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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Zamay G. S., Zamay T. N., Kolovskii V. A., Shabanov A. V., Glazyrin Y. E., Veprintsev D. V., Krat A. V., Zamay S. S., Kolovskaya O. S., Gargaun A., Sokolov A. E., Modestov A. A., Artyukhov I. P., Chesnokov N. V., Petrova M. M., Berezovski M. V., Zamay A. S.
Заглавие : Electrochemical aptasensor for lung cancer-related protein detection in crude blood plasma samples
Коллективы : Ministry of Education and Science of Russian Federation Federal Target Program [14.604.21.0105]
Место публикации : Sci. Rep. - 2016. - Vol. 6. - Ст.34350. - ISSN 2045-2322, DOI 10.1038/srep34350
Примечания : Cited References:24. - Authors thank Dr. Mahmoud Labib and Galina Kudryasheva. This work was supported by Ministry of Education and Science of Russian Federation Federal Target Program #14.604.21.0105 for Anna S. Zamay. Electron microscopy was carried out at the Multiple-Access Center of Krasnoyarsk Research Center Siberian branch of Russian Academy of Science.
Предметные рубрики: SQUARE-WAVE VOLTAMMETRY
GENE-EXPRESSION
SERUM
BIOSENSORS
DIAGNOSIS
ADENOCARCINOMA
BIOMARKERS
SENSOR
Аннотация: The development of an aptamer-based electrochemical sensor for lung cancer detection is presented in this work. A highly specific DNA-aptamer, LC-18, selected to postoperative lung cancer tissues was immobilized onto a gold microelectrode and electrochemical measurements were performed in a solution containing the redox marker ferrocyanide/ferricyanide. The aptamer protein targets were harvested from blood plasma of lung cancer patients by using streptavidin paramagnetic beads and square wave voltammetry of the samples was performed at various concentrations. In order to enhance the sensitivity of the aptasensor, silica-coated iron oxide magnetic beads grafted with hydrophobic C8 and C4 alkyl groups were used in a sandwich detection approach. Addition of hydrophobic beads increased the detection limit by 100 times. The detection limit of the LC-18 aptasensor was enhanced by the beads to 0.023 ng/mL. The formation of the aptamer -protein -bead sandwich on the electrode surface was visualized by electron microcopy. As a result, the electrochemical aptasensor was able to detect cancer-related targets in crude blood plasma of lung cancer patients.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Pyatnov M. V., Bikbaev R. G., Timofeev I. V., Vetrov S. Ya.
Заглавие : Model of a tunable hybrid Tamm mode-liquid crystal device
Коллективы : Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR) [19-52-52006]
Место публикации : Appl. Optics. - 2020. - Vol. 59, Is. 21. - P.6347-6351. - ISSN 1559-128X, DOI 10.1364/AO.395901. - ISSN 2155-3165(eISSN)
Примечания : Cited References: 37. - Russian Foundation for Basic Research (19-52-52006)
Предметные рубрики: PLASMON
PHASE
SENSOR
STATES
Аннотация: A concept of an easily tunable device based on hybrid Tamm modes is proposed. The device can be controlled using a high-sensitivity chiral liquid crystal serving as a mirror. The coupling of the chiral optical Tamm state with the Tamm plasmons is predicted. The Tamm plasmons are excited at different frequencies for the orthogonal linear polarizations, while the chiral Tamm state is excited at only one frequency. The properties of the proposed model are analytically and numerically calculated. The possibility of creating a two- and three-mode laser with tunable characteristics on the basis of the proposed model is discussed.
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