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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Kim P. D., Zamay S. S., Zamay T. N., Prokopenko V. S., Kolovskaya O. S., Zamay G. S., Princ, V. Ya., Seleznev V. A., Komonov A. I., Spivak E. A., Rudenko R. Y., Dubinina A. V., Komarov A. V., Denisenko V. V., Komarova M. A., Sokolov A. E., Narodov A. A., Zjivaev V. P., Zamay A. S.
Заглавие : The antitumor effect of magnetic nanodisks and DNA aptamer conjugates
Коллективы : Russian Science Foundation [14-15-00805]
Место публикации : Dokl. Biochem. Biophys.: MAIK Nauka-Interperiodica / Springer, 2016. - Vol. 466, Is. 1. - P.66-69. - ISSN 1607-6729, DOI 10.1134/S1607672916010154. - ISSN 1608-3091(eISSN)
Примечания : Cited References:7. - This work was supported by the Russian Science Foundation (project no. 14-15-00805).
Предметные рубрики: Nanoparticles
Cells
Аннотация: Here we describe a method of forming large arrays (up to 109 pieces) of free magnetic Ni-nanodisks 50 nm thick coated on both sides with layers of 5 nm thick Au. The antitumor effect of the magnetic nickel gold-coated nanodisks and DNA aptamer conjugates was evaluated in vivo and in vitro. Under the influence of rotating magnetic field, the studied nanodisks can cause the death of Ehrlich ascites carcinoma cells.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gorban A., Popova T., Zinovyev A.
Заглавие : Codon usage trajectories and 7-cluster structure of 143 complete bacterial genornic sequences
Разночтения заглавия :авие SCOPUS: Codon usage trajectories and 7-cluster structure of 143 complete bacterial genomic sequences
Место публикации : Physica A: ELSEVIER SCIENCE BV, 2005. - Vol. 353. - P365-387. - ISSN 0378-4371, DOI 10.1016/j.physa.2005.01.043
Примечания : Cited References: 46
Предметные рубрики: DNA-BASE COMPOSITION
ASYMMETRIC SUBSTITUTION PATTERNS
PROTEIN-CODING REGIONS
MICROBIAL GENOMES
GENE IDENTIFICATION
MARKOV-MODELS
G+C CONTENT
BIAS
PREDICTION
SELECTION
Ключевые слова (''Своб.индексиров.''): genome--cluster--codon usage--correlations--entropy--mean field--cluster--codon usage--correlations--entropy--genome--mean field--approximation theory--correlation methods--database systems--entropy--functions--genes--mathematical models--clusters--codon usage--genomes--mean field--bacteria
Аннотация: Three results are presented. First, we prove the existence of a universal 7-cluster structure in all 143 completely sequenced bacterial genomes available in Genbank in August 2004, and explained its properties. The 7-cluster structure is responsible for the main part of sequence heterogeneity in bacterial genomes. In this sense, our 7 clusters is the basic model of bacterial genome sequence. We demonstrated that there are four basic "pure" types of this model, observed in nature: "parallel triangles", "perpendicular triangles", degenerated case and the flower-like type. Second, we answered the question: how big are the position-specific information and the contribution connected with correlations between nucleotide. The accuracy of the mean-field (context-free) approximation is estimated for bacterial genomes. We show that codon us-age of bacterial genomes is a multi-linear function of their genomic G+C-content with high accuracy (more precisely, by two similar functions, one for eubacterial genomes and the other one for archaea). Description of these two codon-usage trajectories is the third result. All 143 cluster animated 3D-scatters are collected in a database and is made available on our web-site: http://www.ihes.fr/similar to zinovyev/7clusters. (c) 2005 Elsevier B.V. All rights reserved.
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Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Shchugoreva I., Moryachkov R., Zabluda V. N., Sokolov A. E., Spiridonova V. A., Gruzinov A., Zamay A. S., Veprincev D., Zamay G. S., Tomilin F. N., Ovchinnikov S. G.
