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Вид документа : Статья из журнала
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Автор(ы) : Soldatenko A. S., Molokeev M. S., Lazareva N. F.
Заглавие : N-silylmethyl-2-(1-naphthyl)acetamides: Synthesis, structure and computational screening
Колич.характеристики :8 с
Место публикации : Curr. Org. Chem. - 2024. - Vol. 28, Is. 12. - P.959-966. - ISSN 13852728 (ISSN), DOI 10.2174/0113852728296495240409062733. - ISSN 18755348 (eISSN)
Примечания : Cited References: 75. - This work was supported by the Russian Science Foundation using the analytical equipment of the Baikal Center for Collective Use of the SB RAS and the analytical equipment of the Krasnoyarsk Center for Collective Use of SB RAS. M.S. Molokeev’s work was carried out within the framework of the Strategic Academic Leadership Program "Priority-2030" for the Siberian Federal University
Аннотация: Synthesis of new hybrid organosilicon compounds based on the amides 1- naphthylacetic acid was described. N-Organyl-2-(1-naphthyl)-N-[(triethoxysilyl)methyl]- acetamides were obtained by the reaction of 1-naphthylacetyl chloride with α-silylamines RNHCH2Si(OEt)3 (R = Me, i-Pr and Ph). Their subsequent interaction with N(CH2CH2OH)3 led to the formation of N-organyl-2-(1-naphthyl)-N-(silatranylmethyl)acetamides. The structure of these hybrid compounds was characterized by 1H, 13C, and 29Si NMR spectroscopy. The structure of N-methyl- and N-isopropyl-2-(1-naphthyl)-N-(silatranylmethy)acetamides was confirmed by X-ray diffraction analysis. Results of computational screening showed that these silatranes are bioavailable and have drug-likeness.
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