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Magnetic nanoscalpel for the effective treatment of ascites tumors / T. Zamay, S. Zamay, N. Luzan [et al.] // J. Funct. Biomater. - 2023. - Vol. 14, Is. 4. - Ст. 179, DOI 10.3390/jfb14040179. - Cited References: 36. - This research was funded by the Regional State Autonomous Institution “Krasnoyarsk Regional Fund for Support of Scientific and Scientific and Technical Activities”, Competition of scientific, technical, and innovative projects in the interests of the first world-class climate scientific and educational center “Yenisei Siberia”, grant “Carrying out applied research and development aimed at creating technologies for the production of nanoscalpels based on magnetic nanodisks for microsurgery of glial brain tumors” No. 2022060108781 and with the support of a partner company JSC «NPP «Radiosviaz» . - ISSN 2079-4983
Кл.слова (ненормированные):
magnetic nanodisks -- ascitic tumor -- magneto-mechanical therapy -- “smart nanoscalpel” -- DNA aptamers -- apoptosis -- necrosis
Аннотация: One of the promising novel methods for radical tumor resection at a single-cell level is magneto-mechanical microsurgery (MMM) with magnetic nano- or microdisks modified with cancer-recognizing molecules. A low-frequency alternating magnetic field (AMF) remotely drives and controls the procedure. Here, we present characterization and application of magnetic nanodisks (MNDs) as a surgical instrument (“smart nanoscalpel”) at a single-cell level. MNDs with a quasi-dipole three-layer structure (Au/Ni/Au) and DNA aptamer AS42 (AS42-MNDs) on the surface converted magnetic moment into mechanical and destroyed tumor cells. The effectiveness of MMM was analyzed on Ehrlich ascites carcinoma (EAC) cells in vitro and in vivo using sine and square-shaped AMF with frequencies from 1 to 50 Hz with 0.1 to 1 duty-cycle parameters. MMM with the “Nanoscalpel” in a sine-shaped 20 Hz AMF, a rectangular-shaped 10 Hz AMF, and a 0.5 duty cycle was the most effective. A sine-shaped field caused apoptosis, whereas a rectangular-shaped field caused necrosis. Four sessions of MMM with AS42-MNDs significantly reduced the number of cells in the tumor. In contrast, ascites tumors continued to grow in groups of mice and mice treated with MNDs with nonspecific oligonucleotide NO-MND. Thus, applying a “smart nanoscalpel” is practical for the microsurgery of malignant neoplasms.

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Держатели документа:
Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch, Russian Academy of Sciences, Krasnoyarsk 660036, Russia
Laboratory for Biomolecular and Medical Technologies, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk 660022, Russia
JSC «NPP «Radiosviaz», Krasnoyarsk 660021, Russia
Laboratory of Advanced Materials and Technology, Siberian Physical Technical Institute, Tomsk State University, Tomsk 634050, Russia
L.V. Kirensky Institute of Physics, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk 660036, Russia
Institute of Automation and Control Processes (IACP), Far Eastern Branch of the Russian Academy of Science, Vladivostok 690041, Russia
Far Eastern Federal University, Vladivostok 690950, Russia
V.P. Astafiev Krasnoyarsk State Pedagogical University, Krasnoyarsk 660049, Russia

