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Biodegradable polyhydroxyalkanoates formed by 3- and 4-hydroxybutyrate monomers to produce nanomembranes suitable for drug delivery and cell culture / T. G. Volova, A. V. Demidenko, A. V. Murueva [et al.] // Technologies. - 2023. - Vol. 11, Is. 4. - Ст. 106, DOI 10.3390/technologies11040106. - Cited References: 116. - his research was funded by State Assignment of the Ministry of Science and Higher Education of the Russian Federation (project No. 0287-2021-0025) . - ISSN 2227-7080
Кл.слова (ненормированные):
degradable polyhydroxyalkanoates -- copolymers P(3HB-co-4HB) -- electrostatic molding -- membranes -- microstructure and properties -- drugs -- release kinetics -- antibacterial activity -- fibroblast proliferation
Аннотация: Biodegradable polyhydroxyalkanoates, biopolymers of microbiological origin, formed by 3- and 4-hydroxybutyrate monomers P(3HB-co-4HB), were used to obtain nanomembranes loaded with drugs as cell carriers by electrospinning. Resorbable non-woven membranes from P(3HB-co-4HB) loaded with ceftazidime, doripinem, and actovegin have been obtained. The loading of membranes with drugs differently affected the size of fibers and the structure of membranes, and in all cases increased the hydrophilicity of the surface. The release of drugs in vitro was gradual, which corresponded to the Higuchi and Korsmeyer-Peppas models. Antibiotic-loaded membranes showed antibacterial activity against S. aureus and E. coli, in which growth inhibition zones were 41.7 ± 1.1 and 38.6 ± 1.7 mm for ceftazidime and doripinem, respectively. The study of the biological activity of membranes in the NIH 3T3 mouse fibroblast culture based on the results of DAPI and FITC staining of cells, as well as the MTT test, did not reveal a negative effect despite the presence of antibiotics in them. Samples containing actovegin exhibit a stimulating effect on fibroblasts. Biodegradable polyhydroxyalkanoates formed by 3-hydroxybutyrate and 4-hydroxybutyrate monomers provide electrospinning non-woven membranes suitable for long-term delivery of drugs and cultivation of eukaryotic cells, and are promising for the treatment of wound defects complicated by infection.

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Держатели документа:
Institute of Biophysics SB RAS, Federal Research Center “Krasnoyarsk Science Center SB RAS”, 50/50 Akademgorodok, 660036 Krasnoyarsk, Russia
Institute of Fundamental Biology and Biotechnology, Siberian Federal University, 79 Svobodnyi av., 660041 Krasnoyarsk, Russia
Federal Research Center “Krasnoyarsk Science Center SB RAS”, 50 Akademgorodok, 660036 Krasnoyarsk, Russia
L.V. Kirensky Institute of Physics, 50/12 Akademgorodok, 660036 Krasnoyarsk, Russia
Chemistry Engineering Centre, ITMO University, Kronverkskiy Prospekt, 49A, 197101 Saint Petersburg, Russia

Доп.точки доступа:
Volova, Tatiana G.; Demidenko, Aleksey V.; Murueva, Anastasiya V.; Dudaev, Alexey E.; Nemtsev, I. V.; Немцев, Иван Васильевич; Shishatskaya, Ekaterina I.
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