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Вид документа : Статья из сборника (выпуск продолж. издания)
Шифр издания :
Автор(ы) : Sharko D. O., Shabalina A. V., Gotovtseva E. Y., Zamay G. S., Zamay S. S.
Заглавие : Electrochemical Study of Sensor with Aptamer Specific to Glioblastoma
Коллективы : International Conference of Young Specialists on Micro/Nanotechnologies and Electron Devices
Место публикации : 20th International Conference of Young Specialists on Micro/Nanotechnologies and Electron Devices, EDM 2019: (29 June 2019 through 3 July 2019; Erlagol, Altai Republic, Russian Federation): IEEE Computer Society, 2019. - Vol. 2019-June. - Ст.8823563. - P.612-615. - , DOI 10.1109/EDM.2019.8823563
Примечания : Cited References: 10. - The work is supported by the Grant of the President of the Russian Federation (MK-5284.2018.3).
Аннотация: An aptasensor consisting of a gold disc electrode and aptamer Gli-233 specific to glioblastoma was prepared with different methods and studied by electrochemical and microscopic methods. It was found, that the real electro active surface area and electric double layer capacitance changed with the electrode modification. The highest capacitance was registered for the electrode modified with the simultaneous immobilization of Gli-233 and additional blocking agent (mercaptoethanol). It was shown that to develop an impedimetric sensor on the basis of Gli-233, it is necessary to optimize the conditions for the signal registration.
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