Библиотека института физики им. Л.В. Киренского СО РАН

Главная

Базы данных

Труды сотрудников ИФ СО РАН - результаты поиска

Вид поиска

Каталог книг и брошюр библиотеки ИФ СО РАН

Каталог журналов библиотеки ИФ СО РАН

Труды сотрудников ИФ СО РАН

Область поиска

в найденном

Формат представления найденных документов:
полный	информационный	краткий

Отсортировать найденные документы по:
автору	заглавию	году издания	типу документа

Поисковый запрос: (<.>K=cells<.>)

Общее количество найденных документов : 59
Показаны документы с 1 по 20

1-20 21-40 41-59

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Bikbaev R. G., Vetrov S. Ya., Timofeev I. V., Shabanov V. F.
Заглавие : Photosensitivity and reflectivity of the active layer in a Tamm-plasmon-polariton-based organic solar cell
Место публикации : Appl. Opt. - 2021. - Vol. 60, Is. 12. - P.3338-3343. - ISSN 1559128X (ISSN), DOI 10.1364/AO.421374
Примечания : Cited References: 49. - The reported study was funded by the grant of the President of Russian Federation No. MK-46.2021.1.2 and by Russian Foundation for Basic Research, Government of Krasnoyarsk Territory, Krasnoyarsk Region Science and Technology Support Fund to the research project No. 19-42-240004
Аннотация: We report on a model of an organic solar cell in which a photosensitive layer doped with plasmon nanoparticles acts as not only an absorbing element but also a mirror involved in the formation of the Tamm plasmon polariton. It is shown that such solar cells can be fabricated without metal contacts, thus avoiding undesired losses in the system. Methods for an additional increase in the integral absorption by applying metal or dielectric mirrors to the lower boundary of the photonic crystal are proposed. It has been found that the integral absorption in the active layer can be increased by15%compared to classical optimized planar solar cells.
Смотреть статью,
Scopus,
WOS
Найти похожие

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Balaev D. A., Semenov S. V., Varnakov S. N., Radionov E. Y., Tretyakov Al. Y.
Заглавие : High-temperature evolution of the magnetization of aluminum reduction cell steel
Место публикации : J. Sib. Fed. Univ. Math. Phys. - 2021. - Vol. 14, Is. 1. - P.5-11. - ISSN 19971397 (ISSN), DOI 10.17516/1997-1397-2021-14-1-5-11; Журн. СФУ. Матем. и физика
Примечания : Cited References: 17. - We are grateful to A. D. Balaev and S. V.Komogortsev for fruitful discussions. The magnetic measurements were performed on the facility at the Krasnoyarsk Territorial Center for Collective Use, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences. This study was supported by the Russian Foundation for Basic Research, the Government of the Krasnoyarsk Territory, the Krasnoyarsk Territorial Foundation for Support of Scientific and R&D Activities, and the United Company RUSAL, project no. 20-48-242905 "Determining the Effect of Magnetization of Ferromagnets on the MHD Parameters of the Reduction Cell"
Аннотация: The magnetic properties of steel of a structural element of an aluminum reduction cell have been investigated in the temperature range of 300–900 K. The analysis of the temperature dependence of the saturation magnetization Ms(T) showed (i) the applicability of the Bloch’s 3/2 law and a reason- able value of the Bloch’s constant for steel and (ii) the quadratic dependence Ms(T)~(1 - T2) in the temperature range of 380–700 K.В работе исследованы магнитные свойства стали конструктивного элемента алюминиевого электролизера в области температур 300–900 K. Проведенный анализ температурной зависимости намагниченности насыщения MS(T) показал: (i) применимость "закона 3/2" Блоха, а также разумное значение константы Блоха и константы обменного взаимодействия для стали; (ii) квадратичную зависимость MS(T)∼(1 - T2) в температурном диапазоне 380–700 K.
Смотреть статью,
РИНЦ,
Scopus,
WOS,
Читать в сети ИФ
Найти похожие