Доп.точки доступа:
Zamay, Tatiana; Zamay, Sergey; Luzan, Natalia; Fedotovskaya, Victoriya; Masyugin, Albert; Zelenov, F.; Koshmanova, Anastasia; Nikolaeva, Elena; Kirichenko, Daria; Veprintsev, Dmitry; Kolovskaya, Olga; Shchugoreva, Irina; Zamay, Galina; Lapin, I. N.; Lukyanenko, A. V.; Лукьяненко, Анна Витальевна; Borus, Andrey; Борус, Андрей Андреевич; Sukhachev, A. L.; Сухачев, Александр Леонидович; Volochaev, M. N.; Волочаев, Михаил Николаевич; Lukyanenko, Kirill; Shabanov, Alexandr; Zabluda, V. N.; Заблуда, Владимир Николаевич; Zhizhchenko, Alexey; Kuchmizhak, Aleksandr; Sokolov, A. Е.; Соколов, Алексей Эдуардович; Narodov, Andrey; Prokopenko, Vladimir; Galeev, Rinat; Svetlichnyi, Valery; Kichkailo, Anna
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Combined porous-monolithic TiNi materials surface-modified with electron beam for new-generation rib endoprostheses / A. V. Shabalina, S. G. Anikeev, S. A. Kulinich [et al.] // J. Funct. Biomater. - 2023. - Vol. 14, Is. 5. - Ст. 277, DOI 10.3390/jfb14050277. - Cited References: 57. - The study was supported by the Russian Science Foundation (grant no. 19-79-10045). https://rscf.ru/project/19-79-10045/ . - ISSN 2079-4983
Кл.слова (ненормированные):
TiNi -- rib endoprostheses -- porous coating -- powder metallurgy -- high-current pulsed electron beam -- structure -- surface modification -- electrochemical corrosion -- biocompatibility
Аннотация: TiNi alloys are very widely used materials in implant fabrication. When applied in rib replacement, they are required to be manufactured as combined porous-monolithic structures, ideally with a thin, porous part well-adhered to its monolithic substrate. Additionally, good biocompatibility, high corrosion resistance and mechanical durability are also highly demanded. So far, all these parameters have not been achieved in one material, which is why an active search in the field is still underway. In the present study, we prepared new porous-monolithic TiNi materials by sintering a TiNi powder (0–100 μm) on monolithic TiNi plates, followed by surface modification with a high-current pulsed electron beam. The obtained materials were evaluated by a set of surface and phase analysis methods, after which their corrosion resistance and biocompatibility (hemolysis, cytotoxicity, and cell viability) were evaluated. Finally, cell growth tests were conducted. In comparison with flat TiNi monoliths, the newly developed materials were found to have better corrosion resistance, also demonstrating good biocompatibility and potential for cell growth on their surface. Thus, the newly developed porous-on-monolith TiNi materials with different surface porosity and morphology showed promise as potential new-generation implants for use in rib endoprostheses.

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Держатели документа:
Laboratory of Medical Materials Science, Tomsk State University, 634050 Tomsk, Russia
Institute of Physics, Kazan Federal University, 420008 Kazan, Russia
Research Institute of Science and Technology, Tokai University, Hiratsuka 259-1292, Kanagawa, Japan
Research School of High-Energy Physics, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia
Tomsk Scientific Center, Siberian Branch of Russian Academy of Sciences, 634055 Tomsk, Russia
Kirensky Institute of Physics, Federal Research Center, KSC Siberian Branch Russian Academy of Science, 660036 Krasnoyarsk, Russia
School of Engineering Physics and Radio Electronics, Siberian Federal University, 660041 Krasnoyarsk, Russia
Department of Morphology and Physiology of the Medical Institute, Surgut State University, 628403 Surgut, Russia

Доп.точки доступа:
Shabalina, A. V.; Anikeev, S. G.; Kulinich, S. A.; Artyukhova, N. V.; Vlasov, V. A.; Kaftaranova, M. I.; Hodorenko, V. N.; Yakovlev, E. V.; Pesterev, E. A.; Lukyanenko, A. V.; Лукьяненко, Анна Витальевна; Volochaev, M. N.; Волочаев, Михаил Николаевич; Pakholkina, S.; Mamazakirov, O.; Stolyarov, V. V.; Mokshin, A. V.; Gunther, V. E.
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    Impact of nano-biomaterials on the world / I. S. Edelman, S. G. Ovchinnikov, A. Thakur, P. Thakur // Integrated nanomaterials and their applications / ed.: D. Suhag [et al.] : Springer, 2023. - Chapt. 22. - P. 1-34. - Cited References: 77
   Перевод заглавия: Интегрированные наноматериалы и их приложения. Глава 22 "Значение нано-био-материалов в мире"

