive World-Class Labora-tories (Agreement no. 075-15-2019-1886) for financial support. Electron microscopy investigations were conducted with the help of equipment of the Krasnoyarsk Territorial Shared Resource Center, Krasnoyarsk Scientific Center, Russian Academy of Sciences. . - ISSN 0039-9140. - ISSN 1873-3573

РУБ Chemistry, Analytical
Рубрики:
SIMULATION
MODEL
Кл.слова (ненормированные):
Silicon-on-insulator -- Schottky contacts FET -- Si nanowire biosensor -- Back -- gate nanowire FET
Аннотация: A top-down nanofabrication approach involving molecular beam epitaxy and electron beam lithography was used to obtain silicon nanowire-based back gate field-effect transistors with Schottky contacts on silicon-oninsulator (SOI) wafers. The resulting device is applied in biomolecular detection based on the changes in the drain-source current (I-DS). In this context, we have explained the physical mechanisms of charge carrier transport in the nanowire using energy band diagrams and numerical 2D simulations in TCAD. The results of the experiment and numerical modeling matched well and may be used to develop novel types of nanowire-based biosensors.

WOS
Держатели документа:
Fed Res Ctr KSC SB RAS, Kirensky Inst Phys, Krasnoyarsk 660036, Russia.
Fed Res Ctr KSC SB RAS, Krasnoyarsk 660036, Russia.
Fed Res Ctr KSC SB RAS, Inst Biophys, Krasnoyarsk 660036, Russia.
Siberian Fed Univ, Krasnoyarsk 660041, Russia.
Krasnoyarsk State Med Univ, Krasnoyarsk 660022, Russia.

Доп.точки доступа:
Smolyarova, Tatyana E.; Shanidze, Lev, V; Lukyanenko, Anna, V; Baron, Filipp A.; Krasitskaya, Vasilisa V.; Kichkailo, Anna S.; Tarasov, Anton S.; Volkov, Nikita; Tarasov, Anton; Kichkailo, Anna; Baron, Filipp; Smolyarova, Tatyana; RFBRRussian Foundation for Basic Research (RFBR) [20-32-90134]; Krasnoyarsk Regional Fund of Science [20-42-243007, 20-42-240013]; Government of the Russian Feder-ation, Mega Grant for the Creation of Competitive World-Class Labora-tories [075-15-2019-1886]; RFBRRussian Foundation for Basic Research (RFBR); Krasnoyarsk Terri-tory

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