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Stolyar S. V., Kryukova O. V., Yaroslavtsev R. N., Bayukov O. A., Knyazev Yu. V., Gerasimova Yu. V., Pyankov V. F., Latyshev N. V., Shestakov N. P.
Заглавие : Influence of magnetic nanoparticles on cells of Ehrlich ascites carcinoma
Место публикации : AIP Adv. - 2021. - Vol. 11, Is. 1. - Ст.015019. - ISSN 21583226 (ISSN), DOI 10.1063/9.0000165
Примечания : Cited References: 22. - The electron microscopy and magnetic resonance study was carried out on the equipment of the Krasnoyarsk Territorial Center for Collective Use, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences. This work was supported by the Council of the President of the Russian Federation for State Support of Young Scientists and Leading Scientific Schools (project no. MK-1263.2020.3). The research was funded by RFBR, Krasnoyarsk Territory and Krasnoyarsk Regional Fund of Science, project number 20-42-242902
Аннотация: The effect of magnetic nanoparticles coated with arabinogalactan on the viability of Ehrlich ascites carcinoma (EAC) cells was studied. The nanoparticles were studied by transmission electron microscopy, Mossbauer spectroscopy, IR spectroscopy, and ferromagnetic resonance. A correlation between the proportion of dead EAC cells in suspension and the intensity of the EPR signal of dinitrosyl iron complexes was found. This result may be due to the presence of NO molecules.
Смотреть статью,
Scopus,
WOS,
Читать в сети ИФ
Найти похожие

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Moryachkov R. V., Morozov D., Mironov V., Shchugoreva I., Artyushenko P. V., Zamay G. S., Molodenskiy D. S., Zabluda V. N., Kichkailo A.S., Sokolov A. Е.
Заглавие : The role of small-angle X-ray scattering and molecular simulations in 3D structure elucidation of a DNA aptamer-cancer cells magnetic separation agent
Коллективы : International Baltic Conference on Magnetism: focus on nanobiomedicine and smart materials, Балтийский федеральный университет им. И. Канта
Место публикации : 4th International Baltic Conference on Magnetism (IBCM 2021): Book of abstracts. - 2021. - P.168
Примечания : Cited References: 2. - The reported study was funded by RFBR, project number 19-32-90266
Материалы конференции,
Читать в сети ИФ
Найти похожие

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Kostyukov A. S., Isaev I. L., Ershov A. E., Gerasimov V. S., Polyutov S. P., Karpov S. V.
Заглавие : Part II. Nanobubbles around plasmonic nanoparticles in terms of modern simulation modeling: what makes them kill the malignant cells?
Коллективы : Ministry of Science and High Education of Russian Federation [FSRZ-2020-0008]; RFBRRussian Foundation for Basic Research (RFBR); Krasnoyarsk Territory and Krasnoyarsk Regional Fund of Science [20-42-240003]
Место публикации : J. Phys. D. - 2022. - Vol. 55, Is. 17. - Ст.175402. - ISSN 0022-3727, DOI 10.1088/1361-6463/ac4c1f. - ISSN 1361-6463(eISSN)
Примечания : Cited References: 49. - The research was supported by the Ministry of Science and High Education of Russian Federation (Project No. FSRZ-2020-0008), and was funded by RFBR, Krasnoyarsk Territory and Krasnoyarsk Regional Fund of Science, Project No. 20-42-240003
Предметные рубрики: STRESS WAVES
LASER
MEMBRANE
DAMAGE
DEATH
LYSIS
Аннотация: We have established numerically the physical pattern and conditions for formation of nanosized bubbles in aqueous medium around biocompatible plasmonic nanoparticles (NPs) selectively bound to the membrane of the malignant cells by means of DNA-aptamers under the action of picosecond laser radiation. The results obtained are based on the finite volume method and hydrodynamic models underlying the ANSYS Fluent package with extended capabilities. We have found the main features and previously unknown dominant factors of the damage effect on the cell membrane at the moment of the bubble nucleation around the plasmonic NPs of different types taking into account the influence of the closely located membrane. Information on the kinetics of spatial distribution of pressure, temperature and the relative proportion of vapor in the 'nanoparticle-membrane-medium' system have been obtained. The attention is drawn to the advantages of using biocompatible, perfectly absorbing core–shell plasmonic NPs for anti-tumor therapy characterized by an increased mechanical effect on malignant cell membranes at lower laser radiation intensity and the spectral position of their plasmon resonance (λ = 700 nm) in the hemoglobin transparency range. This ensures penetration of laser radiation deep into tissues. The paper is provided with an extensive review of key publications and the state-of-art in this area.
Смотреть статью,
Scopus,
WOS
Найти похожие

