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Вид документа : Однотомное издание
Шифр издания :
Автор(ы) : Edelman I. S., Ovchinnikov S. G., Thakur A., Thakur P.
Заглавие : Impact of nano-biomaterials on the world
Колич.характеристики :34 pp.
Место публикации : Integrated nanomaterials and their applications/ ed.: D. Suhag [et al.]: Springer, 2023. - Chapt. 22. - P.1-34
Примечания : Cited References: 77
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Zamay, Tatiana, Zamay, Sergey, Luzan, Natalia, Fedotovskaya, Victoriya, Masyugin, Albert, Zelenov F., Koshmanova, Anastasia, Nikolaeva, Elena, Kirichenko, Daria, Veprintsev, Dmitry, Kolovskaya, Olga, Shchugoreva, Irina, Zamay, Galina, Lapin I. N., Lukyanenko A. V., Borus, Andrey, Sukhachev A. L., Volochaev M. N., Lukyanenko, Kirill, Shabanov, Alexandr, Zabluda V. N., Zhizhchenko, Alexey, Kuchmizhak, Aleksandr, Sokolov A. Е., Narodov, Andrey, Prokopenko, Vladimir, Galeev, Rinat, Svetlichnyi, Valery, Kichkailo, Anna
Заглавие : Magnetic nanoscalpel for the effective treatment of ascites tumors
Место публикации : J. Funct. Biomater. - 2023. - Vol. 14, Is. 4. - Ст.179. - ISSN 20794983 (eISSN), DOI 10.3390/jfb14040179
Примечания : Cited References: 36. - This research was funded by the Regional State Autonomous Institution “Krasnoyarsk Regional Fund for Support of Scientific and Scientific and Technical Activities”, Competition of scientific, technical, and innovative projects in the interests of the first world-class climate scientific and educational center “Yenisei Siberia”, grant “Carrying out applied research and development aimed at creating technologies for the production of nanoscalpels based on magnetic nanodisks for microsurgery of glial brain tumors” No. 2022060108781 and with the support of a partner company JSC «NPP «Radiosviaz»
Аннотация: One of the promising novel methods for radical tumor resection at a single-cell level is magneto-mechanical microsurgery (MMM) with magnetic nano- or microdisks modified with cancer-recognizing molecules. A low-frequency alternating magnetic field (AMF) remotely drives and controls the procedure. Here, we present characterization and application of magnetic nanodisks (MNDs) as a surgical instrument (“smart nanoscalpel”) at a single-cell level. MNDs with a quasi-dipole three-layer structure (Au/Ni/Au) and DNA aptamer AS42 (AS42-MNDs) on the surface converted magnetic moment into mechanical and destroyed tumor cells. The effectiveness of MMM was analyzed on Ehrlich ascites carcinoma (EAC) cells in vitro and in vivo using sine and square-shaped AMF with frequencies from 1 to 50 Hz with 0.1 to 1 duty-cycle parameters. MMM with the “Nanoscalpel” in a sine-shaped 20 Hz AMF, a rectangular-shaped 10 Hz AMF, and a 0.5 duty cycle was the most effective. A sine-shaped field caused apoptosis, whereas a rectangular-shaped field caused necrosis. Four sessions of MMM with AS42-MNDs significantly reduced the number of cells in the tumor. In contrast, ascites tumors continued to grow in groups of mice and mice treated with MNDs with nonspecific oligonucleotide NO-MND. Thus, applying a “smart nanoscalpel” is practical for the microsurgery of malignant neoplasms.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shabalina A. V., Anikeev S. G., Kulinich S. A., Artyukhova N. V., Vlasov V. A., Kaftaranova M. I., Hodorenko V. N., Yakovlev E. V., Pesterev E. A., Lukyanenko A. V., Volochaev M. N., Pakholkina S., Mamazakirov O., Stolyarov V. V., Mokshin A. V., Gunther V. E.