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Держатели документа:
Kirensky Institute of Physics, Federal Research Center KSC, SB RAS
Centre for Nanotechnology, Amity University Haryana, Gurugram, -122413, India

Доп.точки доступа:
Suhag, D. \ed.\; Thakur, A. \ed.\; Thakur, P. \ed.\; Edelman, I. S.; Эдельман, Ирина Самсоновна; Ovchinnikov, S. G.; Овчинников, Сергей Геннадьевич; Thakur, A.; Thakur, P.
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Polysaccharide-coated iron oxide nanoparticles: Synthesis, properties, surface modification / S. V. Stolyar, V. V. Krasitskaya, L. A. Frank [et al.] // Mater. Lett. - 2021. - Vol. 284. - Ст. 128920, DOI 10.1016/j.matlet.2020.128920. - Cited References: 12. - The reported study was carried out with the financial support of the Russian Foundation for Fundamental Research , the Government of the Krasnoyarsk Territory , the Krasnoyarsk Territory Fund for Support of Scientific and Technical Activity in the framework of scientific Project No. 18-43-243003. This work was supported by the Council of the President of the Russian Federation for State Support of Young Scientists and Leading Scientific Schools (project no. MK-1263.2020.3) . - ISSN 0167-577X
Кл.слова (ненормированные):
Magnetic materials -- Nanoparticles -- Biomaterials -- Magnetic materials -- Polysaccharide
Аннотация: In this work, magnetite nanoparticles coated with polysaccharides were synthesized. Arabinogalactan and chitosan were used as polysaccharides. The possibilities of immobilization of biospecific molecules on the surface of the obtained composites were studied. Experiments on covalent immobilization of biospecific molecules on magnetic nanoparticles coated with a polysaccharide showed a high density of immobilized molecules. This suggests the use of such materials in bioanalytical systems or as affinity sorbents.

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Держатели документа:
Krasnoyarsk Scientific Center, Federal Research Center KSC SB RAS, Krasnoyarsk, Russian Federation
Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russian Federation
Siberian Federal University, Krasnoyarsk, Russian Federation
Institute of Biophysics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russian Federation
Astrakhan State University, Astrakhan, Russian Federation
University of Al-qasim Green, College of Biotechnology, Iraq

Доп.точки доступа:
Stolyar, S. V.; Столяр, Сергей Викторович; Krasitskaya, V. V.; Frank, L. A.; Yaroslavtsev, R. N.; Ярославцев, Роман Николаевич; Chekanova, L. A.; Чеканова, Лидия Александровна; Gerasimova, Yu. V.; Герасимова, Юлия Валентиновна; Volochaev, M. N.; Волочаев, Михаил Николаевич; Bairmani, M. S.; Velikanov, D. A.; Великанов, Дмитрий Анатольевич
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    Morphological aspects of monocyte/macrophage polarization on biopolymer scaffolds in atherosclerosis patients / Menzyanova [et al.] // J. Biotechnol. Biomater. - 2018. - Vol. 8, Is. 3. - Ст. 1000284, DOI 10.4172/2155-952X.1000284. - Cited References: 67. - The study was supported by the State budget allocated to the fundamental research at the Russian Academy of Sciences (project No 01201351505). . - ISSN 2155-952X
   Перевод заглавия: Морфологические аспекты поляризации моноцитов / макрофагов на биополимерных каркасах у пациентов с атеросклерозом
Кл.слова (ненормированные):
Monocytes -- Macrophages -- Cell morphology -- Polyhydroxyalkanoates -- PHA -- Copolymers -- Atherosclerosis -- Intravascular stenting
Аннотация: The morphotypes of human macrophages (MPh) were studied in the culture on nano-structured substrates, made from polyhydroxyalcanoates (PHAs) of various monomer compositions, prepared by casting polymer solutions on a defatted glass and followed by the solvent evaporation. Its surface relief, being further in direct contact with human cells in vitro was analyzed by AFM and SEM scanning. It was shown, that the features of micro/nano relief depend on the monomeric composition of polymer substrates. Monocytes (MNs) of patients with atherosclerosis and cardiac ischemia undergoing stenting and conventional anti-atherosclerotic therapy were harvested prior to and after stenting. After isolation MNs were cultured and transformed into MPh in direct contact with biopolymer culture substrates with different monomer composition and Nano-reliefs in comparison with culture plastic. Sub-populations of cells with characteristic morphology in each phenotypic class were described and their ratios for five samples of polymers were counted as an intermediate result in the development of “smart” material for blood vessel recovery. The results obtained allow us to assume that the processes of MPh differentiation and polarization in vitro depend not only on the features of the micro/nano relief of biopolymer substrates but also on the initial state of MNs in vivo and the general response of patients.