Заглавие : Molecular design of aptamer structure by computer simulations
Коллективы : Euro-Asian Symposium "Trends in MAGnetism", "Trends in MAGnetism", Euro-Asian Symposium, Институт физики им. Л.В. Киренского Сибирского отделения РАН
Место публикации : VI Euro-Asian Symposium "Trends in MAGnetism" (EASTMAG-2016): abstracts/ ed.: O. A. Maksimova, R. D. Ivantsov. - Krasnoyarsk: KIP RAS SB, 2016. - Ст.P12.2. - P.558. - ISBN 978-5-904603-06-9 (Шифр -478014040)
Примечания : We acknowledge the grant by the Ministry of Education and Science (Agreement No.14.607.21.0104 (RFMEFI60714X0104)) for the financial support of this work
Ключевые слова (''Своб.индексиров.''): dna--selex--saxs--qm/mm--aptamer--g-quartets
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Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Sokolov A. E., Ivanova O. S., Zabluda V. N., Dubynina A. V., Semina P. N., Zamay G. S., Zamay T. N., Zamay A. S., Volochaev M. N., Svetlichnyi V., Lapin I. N., Shabalina A.
Заглавие : Magnetic and magnetooptical properties of magnetic nanoparticles and DNA-Aptamers conjugates for medical application
Коллективы : Euro-Asian Symposium "Trends in MAGnetism", "Trends in MAGnetism", Euro-Asian Symposium, Институт физики им. Л.В. Киренского Сибирского отделения РАН
Место публикации : VI Euro-Asian Symposium "Trends in MAGnetism" (EASTMAG-2016): abstracts/ ed.: O. A. Maksimova, R. D. Ivantsov. - Krasnoyarsk: KIP RAS SB, 2016. - Ст.P12.4. - P.561. - ISBN 978-5-904603-06-9 (Шифр -478014040)
Примечания : The work was supported by the Ministry of Education and Science (Agreement No.14.607.21.0104 (RFMEFI60714X0104))
Ключевые слова (''Своб.индексиров.''): magnetic nanoparticles--magnetization--natural and magnetic circular dichroism--aptamers--bionanoconjugates
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Zamay G. S., Belyanina I. V., Zamay A. S., Komarova M. A., Krat A. V., Eremina E. N., Zukov R. A., Sokolov A. Е., Zamay T. N.
Заглавие : Selection of DNA aptamers for breast cancer
Место публикации : Biochem. Mosc.-Suppl. Ser. B-Biomed. Chem. - 2016. - Vol. 10, Is. 2. - P.158-164. - ISSN 1990-7508, DOI 10.1134/S1990750816020128. - ISSN 1990-7516(eISSN)
Примечания : Cited References:23
Предметные рубрики: BIOMARKERS
MORTALITY
PATTERNS
Ключевые слова (''Своб.индексиров.''): selex--dna aptamers--oligonucleotides--breast cancer
Аннотация: A method of selection of DNA aptamers to breast tumor tissue based on the use of postoperative material has been developed. Breast cancer tissues were used as the positive target; the negative targets included benign tumor tissue, adjacent healthy tissues, breast tissues from mastopathy patients, and also tissues of other types of malignant tumors. During selection a pool of DNA aptamers demonstrating selective binding to breast cancer cells and tissues and insignificant binding to breast benign tissues has been obtained. These DNA aptamers can be used for identification of protein markers, breast cancer diagnostics, and targeted delivery of anticancer drugs.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gorelik V. S., Zlobina L. I., Krylov A. S., Sverbil V. P., Sverbil P. P.
Заглавие : Raman scattering in dried DNA and crystalline amino acids
Место публикации : Phys. Wave Phenom.: Allerton Press, 2016. - Vol. 24, Is. 4. - P.272-278. - ISSN 1541308X (ISSN), DOI 10.3103/S1541308X1604004X
Примечания : Cited References: 53. - The work was supported in part by the RFBR Projects 14-02-00190 and 16-52-00026 (BRFFR - RFBR F16R-063).
