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Труды сотрудников ИБФ СО РАН - результаты поиска

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Формат представления найденных документов:
полныйинформационныйкраткий
Поисковый запрос: (<.>S=SURVIVIN<.>)
Общее количество найденных документов : 1
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    N-extended photoprotein obelin to competitively detect small protein tumor markers / E. E. Bashmakova, N. S. Panamarev, A. N. Kudryavtsev, L. A. Frank // Biochem. Biophys. Res. Commun. - 2022. - Vol. 598. - P69-73, DOI 10.1016/j.bbrc.2022.02.011. - Cited References:15. - The work was partially supported by a grant of the President of the Russian Federation for young scientists, the candidates of sciences (project MK-772.2020.4, study of a hybrid protein with melanoma-inhibiting activity) and Government of Krasnoyarsk Territory, Krasnoyarsk Regional Science Foundation (project No 2021012006966, study of a hybrid with protein survivin). . - ISSN 0006-291X. - ISSN 1090-2104
РУБ Biochemistry & Molecular Biology + Biophysics
Рубрики:
MELANOMA INHIBITORY-ACTIVITY
   SURVIVIN

Кл.слова (ненормированные):
Photoprotein obelin -- Genetic fusion -- Tumor marker -- Competitive assay
Аннотация: Two variants of Ca2+-regulated photoprotein obelin, extended from the N-terminus with small tumor markers-melanoma inhibitory activity protein (MIA) and survivin, one of the protein inhibitors of apoptosis, were designed, obtained and studied. Both domains in the obtained hybrid proteins exhibit the properties of the initial molecules: the main features of Ca2+-triggered bioluminescence are close to those of obelin, and the tumor markers' domains are recognized and bound by the corresponding antibodies. The obtained hybrids compete with the corresponding tumor markers for binding with antibodies, immobilized on the surface and their use has been shown to be promising as bioluminescent labels in a one-stage solid-phase competitive immunoassay. (c) 2022 Published by Elsevier Inc.

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Держатели документа:
Fed Res Ctr Krasnoyarsk Sci Ctr SB RAS, Inst Biophys SB RAS, Krasnoyarsk 660036, Russia.
Siberian Fed Univ, Krasnoyarsk 660041, Russia.

Доп.точки доступа:
Bashmakova, Eugenia E.; Panamarev, Nikita S.; Kudryavtsev, Alexander N.; Frank, Ludmila A.; Kudryavtsev, Alexander; Russian Federation for young scientists [MK-772.2020.4]; Government of Krasnoyarsk Territory, Krasnoyarsk Regional Science Foundation [2021012006966]

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