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Biomedical application of biogenic ferrihydrite nanoparticles / C. G. Chilom [et al.] // Rom. J. Phys. - 2017. - Vol. 62, Is. 3-4. - Ст. 701. - P. - Cited References: 13. - The work was accomplished with the financial support of the IUNC Structural and spectrophotometric characterization of biogenic systems, Grants 4-1069-2009/2014 and 04-4-1121-2015/2017. Biological studies were accomplished with the financial support of Romanian National Authority for Scientific Research, CNDI-UEFISCDI, Project number: PN 16 42 02 03. The authors are very much indebted to Virginia Dincă and Gabriel Prodan for TEM images and to Gabriel Socol for FT-IR spectra. . - ISSN 1221-146X
Кл.слова (ненормированные):
Bacterial nanoparticles -- Albumins-ferrihydrite nanoparticles interaction -- Cell lines -- Cytotoxicity -- Hemolytic effect
Аннотация: Spectroscopic properties of biogenic ferrihydrite nanoparticles, produced by Klebsiella oxytoca, were investigated. Their interaction with two serum albumins was moderate. A very weak stabilization of protein structure to denaturation, in the presence of nanoparticles, was put in evidence. Nanoparticle cytotoxicity and their hemolytic effect were studied on healthy and tumour cells.

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Держатели документа:
Department of Electricity, Physics of Solid and Biophysics, Faculty of Physics, University of Bucharest, Romania
Joint Institute for Nuclear Research Dubna, Russian Federation
Department of Nuclear Physics, National Research Institute for Physics and Nuclear Engineering Horia Hulubei (IFIN-HH), Bucharest, Romania
Department of Life and Environmental Physics, National Research Institute for Physics and Nuclear Engineering Horia Hulubei (IFIN-HH), Bucharest, Romania
Siberian Federal University, Krasnoyarsk, Russian Federation
Kirensky Institute of Physics, SB RAS, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Chilom, C. G.; Gazdaru, D. M.; Balasoiu, M.; Bacalum, M.; Stolyar, S. V.; Столяр, Сергей Викторович; Popescu, A. I.
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    Изучение свойств магнитных наночастиц в оториноларингологии (экспериментальное исследование) / К. Г. Добрецов [и др.] // Российская оториноларингология. - 2009. - № 3. - С. 51-56 . - ISSN 1810-4800
   Перевод заглавия: RESEARCH OF MAGNETIC NANOPARTICLES' PECULIARITIES IN OTORHINOLARYNGOLOGY (EXPERIMENTAL RESEARCH)

ГРНТИ	76.29
УДК	615. 847. 8	616. 21

Рубрики:

Кл.слова (ненормированные):
nanoparticles -- magnetic field -- cytotoxicity -- наночастицы -- магнитное поле -- цитотоксичность
Аннотация: Настоящее исследование посвящено изучению возможности целенаправленной доставки антибиотиков с помощью магнитных наночастиц. В результате 30 опытов на удаленной слизистой оболочке, хрящевой и костной тканях носа, 10 опытов на здоровых нейтрофилах человека и 10 опытов на обсемененных бактериями средах, было выявлено, что благодаря градиенту магнитного поля магнитные наночастицы проникают в толщу слизистой оболочки носа, хрящевой и костной тканей носа. Было доказано, что магнитные наночастицы не являются цитотоксичными, а комплекс наночастица-антибиотик является стабильным и обладает бактерицидными свойствами.
We studied opportunities of targeted delivery of antibiotics by magnetic nanoparticles. The results of 30 experiments on extracted mucosa of cartilaginous and bone tissue, 10 experiments on healthy human neutrophils and 10 - environment occupied by bacteria showed that magnetic nanoparticles penetrate in mucosa of cartilaginous and bone tissue of nose due to gradient of magnetic field. It was proved that magnetic nanoparticles are not cytotoxic and complex of nanoparticle-antibiotic is a stable and has

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Держатели документа:
Дорожная клиническая больница на станции Красноярск
Институт биофизики СО РАН, г. Красноярск
Институт физики СО РАН, г. Красноярск
Международный научный центр исследований экстремальных состояний организма при Президиуме КНЦ СО РАН, Красноярск
Московская медицинская академия им. И. М. Сеченова
Сибирский федеральный университет, г. Красноярск

