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Автор(ы) : Chilom, Claudia G., Zorilă, Bogdan, Bacalum M., Bălăşoiu, Maria, Yaroslavtsev R. N., Stolyar S. V., Tyutyunnicov, Sergey
Заглавие : Ferrihydrite nanoparticles interaction with model lipid membranes.
Место публикации : Chem. Phys. Lipids. - 2020. - Vol. 226. - Ст.104851. - ISSN 0009-3084, DOI 10.1016/j.chemphyslip.2019.104851. - ISSN 1873-2941 (eISSN)
Примечания : Cited References: 70. - The work was accomplished with the financial support of the 2019 RO-JINR Project Investigation of biogenic and chemically synthesized systems in interaction with biostructures for applied research, Theme 02-1-1107-2011/2019 and of the Romanian National Authority for Scientific Research, CNDI-UEFISCDI, Project numbers: PN 18 09 02 02/2018 and PN 19 06 02 03/2019. The authors are very much indebted to Professor Dr. Aurel Popescu, for very helpful suggestions and permanent encouragement.
Аннотация: In recent years was observed an increased interest towards the use of metal nanoparticles for various biomedical applications, such as therapeutics, delivery systems or imaging. As biological membranes are the first structures with which the nanoparticles interact, it is necessary to understand better the mechanisms governing these interactions. In the present paper we aim to characterize the effect of three different ferrihydrite nanoparticles (simple or doped with cooper or cobalt) on the fluidity of model lipid membranes. First we evaluated the physicochemical properties of the nanoparticles: size and composition. Secondly, their effect on lipid membranes was also evaluated using Laurdan, TMA-DPH and DPH fluorescence. Our results can help better understand the mechanisms involved in nanoparticles and membrane interactions.
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