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Tyumentseva A. V., Gorbenko A. S., Yaroslavtsev R. N., Stolyar S. V., Gerasimova Yu. V., Komogortsev S. V., Bayukov O. A., Knyazev Yu. V., Volochaev M. N., Olkhovskiy I. A., Iskhakov R. S.
Заглавие : Iron oxide nanoparticles for isolating DNA from blood cells
Место публикации : Bull. Russ. Acad. Sci. Phys. - 2021. - Vol. 85, Is. 9. - P.965-969. - ISSN 10628738 (ISSN), DOI 10.3103/S1062873821090185
Примечания : Cited References: 13. - This work was supported by the Russian Foundation for Basic Research; the Government of Krasnoyarsk Territory; the Krasnoyarsk Regional Fund for the Support of Scientific and Scientific and Technical Activities, project no. 20-42-242902; and the RF Presidential Council of Grants for the State Support of Young Russian Scientists (Candidates of Science), project no. MK-1263.2020.3
Аннотация: Magnetic iron oxide nanoparticles for separating DNA from blood cells are synthesized. Magnetic nanoparticles with a silicate coating are obtained, and their physical and chemical properties are studied. The possibility of using the nanocomposites to isolate DNA from leukocytes for hematological studies is confirmed experimentally.
Смотреть статью,
Scopus,
Читать в сети ИФ
Найти похожие

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Belousov A. L., Patrusheva T. N., Karacharov A. A., Ivanenko A. A., Kirik S. D., Khol'kin A. I.
Заглавие : Amorphous and Crystalline Nickel Oxide Films Obtained by the Extraction-Pyrolysis Method for Electrochromic Cells
Коллективы : program "Research and Development for the Priority Areas of the Russian Science-and-Technology Sector for 2014-2020" [075-15-2019-1843]; [RFMEFI60719X0307]
Место публикации : Theor. Found. Chem. Eng. - 2020. - Vol. 54, Is. 4. - P.699-705. - ISSN 0040-5795, DOI 10.1134/S0040579520040041. - ISSN 1608-3431(eISSN)
Примечания : Cited References: 8. - This work was performed as part of the program "Research and Development for the Priority Areas of the Russian Science-and-Technology Sector for 2014-2020"; Grant Agreement no. 075-15-2019-1843; the Project Unique Identifier RFMEFI60719X0307
Предметные рубрики: NIO THIN-FILMS
Аннотация: This paper reports studies of thin films of nickel oxide obtained by the extraction–pyrolysis method on glass and quartz substrates at temperatures of 380–600°C. The films have been characterized by atomic force microscopy and X-ray diffraction. It is shown that amorphous and crystalline nickel oxide films are formed on the glass. The grain size depends on the annealing temperature, while increased annealing temperatures lead to recrystallization and a decrease in the grain size in NiO films from 130 to 35 nm.
Смотреть статью,
Scopus,
WOS,
Читать в сети ИФ
Найти похожие

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Bondarenko L. S., Kovel E. S., Kydralieva K. A., Dzhardimalieva G. I., Illes E., Tombacz E., Kicheeva A. G., Kudryasheva N. S.
Заглавие : Effects of modified magnetite nanoparticles on bacterial cells and enzyme reactions
Место публикации : Nanomaterials. - 2020. - Vol. 10, Is. 8. - Ст.1499. - P.1-20. - ISSN 20794991 (ISSN), DOI 10.3390/nano10081499
Примечания : Cited References: 83. - This research was funded by the Russian Foundation for Basic Research (#19-315-50048, #19-33-90149, and #18-29-19003)
Аннотация: Current paper presents biological effects of magnetite nanoparticles (MNPs). Analyzing effects of MNP’ characteristics (zeta-potential and hydrodynamic diameters) on bacteria and their enzyme reactions was the main focus. Photobacterium phosphoreum and bacterial enzymatic reactions were chosen as bioassays. Three types of MNPs were under study: bare Fe3O4, Fe3O4 modified with 3-aminopropyltriethoxysilane (Fe3O4/APTES), and humic acids (Fe3O4/HA). Effects of the MNPs were studied at a low concentration range (< 2 mg/L) and attributed to availability and oxidative activity of Fe3+, high negative surface charge, and low hydrodynamic diameter of Fe3O4/HA, as well as higher Fe3+ content in suspensions of Fe3O4/HA. Low-concentration suspensions of bare Fe3O4 provided inhibitory effects in both bacterial and enzymatic bioassays, whereas the MNPs with modified surface (Fe3O4/APTES and Fe3O4/HA) did not affect the enzymatic activity. Under oxidative stress (i.e., in the solutions of model oxidizer, 1,4-benzoquinone), MNPs did not reveal antioxidant activity, moreover, Fe3O4/HA demonstrated additional inhibitory activity. The study contributes to the deeper understanding of a role of humic substances and silica in biogeochemical cycling of iron. Bioluminescence assays, cellular and enzymatic, can serve as convenient tools to evaluate bioavailability of Fe3+ in natural dispersions of iron-containing nanoparticles, e.g., magnetite, ferrihydrite, etc.
Смотреть статью,
Scopus,
WOS,
Читать в сети ИФ
Найти похожие

