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    Structure and optical properties of Li2Ga2GeS6 nonlinear crystal / L. I. Isaenko [et al.] // Opt. Mater. - 2015. - Vol. 47. - P. 413-419, DOI 10.1016/j.optmat.2015.06.014. - Cited References:23. - This work was supported by the Russian Foundation of Basic Research (Grant No. 15-02-03408a) . - ISSN 0925-3467
   Перевод заглавия: Структура и оптические свойства нелинейного кристалла Li2Ga2GeS6

РУБ Materials Science, Multidisciplinary + Optics
Рубрики:
PHASE-MATCHING PROPERTIES
   MID-IR
   PARAMETRIC AMPLIFICATION
   GENERATION
   LiGaS2
   GROWTH
   DAMAGE
   Ga
   Te
   Se
Кл.слова (ненормированные):
Li2Ga2GeS6 -- Structure -- Absorption -- Raman -- Luminescence -- Excitons
Аннотация: Structure and optical properties of new nonlinear crystal - Li2Ga2GeS6 single crystal of optical quality, grown by the Bridgman technique were studied. The data on transmission, Raman scattering, luminescence emission, excitation and thermal quenching as well as thermostimulated luminescence are presented. Fundamental absorption edge is determined by the direct allowed electronic transitions: The values of optical band gap are estimated. Absorption band at 8.0 mu m is due to S-S vibrations. Features in photoluminescence spectra are associated with excitons: both free (narrow line at 371 nm) and self-trapped ones (broad bands at 596, 730 and 906 nm). Spontaneous emission in the 80-170 K range, both at crystal heating and cooling, is typical of pyroelectrics: This confirms the absence of symmetry center in Li2Ga2GeS6 and an opportunity of laser frequency nonlinear conversion. (C) 2015 Elsevier B.V. All rights reserved.

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Держатели документа:
SB RAS, VS Sobolev Inst Geol & Mineral, Novosibirsk 630090, Russia.
Novosibirsk State Univ, Novosibirsk 630090, Russia.
SB RAS, LV Kirensky Phys Inst, Krasnoyarsk 660036, Russia.
Far Eastern State Transport Univ, Khabarovsk 680021, Russia.

Доп.точки доступа:
Isaenko, L. I.; Исаенко Л. И.; Yelisseyev, A. P.; Елисеев, Александр Павлович; Lobanov, S. I.; Лобанов С. И.; Krinitsin, P. G.; Криницын, Павел Геннадьевич; Molokeev, M. S.; Молокеев, Максим Сергеевич; Russian Foundation of Basic Research [15-02-03408a]
}
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Silica-coated iron oxide nanoparticles for DNA isolation for molecular genetic studies in hematology / A. V. Tyumentseva, R. N. Yaroslavtsev, S. V. Stolyar [et al.] // Genet. Test. Mol. Biomark. - 2021. - Vol. 25, Is. 9. - P. 611-614, DOI 10.1089/gtmb.2021.0067. - Cited References: 16 . - ISSN 1945-0265. - ISSN 1945-0257

РУБ Biochemistry & Molecular Biology + Genetics & Heredity
Рубрики:
OXIDATIVE STRESS
MUTATION
DAMAGE
Кл.слова (ненормированные):
magnetic nanoparticles -- DNA isolation -- myeloproliferative neoplasms -- JAK2 V617F
Аннотация: Aim: To develop magnetic nanoparticles (MNPs) based on iron oxide for DNA isolation from blood cells for quantitative molecular genetic analyses of the V617F mutation in the Januskinase 2 (JAK2) gene. Materials and Methods: MNPs were synthesized by the coprecipitation method and coated with tetraethyl orthosilicate (TEOS). The size and shape of the complexes were estimated using transmission electron microscopy. Twenty blood samples from patients with myeloproliferative disorders were used for DNA isolation with the MNPs. DNA quality and compatibility for molecular genetic studies of the JAK2 V617F mutation were investigated by gel electrophoresis and real-time polymerase chain reaction (RT-PCR). Results: The average amount of DNA isolated from 150 μL of whole blood was 75.2 ng when MNPs were used and 72.5 ng when standard silica sorbent was used. There was no DNA damage observed after interaction with MNPs. RT-PCR demonstrated similar values for the JAK2 V617F mutant DNA ratios in the samples after DNA isolation with MNPs and by standard sorption on silica. Conclusions: MNPs with silicate capsules of sufficient thickness were obtained and the undesirable damaging effect of iron oxides on nucleic acids during isolation from cells were eliminated. Designed MNPs allow obtaining intact DNA for molecular genetic studies using the example of the JAK2 V617F for study.