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Держатели документа:
Siberian Federal University, Svobodny, Krasnoyarsk, Russia
L.V. Kirensky Institute of Physics, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia
Federal Research Centre Krasnoyarsk Scientific Centre of the Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia
Federal Centres for Cardiovascular Surgery, Krasnoyarsk, Russia

Доп.точки доступа:
Menzyanova, Natalia G.; Pyatina, Svetlana V.; Nikolaeva, Elena D.; Shabanov, A. V.; Шабанов, Александр Васильевич; Nemtsev, I. V.; Stolyarov, D. P.; Dryganov, Dmitry B.; Sakhnov, Eugene V.; Vinokurova, Daria A.; Shishatskaya, Ekaterina I.
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    Влияние биоматериалов медицинского назначения на структурно-функциональные особенности моноцитов / Н. Г. Мензянова [и др.] // Журн. СФУ. Сер. "Биология". - 2016. - Т. 9, № 1. - С. 33-42, DOI 10.17516/1997-1389-2015-9-1-33-42 . - ISSN 1997-1389
   Перевод заглавия: Effect of Biomaterials of Medical Purpose on the Structural and Functional Features of Monocytes
Кл.слова (ненормированные):
biomaterials for medical uses -- Polyhydroxyalkanoates -- monocytes -- nanodiamonds -- fullerenes -- биоматериалы медицинского назначения -- моноциты -- наноалмазы -- фуллерены -- полигидроксиалканоаты
Аннотация: Изучены морфофункциональные особенности моноцитов в условиях кратковременного культивирования in vitro на носителях из биополимера полигидроксиалканоата (ПГА) в присутствии наноалмазов (НА) и фуллеренов (Ф). Показано, что НА и Ф в исследованных концентрациях не влияли на жизнеспособность моноцитов в кратковременной культуре. Соотношение морфологических классов моноцитов в присутствии НА и Ф существенно отличалось от контрольного варианта культивирования. Влияние НА и Ф характеризовалось дозовой зависимостью. Воздействие наночастиц на культуру моноцитов значительно изменялось при формировании белковой короны на поверхности НА и Ф, что приводило к возникновению новых количественных соотношений между морфологическими классами моноцитов в культуре in vitro. Полученные результаты позволяют рассматривать кратковременную культуру моноцитов in vitro как адекватную модельную систему для оценки влияния новых материалов на процессы дифференцировки субпопуляций моноцитов.
The morphological and functional features of the monocytes in a short-term in vitro cultivation on substrates of biopolymer polyhydroxyalkanoate (PHA) in the presence of nanodiamonds (ND) and fullerene (F) were studied. It has been shown that ND and F in the studied concentrations did not affect the viability of monocytes in the short-term culture. The ratio of morphological classes in the presence of ND and F signi?cantly different from the control group of cultivation. Effects of NA and F were characterized by dose-dependent. The formation of a protein corona on the surface of NA and F led to signi?cant changes in the effects of nanoparticles and the formation of new quantitative relationships between morphological classes of monocytes in culture in vitro. The results allow to consider a short-term culture of monocytes in vitro as a model system for adequate assessment of the impact of new materials on the processes of differentiation of monocyte subpopulations.