10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Blyakhman F. A., Makarova E. B., Shabadrov P. A., Fadeyev F. A., Shklyar T. F., Safronov A. P., Komogortsev S. V., Kurlyandskaya, G., V
Заглавие : Magnetic nanoparticles as a strong contributor to the biocompatibility of ferrogels
Коллективы : Russian Science FoundationRussian Science Foundation (RSF) [18-19-00090]
Место публикации : Phys. Metals Metallogr. - 2020. - Vol. 121, Is. 4. - P.299-304. - ISSN 0031-918X, DOI 10.1134/S0031918X2004002X. - ISSN 1555-6190(eISSN)
Примечания : Cited References: 17. - This study was supported by the Russian Science Foundation, grant no. 18-19-00090.
Предметные рубрики: STIFFNESS
Аннотация: Biomedical engineering is the most promising field for the application of ferrogels as scaffolds for cell culturing in regenerative medicine, targeted drug delivery, and biosensorics. This study is focused on the contribution of ferric-oxide magnetic nanoparticles (MNPs) to the biocompatibility of ferrogels with human dermal fibroblasts. The results of experiments with polyacrylamide gels filled with MNPs are presented. These experiments demonstrate that, regardless of the mechanical and electrical characteristics of ferrogels, MNPs have a significant effect on the biological activity of cells.
Смотреть статью,
Scopus,
WOS,
Читать в сети ИФ
Найти похожие

11.

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Stolyar S. V., Kryukova O. V., Yaroslavtsev R. N., Latyshev N. V.
Заглавие : Influence of Magnetic Nanoparticles on Cells of Ehrlich Ascites Carcinoma
Коллективы : Annual conference on мagnetism and мagnetic мaterials
Место публикации : 65th Annual conference on мagnetism and мagnetic мaterials (MMM-2020): abstract book. - 2020. - Ст.Q5-07. - P.530
Примечания : Cited References: 1
Материалы конференции, , ,
Читать в сети ИФ
Найти похожие

12.

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Denissenko P., Denisenko V. V., Denisov I., Kantsler V., Kolovskaya O. S., Lapin I. N., Sokolov A. Е., Svetlichnyi V., Zabluda V. N., Zamay S. S., Kichkailo A.S.
Заглавие : Magnetic sorting of tumor cells with attached magnetic nanoparticles in a microchannel
Коллективы : Aptamers in Russia, international conference
Место публикации : Aptamers in Russia, international conference (1 ; 2019 ; Aug. 27-30 ; Krasnoyarsk). Molecular Therapy - Nucleic Acids: book of abstracts of the 1st Int. conf. "Aptamers in Russia 2019". - 2019. - Vol. 17, Suppl. 1. - P.14
Материалы конференции
Найти похожие

13.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Komina A. V., Yaroslavtsev R. N., Gerasimova Yu. V., Stolyar S. V., Olkhovsky I. A., Bairmani M. S.
Заглавие : Magnetic Nanoparticles for Extracting DNA from Blood Cells
Место публикации : Bull. Russ. Acad. Sci. Phys. - 2020. - Vol. 84, Is. 11. - P.1362-1365. - ISSN 10628738 (ISSN), DOI 10.3103/S1062873820110155
Примечания : Cited References: 15
Аннотация: A technique for extracting DNA from blood cells using magnetic particles offers the advantage of saving time and prospects of automating the extraction process. A way of obtaining magnetic iron nanoparticles for extracting DNA from blood cells is developed. Magnetic nanoparticles with characteristics suitable for extracting genomic DNA from leukocytes are obtained and investigated.
Смотреть статью,
Scopus,
Читать в сети ИФ
Найти похожие

14.

