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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Gerasimov V. S., Ershov A. E., Karpov S. V., Polyutov S. P., Semina P. N.
Заглавие : Optimization of photothermal methods for laser hyperthermia of malignant cells using bioconjugates of gold nanoparticles
Место публикации : Colloid J.: MAIK Nauka-Interperiodica / Springer, 2016. - Vol. 78, Is. 4. - P.435-442. - ISSN 1061933X (ISSN), DOI 10.1134/S1061933X16040050
Примечания : Cited References: 33. - This work was supported by the Ministry of Education and Science of the Russian Federation (contract no. 14.607.21.0104 RFMEFI60714X0104) (Section 3) and the State Assignment of the Ministry of Education and Science of the Russian Federation for Siberian Federal University (contract no. 1792) (Section 2). The numerical calculations were performed using the MVS-1000 M cluster at the Institute of Computational Modeling, Siberian Branch, Russian Academy of Sciences.
Предметные рубрики: THERMAL THERAPY
PLASMONIC NANOPARTICLES
OPTICAL-PROPERTIES
TUMOR-CELLS
CARCINOMA
CLUSTERS
CANCER
Аннотация: Selective action of laser radiation on membranes of malignant cells has been studied in different regimes using conjugates of gold nanoparticles with oligonucleotides by the example of DNA aptamers. Under the conditions of a contact between a bioconjugate and a cell surface and the development of substantial and rapidly relaxing temperature gradients near a nanoparticle, the membranes of malignant cells alone are efficiently damaged due to the local hyperthermia of a cellular membrane. It has been shown that employment of pulsed instead of continuous wave laser radiation provides the localization of the damaging action, which does not involve healthy cells. © 2016, Pleiades Publishing, Ltd.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Ranjan, Rajeev, Kirillova, Maria A., Esimbekova, Elena N., Zharkov S. M., Kratasyuk, Valentina A.
Заглавие : Agglomeration behavior of lipid-capped gold nanoparticles
Коллективы : Russian Foundation for Basic Research [16-34-60100]; [0356-2017-0017]
Место публикации : J. Nanopart. Res. - 2018. - Vol. 20, Is. 4. - Ст.107. - ISSN 1388-0764, DOI 10.1007/s11051-018-4215-5. - ISSN 1572-896X(eISSN)
Примечания : Cited References:35. - The research was supported by the Russian Foundation for Basic Research [project no. 16-34-60100] and the state budget allocated to the fundamental research (project no. 0356-2017-0017). The authors thank Prof. Tatiana Volova, Prof. Evgenia Slyusareva, and Ms. Nina Slyusarenko of the Siberian Federal University for their assistance in the zeta potential and zeta-average analysis.
Предметные рубрики: COLORIMETRIC SENSOR ARRAY
OPTICAL-PROPERTIES
AGGREGATION
CANCER
Ключевые слова (''Своб.индексиров.''): gold nanoparticles--ionic interference--agglomeration--stabilization--lipid capping--nanobiotechnology applications
Аннотация: The current investigation deciphers aggregation pattern of gold nanoparticles (AuNPs) and lipid-treated AuNPs when subjected to aqueous sodium chloride solution with increasing ionic strengths (100–400 nM). AuNPs were synthesized using 0.29 mM chloroauric acid and by varying the concentrations of trisodium citrate (AuNP1 1.55 mM, AuNP2 3.1 mM) and silver nitrate (AuNP3 5.3 μM, AuNP4 10.6 μM) with characteristic LSPR peaks in the range of 525–533 nm. TEM analysis revealed AuNPs to be predominantly faceted nanocrystals with the average size of AuNP1 to be 35 ± 5 nm, AuNP2 15 ± 5 nm, AuNP3 30 ± 5 nm, and AuNP4 30 ± 5 nm and the zeta-average for AuNPs were calculated to be 31.23, 63.80, 26.08, and 28 nm respectively. Induced aggregation was observed within 10 s in all synthesized AuNPs while lipid-treated AuNP2 (AuNP2-L) was found to withstand ionic interferences at all concentration levels. However, lipid-treated AuNPs synthesized using silver nitrate and 1.55 mM trisodium citrate (AuNP3, AuNP4) showed much lower stability. The zeta potential values of lipid-treated AuNPs (AuNP1-L-1x/200, − 17.93 ± 1.02 mV; AuNP2-L-1x/200, − 21.63 ± 0.70; AuNP3-L-1x/200, − 14.54 ± 0.90; AuNP3-L-1x/200 − 13.77 ± 0.83) justified these observations. To summarize, AuNP1 and AuNP2 treated with lipid mixture 1 equals or above 1x/200 or 1x/1000 respectively showed strong resistance against ionic interferences (up to 400 mM NaCl). Use of lipid mixture 1 for obtaining highly stable AuNPs also provided functional arms of various lengths which can be used for covalent coupling.
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