Заглавие : Combined porous-monolithic TiNi materials surface-modified with electron beam for new-generation rib endoprostheses
Место публикации : J. Funct. Biomater. - 2023. - Vol. 14, Is. 5. - Ст.277. - ISSN 20794983 (eISSN), DOI 10.3390/jfb14050277
Примечания : Cited References: 57. - The study was supported by the Russian Science Foundation (grant no. 19-79-10045). https://rscf.ru/project/19-79-10045/
Аннотация: TiNi alloys are very widely used materials in implant fabrication. When applied in rib replacement, they are required to be manufactured as combined porous-monolithic structures, ideally with a thin, porous part well-adhered to its monolithic substrate. Additionally, good biocompatibility, high corrosion resistance and mechanical durability are also highly demanded. So far, all these parameters have not been achieved in one material, which is why an active search in the field is still underway. In the present study, we prepared new porous-monolithic TiNi materials by sintering a TiNi powder (0–100 μm) on monolithic TiNi plates, followed by surface modification with a high-current pulsed electron beam. The obtained materials were evaluated by a set of surface and phase analysis methods, after which their corrosion resistance and biocompatibility (hemolysis, cytotoxicity, and cell viability) were evaluated. Finally, cell growth tests were conducted. In comparison with flat TiNi monoliths, the newly developed materials were found to have better corrosion resistance, also demonstrating good biocompatibility and potential for cell growth on their surface. Thus, the newly developed porous-on-monolith TiNi materials with different surface porosity and morphology showed promise as potential new-generation implants for use in rib endoprostheses.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Pol S. V., Pol V. G., Gedanken A., Frydman A., Churilov G. N.
Заглавие : Fabrication and magnetic properties of ni nanospheres encapsulated in a fullerene-like carbon
Место публикации : Journal of Physical Chemistry B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter: American Chemical Society, 2005. - Т. 109, № 19. - P.9495-9498. - ISSN 1520-6106, DOI 10.1021/jp050692j
Примечания : Библиогр.: 27
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Stolyar S. V., Krasitskaya V. V., Frank L. A., Yaroslavtsev R. N., Chekanova L. A., Gerasimova Yu. V., Volochaev M. N., Bairmani M. S., Velikanov D. A.
Заглавие : Polysaccharide-coated iron oxide nanoparticles: Synthesis, properties, surface modification
Место публикации : Mater. Lett. - 2021. - Vol. 284. - Ст.128920. - ISSN 0167577X (ISSN), DOI 10.1016/j.matlet.2020.128920
Примечания : Cited References: 12. - The reported study was carried out with the financial support of the Russian Foundation for Fundamental Research , the Government of the Krasnoyarsk Territory , the Krasnoyarsk Territory Fund for Support of Scientific and Technical Activity in the framework of scientific Project No. 18-43-243003. This work was supported by the Council of the President of the Russian Federation for State Support of Young Scientists and Leading Scientific Schools (project no. MK-1263.2020.3)
Аннотация: In this work, magnetite nanoparticles coated with polysaccharides were synthesized. Arabinogalactan and chitosan were used as polysaccharides. The possibilities of immobilization of biospecific molecules on the surface of the obtained composites were studied. Experiments on covalent immobilization of biospecific molecules on magnetic nanoparticles coated with a polysaccharide showed a high density of immobilized molecules. This suggests the use of such materials in bioanalytical systems or as affinity sorbents.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Мензянова Н. Г., Николаева Е. Д., Винокурова Д. В., Шабанов, Александр Васильевич, Шершнева А. М., Шишацкая, Екатерина Игоревна, Сухова К. В.