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Бикбаев, Рашид Гельмединович, Ветров, Степан Яковлевич, Тимофеев, Иван Владимирович, Шабанов, Василий Филиппович
Заглавие : Таммовские плазмон-поляритоны увеличивающие поглощение в органических солнечных элементах
Коллективы : Международная конференция по фотонике и информационной оптике, Российская академия наук, Национальный исследовательский ядерный университет "МИФИ", Государственная корпорация по атомной энергии "РОСАТОМ"
Место публикации : Международная конференция по фотонике и информационной оптике (9 ; 2020 ; янв. ; 29-31 ; Москва). IX Международная конференция по фотонике и информационной оптике: сборник научных трудов. - 2020. - С. 437-438. - ISBN 978-5-7262-2648-4
Примечания : Библиогр.: 2
Аннотация: В работе предложена модель органического солнечного элемента на основе таммовского плазмон-поляритона, локализованного на границе активного слоя, допированного плазмонными наночастицами, и многослойного зеркала. Показано, что интегральное поглощение в активном слое может быть увеличено на 10% по сравнению с оптимизированным планарным солнечным элементом.
,
Материалы конференции,
Читать в сети ИФ
Найти похожие

15.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Zyryanov V. Ya., Myslivets S. A., Gunyakov V. A., Parshin A. M., Arkhipkin V. G., Shabanov V. F., Lee, Wei
Заглавие : Magnetic-field tunable defect modes in a photonic-crystal/liquid-crystal cell
Место публикации : Opt. Express. - 2010. - Vol. 18, Is. 2. - P.1283-1288. - JAN 18. - ISSN 1094-4087, DOI 10.1364/OE.18.001283
Примечания : Cited Reference Count: 15. - Гранты: This work was partially supported by the Russian Federal Grant No. 02.740.11.0220 and SB RAS Grant Nos. 5, 27.1 and 144. W. Lee gratefully acknowledges financial support from the National Science Council of the Republic of China (Taiwan) under Grant No. NSC 98-2923-M-033-001-MY3 dedicated to an internationally joint effort between Russia and Taiwan.Финансирующая организация: Russian Federal [02.740.11.0220]; SB RAS [5, 27.1, 144]; National Science Council of the Republic of China (Taiwan) [NSC 98-2923-M-033-001-MY3]
Предметные рубрики: NEMATIC LIQUID-CRYSTAL
BAND-GAP MATERIALS
SPONTANEOUS EMISSION
SPECTRUM
Ключевые слова (''Своб.индексиров.''): crystal defects--magnetic fields--photonic crystals--applied magnetic fields--crossed polarizers--crystal cells--defect mode--homeotropic--light transmission spectra--light wave--nematic director--optical cells--planar alignment--spectral shift--tunable defect--light transmission--article--artifact--chemistry--electromagnetic field--liquid crystal--materials--materials testing--radiation exposure--refractometry--artifacts--electromagnetic fields--liquid crystals--manufactured materials--materials testing--refractometry
Аннотация: Light transmission spectrum of a multilayer photonic crystal with a central liquid-crystal defect layer placed between crossed polarizers has been studied. Transmittance was varied due to the magnetically induced reorientation of the nematic director from homeotropic to planar alignment. Two notable effects were observed for this scheme: the spectral shift of defect modes corresponding to the extraordinary light wave and its superposition with the ordinary one. As a result, the optical cell allows controlling the intensity of interfering defect modes by applied magnetic field. (C) 2010 Optical Society of America
WOS,
Scopus,
eLibrary
Найти похожие

