Библиотека института физики им. Л.В. Киренского СО РАН

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Каталог книг и брошюр библиотеки ИФ СО РАН

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Труды сотрудников ИФ СО РАН

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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Kim P. D., Zamay S. S., Zamay T. N., Prokopenko V. S., Kolovskaya O. S., Zamay G. S., Princ, V. Ya., Seleznev V. A., Komonov A. I., Spivak E. A., Rudenko R. Y., Dubinina A. V., Komarov A. V., Denisenko V. V., Komarova M. A., Sokolov A. E., Narodov A. A., Zjivaev V. P., Zamay A. S.
Заглавие : The antitumor effect of magnetic nanodisks and DNA aptamer conjugates
Коллективы : Russian Science Foundation [14-15-00805]
Место публикации : Dokl. Biochem. Biophys.: MAIK Nauka-Interperiodica / Springer, 2016. - Vol. 466, Is. 1. - P.66-69. - ISSN 1607-6729, DOI 10.1134/S1607672916010154. - ISSN 1608-3091(eISSN)
Примечания : Cited References:7. - This work was supported by the Russian Science Foundation (project no. 14-15-00805).
Предметные рубрики: Nanoparticles
Cells
Аннотация: Here we describe a method of forming large arrays (up to 109 pieces) of free magnetic Ni-nanodisks 50 nm thick coated on both sides with layers of 5 nm thick Au. The antitumor effect of the magnetic nickel gold-coated nanodisks and DNA aptamer conjugates was evaluated in vivo and in vitro. Under the influence of rotating magnetic field, the studied nanodisks can cause the death of Ehrlich ascites carcinoma cells.
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Вид документа : Статья из сборника (выпуск продолж. издания)
Шифр издания :
Автор(ы) : Ershov A. E., Bikbaev R. G., Rasskazov I. L., Gerasimov V. S., Timofeev I. V., Polyutov S. P., Karpov S. V.
Заглавие : Collective resonances in hybrid photonic-plasmonic nanostructures
Коллективы : International Conference on Metamaterials and Nanophotonics
Место публикации : J. Phys.: Conf. Ser. - 2020. - Vol. 1461, Is. 1. - Ст.012046. - DOI 10.1088/1742-6596/1461/1/012046
Примечания : Cited References: 11. - The reported study was funded by Russian Foundation for Basic Research, Government of Krasnoyarsk Territory, Krasnoyarsk Regional Fund of Science (Grant No. 18-42-240013); A.E. thanks the grant of the President of Russian Federation (agreement 075-15-2019-676)
Аннотация: We present the theoretical model to predict the spectral position of Rayleigh anomalies emerged in hybrid system consisting of periodic array of plasmonic nanodisks embeded into the middle of defect layer of 1D photonic crystal (PhC). The spectral positions of these new emerged Rayleigh anomalies agree well with the results of exact simulations with Finite-Difference Time-Domain (FDTD) method.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Zamay, Tatiana, Zamay, Sergey, Luzan, Natalia, Fedotovskaya, Victoriya, Masyugin, Albert, Zelenov F., Koshmanova, Anastasia, Nikolaeva, Elena, Kirichenko, Daria, Veprintsev, Dmitry, Kolovskaya, Olga, Shchugoreva, Irina, Zamay, Galina, Lapin I. N., Lukyanenko A. V., Borus, Andrey, Sukhachev A. L., Volochaev M. N., Lukyanenko, Kirill, Shabanov, Alexandr, Zabluda V. N., Zhizhchenko, Alexey, Kuchmizhak, Aleksandr, Sokolov A. Е., Narodov, Andrey, Prokopenko, Vladimir, Galeev, Rinat, Svetlichnyi, Valery, Kichkailo, Anna
Заглавие : Magnetic nanoscalpel for the effective treatment of ascites tumors
Место публикации : J. Funct. Biomater. - 2023. - Vol. 14, Is. 4. - Ст.179. - ISSN 20794983 (eISSN), DOI 10.3390/jfb14040179
Примечания : Cited References: 36. - This research was funded by the Regional State Autonomous Institution “Krasnoyarsk Regional Fund for Support of Scientific and Scientific and Technical Activities”, Competition of scientific, technical, and innovative projects in the interests of the first world-class climate scientific and educational center “Yenisei Siberia”, grant “Carrying out applied research and development aimed at creating technologies for the production of nanoscalpels based on magnetic nanodisks for microsurgery of glial brain tumors” No. 2022060108781 and with the support of a partner company JSC «NPP «Radiosviaz»
Аннотация: One of the promising novel methods for radical tumor resection at a single-cell level is magneto-mechanical microsurgery (MMM) with magnetic nano- or microdisks modified with cancer-recognizing molecules. A low-frequency alternating magnetic field (AMF) remotely drives and controls the procedure. Here, we present characterization and application of magnetic nanodisks (MNDs) as a surgical instrument (“smart nanoscalpel”) at a single-cell level. MNDs with a quasi-dipole three-layer structure (Au/Ni/Au) and DNA aptamer AS42 (AS42-MNDs) on the surface converted magnetic moment into mechanical and destroyed tumor cells. The effectiveness of MMM was analyzed on Ehrlich ascites carcinoma (EAC) cells in vitro and in vivo using sine and square-shaped AMF with frequencies from 1 to 50 Hz with 0.1 to 1 duty-cycle parameters. MMM with the “Nanoscalpel” in a sine-shaped 20 Hz AMF, a rectangular-shaped 10 Hz AMF, and a 0.5 duty cycle was the most effective. A sine-shaped field caused apoptosis, whereas a rectangular-shaped field caused necrosis. Four sessions of MMM with AS42-MNDs significantly reduced the number of cells in the tumor. In contrast, ascites tumors continued to grow in groups of mice and mice treated with MNDs with nonspecific oligonucleotide NO-MND. Thus, applying a “smart nanoscalpel” is practical for the microsurgery of malignant neoplasms.
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