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INTRONS DIFFER FROM EXONS BY THEIR REDUNDANCY [Текст] / T. G. POPOVA, M. G. SADOVSKII // Genetika. - 1995. - Vol. 31, Is. 10. - P. 1365-1369. - Cited References: 12 . - ISSN 0016-6758

РУБ Genetics & Heredity
Рубрики:
SEQUENCES
DNA
Аннотация: This paper is devoted to an analysis of the intrinsic structure of the gene from the point of view of the redundancy of different structural units - exons and introns. Human genes for which the exon-intron structure has - been clearly established were Studied. The redundancy of each exon and intron in the gene was determined. It was shown that, in human genes, introns are more redundant than exons. Redundancy is determined as the smallest length of a word (oligonucleotide) beginning with which all words in the studied nucleotide sequence are found exactly once. Mechanisms leading to the disruption of the general pattern of ratios of redundancy of exons and introns are studied.

WOS : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
POPOVA, T.G.; SADOVSKII, M.G.

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REDUNDANCY OF EUKARYOTIC DNA DECREASES AFTER EXCISION OF INTRONS [Text] / T. G. POPOVA, M. G. SADOVSKII // Mol. Biol. - 1995. - Vol. 29, Is. 3. - P. 281-285. - Cited References: 23 . - ISSN 0026-8933

РУБ Biochemistry & Molecular Biology
Рубрики:
SEQUENCES
Кл.слова (ненормированные):
EXON -- INTRON -- WORD -- FREQUENCY -- REDUNDANCY
Аннотация: The article is devoted to analysis of the internal gene structure with respect to redundancy of exons and introns. Human genes with precisely determined exon-intron structure were studied. Redundancy of each exon and intron within a certain gene was measured. In the analyzed human genes, introns were more redundant than exons. Redundancy was determined as the minimal length of a word (oligonucleotide) that is present as a single copy within the nucleotide sequence studied. Mechanisms are discussed that lead to disturbances in the relationships found between the redundancies of exons and introns.

WOS : 660036, Красноярск, Академгородок, д. 50, стр. 50

Доп.точки доступа:
POPOVA, T.G.; SADOVSKII, M.G.

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Development and characterization of novel 2 '-F-RNA aptamers specific to human total and glycated hemoglobins / A. Davydova [et al.] // Anal. Biochem. - 2019. - Vol. 570. - P43-50, DOI 10.1016/j.ab.2019.02.004. - Cited References:32. - We want to thank Dr. Alexander Lomzov (ICBFM SB RAS) for his valuable assistance with circular dichroism studies. The work was supported by the Russian Science Foundation (grant number 16-14-10296). . - ISSN 0003-2697. - ISSN 1096-0309

РУБ Biochemical Research Methods + Biochemistry & Molecular Biology
Рубрики:
RNA APTAMER
   SEQUENCES
   PROTEIN
   DNA
Аннотация: Aptamers are short DNA and RNA fragments which bind their molecular targets with affinity and specificity comparable to those of antibodies. Here, we describe the selection of novel 2'-F-RNA aptamers against total human hemoglobin or its glycated form HbA1c. After SELEX and high-throughput sequencing of the enriched libraries, affinities and specificities of candidate aptamers and their truncated variants were examined by the solid-phase bioluminescent assay. As a result, we identified aptamers specific to both hemoglobins or only glycated HbA1c. The developed 2'-F-RNA aptamers have shown their applicability for detection of total and glycated hemoglobin in one sample.

WOS,
Смотреть статью,
Scopus
Держатели документа:
Inst Chem Biol & Fundamental Med SB RAS, Novosibirsk, Russia.
Krasnoyarsk Sci Ctr SB RAS, Fed Res Ctr, Inst Biophys SB RAS, Krasnoyarsk, Russia.
Novosibirsk State Univ, Dept Nat Sci, Pirogova St 2, Novosibirsk 630090, Russia.
Siberian Fed Univ, Krasnoyarsk 660041, Russia.

Доп.точки доступа:
Davydova, Anna; Vorobyeva, Mariya; Bashmakova, Eugenia; Vorobjev, Pavel; Krasheninina, Olga; Tupikin, Alexey; Kabilov, Marsel; Krasitskaya, Vasilisa; Frank, Ludmila; Venyaminova, Alya; Krasitskaya, Vasilisa V; Frank, Ludmila A; Russian Science Foundation [16-14-10296]

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Reporter-recruiting bifunctional aptasensor for bioluminescent analytical assays / A. Davydova, V. Krasitskaya, P. Vorobjev [et al.] // RSC Adv. - 2020. - Vol. 10, Is. 54. - P32393-32399, DOI 10.1039/d0ra05117a. - Cited References:33. - The work was supported by the Russian Science Foundation (grant #16-14-10296), Russian State funded budget projects #AAAA-A17-117020210021-7 to ICBFM SB RAS and #AAAA-A19-119031890015-0 to IBP SB RAS. . - ISSN 2046-2069

