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Elimination of iron-containing magnetic nanoparticles from the site of injection in mice: a magnetic-resonance imaging study / E. V. Inzhevatkin [et al.] // Bull. Exp. Biol. Med. - 2015. - Vol. 158, Is. 6. - P. 807-811, DOI 10.1007/s10517-015-2867-z. - Cited References:7 . - ISSN 0007. - ISSN 1573-8221. -

РУБ Medicine, Research & Experimental

Кл.слова (ненормированные):
magnetic nanoparticles -- Klebsiella oxytoca -- magnetic resonance imaging -- elimination
Аннотация: Suspension of magnetic nanoparticles (0.7 g/liter) obtained from Klebsiella oxytoca culture was injected intraperitoneally (1 ml), intramuscularly (in the hip; 100 mu l), and subcutaneously (200 mu l) or administered orally instead of drinking water for 2 days. The presence of magnetic nanoparticles was evaluated detected by MRI in 15 min and 2 h after injections and in 1 and 2 days after the beginning of oral consumption of the suspension. Magnetic nanoparticles were eliminated from the site of intramuscular and intraperitoneal injections and after oral consumption. The period of elimination after intramuscular and intraperitoneal injections did not exceed 2 h, while after oral consumption it corresponded to the time of gastrointestinal tract contents evacuation.

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Публикация на русском языке Исследование элиминации железосодержащих магнитных наночастиц из области введения в организме мышей с использованием ЯМР–томографии [Текст] / Е. В. Инжеваткин [и др.] // Бюлл. эксперим. биол. и мед. - 2014. - Т. 158 № 12. - С. 777-781

Держатели документа:
Russian Acad Sci, Krasnoyarsk Res Ctr, Siberian Div, Krasnoyarsk, Russia
LV Kirenskii Inst Phys, Krasnoyarsk 660036, Russia
Russian Acad Sci, Nauka Special Designing & Technol Bur, Krasnoyarsk Res Ctr, Siberian Div, Krasnoyarsk, Russia
Siberian Fed Univ, Krasnoyarsk, Russia

Доп.точки доступа:
Inzhevatkin, E. V.; Morozov, E. V.; Морозов, Евгений Владимирович; Khilazheva, E. D.; Ladygina, V. P.; Stolyar, S. V.; Столяр, Сергей Викторович; Falaleev, O. V.
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In vivo cancer cells elimination guided by aptamer-functionalized gold-coated magnetic nanoparticles and controlled with low frequency alternating magnetic field / I. V. Belyanina [et al.] // Theranostics. - 2017. - Vol. 7, Is. 13. - P. 3326-3337, DOI 10.7150/thno.17089. - Cited References:35. - The authors are grateful to George Y. Vorogeikin, Yuri I. Vorogeikin and "OKB ART". Andrey Barinov and "OPTEC Group" for help with 3D laser scanning imaging. Microscopic analyses using Carl Zeiss LSM 800 were done in the "Center for bioassay, nanotechnology and nanomaterials safety" ("Biotest-Nano") (Multiple-Access Center, Tomsk State University, Tomsk, Russia). Toxicity studies have been performed in Multiple-Access Center, Central Scientific Research Laboratory in Krasnoyarsk State Medical University named after prof. V.F. Voino-Yasenecky. This work was supported by the Russian Scientific Fund (grant #14-15-00805). . - ISSN 1838-7640

РУБ Medicine, Research & Experimental
Рубрики:
PHOTOTHERMAL THERAPY
   INTEGRIN ACTIVATION
   FIBRONECTIN
   STIMULATION
Кл.слова (ненормированные):
cancer therapy -- gold coated magnetic nanoparticles -- DNA aptamers -- low -- frequency alternating magnetic field -- fibronectin -- integrin -- apoptosis -- necrosis
Аннотация: Biomedical applications of magnetic nanoparticles under the influence of a magnetic field have been proved useful beyond expectations in cancer therapy. Magnetic nanoparticles are effective heat mediators, drug nanocarriers, and contrast agents; various strategies have been suggested to selectively target tumor cancer cells. Our study presents magnetodynamic nanotherapy using DNA aptamer-functionalized 50 nm gold-coated magnetic nanoparticles exposed to a low frequency alternating magnetic field for selective elimination of tumor cells in vivo. The cell specific DNA aptamer AS-14 binds to the fibronectin protein in Ehrlich carcinoma hence helps deliver the gold-coated magnetic nanoparticles to the mouse tumor. Applying an alternating magnetic field of 50 Hz at the tumor site causes the nanoparticles to oscillate and pull the fibronectin proteins and integrins to the surface of the cell membrane. This results in apoptosis followed by necrosis of tumor cells without heating the tumor, adjacent healthy cells and tissues. The aptamer-guided nanoparticles and the low frequency alternating magnetic field demonstrates a unique non-invasive nanoscalpel technology for precise cancer surgery at the single cell level.

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Держатели документа:
Krasnoyarsk State Med Univ, Krasnoyarsk, Russia.
Russian Acad Sci, KSC Siberian Branch, Fed Res Ctr, Krasnoyarsk, Russia.
Siberian Fed Univ, Krasnoyarsk, Russia.
Univ Ottawa, Dept Chem & Biomol Sci, Ottawa, ON, Canada.
Inst Computat Modeling RAS SB, Krasnoyarsk, Russia.

Доп.точки доступа:
Belyanina, I. V.; Zamay, T. N.; Замай Т. Н.; Zamay, G. S.; Замай, Галина Сергеевна; Zamay, S. S.; Замай С. С.; Kolovskaya, Olga S.; Ivanchenko, Tatiana I.; Denisenko, Valery V.; Kirichenko, Andrey K.; Glazyrin, Yury E.; Garanzha, Irina V.; Grigorieva, Valentina V.; Shabanov, A. V.; Шабанов, Александр Васильевич; Veprintsev, Dmitry V.; Sokolov, A. E.; Соколов, Алексей Эдуардович; Sadovskii, Vladimir M.; Gargaun, Ana; Berezovski, M. V.; Kichkailo, Anna S.; Russian Scientific Fund [14-15-00805]
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