Заглавие : Влияние биоматериалов медицинского назначения на структурно-функциональные особенности моноцитов
Место публикации : Журн. СФУ. Сер. "Биология". - 2016. - Т. 9, № 1. - С. 33-42. - ISSN 1997-1389, DOI 10.17516/1997-1389-2015-9-1-33-42
Ключевые слова (''Своб.индексиров.''): biomaterials for medical uses--polyhydroxyalkanoates--monocytes--nanodiamonds--fullerenes--биоматериалы медицинского назначения--моноциты--наноалмазы--фуллерены--полигидроксиалканоаты
Аннотация: Изучены морфофункциональные особенности моноцитов в условиях кратковременного культивирования in vitro на носителях из биополимера полигидроксиалканоата (ПГА) в присутствии наноалмазов (НА) и фуллеренов (Ф). Показано, что НА и Ф в исследованных концентрациях не влияли на жизнеспособность моноцитов в кратковременной культуре. Соотношение морфологических классов моноцитов в присутствии НА и Ф существенно отличалось от контрольного варианта культивирования. Влияние НА и Ф характеризовалось дозовой зависимостью. Воздействие наночастиц на культуру моноцитов значительно изменялось при формировании белковой короны на поверхности НА и Ф, что приводило к возникновению новых количественных соотношений между морфологическими классами моноцитов в культуре in vitro. Полученные результаты позволяют рассматривать кратковременную культуру моноцитов in vitro как адекватную модельную систему для оценки влияния новых материалов на процессы дифференцировки субпопуляций моноцитов.The morphological and functional features of the monocytes in a short-term in vitro cultivation on substrates of biopolymer polyhydroxyalkanoate (PHA) in the presence of nanodiamonds (ND) and fullerene (F) were studied. It has been shown that ND and F in the studied concentrations did not affect the viability of monocytes in the short-term culture. The ratio of morphological classes in the presence of ND and F signi?cantly different from the control group of cultivation. Effects of NA and F were characterized by dose-dependent. The formation of a protein corona on the surface of NA and F led to signi?cant changes in the effects of nanoparticles and the formation of new quantitative relationships between morphological classes of monocytes in culture in vitro. The results allow to consider a short-term culture of monocytes in vitro as a model system for adequate assessment of the impact of new materials on the processes of differentiation of monocyte subpopulations.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Volova T., Goncharov D., Sukovatyi A. G., Shabanov A. V., Nikolaeva E., Shishatskaya E.
Заглавие : Electrospinning of polyhydroxyalkanoate fibrous scaffolds: effects on electrospinning parameters on structure and properties
Коллективы : Project 'Biotechnologies of novel biomaterials: innovative biopolymers and devices for biomedicine' [1, 11.G34.31.0013]; Government of the Russian Federation [220]; RF President for supporting young Doctors of Sciences [MD-3112.2012.4]
Место публикации : J. Biomater. Sci.-Polym. Ed.: Taylor & Francis, 2014. - Vol. 25, Is. 4. - P.370-393. - ISSN 0920-5063, DOI 10.1080/09205063.2013.862400. - ISSN 1568-5624
Примечания : Cited References: 52. - This study was financially supported by Project 'Biotechnologies of novel biomaterials: innovative biopolymers and devices for biomedicine' (Agreement No. 1 of 15.02.2013 to Agreement No. 11.G34.31.0013) in accordance with Resolution No. 220 of the Government of the Russian Federation of April 9, 2010, 'On measures designed to attract leading scientists to the Russian institutions of higher learning' and Grant of the RF President for supporting young Doctors of Sciences No. MD-3112.2012.4.
Предметные рубрики: TISSUE ENGINEERING APPLICATIONS
FIBER MATS
POLY 3-HYDROXYBUTYRATE
POLY(3-HYDROXYBUTYRATE-CO-3-HYDROXYVALERATE)
BIOCOMPATIBILITY
PROLIFERATION
FABRICATION
NANOFIBERS
COPOLYMERS
MEMBRANES
Ключевые слова (''Своб.индексиров.''): electrospinning--polyhydroxyalkanoates--ultrafine fibers--physical-mechanical properties--fibroblast cells
Аннотация: IIn this study, electrospinning was used to prepare ultrafine fibers from PHAs with different chemical compositions: P(3HB) and copolymers: P(3HB-co-4HB), P(3HB-co-3HV), and P(3HB-co-3HHx). The main process parameters that influence ultrafine fiber diameter and properties (polymer concentration, solution feeding rate, working distance, and applied voltage) have been investigated and their effects evaluated. The study revealed electrospinning parameters for the production of high-quality ultrafine fibers and determined which parameters should be varied to tailor the properties of the products. This study is the first to compare biological and physical-mechanical parameters of PHAs with different chemical compositions as dependent upon the fractions of monomers constituting the polymers and ultrafine fiber orientation. Mechanical strength of aligned ultrafine fibers prepared from different PHAs is higher than that of randomly oriented ones; no significant effect of ultrafine fiber orientation on surface properties has been found. None of the fibrous scaffolds produced by electrospinning from PHAs had any adverse effects on attachment, growth, and viability of NIH 3T3 mouse fibroblast cells, and all of them were found to be suitable for tissue engineering applications.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Menzyanova, Natalia G., Pyatina, Svetlana V., Nikolaeva, Elena D., Shabanov A. V., Nemtsev I. V., Stolyarov D. P., Dryganov, Dmitry B., Sakhnov, Eugene V., Vinokurova, Daria A., Shishatskaya, Ekaterina I.