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Держатели документа:
Институт физики им. Л.В. Киренского СО РАН
Сибирский федеральный университет

Доп.точки доступа:
Мензянова, Н. Г.; Menzyanova N. G.; Николаева, Е. Д.; Nikolaeva E. D.; Винокурова, Д. В.; Vinokurova Daria V.; Шабанов, Александр Васильевич; Shabanov, A. V.; Шершнева, А. М.; Shershneva Anna M.; Шишацкая, Екатерина Игоревна; Shishatskaya E. I.; Сухова, К. В.; Sukhova Kristina V.
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Short-term culture of monocytes as an in vitro evaluation system for bionanomaterials designated for medical use / E. I. Shishatskaya [et al.] // Food Chem. Toxicol. - 2016. - Vol. 96. - P. 302-308, DOI 10.1016/j.fct.2016.08.025. - Cited References: 46 . - ISSN 0278-6915

РУБ Food Science & Technology + Toxicology
Рубрики:
MAGNETIC NANOPARTICLES
   CELLULAR REDUCTION
   PROTEIN CORONA
   CELLS
   MECHANOTRANSDUCTION
   NANOMATERIALS
   LOCALIZATION
   BIOMATERIALS
   CYTOSKELETON
   ACTIVATION
Кл.слова (ненормированные):
Biocompatible biopolymers -- Polyhydroxyalkanoates -- Nanomaterials -- Nanodiamonds -- Fullerenes -- Bio-nanomaterials -- Monocytes
Аннотация: We studied the feasibility of using a short-term culture of monocytes, isolated from peripheral donor blood, to assess the biological activity of different types of bionanomaterials (BNM): biodegradable polimeric particles, fiber and film substrates of micro- and nano-dimensions, fullerenes (F) and nanodiamonds (ND), which are either currently in use and/or potentially applicable in medicine. Additionally, the effect of creating a protein corona on ND and F particles was investigated. The cellular reduction of (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) is a well-established tool for assessing the viability/metabolic activity of cells. The scanning electron microscopy assay can detect fine changes in cell morphology. In the present study BNM have been shown to affect; in a size, chemical composition and morphological characteristics-dependent manner, the ability of monocytes to reduce MTT as well as their morphology. Moreover, the specific effects of ND and F on MTT reduction and cell morphology were exhibited in a dose-dependent manner and sensitive to the formation of surface protein corona. Our results suggest that short-term culture of monocytes is a sensitive model system for assessing the biological effects of BMPs in vitro. © 2016 Elsevier Ltd

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Держатели документа:
Siberian Federal University, Svobodnuy Av. 79, Krasnoyarsk, Russian Federation
Laboratory of Anatomy, Histology, Embryology, School of Medicine, University of Crete, Heraklion, Greece
Institute of Physics, Russian Academy of Science, Siberian Division, Akademgorodok, 50, Build. 38, Krasnoyarsk, Russian Federation
Laboratory of Toxicology, Medical School, University of Crete, Heraklion, Greece

Доп.точки доступа:
Shishatskaya, E. I.; Шишацкая, Екатерина Игоревна; Nikitovic, D.; Shabanov, A. V.; Шабанов, Александр Васильевич; Tzanakakis, G. N.; Tsatsakis, A. M.; Menzianova, N. G.
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Electrospinning of polyhydroxyalkanoate fibrous scaffolds: effects on electrospinning parameters on structure and properties / T. . Volova [et al.] // J. Biomater. Sci.-Polym. Ed. - 2014. - Vol. 25, Is. 4. - P. 370-393, DOI 10.1080/09205063.2013.862400. - Cited References: 52. - This study was financially supported by Project 'Biotechnologies of novel biomaterials: innovative biopolymers and devices for biomedicine' (Agreement No. 1 of 15.02.2013 to Agreement No. 11.G34.31.0013) in accordance with Resolution No. 220 of the Government of the Russian Federation of April 9, 2010, 'On measures designed to attract leading scientists to the Russian institutions of higher learning' and Grant of the RF President for supporting young Doctors of Sciences No. MD-3112.2012.4. . - ISSN 0920-5063. - ISSN 1568-5624

