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1.


   
    Electrochemical aptasensor for lung cancer-related protein detection in crude blood plasma samples / G. S. Zamay [et al.] // Sci. Rep. - 2016. - Vol. 6. - Ст. 34350, DOI 10.1038/srep34350. - Cited References:24. - Authors thank Dr. Mahmoud Labib and Galina Kudryasheva. This work was supported by Ministry of Education and Science of Russian Federation Federal Target Program #14.604.21.0105 for Anna S. Zamay. Electron microscopy was carried out at the Multiple-Access Center of Krasnoyarsk Research Center Siberian branch of Russian Academy of Science. . - ISSN 2045-2322
РУБ Multidisciplinary Sciences
Рубрики:
SQUARE-WAVE VOLTAMMETRY
   GENE-EXPRESSION

   SERUM

   BIOSENSORS

   DIAGNOSIS

   ADENOCARCINOMA

   BIOMARKERS

   SENSOR

Аннотация: The development of an aptamer-based electrochemical sensor for lung cancer detection is presented in this work. A highly specific DNA-aptamer, LC-18, selected to postoperative lung cancer tissues was immobilized onto a gold microelectrode and electrochemical measurements were performed in a solution containing the redox marker ferrocyanide/ferricyanide. The aptamer protein targets were harvested from blood plasma of lung cancer patients by using streptavidin paramagnetic beads and square wave voltammetry of the samples was performed at various concentrations. In order to enhance the sensitivity of the aptasensor, silica-coated iron oxide magnetic beads grafted with hydrophobic C8 and C4 alkyl groups were used in a sandwich detection approach. Addition of hydrophobic beads increased the detection limit by 100 times. The detection limit of the LC-18 aptasensor was enhanced by the beads to 0.023 ng/mL. The formation of the aptamer -protein -bead sandwich on the electrode surface was visualized by electron microcopy. As a result, the electrochemical aptasensor was able to detect cancer-related targets in crude blood plasma of lung cancer patients.

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Держатели документа:
Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, 1 P Zheleznyaka, Krasnoyarsk 660022, Russia.
Russian Acad Sci, Siberian Branch, Inst Chem & Chem Technol, 50-24 Akademgorodok, Krasnoyarsk 660036, Russia.
Design Dept Iskra, 1 Televizornaya, Krasnoyarsk 660028, Russia.
Russian Acad Sci, Siberian Branch, Krasnoyarsk Res Ctr, 50 Akademgorodok, Krasnoyarsk 660036, Russia.
Krasnoyarsk Reg Clin Canc Ctr, 1 Smolenskaya, Krasnoyarsk 660022, Russia.
Univ Ottawa, Dept Chem, 10 Marie Curie,DIorio Hall,Room 201, Ottawa, ON K1N 6N5, Canada.
Russian Acad Sci, Siberian Branch, Inst Phys, 50-38 Akademgorodok, Krasnoyarsk 660036, Russia.

Доп.точки доступа:
Zamay, G. S.; Zamay, T. N.; Kolovskii, V. A.; Shabanov, A. V.; Шабанов, Александр Васильевич; Glazyrin, Y. E.; Veprintsev, D. V.; Krat, A. V.; Zamay, S. S.; Kolovskaya, O. S.; Gargaun, A.; Sokolov, A. E.; Соколов, Алексей Эдуардович; Modestov, A. A.; Artyukhov, I. P.; Chesnokov, N. V.; Petrova, M. M.; Berezovski, M. V.; Zamay, A. S.; Ministry of Education and Science of Russian Federation Federal Target Program [14.604.21.0105]
}
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2.


   
    Model of a tunable hybrid Tamm mode-liquid crystal device / M. V. Pyatnov, R. G. Bikbaev, I. V. Timofeev, S. Y. Vetrov // Appl. Optics. - 2020. - Vol. 59, Is. 21. - P. 6347-6351, DOI 10.1364/AO.395901. - Cited References: 37. - Russian Foundation for Basic Research (19-52-52006) . - ISSN 1559-128X. - ISSN 2155-3165
РУБ Optics
Рубрики:
PLASMON
   PHASE

   SENSOR

   STATES

Аннотация: A concept of an easily tunable device based on hybrid Tamm modes is proposed. The device can be controlled using a high-sensitivity chiral liquid crystal serving as a mirror. The coupling of the chiral optical Tamm state with the Tamm plasmons is predicted. The Tamm plasmons are excited at different frequencies for the orthogonal linear polarizations, while the chiral Tamm state is excited at only one frequency. The properties of the proposed model are analytically and numerically calculated. The possibility of creating a two- and three-mode laser with tunable characteristics on the basis of the proposed model is discussed.

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Держатели документа:
Russian Acad Sci, Fed Res Ctr, Kirensky Inst Phys, Siberian Branch,Krasnoyarsk Sci Ctr, Krasnoyarsk, Russia.
Siberian Fed Univ, Krasnoyarsk, Russia.

Доп.точки доступа:
Pyatnov, M. V.; Пятнов, Максим Владимирович; Bikbaev, R. G.; Бикбаев, Рашид Гельмединович; Timofeev, I. V.; Тимофеев, Иван Владимирович; Vetrov, S. Ya.; Ветров, Степан Яковлевич; Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR) [19-52-52006]
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