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Автор(ы) : Zamay S. S., Narodov A. A., Galeev R. G., Prokopenko V. S., Sokolov A. Е., Borus A. A., Zabluda V. N., Lukyanenko A. V., Baron F. A., Garifullin V. F., Masyugin A. N., Zelenov F. V., Grek D. S., Voronkovskii I. I., Gorbushin A., Kolovskaya O. S., Lukyanenko K. A., Nikolaeva E. D., Luzan N. A., Kichkailo A. S.
Заглавие : "Smart" nanoscalpel for microsurgery of glial tumors of the human brain
Место публикации : Sib. Med. Rev. - 2022. - Is. 5. - P.109-110. - ISSN 18199496 (ISSN), DOI 10.20333/25000136-2022-5-109-110; Сиб. мед. обозрение
Примечания : Cited References: 2. - This research was funded by the Regional State Autonomous Institution "Krasnoyarsk Regional Fund for Support of Scientific and Scientific and Technical Activities", Competition of scientific, technical and innovative projects in the interests of the first world-class climate scientific and educational center "Yenisei Siberia", grant “Carrying out applied research and development aimed at creating technologies for the production of nanoscalpels based on magnetic nanodisks for microsurgery of glial brain tumors” № 2022060108781 and with the support of a partner company JSC «NPP «Radiosviaz»
Аннотация: We studied the effectiveness of magnetomechanical therapy in the treatment of brain glial tumors using magnetic nanodiscs functionalized with DNA aptamers to human brain tumor glial cells. Materials and methods. The formation of a model of human glioblastoma was carried out by intracranial injection of tumor cells of glioblastoma obtained from a patient with glioblastoma. Antitumor therapy was carried out using nanodiscs modified with the Gli233 aptamer. The growth of the glial tumor was monitored using NMR tomography. Results and discussion. Therapy of a glial tumor during 4 sessions of magnetomechanical therapy using a "smart" nanoscalpel in MF (10Hz, 100Oe) led to a significant reduction in its size, while glial tumors in mice that were treated with nanodiscs modified with nonspecific aptamers continued to increase in size. Conclusion. Microsurgery using three-layer magnetic nanodisks with a quasi-dipole structure (Au/Ni/Au) modified with the specific for glial cells Gli233 aptamer (“smart” nanoscalpel) is effective for the treatment of human glial tumors in the brain.
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