РУБ Engineering, Biomedical + Materials Science, Biomaterials + Polymer Science
Рубрики:
TISSUE ENGINEERING APPLICATIONS
   FIBER MATS
   POLY 3-HYDROXYBUTYRATE
   POLY(3-HYDROXYBUTYRATE-CO-3-HYDROXYVALERATE)
   BIOCOMPATIBILITY
   PROLIFERATION
   FABRICATION
   NANOFIBERS
   COPOLYMERS
   MEMBRANES
Кл.слова (ненормированные):
electrospinning -- polyhydroxyalkanoates -- ultrafine fibers -- physical-mechanical properties -- fibroblast cells
Аннотация: IIn this study, electrospinning was used to prepare ultrafine fibers from PHAs with different chemical compositions: P(3HB) and copolymers: P(3HB-co-4HB), P(3HB-co-3HV), and P(3HB-co-3HHx). The main process parameters that influence ultrafine fiber diameter and properties (polymer concentration, solution feeding rate, working distance, and applied voltage) have been investigated and their effects evaluated. The study revealed electrospinning parameters for the production of high-quality ultrafine fibers and determined which parameters should be varied to tailor the properties of the products. This study is the first to compare biological and physical-mechanical parameters of PHAs with different chemical compositions as dependent upon the fractions of monomers constituting the polymers and ultrafine fiber orientation. Mechanical strength of aligned ultrafine fibers prepared from different PHAs is higher than that of randomly oriented ones; no significant effect of ultrafine fiber orientation on surface properties has been found. None of the fibrous scaffolds produced by electrospinning from PHAs had any adverse effects on attachment, growth, and viability of NIH 3T3 mouse fibroblast cells, and all of them were found to be suitable for tissue engineering applications.

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Держатели документа:
Russian Acad Sci, Inst Biophys, Siberian Branch, Krasnoyarsk 660036, Russia
Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Krasnoyarsk 660041, Russia
Russian Acad Sci, LV Kirenskii Inst Phys, Siberian Branch, Krasnoyarsk 660036, RussiaИФ СО РАН;

Доп.точки доступа:
Volova, T.; Волова, Татьяна Григорьевна; Goncharov, D.; Sukovatyi, A. G.; Суковатый, Алексей Григорьевич; Shabanov, A. V.; Шабанов, Александр Васильевич; Nikolaeva, E.; Shishatskaya, E.; Project 'Biotechnologies of novel biomaterials: innovative biopolymers and devices for biomedicine' [1, 11.G34.31.0013]; Government of the Russian Federation [220]; RF President for supporting young Doctors of Sciences [MD-3112.2012.4]
}
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Fabrication and magnetic properties of ni nanospheres encapsulated in a fullerene-like carbon / S. V. Pol [et al.] // Journal of Physical Chemistry B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter. - 2005. - Т. 109, № 19. - P. 9495-9498, DOI 10.1021/jp050692j. - Библиогр.: 27 . - ISSN 1520-6106

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Держатели документа:
Department of Chemistry,Center for Advanced Materials and Nanotechnology,Bar-Ilan University
Department of Physics,Bar-Ilan University
L.V. Kirensky Institute of Physics,SB RAS

Доп.точки доступа:
Pol, S. V.; Pol, V. G.; Gedanken, A.; Frydman, A.; Churilov, G. N. ; Чурилов Григорий Николаевич
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