Доп.точки доступа:
Добрецов, К. Г.; Афонькин, В. Ю.; Столяр, Сергей Викторович; Stolyar, S. V.; Ладыгина, Валентина Петровна; Сипкин, А. В.; Пуртов, К. В.; Баюков, Олег Артемьевич; Bayukov, O. A.; Лопатин, А. С.
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Collagen conjugation to carboxyl-modified poly(3-hydroxybutyrate) microparticles: preparation, characterization and evaluation in vitro / A. V. Murueva, A. M. Shershneva, I. V. Nemtsev [et al.] // J. Polym. Res. - 2022. - Vol. 29, Is. 8. - Ст. 324, DOI 10.1007/s10965-022-03181-5. - Cited References: 45. - This work was supported by the State Assignment of the Ministry of Science and Higher Education of the Russian Federation No. FSRZ-2020–0006 . - ISSN 1022-9760
Кл.слова (ненормированные):
Poly(3-hydroxybutyrate) -- Collagen -- Microparticles -- Surface conjugation -- Cytotoxicity
Аннотация: The objective of this study was to produce and characterize collagen conjugated poly(3-hydroxybutyrate) (P3HB) microparticles. The double emulsion solvent evaporation technique was used to fabricate biopolymer microparticles. Alkaline hydrolysis method was used for carboxylation of P3HB microparticles followed by collagen (type I) conjugation using 1-ethyl-3-(3-dime-thylaminopropyl) carbodiimide and N-hydroxysuccinimide cross linkers. The successful chemical modification of P3HB-MP surface was evidenced by XPS analysis and FTIR spectroscopy, confirming an increase in the number of carboxyl groups and covalent bonding of collagen on the surface of functionalized P3HB microparticles (Col-P3HB-MPs). The amount of collagen present on Col-P3HB-MPs microparticles was quantified by the Lowry method. The average diameter and zeta-potential of microparticles were found to be dependent upon the method of preparation. The absence of cytotoxicity of modified Col-P3HB-MPs to fibroblast NIH 3T3 cells in vitro was corroborated by results of MTT assay. Staining with the fluorescent dye showed enhanced adhesion of fibroblasts onto Col-P3HB-MPs compared to the unmodified P3HB-MPs.

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Держатели документа:
Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences (IBP SB RAS), 50/50 Akademgorodok, Krasnoyarsk, Russian Federation
Institute of Fundamental Biology and Biotechnology, Siberian Federal University, 79 Svobodny, Krasnoyarsk, 660041, Russian Federation
Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the RAS (FRC KSC SB RAS), 50 Akademgorodok, Krasnoyarsk, 660036, Russian Federation
L.V. Kirensky Institute of Physics SB RAS, Federal Research Center “Krasnoyarsk Science Center SB RAS, 50/38 Akademgorodok, Krasnoyarsk, Russian Federation

Доп.точки доступа:
Murueva, A. V.; Shershneva, A. M.; Nemtsev, I. V.; Немцев, Иван Васильевич; Shishatskaya, E. I.; Volova, T. G.
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Fe3O4/Au nanocomposites: Characterization and cytotoxicity effects in vitro / R. N. Yaroslavtsev, A. V. Tyumentseva, D. A. Velikanov [et al.] // Mater. Chem. Phys. - 2024. - Vol. 322. - Ст. 129524, DOI 10.1016/j.matchemphys.2024.129524. - Cited References: 44 . - ISSN 0254-0584. - ISSN 1879-3312
Кл.слова (ненормированные):
Magnetic nanoparticles -- Magnetite -- Gold nanoparticles -- Cytotoxicity
Аннотация: Magnetic nanocomposites containing iron oxide and gold components take great attention last years because of their relative biocompatibility and the ability to combine the magnetic properties of iron and the chemical bonding properties of gold for the possible drug delivery or diagnostics for various diseases. However, such particles have some toxicity to living cells, and the effect depends on many factors, including size, shape, the ratio of components in the composites, and the type of cells affected. And thus, the search for compositions and technologies for producing iron-gold particles with improved properties and reduced cytotoxicity remains relevant. The aim of the study was to synthesize and characterize Fe3O4/Au nanocomposites and evaluate their influence on living cells using the example of cell line HEK293. Fe3O4 nanoparticles (NPs) were synthesized by co-precipitation of Fe2+/Fe3+ water solution in alkaline conditions and then boiled with HAuCl4 in 0.1 M sodium citrate. The NPs properties were estimated by transmission electron microscopy (TEM), vibration magnetometry and ferromagnetic resonance (FMR). According to magnetometric measurements, nanoparticles are mainly in a superparamagnetic state. By fitting magnetization curves, the magnetic characteristics of nanoparticles were determined: saturation magnetization (59.3 emu/g) and magnetic anisotropy constant (K = 0.86·105 erg/cm3). The average particle size estimated from magnetic measurements was 8.7 nm. Considering the presence of a magnetically dead layer, this is in good agreement with the TEM results. The temperature dependence of the FMR linewidth was analyzed using two models. As a result, the parameters MSV and K/MS were determined. The models used showed good agreement. The values of the anisotropy constant (K = 1.06·105 erg/cm3) and the average particle size (6.8 nm) are estimated. The effect of the NPs on the HEK293 cells was studied by MTT-assay, flow cytometry and RT-PCR. The exposure with the NPs lead to a significant decrease of cell metabolic activity in HEK293 cell culture, but this effect was not accompanied by cell death. It was shown that the expression of antioxidant enzymes SOD1 and GPX1 was reduced at the mRNA stage. So the NPs synthesized may affect gene expression and metabolism of HEK293 cells, but this does not have fatal consequences for cell viability.

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Держатели документа:
Krasnoyarsk Science Center, Federal Research Center KSC SB RAS, Akademgorodok 50, Krasnoyarsk, 660036, Russia
Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Akademgorodok 50, bld. 38, Krasnoyarsk, 660036, Russia

Доп.точки доступа:
Yaroslavtsev, R. N.; Ярославцев, Роман Николаевич; Tyumentseva, A.V.; Velikanov, D. A.; Великанов, Дмитрий Анатольевич; Vazhenina, I. G.; Важенина, Ирина Георгиевна; Volochaev, M. N.; Волочаев, Михаил Николаевич; Stolyar, S. V.; Столяр, Сергей Викторович
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