16.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Kolovskaya, Olga S., Zyuzyukina, Alena V., Dassie, Justin P., Zamay, Galina S., Zamay, Tatiana N., Boyakova, Nina V., Khorzhevskii, Vladimir A., Kirichenko, Daria A., Lapin I. N., Shchugoreva, Irina A., Artyushenko, Polina V., Tomilin F. N., Veprintsev, Dmitry V., Glazyrin, Yury E., Minic, Zoran, Bozhenko, Vladimir K., Kudinova, Elena A., Kiseleva, Yana Y., Krat, Alexey V., Slepov, Eugene V., Bukatin, Anton S., Zukov, Ruslan A., Shesternya, Pavel A., Berezovski, Maxim V., Giangrande, Paloma H., Kichkailo, Anna S.
Заглавие : Monitoring of breast cancer progression via aptamer-based detection of circulating tumor cells in clinical blood samples
Место публикации : Front. Mol. Biosci. - 2023. - Vol. 10. - Ст.1184285. - ISSN 2296889X (eISSN), DOI 10.3389/fmolb.2023.1184285
Примечания : Cited References: 37. - CTCs isolation method development and clinical sample analyses were supported by the Ministry of Healthcare of Russian Federation project REYC-2023-0012. The Ministry of Science and Higher Education of the Russian Federation project FWES-2022-0005 supported aptamer characterization, molecular modeling. MDA-231/LUC cells were from R. Domann (Jenkin et al. Breast Cancer Research, 2005). Technical and instrumental support was provided by the Shared Core Facilities of Molecular and Cell Technologies at Krasnoyarsk State Medical University and Krasnoyarsk Regional Centre for Collective Use at the Federal Research Centre “KSC SB RAS.” The confocal fluorescence microscopy research was carried out with the equipment of the Tomsk Regional Core Shared Research Facilities Center of the National Research Tomsk State University. The Center was supported by the Ministry of Science and Higher Education of the Russian Federation, grant no. 075-15-2021-693 (No. 13.RFC.21.0012)The authors are grateful to all the patients and hospital staff participating in this research. We acknowledge the assistance of the AptamerLab LCC (www.aptamerlab.com) and personally Vasily Mezko for the technical support. The authors thank Valentina L. Grigoreva, and Irina V. Gildebrand for the help with СTC staining
Аннотация: Introduction: Breast cancer (BC) diagnostics lack noninvasive methods and procedures for screening and monitoring disease dynamics. Admitted CellSearch® is used for fluid biopsy and capture of circulating tumor cells of only epithelial origin. Here we describe an RNA aptamer (MDA231) for detecting BC cells in clinical samples, including blood. The MDA231 aptamer was originally selected against triple-negative breast cancer cell line MDA-MB-231 using cell-SELEX. Methods: The aptamer structure in solution was predicted using mFold program and molecular dynamic simulations. The affinity and specificity of the evolved aptamers were evaluated by flow cytometry and laser scanning microscopy on clinical tissues from breast cancer patients. CTCs were isolated form the patients’ blood using the developed method of aptamer-based magnetic separation. Breast cancer origin of CTCs was confirmed by cytological, RT-qPCR and Immunocytochemical analyses. Results: MDA231 can specifically recognize breast cancer cells in surgically resected tissues from patients with different molecular subtypes: triple-negative, Luminal A, and Luminal B, but not in benign tumors, lung cancer, glial tumor and healthy epithelial from lungs and breast. This RNA aptamer can identify cancer cells in complex cellular environments, including tumor biopsies (e.g., tumor tissues vs. margins) and clinical blood samples (e.g., circulating tumor cells). Breast cancer origin of the aptamer-based magnetically separated CTCs has been proved by immunocytochemistry and mammaglobin mRNA expression. Discussion: We suggest a simple, minimally-invasive breast cancer diagnostic method based on non-epithelial MDA231 aptamer-specific magnetic isolation of circulating tumor cells. Isolated cells are intact and can be utilized for molecular diagnostics purposes.
Смотреть статью,
WOS,
Читать в сети ИФ
Найти похожие