Аннотация: Raman spectrum characteristics of dried deoxyribonucleic acid (DNA) and two types of crystalline amino acids (L-lysine, D-asparagine) are compared in a wide range of frequencies, including the regions of lattice (7 to 200 cm−1) and intramolecular (200 to 4000 cm−1) vibrations. It is found that the spectral position of the low-frequency band in the Raman spectrum of DNA with a peak near 26 cm−1 correlates with the Raman spectrum of high-Q low-frequency modes that manifest themselves in the crystalline amino acids under investigation. The low-frequency band of DNA refers to a twist-like vibrational mode of nucleobases. The intensities of this DNA mode and the high-Q lattice modes of the crystalline amino acids L-lysine and D-asparagine are several times as high as those of the Raman lines corresponding to the intramolecular modes. Resonant coupling of low-frequency modes of DNA and amino acid molecular chains is analyzed. © 2016, Allerton Press, Inc.
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Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Sokolov A. Е., Zamay S. S., Zamay T. , Svetlichnyi V., Velikanov D. A.
Заглавие : Magnetic nanoparticles and DNA-aptamers conjugates for diagnostics and therapy of cancer : Invited
Коллективы : Federal Research Center KSC SB RAS, Kirensky Institute of Physics, Siberian Federal Univercity, International Workshop on Actual Problems of Condensed Matter Physics
Место публикации : International workshop on actual problems of condensed matter physics: Program. Book of abstracts/ Fed. Res. Center KSC SB RAS, Kirensky Inst. of phys., Sib. Fed. Univ. - Krasnoyarsk, 2017. - P.13 (Шифр В37/H99-812624296)
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Вид документа : Однотомное издание
Шифр издания :
Заглавие : International workshop on actual problems of condensed matter physics : Program. Book of abstracts
Выходные данные : Krasnoyarsk, 2017
Колич.характеристики :30 с
Коллективы : Federal Research Center KSC SB RAS, Kirensky Institute of Physics, Siberian Federal Univercity, International Workshop on Actual Problems of Condensed Matter Physics (27 Mar. - 1 Apr. 2017; Krasnoyarsk/ Cheremushki) :
Содержание : Magnetic and transport properties of the epitaxial Fe3Si film on a Si substrate/ I. A. Bondarev. The magnetic anisotropy of the Fe and Fe(1-x)Si(x) thin films depend on/ I. A. Yakovlev [и др.]. Inverted opals as the Josephson networks of weak links/ S. I. Popkov [и др.]. Electronic structure and Fermi surface within the cluster perturbation theory in X-operators representation/ S. Nikolaev, V. I. Kuz'min, S. G. Ovchinnikov. DFT investigation of electronic and optical magnetic properties of one dimensional transition metal halide structuresTmHaI3/ A. S. Fedorov [и др.]. Effect of interatomic exchange interaction on spin crossover and Mott-Hubbard transition under high pressure and the physical properties of the low Earth’s mantle/ S. G. Ovchinnikov [и др.]. Extremely high magnetic-field sensitivity of charge transport in the Mn/SiO2/p-Si hybrid structure/ I. A. Tarasov [и др.]. Marnetic-field sensitivity of charge transport in silicon-based hybrid structures/ N. V. Volkov [et al.]. Fabrication of multi-terminal planar devices based on epitaxial Fe1-xSix films grown on Si(111)/ A. V. Lukyanenko, A. S. Tarasov, I. A. Tarasov [et al.] ; A. V. Luyanenko [и др.]. Magnetic field-driven lateral photovoltaic effect in the Fe/SiO2/p-Si hibrid structure with the Scottky barrier/ M. V. Rautskii [и др.]. Small angle X-ray scattering and atomic structure of aptamer biomolecules/ R. Moryachkov [и др.]. Iron silicides and pure iron epitaxial and highly-textured nanostructures on silicon: growth and their physical properties/ I. A. Tarasov [и др.]. Magnetic nanoparticles and DNA-aptamers conjugates for diagnostics and therapy of cancer/ A. E. Sokolov [и др.]. The microscopic origin of ferromagnetism in Fe silicides/ I. S. Sandalov [и др.].