Заглавие : Morphological aspects of monocyte/macrophage polarization on biopolymer scaffolds in atherosclerosis patients
Место публикации : J. Biotechnol. Biomater. - 2018. - Vol. 8, Is. 3. - Ст.1000284. - ISSN 2155-952X, DOI 10.4172/2155-952X.1000284
Примечания : Cited References: 67. - The study was supported by the State budget allocated to the fundamental research at the Russian Academy of Sciences (project No 01201351505).
Ключевые слова (''Своб.индексиров.''): monocytes--macrophages--cell morphology--polyhydroxyalkanoates--pha--copolymers--atherosclerosis--intravascular stenting
Аннотация: The morphotypes of human macrophages (MPh) were studied in the culture on nano-structured substrates, made from polyhydroxyalcanoates (PHAs) of various monomer compositions, prepared by casting polymer solutions on a defatted glass and followed by the solvent evaporation. Its surface relief, being further in direct contact with human cells in vitro was analyzed by AFM and SEM scanning. It was shown, that the features of micro/nano relief depend on the monomeric composition of polymer substrates. Monocytes (MNs) of patients with atherosclerosis and cardiac ischemia undergoing stenting and conventional anti-atherosclerotic therapy were harvested prior to and after stenting. After isolation MNs were cultured and transformed into MPh in direct contact with biopolymer culture substrates with different monomer composition and Nano-reliefs in comparison with culture plastic. Sub-populations of cells with characteristic morphology in each phenotypic class were described and their ratios for five samples of polymers were counted as an intermediate result in the development of “smart” material for blood vessel recovery. The results obtained allow us to assume that the processes of MPh differentiation and polarization in vitro depend not only on the features of the micro/nano relief of biopolymer substrates but also on the initial state of MNs in vivo and the general response of patients.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shishatskaya E. I., Nikitovic D., Shabanov A. V., Tzanakakis G. N., Tsatsakis A. M., Menzianova N. G.
Заглавие : Short-term culture of monocytes as an in vitro evaluation system for bionanomaterials designated for medical use
Место публикации : Food Chem. Toxicol.: Elsevier, 2016. - Vol. 96. - P.302-308. - ISSN 02786915 (ISSN), DOI 10.1016/j.fct.2016.08.025
Примечания : Cited References: 46
Предметные рубрики: MAGNETIC NANOPARTICLES
CELLULAR REDUCTION
PROTEIN CORONA
CELLS
MECHANOTRANSDUCTION
NANOMATERIALS
LOCALIZATION
BIOMATERIALS
CYTOSKELETON
ACTIVATION
Ключевые слова (''Своб.индексиров.''): biocompatible biopolymers--polyhydroxyalkanoates--nanomaterials--nanodiamonds--fullerenes--bio-nanomaterials--monocytes
Аннотация: We studied the feasibility of using a short-term culture of monocytes, isolated from peripheral donor blood, to assess the biological activity of different types of bionanomaterials (BNM): biodegradable polimeric particles, fiber and film substrates of micro- and nano-dimensions, fullerenes (F) and nanodiamonds (ND), which are either currently in use and/or potentially applicable in medicine. Additionally, the effect of creating a protein corona on ND and F particles was investigated. The cellular reduction of (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) is a well-established tool for assessing the viability/metabolic activity of cells. The scanning electron microscopy assay can detect fine changes in cell morphology. In the present study BNM have been shown to affect; in a size, chemical composition and morphological characteristics-dependent manner, the ability of monocytes to reduce MTT as well as their morphology. Moreover, the specific effects of ND and F on MTT reduction and cell morphology were exhibited in a dose-dependent manner and sensitive to the formation of surface protein corona. Our results suggest that short-term culture of monocytes is a sensitive model system for assessing the biological effects of BMPs in vitro. © 2016 Elsevier Ltd
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