17.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Мензянова Н. Г., Пятина С. А., Шабанов, Александр Васильевич, Шишацкая Е. И.
Заглавие : Дозозависимые эффекты наноразмерных форм гуминовых кислот в гидропонной культуре Triticum aestivum: индукция окислительного стресса и увеличение численности пограничных клеток
Место публикации : Журн. СФУ. Биол. - 2023. - Т. 16, № 1. - С. 64-86. - ISSN 19971389 (ISSN); J. Sib. Fed. Univ. Biol. - ISSN 23135530 (eISSN)
Примечания : Библиогр.: 63
Аннотация: В гидропонной культуре Triticum aestivum L. изучали биологическую активность гуминовых кислот в форме наночастиц размером 6,5 нм и 68 нм. Гуминовые наночастицы (мелкие и крупные) в изученных концентрациях не ингибировали рост корня и не вызывали деструктивных изменений корневого апекса 2-дневных проростков. На средах с гуминовыми наночастицами в корнях проростков наблюдалось дозозависимое увеличение содержания карбонилированных белков, малонового альдегида и пролина – маркеров индуцированного окислительного стресса. Для мелких наночастиц основным продуктом свободнорадикального окисления был малоновый диальдегид, для крупных – карбонилированные белки. Индуцированный гуминовыми наночастицами окислительный стресс сопровождался дозозависимым увеличением численности свободных пограничных клеток и размеров гелевого чехла в корневом апексе 2-дневных проростков. Для мелких наночастиц (6,5 нм) эти изменения были выражены в значительно большей степени, чем для крупных наночастиц (68 нм). Полученные результаты позволяют рассматривать гуминовые наночастицы в качестве адаптогенов: способствуя увеличению численности популяции пограничных клеток и системы гелевого чехла (как продукта экскреторной активности пограничных клеток), наночастицы увеличивают устойчивость корневого апекса к воздействию неблагоприятных биотических и абиотических факторов.The biological activity of humic acids in the form of nanoparticles with a size of 6.5 nm and 68 nm was studied in a hydroponic culture of Triticum aestivum L. Both smaller and larger humic nanoparticles at the studied concentrations neither inhibited root growth nor caused destructive changes in the root apexes of 2-day-old seedlings. A dose-dependent increase in the contents of markers of induced oxidative stress such as carbonylated proteins, malonaldehyde, and proline was observed in the roots of seedlings on media with humic nanoparticles. Malondialdehyde was the main product of free radical oxidation for smaller nanoparticles and carbonylated proteins – for larger ones. Oxidative stress induced by humic nanoparticles was accompanied by a dose-dependent increase in the number of free border cells and the size of the mucilaginous sheaths on the root apexes of 2-day-old seedlings. For smaller (6.5 nm) nanoparticles, these changes were much more pronounced than for larger (68 nm) nanoparticles. The results obtained allow us to consider humic nanoparticles as adaptogens: contributing to an increase in the population of border cells and the mucilaginous sheath system (as a product of the excretory activity of border cells), nanoparticles enhance the resistance of the root apex to the effects of unfavorable biotic and abiotic factors.
Смотреть статью,
РИНЦ,
Scopus,
Читать в сети ИФ
Найти похожие