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Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Sokolov A. Е., Ivanova O. S., Zabluda V. N., Dubinina A. V., Semina P. N., Zamay G. S., Zamay T. N., Zamay S. S., Volochaev M. N., Svetlichnyi V., Lapin I. N., Shabalina A., Solodova O. V.
Заглавие : Magnetic nanoparticles and DNA-aptamers conjugates for cancer therapy
Коллективы : International Baltic Conference on Magnetism: Focus on funcshionalized magnetic structures for energy and biotechnology , Балтийский федеральный университет им. И. Канта
Место публикации : Int. Baltic Conf. Magnet. (IBCM-2017) : Focus on funcshionalized magnetic struct. for energy and biotech.: book of abstracts. - 2017. - P.77
Примечания : Библиогр.: 4
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10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Belyanina I. V., Zamay T. N., Zamay G. S., Zamay S. S., Kolovskaya, Olga S., Ivanchenko, Tatiana I., Denisenko, Valery V., Kirichenko, Andrey K., Glazyrin, Yury E., Garanzha, Irina V., Grigorieva, Valentina V., Shabanov A. V., Veprintsev, Dmitry V., Sokolov A. E., Sadovskii, Vladimir M., Gargaun, Ana, Berezovski M. V., Kichkailo, Anna S.
Заглавие : In vivo cancer cells elimination guided by aptamer-functionalized gold-coated magnetic nanoparticles and controlled with low frequency alternating magnetic field
Коллективы : Russian Scientific Fund [14-15-00805]
Место публикации : Theranostics. - 2017. - Vol. 7, Is. 13. - P.3326-3337. - ISSN 1838-7640, DOI 10.7150/thno.17089
Примечания : Cited References:35. - The authors are grateful to George Y. Vorogeikin, Yuri I. Vorogeikin and "OKB ART". Andrey Barinov and "OPTEC Group" for help with 3D laser scanning imaging. Microscopic analyses using Carl Zeiss LSM 800 were done in the "Center for bioassay, nanotechnology and nanomaterials safety" ("Biotest-Nano") (Multiple-Access Center, Tomsk State University, Tomsk, Russia). Toxicity studies have been performed in Multiple-Access Center, Central Scientific Research Laboratory in Krasnoyarsk State Medical University named after prof. V.F. Voino-Yasenecky. This work was supported by the Russian Scientific Fund (grant #14-15-00805).
Предметные рубрики: PHOTOTHERMAL THERAPY
INTEGRIN ACTIVATION
FIBRONECTIN
STIMULATION
Ключевые слова (''Своб.индексиров.''): cancer therapy--gold coated magnetic nanoparticles--dna aptamers--low--frequency alternating magnetic field--fibronectin--integrin--apoptosis--necrosis
Аннотация: Biomedical applications of magnetic nanoparticles under the influence of a magnetic field have been proved useful beyond expectations in cancer therapy. Magnetic nanoparticles are effective heat mediators, drug nanocarriers, and contrast agents; various strategies have been suggested to selectively target tumor cancer cells. Our study presents magnetodynamic nanotherapy using DNA aptamer-functionalized 50 nm gold-coated magnetic nanoparticles exposed to a low frequency alternating magnetic field for selective elimination of tumor cells in vivo. The cell specific DNA aptamer AS-14 binds to the fibronectin protein in Ehrlich carcinoma hence helps deliver the gold-coated magnetic nanoparticles to the mouse tumor. Applying an alternating magnetic field of 50 Hz at the tumor site causes the nanoparticles to oscillate and pull the fibronectin proteins and integrins to the surface of the cell membrane. This results in apoptosis followed by necrosis of tumor cells without heating the tumor, adjacent healthy cells and tissues. The aptamer-guided nanoparticles and the low frequency alternating magnetic field demonstrates a unique non-invasive nanoscalpel technology for precise cancer surgery at the single cell level.
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