РУБ Chemistry, Multidisciplinary
Рубрики:
DNA APTAMER
   RNA APTAMER
   OBELIN
   PURIFICATION
   EXPRESSION
   SEQUENCES
Аннотация: We report a novel bioluminescent aptasensor, which consists of 2 '-F-RNA aptamer modules joined into a bi-specific aptamer construct. One aptamer module binds the analyte, then after structural rearrangement the second module recruits non-covalently Ca2+-dependent photoprotein obelin from the solution, thus providing a bioluminescent signal. This concept allows using free protein as a reporter, which brings such advantages as no need for aptamer-protein conjugation, a possibility of thermal re-folding of aptamer component with no harm to a protein, and simpler detection protocol. We developed the new 2 '-F-RNA aptamer for obelin, and proposed the strategy for engineering structure-switching bi-modular aptamer constructs which bind the analyte and the obelin in a sequential manner. With the use of hemoglobin as a model analyte, we showed the feasibility of utilizing the aptasensor in a fast and straightforward bioluminescent microplate assay. With a proper design of a secondary structure, this strategy of aptasensor engineering might be further extended to bi-specific aptamer-based bioluminescent sensors for other analytes of interest.

WOS
Держатели документа:
SB RAS, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia.
SB RAS, Inst Biophys, Fed Res Ctr, Krasnoyarsk Sci Ctr, Krasnoyarsk 660036, Russia.
Novosibirsk State Univ, Pimgova St 2, Novosibirsk 630090, Russia.
Siberian Fed Univ, Krasnoyarsk 660041, Russia.

Доп.точки доступа:
Davydova, Anna; Krasitskaya, Vasilisa; Vorobjev, Pavel; Timoshenko, Valentina; Tupikin, Alexey; Kabilov, Marsel; Frank, Ludmila; Venyaminova, Alya; Vorobyeva, Mariya; Russian Science FoundationRussian Science Foundation (RSF) [16-14-10296]; Russian State funded budget projects [AAAA-A17-117020210021-7, AAAA-A19-119031890015-0]

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Bacteria of Lake Pyasino and Adjacent Rivers after an Accidental Diesel Spill in 2020 / O. V. Kolmakova, M. Y. Trusova, O. A. Baturina, M. R. Kabilov // Contemp. Probl. Ecol. - 2021. - Vol. 14, Is. 4. - P356-367, DOI 10.1134/S1995425521040053. - Cited References:22. - This work was supported by economic agreement no. 223-EP-2020/07 with the Siberian Branch of the Russian Academy of Sciences and the Project Office for the Development of the Arctic (PORA), and State Task of the Fundamental Research Program of the Russian Federation, topic no. 51.1.1. Bioinformatics analysis was supported by basic budget funding from the ICBFM SB RAS (AAAAA17-117020210021-7). . - ISSN 1995-4255. - ISSN 1995-4263

РУБ Ecology
Рубрики:
SP-NOV.
   GEN. NOV.
   OIL
   BACTERIOPLANKTON
   SEQUENCES
Кл.слова (ненормированные):
bacterioplankton -- sediments -- high-throughput sequencing -- oil spill -- Lake -- Pyasino -- 16S rRNA
Аннотация: The bacterial composition of water and sediments in Lake Pyasino and adjacent rivers has been studied by high-throughput sequencing for the first time. No hydrocarbon-degrading bacteria are found in the river sections exposed to the diesel spillage in May 2020. The Daldykan and Ambarnaya rivers, located downstream of the spill site, are dominated by bacteria that oxidize sulfur and heavy metals. At the same time, these bacteria are not found in Lake Pyasino, which is dominated by small cyanobacteria. Thus, the composition of bacteria in the water and sediments of the Norilsk-Pyasino lake-river system corresponds to the technogenic impact to which it is exposed and also demonstrates the buffer properties of Lake Pyasino as water flows into the Kara Sea.

WOS
Держатели документа:
Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Inst Biophys, Krasnoyarsk 660036, Akademgorodok, Russia.
Siberian Fed Univ, Krasnoyarsk 660041, Russia.
Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Genom Core Facil, Novosibirsk 630090, Russia.

Доп.точки доступа:
Kolmakova, O. V.; Trusova, M. Yu.; Baturina, O. A.; Kabilov, M. R.; Siberian Branch of the Russian Academy of SciencesRussian Academy of Sciences [223-EP-2020/07]; Project Office for the Development of the Arctic (PORA); State Task of the Fundamental Research Program of the Russian Federation [51.1.1]; ICBFM SB RAS [AAAAA17-117020210021-7]

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