18.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Kichkailo A. S., Narodov A. A., Komarova M. A., Zamay T. N., Zamay G. S., Kolovskaya O. S., Erakhtin E. E., Glazyrin Y. E., Veprintsev D. V., Moryachkov R. V., Zabluda V. N., Shchugoreva I., Artyushenko P., Mironov V. A., Morozov D. I., Gorbushin A. V., Khorzhevskii V. A., Koshmanova A. A., Nikolaeva E. D., Grinev I. P., Voronkovskii I. I., Grek D. S., Belugin K. V., Volzhentsev A. A., Badmaev O. N., Luzan N., Lukyanenko K. A., Peters G., Lapin I. N., Kirichenko A. K., Konarev P. V., Morozov E. V, Mironov G. G., Gargaun A., Muharemagic D., Zamay S. S., Kochkina E. V., Dymova M. A., Smolyarova T. E., Sokolov A. Е., Modestov A. A., Tokarev N. A., Shepelevich N., Ozerskaya A. V., Chanchikova N. G., Krat A. V., Zukov R. A., Bakhtina V. I., Shnyakin P. G., Shesternya P. A., Svetlichnyi V. A., Petrova M. M., Artyukhov I. P., Tomilin F. N., Berezovski, Maxim V.
Заглавие : Development of DNA aptamers for visualization of glial brain tumors and detection of circulating tumor cells
Место публикации : Mol. Ther. - Nucleic Acids. - 2023. - Vol. 32. - P.267-288. - ISSN 21622531 (eISSN), DOI 10.1016/j.omtn.2023.03.015
Примечания : Cited References: 69. - The authors are grateful to all the patients and hospital staff participating in this research. We acknowledge the assistance of the AptamerLab LCC (www.aptamerlab.com) and personally Mr. Vasily Mezko for the aptamer 3D structure optimization and financial and technical support. The authors thank Mr. Alexey Kichkailo, Dr. Arkady B. Kogan, and Dr. Rinat G. Galeev for their general support. Mrs. Valentina L. Grigoreva, and Irina V. Gildebrand for the help with histological staining. Technical and instrumental support was provided by the Multiple-Access Center at Tomsk State University; the Krasnoyarsk Inter-District Ambulance Hospital, named after N.S. Karpovich; John L. Holmes Mass Spectrometry Facility at the University of Ottawa; Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency; Shared Core Facilities of Molecular and Cell Technologies at Krasnoyarsk State Medical University and Krasnoyarsk Regional Centre for Collective Use at the Federal Research Centre “KSC SB RAS”. The confocal fluorescence microscopy research was carried out with the equipment of the Tomsk Regional Core Shared Research Facilities Center of the National Research Tomsk State University. The Center was supported by the Ministry of Science and Higher Education of the Russian Federation, grant no. 075-15-2021-693 (no. 13.RFC.21.0012). Acute toxicity studies were performed in a laboratory certified for preclinical studies, Laboratory of Biological Testing, Institute of Bioorganic Chemistry named after academics M.M. Shemyakin and Y.A. Ovchinnikov Russian Academy of Sciences. The authors are grateful to the Joint Super Computer Center of the Russian Academy of Sciences for providing supercomputers for computer simulations. Development of the glioma tumor model in immunosuppressed mice was supported by the Russian Science Foundation grant No. 22-64-00041 (M.A.D.), https://rscf.ru/en/project/22-64-00041/. Synthesis of 11C-aptamer and PET/CT visualization was funded by the Federal Medical Biological Agency; project 122041800132-2 (A.V.O.). Aptamer selection and their clinical applications were funded by the Ministry of Healthcare of the Russian Federation; project АААА-Б19-219090690032-5 (T.N.Z.). The Ministry of Science and Higher Education of the Russian Federation project FWES-2022-0005 (A.S.K.) supported aptamer characterization, molecular modelling, and in vivo experiments. Mass spectrometry analyses, DNA sequencing, and synthesis were supported by NSERC Discovery Grant (M.V.B.). We acknowledge the European Synchrotron Radiation Facility for SAXS experiments and thank Dr. Bart Van Laer for assistance in using a beamline BM29. SAXS measurements were supported by RFBR № 18-32-00478 for young scientists (R.V.M.). The synchrotron SEC-SAXS data for Gli-55 aptamer were also collected at beamline P12 operated by EMBL Hamburg at the PETRA III storage ring (DESY, Hamburg, Germany)
Аннотация: Here, we present DNA aptamers capable of specific binding to glial tumor cells in vitro, ex vivo, and in vivo for visualization diagnostics of central nervous system tumors. We selected the aptamers binding specifically to the postoperative human glial primary tumors and not to the healthy brain cells and meningioma, using a modified process of systematic evolution of ligands by exponential enrichment to cells; sequenced and analyzed ssDNA pools using bioinformatic tools and identified the best aptamers by their binding abilities; determined three-dimensional structures of lead aptamers (Gli-55 and Gli-233) with small-angle X-ray scattering and molecular modeling; isolated and identified molecular target proteins of the aptamers by mass spectrometry; the potential binding sites of Gli-233 to the target protein and the role of post-translational modifications were verified by molecular dynamics simulations. The anti-glioma aptamers Gli-233 and Gli-55 were used to detect circulating tumor cells in liquid biopsies. These aptamers were used for in situ, ex vivo tissue staining, histopathological analyses, and fluorescence-guided tumor and PET/CT tumor visualization in mice with xenotransplanted human astrocytoma. The aptamers did not show in vivo toxicity in the preclinical animal study. This study demonstrates the potential applications of aptamers for precise diagnostics and fluorescence-guided surgery of brain tumors.
Смотреть статью,
Scopus,
WOS,
Читать в сети ИФ
Найти похожие

19.

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Zyryanov V. Ya., Smorgon S. L., Shabanov V. F., Pozhidaev E. P., Andreev A. L., Kompanets I. N., Shin S. T.
Заглавие : Optimization of the contrast and transmittance in one-polarizer PDFLC cells
Коллективы : international display research conference "Asia Display'98", Asia Display
Место публикации : Proceedings of the international display research conference "Asia Display'98". - 2009. - P.1037-1039
Найти похожие

20.

Вид документа : Статья из сборника (однотомник)
Шифр издания :
Автор(ы) : Zyryanov V. Ya., Smorgon S. L., Shabanov V. F., Pozhidaev E. P., Andreev A. L., Kompanets I. N., Maltese P., Haase W.
Заглавие : Optimization of light modulation characteristics of polarizer-free PDFLC cells
Коллективы : "Advanced Display Technologies : basic studies of problems in information display", International Symposium
Место публикации : 9th International Symposium "Advanced Display Technologies : basic studies of problems in information display" (FLOWERS 2000): abstracts. - 2000. - С. 44-45; \b Proceedings of SPIE - The International Society for Optical Engineering. - 2001. - Vol. 4511
Материалы конференции
Найти похожие