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Держатели документа:
RAS, Krasnoyarsk Sci Ctr, Fed Res Ctr, Siberian Branch, Akademgorodok 50,Str 12-2, Krasnoyarsk 660036, Russia.
Fed Res Ctr KSC SB RAS, Kirensky Inst Phys, Krasnoyarsk, Russia.
Siberian Fed Univ, Krasnoyarsk, Russia.
Fed Med Biol Agcy, Fed Siberian Res Clin Ctr, Fed State Financed Inst, Krasnoyarsk, Russia.
Natl Res Ctr Hematol, Dept Hlth, Krasnoyarsk Branch, Krasnoyarsk, Russia.

Доп.точки доступа:
Tyumentseva, Anna, V; Yaroslavtsev, R. N.; Ярославцев, Роман Николаевич; Stolyar, S. V.; Столяр, Сергей Викторович; Saitova, Alina T.; Саитова, Алина Тимуровна; Tyutrina, Ekaterina S.; Gorbenko, Alexey S.; Stolyar, Marina A.; Olkhovskiy, Igor A.
}
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    Part II. Nanobubbles around plasmonic nanoparticles in terms of modern simulation modeling: what makes them kill the malignant cells? / A. S. Kostyukov, I. L. Isaev, A. E. Ershov [et al.] // J. Phys. D. - 2022. - Vol. 55, Is. 17. - Ст. 175402, DOI 10.1088/1361-6463/ac4c1f. - Cited References: 49. - The research was supported by the Ministry of Science and High Education of Russian Federation (Project No. FSRZ-2020-0008), and was funded by RFBR, Krasnoyarsk Territory and Krasnoyarsk Regional Fund of Science, Project No. 20-42-240003 . - ISSN 0022-3727. - ISSN 1361-6463
   Перевод заглавия: Часть II. Нанопузырьки вокруг плазмонных наночастиц с точки зрения современного имитационного моделирования: что заставляет их убивать злокачественные клетки?

РУБ Physics, Applied
Рубрики:
STRESS WAVES
   LASER
   MEMBRANE
   DAMAGE
   DEATH
   LYSIS
Кл.слова (ненормированные):
photothermal effect -- plasmonic nanoparticle -- malignant cell membrane -- pulsed laser radiation -- finite elements analysis -- anticancer therapy -- aptamer
Аннотация: We have established numerically the physical pattern and conditions for formation of nanosized bubbles in aqueous medium around biocompatible plasmonic nanoparticles (NPs) selectively bound to the membrane of the malignant cells by means of DNA-aptamers under the action of picosecond laser radiation. The results obtained are based on the finite volume method and hydrodynamic models underlying the ANSYS Fluent package with extended capabilities. We have found the main features and previously unknown dominant factors of the damage effect on the cell membrane at the moment of the bubble nucleation around the plasmonic NPs of different types taking into account the influence of the closely located membrane. Information on the kinetics of spatial distribution of pressure, temperature and the relative proportion of vapor in the 'nanoparticle-membrane-medium' system have been obtained. The attention is drawn to the advantages of using biocompatible, perfectly absorbing core–shell plasmonic NPs for anti-tumor therapy characterized by an increased mechanical effect on malignant cell membranes at lower laser radiation intensity and the spectral position of their plasmon resonance (λ = 700 nm) in the hemoglobin transparency range. This ensures penetration of laser radiation deep into tissues. The paper is provided with an extensive review of key publications and the state-of-art in this area.

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Держатели документа:
Siberian Fed Univ, Int Res Ctr Spect & Quantum Chem IRC SQC, Krasnoyarsk 660041, Russia.
Russian Acad Sci, Inst Computat Modelling, Siberian Branch, Krasnoyarsk 660036, Russia.
Fed Med Biol Agcy Russian Federat, Fed Siberian Res Clin Ctr, Krasnoyarsk 660037, Russia.
Russian Acad Sci, LV Kirensky Inst Phys, Fed Res Ctr KSC, Siberian Branch, Krasnoyarsk 660036, Russia.

Доп.точки доступа:
Kostyukov, A. S.; Isaev, I. L.; Ershov, A. E.; Gerasimov, V. S.; Polyutov, S. P.; Karpov, S. V.; Карпов, Сергей Васильевич; Ministry of Science and High Education of Russian Federation [FSRZ-2020-0008]; RFBRRussian Foundation for Basic Research (RFBR); Krasnoyarsk Territory and Krasnoyarsk Regional Fund of Science [20-42-240003]
}
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